Abstract
The point mutations in the form of single nucleotide replacements occurring during the human–chimpanzee divergence process are analyzed in order to obtain an insight into the nature of the constraints that are imposed on various levels of cellular machinery upon the mutational events. The replacement patterns were examined separately for CpG islands (CGI), coding DNA regions, repetitive and nonrepetitive regions and for average genomic regions. The replacement counts were processed by the algebra based upon the rate equations. The starting point was the replacement count matrix. On this basis the replacement probability matrices were calculated. A model replacement probability matrix with three free parameters was constructed and the optimization procedure was used to determine the parameters. The replacements within the CGI and non-CGI regions were reproduced to the extent where the correlation coefficients attained values close to r = 0.9. For the exonic sequences the relative matrix of mutation rejections was calculated and it was found that the differences in the amino acid polarities and their opposites—the hydrophobicities—correlate in the greatest extent with the mutation rejection probabilities.
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This work was financed by the Slovenian Research Agency.
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Borštnik, B., Oblak, B., Pumpernik, D. (2009). The Evolutionary Constraints in Mutational Replacements. In: Pontarotti, P. (eds) Evolutionary Biology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00952-5_15
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DOI: https://doi.org/10.1007/978-3-642-00952-5_15
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