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Regulation of p27kip1 mRNA Expression by MicroRNAs

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miRNA Regulation of the Translational Machinery

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 50))

Abstract

p27kip1 (p27) is a cell cycle inhibitor and tumor suppressor whose expression is highly regulated in the cell. Low levels of p27 have been associated with poor prognosis in cancer. Recently, several microRNAs have been described to control p27 expression in various tumor types. In this chapter, we will provide an overview on the role of microRNAs in cancer, and will discuss how microRNAs regulate p27 expression and the implications for tumor progression.

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Acknowledgments

Work in the author’s laboratory was supported by grants 02/028-00 from La Caixa Foundation, grants BMC2003-04108 and BFU2006-01874 from the Spanish Ministry of Education and Science, and grant 2005SGR00669 from the Department of Universities, Information and Sciences of the Generalitat of Catalunya (DURSI).

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  1. Centre de Regulació Genòmica (CRG-UPF), Gene Regulation Programme, Dr Aiguader 88, 08003, Barcelona, Spain

    Aida Martínez-Sánchez & Fátima Gebauer

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  1. Aida Martínez-Sánchez
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  2. Fátima Gebauer
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Correspondence to Fátima Gebauer .

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  1. Health Science Center, Dept. Biochemistry & Molecular Biology, Louisiana State University, Kings Highway 1501, Shreveport, 71130-3932, Louisiana, USA

    Robert E. Rhoads

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Martínez-Sánchez, A., Gebauer, F. (2010). Regulation of p27kip1 mRNA Expression by MicroRNAs. In: Rhoads, R. (eds) miRNA Regulation of the Translational Machinery. Progress in Molecular and Subcellular Biology(), vol 50. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03103-8_4

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