Abstract
Each year millions of new cancers are diagnosed, and chemotherapy remains the principal mode of treatment for many of them. Development of chemoresistance, first described in 1970, is a challenging obstacle during the treatment of local and disseminated malignancies and has been described as the single most common reason for discontinuation of a chemotherapeutic agent. The phenomenon of multi-drug resistance (MDR), as one of the major causes of chemotherapy failure, has been defined as the insensitivity of various tumors to a variety of chemically related or unrelated anti-neoplastic or cytotoxic agents, mediated by a process of inactivating the drug or removing it from the target tumor cells [1].
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References
Luqmani YA (2005) Mechanisms of drug resistance in cancer chemotherapy. Med Princ Pract 14(Suppl 1):35–48
Georges E, Bradley G, Gariepy J, Ling V (1990) Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc Natl Acad Sci USA 87:152–156
Rothenberg M, Ling V (1989) Multidrug resistance: molecular biology and clinical relevance. J Natl Cancer Inst 81:907–910
Pichler A, Zelcer N, Prior JL, Kuil AJ, Piwnica-Worms D (2005) In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res 11:4487–4494
Ferry DR, Kerr DJ (1994) Multidrug resistance in cancer. BMJ 308:148–149
Mohan HK, Miles KA (2009) Cost-effectiveness of 99mTc-sestamibi in predicting response to chemotherapy in patients with lung cancer: systematic review and meta-analysis. J Nucl Med 50:376–381
Piwnica-Worms D, Chiu ML, Budding M, Kronauge JF, Kramer RA, Croop JM (1993) Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res 53:977–984
Perek N, Le Jeune N, Denoyer D, Dubois F (2005) MRP-1 protein expression and glutathione content of in vitro tumor cell lines derived from human glioma carcinoma U-87-MG do not interact with 99mTc-glucarate uptake. Cancer Biother Radiopharm 20:391–400
Lorke DE, Kruger M, Buchert R, Bohuslavizki KH, Clausen M, Schumacher U (2001) In vitro and in vivo tracer characteristics of an established multidrug-resistant human colon cancer cell line. J Nucl Med 42:646–654
Ballinger JR, Hua HA, Berry BW, Firby P, Boxen I (1995) 99Tcm-sestamibi as an agent for imaging P-glycoprotein-mediated multi-drug resistance: in vitro and in vivo studies in a rat breast tumour cell line and its doxorubicin-resistant variant. Nucl Med Commun 16:253–257
Moretti JL, Duran Cordobes M, Starzec A et al (1998) Involvement of glutathione in loss of technetium-99m-MIBI accumulation related to membrane MDR protein expression in tumor cells. J Nucl Med 39:1214–1218
Yamaguchi S, Yachiku S, Hashimoto H et al (2002) Relation between technetium 99m-methoxyisobutylisonitrile accumulation and multidrug resistance protein in the parathyroid glands. World J Surg 26:29–34
Utsunomiya K, Ballinger JR, Piquette-Miller M et al (2000) Comparison of the accumulation and efflux kinetics of technetium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line. Eur J Nucl Med 27:1786–1792
Tsai SC, Shiau YC, Wang JJ, Ho YJ, Kao CH (2001) Comparison of the uptake and clearance of Tc-99m MIBI, Tl-201 and Ga-67 in drug-resistant lymphoma cell lines. Cancer Lett 171:147–152
Marian T, Szabo G, Goda K et al (2003) In vivo and in vitro multitracer analyses of P-glycoprotein expression-related multidrug resistance. Eur J Nucl Med Mol Imaging 30:1147–1154
Ballinger JR, Bannerman J, Boxen I, Firby P, Hartman NG, Moore MJ (1996) Technetium-99m-tetrofosmin as a substrate for P-glycoprotein: in vitro studies in multidrug-resistant breast tumor cells. J Nucl Med 37:1578–1582
