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Receptor-Mediated Endocytosis and Intracellular Trafficking of Lipoproteins

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Cellular Lipid Metabolism

Abstract

Members of the low-density lipoprotein receptor (LDLR) gene family are structurally related receptors involved in receptor-mediated endocytosis and signal transduction that regulate a wide range of physiological processes. Receptor-mediated endocytosis of cholesterol-rich LDL and triglyceride-rich lipoproteins (TRL) into the liver via the LDLR and the LDLR-related protein 1 (LRP1) determine the plasma concentrations of proatherogenic lipoproteins. Recent studies indicate that LDLR-mediated internalisation of LDL and very (V)LDL engages a differentially regulated intracellular sorting machinery, suggesting that the LDLR is more than a simple constitutive endocytotic receptor. The binding and internalisation of TRL via hepatic LRP1 is even more complex. After internalisation, LDLR and LRP1 facilitate a different intracellular fate of their ligands. Whereas LDL follows the classical pathway for degradation, TRL disintegrate in late and peripheral endosomes, allowing a differential sorting of TRL components. This chapter summarises current understanding of the molecular mechanisms which are important for the internalisation and subsequent intracellular transport of LDL and TRL mediated by the LDLR and LRP1.

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  1. Institute for Biochemistry and Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg – Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Joerg Heeren & Ulrike Beisiegel

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  1. Joerg Heeren
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  2. Ulrike Beisiegel
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Correspondence to Joerg Heeren .

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    © 2009 Springer-Verlag Berlin Heidelberg

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    Heeren, J., Beisiegel, U. (2009). Receptor-Mediated Endocytosis and Intracellular Trafficking of Lipoproteins. In: Ehnholm, C. (eds) Cellular Lipid Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00300-4_8

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