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Immune Chemistry of ASA

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Immune Infertility

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Abstract

Immune chemistry of antisperm antibody (ASA) encompasses all the types of antisperm antibody reactions in humans that are ontogenically driven by (a) “natural” antibodies, (b) prepubertally derived ASA due to testicular failure, (c) adult ASA in males and females, and (d) carbohydrate-mediated epitopes. Both sexes (with exception of boys before puberty) present active immune tolerance to male gametes which allows to resume a natural intercourse as well as permanent gamete differentiation in spermatogenesis. “Natural” antibodies are developed as a part of immune history of the individual but they are also essential elements of innate immunity in both sexes. ASA developed before puberty are well characterized by proteomic approach and deserve more attention. ASA reactions in males and females are fairly well studied while carbohydrate-mediated chemistry of ASA activity is still a complex issue under study.

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Authors and Affiliations

  1. Department of Reproductive Biology and Stem Cells, Institute of Human Genetics, Polish Academy of Sciences, Strzeszynska 32, 60-479, Poznan, Poland

    Maciej Kurpisz

Authors
  1. Maciej Kurpisz
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  2. Marzena Kamieniczna
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Correspondence to Maciej Kurpisz .

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Editors and Affiliations

  1. Klinik für Andrologie und Venerologie, Universitätsklinikum Marburg, Deutschhausstr. 9, Marburg, 35033, Germany

    Walter K.H. Krause

  2. School of Medicine, West Virginia University, Morgantown, 26506, U.S.A.

    Rajesh K. Naz

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© 2009 Springer-Verlag Berlin Heidelberg

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Kurpisz, M., Kamieniczna, M. (2009). Immune Chemistry of ASA. In: Krause, W., Naz, R. (eds) Immune Infertility. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01379-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-01379-9_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01378-2

  • Online ISBN: 978-3-642-01379-9

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