Piwnica-Worms D, Rao VV, Kronauge JF, Croop JM (1995) Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation. Biochemistry 34:12210–12220
Cordobes MD, Starzec A, Delmon-Moingeon L et al (1996) Technetium-99m-sestamibi uptake by human benign and malignant breast tumor cells: correlation with mdr gene expression. J Nucl Med 37:286–289
Ballinger JR, Sheldon KM, Boxen I, Erlichman C, Ling V (1995) Differences between accumulation of 99mTc-MIBI and 201Tl-thallous chloride in tumour cells: role of P-glycoprotein. Q J Nucl Med 39:122–128
Gomes CM, Abrunhosa AJ, Pauwels EK, Botelho MF (2009) P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin. Cancer Biother Radiopharm 24:215–227
van Leeuwen FW, Buckle T, Kersbergen A, Rottenberg S, Gilhuijs KG (2009) Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity. Eur J Nucl Med Mol Imaging 36:406–412
Bae KT, Piwnica-Worms D (1997) Pharmacokinetic modeling of multidrug resistance P-glycoprotein transport of gamma-emitting substrates. Q J Nucl Med 41:101–110
Vecchio SD, Ciarmiello A, Potena MI et al (1997) In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients. Eur J Nucl Med 24:150–159
Salvatore M, Del Vecchio S (1998) Dynamic imaging: scintimammography. Eur J Radiol 27(Suppl 2):S259–S264
Cayre A, Cachin F, Maublant J et al (2002) Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression. Int J Oncol 20:1049–1055
Sergieva SB, Timcheva KV, Hadjiolov ND (2006) 99mTc-MIBI scintigraphy as a functional method for the evaluation of multidrug resistance in breast cancer patients. J BUON 11:61–68
Liu Z, Stevenson GD, Barrett HH et al (2005) Imaging recognition of inhibition of multidrug resistance in human breast cancer xenografts using 99mTc-labeled sestamibi and tetrofosmin. Nucl Med Biol 32:573–583
Liu Z, Stevenson GD, Barrett HH et al (2004) Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. Nucl Med Biol 31:53–65
Dirlik A, Burak Z, Goksel T et al (2002) The role of Tc-99m sestamibi imaging in predicting clinical response to chemotherapy in lung cancer. Ann Nucl Med 16:103–108
Moretti JL, Caglar M, Boaziz C, Caillat-Vigneron N, Morere JF (1995) Sequential functional imaging with technetium-99m hexakis-2-methoxyisobutylisonitrile and indium-111 octreotide: Can we predict the response to chemotherapy in small cell lung cancer? Eur J Nucl Med 22:177–180
Del Vecchio S, Ciarmiello A, Salvatore M (2000) Scintigraphic detection of multidrug resistance in cancer. Cancer Biother Radiopharm 15:327–337
Chen WS, Luker KE, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D (2000) Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin. Biochem Pharmacol 60:413–426
Muzzammil T, Moore MJ, Ballinger JR (2000) In vitro comparison of sestamibi, tetrofosmin, and furifosmin as agents for functional imaging of multidrug resistance in tumors. Cancer Biother Radiopharm 15:339–346
Dyszlewski M, Blake HM, Dahlheimer JL, Pica CM, Piwnica-Worms D (2002) Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity. Mol Imaging 1:24–35
Ballinger JR, Muzzammil T, Moore MJ (1997) Technetium-99m-furifosmin as an agent for functional imaging of multidrug resistance in tumors. J Nucl Med 38:1915–1919
Rao VV, Herman LW, Kronauge JF, Piwnica-Worms D (1998) A novel areneisonitrile Tc complex inhibits the transport activity of MDR P-glycoprotein. Nucl Med Biol 25:225–232
Crankshaw CL, Marmion M, Luker GD et al (1998) Novel technetium (III)-Q complexes for functional imaging of multidrug resistance (MDR1) P-glycoprotein. J Nucl Med 39:77–86
