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Comparative Aspects of Hypoxia Tolerance of the Ectothermic Vertebrate Heart

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Cardio-Respiratory Control in Vertebrates

Abstract

This chapter reviews cardiac contractile performance and its regulation during hypoxia/anoxia with regard to cellular metabolism and energy state, in particular hypoxia-tolerant ectothermic vertebrates. Overall the contractile performance of the hypoxic isolated heart muscle varies in a way that relates to the occurrence of hypoxia/anoxia in the natural life of the animal. The hypoxic/anoxic performance of the heart muscle correlates positively with the glycolytic capacity relative to the aerobic capacity, and this performance also tends to be high in hearts having a low aerobic or maximal working capacity. Indirect evidence suggests a particular role for creatine kinase, and that mechanical efficiency may increase in some species. Despite the restricted energy production, hypoxic/anoxic performance is often strongly stimulated by agents such as adrenaline. Frequently, mechanical performance is reduced less by the oxygen lack itself than by factors commonly associated with it, such as increases in extracellular K+.

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Authors and Affiliations

  1. Department of Zoophysiology, Aarhus University, 8000, Aarhus C, Denmark

    H. Gesser & J. Overgaard

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  1. H. Gesser
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  2. J. Overgaard
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Correspondence to H. Gesser .

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  1. Fac. Medicina, Universidade de São Paulo, Avenida Bandeirantes 3900, Ribeirao Preto, 14040-901, Brazil

    Mogens L. Glass

  2. School of Medicine, University of New Mexico, Albuquerque, 87131, U.S.A.

    Stephen C. Wood

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Gesser, H., Overgaard, J. (2009). Comparative Aspects of Hypoxia Tolerance of the Ectothermic Vertebrate Heart. In: Glass, M., Wood, S. (eds) Cardio-Respiratory Control in Vertebrates. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-93985-6_12

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