Zusammenfassung
Die Bildung eines thrombozytenreichen Thrombus v. a. im Bereich arterieller Gefäßschädigungen nimmt ihren Anfang mit der raschen Adhäsion und Aktivierung zirkulierender Thrombozyten an der nach Endothelschädigung exponierten extrazellulären Matrix. Insbesondere die Exposition subendothelialer Kollagenfasern nach Verletzung oder Plaqueruptur stellt einen sehr starken thrombozytenaktivierenden Reiz dar, der eine Kaskade von Prozessen in Gang setzt. Unmittelbar im Anschluss daran werden weitere Thrombozyten rekrutiert und das koagulatorische System wird aktiviert, was schließlich zur Bildung des durch Fibrin stabilisierten Thrombus führt.
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Offermanns, S. (2010). Thrombozytäre Signaltransduktion. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_10
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