Bergmann R, Brust P, Scheunemann M et al (2000) Assessment of the in vitro and in vivo properties of a (99m)Tc-labeled inhibitor of the multidrug resistant gene product P-glycoprotein. Nucl Med Biol 27:135–141
Ballinger JR (2001) 99mTc-tetrofosmin for functional imaging of P-glycoprotein modulation in vivo. J Clin Pharmacol 41(Suppl):39S–47S
Yokogami K, Kawano H, Moriyama T et al (1998) Application of SPET using technetium-99m sestamibi in brain tumours and comparison with expression of the MDR-1 gene: Is it possible to predict the response to chemotherapy in patients with gliomas by means of 99mTc-sestamibi SPET? Eur J Nucl Med 25:401–409
Hendrikse NH (2000) Monitoring interactions at ATP-dependent drug efflux pumps. Curr Pharm Des 6:1653–1668
Lewis JS, Dearling JL, Sosabowski JK et al (2000) Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET. Eur J Nucl Med 27:638–646
Kabasakal L, Ozker K, Hayward M et al (1996) Technetium-99m sestamibi uptake in human breast carcinoma cell lines displaying glutathione-associated drug-resistance. Eur J Nucl Med 23:568–570
Del Vecchio S, Ciarmiello A, Pace L et al (1997) Fractional retention of technetium-99m-sestamibi as an index of P-glycoprotein expression in untreated breast cancer patients. J Nucl Med 38:1348–1351
Muzzammil T, Ballinger JR, Moore MJ (1999) 99Tcm-sestamibi imaging of inhibition of the multidrug resistance transporter in a mouse xenograft model of human breast cancer. Nucl Med Commun 20:115–122
Kostakoglu L, Elahi N, Kiratli P et al (1997) Clinical validation of the influence of P-glycoprotein on technetium-99m-sestamibi uptake in malignant tumors. J Nucl Med 38:1003–1008
Sun SS, Hsieh JF, Tsai SC, Ho YJ, Kao CH (2000) Expression of drug resistance protein related to Tc-99m MIBI breast imaging. Anticancer Res 20:2021–2025
Sun SS, Hsieh JF, Tsai SC, Ho YJ, Lee JK, Kao CH (2000) Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results. Cancer Lett 153:95–100
Kao CH, Tsai SC, Liu TJ et al (2001) P-Glycoprotein and multidrug resistance-related protein expressions in relation to technetium-99m methoxyisobutylisonitrile scintimammography findings. Cancer Res 61:1412–1414
Alonso O, Delgado L, Nunez M et al (2002) Predictive value of (99m)Tc sestamibi scintigraphy in the evaluation of doxorubicin based chemotherapy response in patients with advanced breast cancer. Nucl Med Commun 23:765–771
Kim R, Osaki A, Hirai T, Toge T (2002) Utility of technetium-99m methoxyisobutyl isonitrile uptake analysis for prediction of the response to chemotherapy in advanced and relapsed breast cancer. Breast Cancer 9:240–247
Baena-Canada JM, Partida-Palma F, Palomo-Gonzalez MJ, Benitez E, Rueda-Ramos A, Garcia-Curiel A (2005) Evaluation of response to neoadjuvant chemotherapy using breast scintigraphy in breast cancer. Med Clin Barc 125:601–605
Fujii H, Nakamura K, Kubo A et al (1998) Preoperative evaluation of the chemosensitivity of breast cancer by means of double phase 99mTc-MIBI scintimammography. Ann Nucl Med 12:307–312
Cui SD, Liu ZZ, Liu H, Li LF, Yang H, Li WL (2005) The relationship between 99mTc-MIBI scintimammography of breast cancer and multidrug-resistant proteins. Zhonghua Zhong Liu Za Zhi 27:606–608
Mubashar M, Harrington KJ, Chaudhary KS et al (2002) 99mTc-sestamibi imaging in the assessment of toremifene as a modulator of multidrug resistance in patients with breast cancer. J Nucl Med 43:519–525
Kim IJ, Bae YT, Kim SJ, Kim YK, Kim DS, Lee JS (2006) Determination and prediction of P-glycoprotein and multidrug-resistance-related protein expression in breast cancer with double-phase technetium-99m sestamibi scintimammography. Visual and quantitative analyses. Oncology 70:403–410
