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The Wide Variety of miRNA Expression Profiles in the Developing and Mature CNS

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Macro Roles for MicroRNAs in the Life and Death of Neurons

Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Abstract

Although microRNA (miRNA) expression is prominent in the central nervous system (CNS), very few miRNAs have been studied in detail in this system. We performed a comprehensive analysis of the neuroanatomical expression profiles of 38 abundantly conserved miRNAs in developing and adult zebrafish brain. We observed a wide variety of different miRNA expression profiles in neural cells, ranging from single cell types to the majority of CNS cells and from transient to constitutive expression. The survey of miRNA expression patterns suggested several modes of action within neural cells, such as function in neural stem cells/progenitors, clearance of target mRNAs at spatial or temporal transitions, silencing of aberrant transcription and spatial and/or temporal regulation of target mRNA translation within mature neural cells.

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Acknowledgments

I am indebted to Steve Wilson, Ronald Plasterk, Wigard Kloosterman and Ewart de Bruijn for establishing this collaborative project. I am grateful to Frederic Rosa for all his support during this work and to the IPSEN foundation for giving me the opportunity to present our data in their conference. Finally, I would like to thank the funding organisms of this project (ZF-Models integrated project, CNRS, INSERM, Wellcome Trust, BBSRC, Council for Earth and Life Sciences from the Netherlands Organization for Scientific Research and ZonMw).

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Authors and Affiliations

  1. INSERM U784, Génétique Moléculaire du Développement, Ecole Normale Supérieure, 46, rue d´Ulm, 7530, Paris Cedex 05, France

    Marika Kapsimali

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  1. Marika Kapsimali
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Editors and Affiliations

  1. Center Human Genetics, Katholieke Universiteit Leuven, Herestraat 49, Leuven, 3000, Belgium

    Bart De Strooper

  2. Recherche Therapeutique, Fondation IPSEN pour la, quai George Gorse 65, Boulogne Billancourt Cedex, 92650, France

    Yves Christen

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Kapsimali, M. (2010). The Wide Variety of miRNA Expression Profiles in the Developing and Mature CNS. In: De Strooper, B., Christen, Y. (eds) Macro Roles for MicroRNAs in the Life and Death of Neurons. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04298-0_2

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