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Dengue Vaccine Candidates in Development

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Dengue Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 338))

Abstract

Each of the DENV serotypes can cause the full spectrum of dengue illness. Epidemiological studies have implicated preexisting heterotypic DENV antibody as a risk factor for more severe disease upon secondary DENV infection. For these reasons, a successful DENV vaccine must protect against all four DENV serotypes. Live attenuated DENV vaccine candidates are the furthest along in development and clinical evaluation. Two live attenuated tetravalent vaccine candidates are in Phase 2 clinical trials in DENV endemic regions. Numerous other vaccine candidates including inactivated whole virus, recombinant subunit protein, DNA and virus-vectored vaccines are also under development. Those DENV vaccine candidates that have been evaluated in preclinical animal models or in clinical trials will be discussed.

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Authors and Affiliations

  1. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA

    Anna P. Durbin

  2. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

    Stephen S. Whitehead

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  1. Anna P. Durbin
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  2. Stephen S. Whitehead
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Correspondence to Anna P. Durbin .

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  1. Medical School, University of Massachusetts, Lake Avenue N. 55, Worcester, 01655, U.S.A.

    Alan L. Rothman

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Durbin, A.P., Whitehead, S.S. (2010). Dengue Vaccine Candidates in Development. In: Rothman, A. (eds) Dengue Virus. Current Topics in Microbiology and Immunology, vol 338. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02215-9_10

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