Yamamoto Y, Nishiyama Y, Fukunaga K, Satoh K, Fujita J, Ohkawa M (2001) 99mTc-MIBI SPECT in small cell lung cancer patients before chemotherapy and after unresponsive chemotherapy. Ann Nucl Med 15:329–335
Yüksel M, Cermik TF, Karlikaya C et al (2001) Monitoring the chemotherapeutic response in primary lung cancer using 99mTc-MIBI SPET. Eur J Nucl Med Mol Imaging 28:799–806
Yüksel M, Cermik TF, Doğanay L et al (2002) 99mTc-MIBI SPET in non-small cell lung cancer in relationship with Pgp and prognosis. Eur J Nucl Med Mol Imaging 29:876–881
Kao A, Shiun SC, Hsu NY, Sun SS, Lee CC, Lin CC (2001) Technetium-99m methoxyisobutylisonitrile chest imaging for small-cell lung cancer: relationship to chemotherapy response (six courses of combination of cisplatin and etoposide) and p-glycoprotein or multidrug resistance related protein expression. Ann Oncol 12:1561–1566
Nishiyama Y, Yamamoto Y, Satoh K et al (2000) Comparative study of Tc-99m MIBI and Tl-201 SPECT in predicting chemotherapeutic response in non-small-cell lung cancer. Clin Nucl Med 25:364–369
Kao CH, Hsieh JF, Tsai SC, Ho YJ, Lee JK (2000) Quickly predicting chemotherapy response to paclitaxel-based therapy in non-small cell lung cancer by early technetium-99m methoxyisobutylisonitrile chest single-photon-emission computed tomography. Clin Cancer Res 6:820–824
Ceriani L, Giovanella L, Bandera M, Beghe B, Ortelli M, Roncari G (1997) Semiquantitative assessment of 99Tcm-sestamibi uptake in lung cancer: relationship with clinical response to chemotherapy. Nucl Med Commun 18:1087–1097
Bom HS, Lim SC, Kim YC et al (1999) Dipyridamole modulated Tc-99m sestamibi lung SPECT in small cell lung cancer. Clin Nucl Med 24:97–101
Kostakoglu L, Kiratli P, Ruacan S et al (1998) Association of tumor washout rates and accumulation of technetium-99m-MIBI with expression of P-glycoprotein in lung cancer. J Nucl Med 39:228–234
Bom HS, Kim YC, Song HC, Min JJ, Kim JY, Park KO (1998) Technetium-99m-MIBI uptake in small cell lung cancer. J Nucl Med 39:91–94
Kao CH, ChangLai SP, Chieng PU, Yen TC (1998) Technetium-99m methoxyisobutylisonitrile chest imaging of small cell lung carcinoma: relation to patient prognosis and chemotherapy response–a preliminary report. Cancer 83:64–68
Shih CM, Hsu WH, Huang WT, Wang JJ, Ho ST, Kao A (2003) Usefulness of chest single photon emission computed tomography with technetium-99m methoxyisobutylisonitrile to predict taxol based chemotherapy response in advanced non-small cell lung cancer. Cancer Lett 199:99–105
Koukourakis MI, Koukouraki S, Giatromanolaki A, Skarlatos J, Georgoulias V, Karkavitsas N (1997) Non-small cell lung cancer functional imaging: increased hexakis-2-methoxy-isobutyl-isonitrile tumor clearance correlates with resistance to cytotoxic treatment. Clin Cancer Res 3:749–754
Zhou J, Higashi K, Ueda Y et al (2001) Expression of multidrug resistance protein and messenger RNA correlate with (99m)Tc-MIBI imaging in patients with lung cancer. J Nucl Med 42:1476–1483
Ak I, Gulbas Z, Ocak S et al (2007) TC-99m MIBI SPECT imaging in patients with lung carcinoma: Is it a functional probe of multidrug resistance genes? J Comput Assist Tomogr 31:795–799
Sasajima T, Shimada N, Naitoh Y et al (2007) (99m)Tc-MIBI imaging for prediction of therapeutic effects of second-generation MDR1 inhibitors in malignant brain tumors. Int J Cancer 121:2637–2645
Andrews DW, Das R, Kim S, Zhang J, Curtis M (1997) Technetium-MIBI as a glioma imaging agent for the assessment of multi-drug resistance. Neurosurgery 40:1323–1332, discussion 33–34
