Abstract
The term “pineal region tumors” includes both the neoplasms originating from the pineal body and those originating from the adjacent anatomical structures, such as the thalamus, the dorsal midbrain, and the fal-cotentorium. The term “pineal tumors” indicates the former. Glial tumors originating from the tectum and meningiomas originating from the falcotentorial junction are not a true pineal tumor. Primary pineal tumors are mainly composed of two categories of brain neoplasms, pineal parenchymal tumors and germ cell tumors (Table 14.1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Allen JC, Kim JH, Packer RJ. (1987) Neoadjuvant chemotherapy for newly diagnosed germ-cell tumors of the central nervous system. J Neurosurg 67:65–70
Allen JC, DaRosso RC, Donahue B, Nirenberg A. (1994) A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous system. Cancer 74:940–944
Aoyama H, Shirato H, Ikeda J, Fujieda K, Miyasaka K, Sawamura Y. (2002) Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors. J Clin Oncol 20:857–865
Bader JL, Miller RW, Meadows AT, Zimmerman LE, Champion LA, Voute PA. (1980) Trilateral retinoblastoma. Lancet 2:582–583
Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, Maher P, Vlamis V, Walker RW, Leibel S, Finlay JL. (1996) Chemotherapy without irradiation — a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. J Clin Oncol 14:2908–2915
Bamberg M, Kortmann RD, Calaminus G, Becker G, Meisner C, Harms D, Gobel U. (1999) Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol 17:2585–2592
Bayens YC, Helle PA, Van Putten WL, Mali SP. (1992) Orchidectomy followed by radiotherapy in 176 stage I and II testicular seminoma patients: benefits of a 10-year follow-up study. Radiother Oncol 25:97–102
Brown AE, Leibundgut K, Niggli FK, Betts DR. (2006) Cytogenetics of pineoblastoma: four new cases and a literature review. Cancer Genet Cytogenet 170:175–179
Calaminus G, Bamberg M, Baranzelli MC, Benoit Y, di Montezemolo LC, Fossati-Bellani F, Jurgens H, Kuhl HJ, Lenard HG, Curto ML. (1994) Intracranial germ cell tumors: a comprehensive update of the European data. Neuropediatrics 25:26–32
Chang SM, Lillis-Hearne PK, Larson DA, Wara WM, Bollen AW, Prados MD. (1995) Pineoblastoma in adults. Neurosurgery 37:383–390
Chiechi M V, Smirniotopoulos JG, Mena H. (1995) Pineal parenchymal tumors: CT and MR features. J Comput Assist Tomogr 19:509–171
D'Andrea AD, Packer RJ, Rorke LB, Bilaniuk LT, Sutton LN, Bruce DA, Schut L. (1987) Pineocytomas of childhood. A reappraisal of natural history and response to therapy. Cancer 59:1353–1357
Echevarria ME, Fangusaro J, Goldman S. (2008) Pediatric central nervous system germ cell tumors: a review. Oncologist 13:690–699
Fauchon F, Jouvet A, Paquis P, Saint-Pierre G, Mottolese C, Ben Hassel M, Chauveinc L, Sichez JP, Philippon J, Schlienger M, Bouffet E. (2000) Parenchymal pineal tumors: a clinicopathological study of 76 cases. Int J Radiat Oncol Biol Phys 46(4):959–68
Fevre-Montange M, Champier J, Szathmari A, Wierinckx A, Mottolese C, Guyotat J, Figarella-Branger D, Jouvet A, Lachuer J. (2006) Microarray analysis reveals differential gene expression patterns in tumors of the pineal region. J Neuropathol Exp Neurol 65:675–684
Horwich A, Shipley J, Huddart R. (2006) Testicular germ-cell cancer. Lancet 367:754–765
Jakacki RI, Zeltzer PM, Boyett JM, Albright AL, Allen JC, Geyer JR, Rorke LB, Stanley P, Stevens KR, Wisoff J, et al (1995) Survival and prognostic factors following radiation and/or chemotherapy for primitive neuroectodermal tumors of the pineal region in infants and children: a report of the Childrens Cancer Group. J Clin Oncol 13:1377–1383
Jouvet A, Saint-Pierre G, Fauchon F, Privat K, Bouffet E, Ruchoux MM, Chauveinc L, Fevre-Montange M. (2000) Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases. Brain Pathol 10(1):49–60
Kamakura Y, Hasegawa M, Minamoto T, Yamashita J, Fujisawa H. (2006) C-kit gene mutation: common and widely distributed in intracranial germinomas. J Neurosurg 104:173–180
Kochi M, Itoyama Y, Shiraishi S, Kitamura I, Marubayashi T, Ushio Y. (2003) Successful treatment of intracranial non-germinomatous malignant germ cell tumors by administering neoadjuvant chemotherapy and radiotherapy before excision of residual tumors. J Neurosurg 99:106–114
Li MH, Bouffet E, Hawkins CE, Squire JA, Huang A. (2005) Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. Neurosurg Focus 19:E3
Lutterbach J, Fauchon F, Schild SE, Chang SM, Pagenstecher A, Volk B, Ostertag C, Momm F, Jouvet A. (2002) Malignant pineal parenchymal tumors in adult patients: patterns of care and prognostic factors. Neurosurgery 51:44–55
Sawamura Y, de Tribolet N, Ishii N, Abe H. (1997) Surgical management of primary intracranial germinomas: diagnostic surgery or radical Resection ? J Neurosurg 87:262–266
Sawamura Y, Ikeda J, Shirato H, Tada M, Abe H. (1998) Germ cell tumors of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes. Eur J Cancer 34:104–110
Sawamura Y, de Tribolet N. (2001) Neurosurgical management of pineal tumors. Adv Tech Stand Neurosurg 27:1–22
Schild SE, Scheithauer BW, Schomberg PJ, Hook CC, Kelly PJ, Frick L, Robinow JS, Buskirk SJ. (1993) Pineal parenchymal tumors. Clinical, pathologic, and therapeutic aspects. Cancer 72:870–880
Schneider DT, Zahn S, Sievers S, Alemazkour K, Reifenberger G, Wiestler OD, Calaminus G, Gobel U, Perlman EJ. (2006) Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization. Mod Pathol 19:864–873
Shirato H, Aoyama H, Ikeda J, Fujieda K, kato N, Ishi N, Miyasaka K, Iwasaki Y, Sawamura Y. (2004) Impact of margin for target volume in low-dose involved field radiotherapy after induction chemotherapy for intracranial germinoma. Int J Radiat Oncol Biol Phys 60:214–217
The Committee of Brain Tumor Registry of Japan (BTRJ). (2003) Brain Tumor Registry of Japan (BTRJ 1969–1996). 11th edition, Neurol-Med Chir 43(Suppl):29
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Sawamura, Y., Radovanovic, I., de Tribolet, N. (2010). Tumors of the Pineal Region. In: Tonn, JC., Westphal, M., Rutka, J.T. (eds) Oncology of CNS Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02874-8_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-02874-8_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-02873-1
Online ISBN: 978-3-642-02874-8
eBook Packages: MedicineMedicine (R0)