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Apoptosis in Fungal Development and Ageing

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Physiology and Genetics

Part of the book series: The Mycota ((MYCOTA,volume 15))

Abstract

Although questioned for a long time, accumulating evidence now strongly supports the presence of apoptotic processes in lower eukaryotes. Especially in fungi, both yeasts and filamentous fungi, more and more examples of an apoptotic cell death programme emerged during the past decade. This work revealed that, although fungal apoptosis shares significant similarity with mammalian apoptosis, the mechanistic details involved in the regulation and execution are different. Here we summarise current knowledge about apoptosis in yeasts and in filamentous fungi and we focus on a comprehensive description and evaluation of the role in development and ageing. Specific emphasis is laid on the impact of apoptosis in host--pathogen interactions, sexual development and lifespan control. In addition, we evaluate the differences between fungal and mammalian apoptosis.

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Acknowledgements.

The authors gratefully acknowledge the European Commission (LSHM-CT-2004-512020) and the Deutsche Forschungsgemeinschaft (Bonn, Germany) for supporting experimental work referenced from the authors' laboratory.

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Authors and Affiliations

  1. Institute for Molecular Biosciences, Department of Biosciences and Cluster of Excellence Macromolecular Complexes, Goethe-University, Max-von-Laue-Strasse 9, 60438, Frankfurt, Germany

    Diana Brust, Andrea Hamann & Heinz D. Osiewacz

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  1. Diana Brust
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  2. Andrea Hamann
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  3. Heinz D. Osiewacz
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Correspondence to Diana Brust .

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  1. Inst. Biotechnologie und, TU Kaiserslautern, Erwin-Schrödinger-Str. 56, Kaiserslautern, 67663, Germany

    Timm Anke

  2. MIP Pharma GmbH, Mühlstr. 50, St.Ingbert, 66386, Germany

    Daniela Weber

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Brust, D., Hamann, A., Osiewacz, H.D. (2009). Apoptosis in Fungal Development and Ageing. In: Anke, T., Weber, D. (eds) Physiology and Genetics. The Mycota, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00286-1_4

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