Shibata Y, Matsumura A, Nose T (2002) Effect of expression of P-glycoprotein on technetium-99m methoxyisobutylisonitrile single photon emission computed tomography of brain tumors. Neurol Med Chir Tokyo 42:325–330, discussion 30–31
Hau P, Fabel K, Baumgart U et al (2004) Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma. Cancer 100:1199–1207
Kunishio K, Morisaki K, Matsumoto Y, Nagao S, Nishiyama Y (2003) Technetium-99m sestamibi single photon emission computed tomography findings correlated with P-glycoprotein expression, encoded by the multidrug resistance gene-1 messenger ribonucleic acid, in intracranial meningiomas. Neurol Med Chir Tokyo 43:573–580, discussion 81
Kunishio K, Okada M, Matsumoto Y, Nagao S, Nishiyama Y (2006) Technetium-99m sestamibi single photon emission computed tomography findings correlated with P-glycoprotein expression in pituitary adenoma. J Med Invest 53:285–291
Kao CH, Tsai SC, Wang JJ, Ho YJ, Ho ST, Changlai SP (2001) Technetium-99m-sestamethoxyisobutylisonitrile scan as a predictor of chemotherapy response in malignant lymphomas compared with P-glycoprotein expression, multidrug resistance-related protein expression and other prognosis factors. Br J Haematol 113:369–374
Qiao SK, Guo XN, Wang Y, Xu SR (2007) The clinical value of the 99Tcm-MIBI imaging in predicting the prognosis of malignant lymphoma. Zhonghua Yi Xue Za Zhi 87:2003–2006
Shih WJ, Rastogi A, Stipp V, Magoun S, Coupal J (1998) Functional retention of Tc-99m MIBI in mediastinal lymphomas as a predictor of chemotherapeutic response demonstrated by consecutive thoracic SPECT imaging. Clin Nucl Med 23:505–508
Kostakoglu L (2002) Noninvasive detection of multidrug resistance in patients with hematological malignancies: Are we there yet? Clin Lymphoma 2:242–248
Ak I, Aslan V, Vardareli E, Gulbas Z (2003) Assessment of the P-glycoprotein expression by 99mTc-MIBI bone marrow imaging in patients with untreated leukaemia. Nucl Med Commun 24:397–402
Pace L, Catalano L, Del Vecchio S et al (2005) Washout of [99mTc] sestamibi in predicting response to chemotherapy in patients with multiple myeloma. Q J Nucl Med Mol Imaging 49:281–285
Fallahi B, Beiki D, Mousavi SA et al (2009) 99mTc-MIBI whole body scintigraphy and P-glycoprotein for the prediction of multiple drug resistance in multiple myeloma patients. Hell J Nucl Med 12:255–259
Fonti R, Del Vecchio S, Zannetti A et al (2004) Functional imaging of multidrug resistant phenotype by 99mTc-MIBI scan in patients with multiple myeloma. Cancer Biother Radiopharm 19:165–170
Leitha T, Glaser C, Lang S (1998) Is early sestamibi imaging in head and neck cancer affected by MDR status, p53 expression, or cell proliferation? Nucl Med Biol 25:539–541
Burak Z, Yuksel DA, Cetingul N, Kantar M, Ozkilic H, Moretti JL (1999) The role of 99Tcm-sestamibi scintigraphy in the staging and prediction of the therapeutic response of stage IV neuroblastoma: comparison with 131I-MIBG and 99Tcm-MDP scintigraphy. Nucl Med Commun 20:991–1000
De Moerloose B (2005) The prognostic significance of P-glycoprotein in children with acute lymphoblastic leukemia and neuroblastoma. Verh K Acad Geneeskd Belg 67:45–54
Ozcan Z, Erenel G, Aksoylar S, Kansoy S, Burak Z, Ozkilic H (1999) False-negative scintigraphy with Tc-99m sestamibi in stage IV neuroblastoma. Clin Nucl Med 24:267–270
Han Y, Chen XP, Huang ZY, Zhu H (2005) Nude mice multi-drug resistance model of orthotopic transplantation of liver neoplasm and Tc-99m MIBI SPECT on p-glycoprotein. World J Gastroenterol 11:3335–3338
Chang CS, Yang SS, Yeh HZ, Kao CH, Chen GH (2004) Tc-99m MIBI liver imaging for hepatocellular carcinoma: correlation with P-glycoprotein-multidrug-resistance gene expression. Hepatogastroenterology 51:211–214
Kawata K, Kanai M, Sasada T, Iwata S, Yamamoto N, Takabayashi A (2004) Usefulness of 99mTc-sestamibi scintigraphy in suggesting the therapeutic effect of chemotherapy against gastric cancer. Clin Cancer Res 10:3788–3793
Kim YS, Cho SW, Lee KJ et al (1999) Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma. Clin Nucl Med 24:874–879
Burak Z, Ersoy O, Moretti JL et al (2001) The role of 99mTc-MIBI scintigraphy in the assessment of MDR1 overexpression in patients with musculoskeletal sarcomas: comparison with therapy response. Eur J Nucl Med 28:1341–1350
Burak Z, Moretti JL, Ersoy O et al (2003) 99mTc-MIBI imaging as a predictor of therapy response in osteosarcoma compared with multidrug resistance-associated protein and P-glycoprotein expression. J Nucl Med 44:1394–1401
Gomes CM, Welling M, Que I et al (2007) Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using 99mTc-sestamibi. Eur J Nucl Med Mol Imaging 34:1793–1803
Gorlick R, Liao AC, Antonescu C et al (2001) Lack of correlation of functional scintigraphy with (99m)technetium-methoxyisobutylisonitrile with histological necrosis following induction chemotherapy or measures of P-glycoprotein expression in high-grade osteosarcoma. Clin Cancer Res 7:3065–3070
Moretti JL, Hauet N, Caglar M, Rebillard O, Burak Z (2005) To use MIBI or not to use MIBI? That is the question when assessing tumour cells. Eur J Nucl Med Mol Imaging 32:836–842
Pusztai L, Wagner P, Ibrahim N et al (2005) Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma. Cancer 104:682–691
Fuster D, Vinolas N, Mallafre C, Pavia J, Martin F, Pons F (2003) Tetrofosmin as predictors of tumour response. Q J Nucl Med 47:58–62
Gruber A, Arestrom I, Xu D, Liliemark J, Larsson SA, Jacobsson H (1998) Multidrug resistance phenotype in leukaemic cells from patients with acute myelocytic leukaemia can be detected with 99Tc(m)-MIBI. Br J Cancer 77:1732–1736
Bates SF, Chen C, Robey R, Kang M, Figg WD, Fojo T (2002) Reversal of multidrug resistance: lessons from clinical oncology. Novartis Found Symp 243:83–96, discussion 102, 80–85
Jekerle V, Wang JH, Scollard DA, Reilly RM, Wiese M, Piquette-Miller M (2006) 99mTc-Sestamibi, a sensitive probe for in vivo imaging of P-glycoprotein inhibition by modulators and mdr1 antisense oligodeoxynucleotides. Mol Imaging Biol 8:333–339
Tatsumi M, Tsuruo T, Nishimura T (2002) Evaluation of MS-209, a novel multidrug-resistance-reversing agent, in tumour-bearing mice by technetium-99m-MIBI imaging. Eur J Nucl Med Mol Imaging 29:288–294
Chen CC, Meadows B, Regis J et al (1997) Detection of in vivo P-glycoprotein inhibition by PSC 833 using Tc-99m sestamibi. Clin Cancer Res 3:545–552
Tunggal JK, Melo T, Ballinger JR, Tannock IF (2000) The influence of expression of P-glycoprotein on the penetration of anticancer drugs through multicellular layers. Int J Cancer 86:101–107
Cayre A, Moins N, Finat-Duclos F, Verrelle P, Maublant J (1997) Comparison between technetium-99m-sestamibi and hydrogen-3-daunomycin myocardial cellular retention in vitro. J Nucl Med 38:1674–1677
Del Vecchio S, Ciarmiello A, Salvatore M (1999) Clinical imaging of multidrug resistance in cancer. Q J Nucl Med 43:125–131
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Gholamrezanezhad, A. (2012). Oncologic Applications of Sestamibi: In Vivo Imaging of Multi-Drug Resistance. In: Bucerius, J., Ahmadzadehfar, H., Biersack, HJ. (eds) 99mTc-Sestamibi. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04233-1_9
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