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Hepatocellular Transport

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Clinical Hepatology

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References

  1. Bu G, Schwartz AL (1994) Receptor-mediated endocytosis. In: Arias IM, Boyer JL, Jakoby WB, Fausto N, Schachter D, Shafritz DA (eds). The liver. Biology and pathobiology. 3rd edn. Raven Press, New York, pp 259–74

    Google Scholar 

  2. Crawford JM (1996) Role of vesicle-mediated transport pathways in hepatocellular bile secretion. Semin Liv Dis 16: 169–89

    Article  CAS  Google Scholar 

  3. Enrich C, Pol A, Calvo M, et al (1999) Dissection of the multifunctional “receptor-recycling” endocytic compartment of hepatocytes. Hepatology 30: 1115–20

    Article  CAS  PubMed  Google Scholar 

  4. Green RM, Beier D, Gollan JL (1996) Regulation of hepato-cyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111: 193–8

    Article  CAS  PubMed  Google Scholar 

  5. Hagenbuch B, Meier PJ (1996) Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liv Dis 16: 129–36

    Article  CAS  Google Scholar 

  6. Kamisako T, Gabazza EC, Ishihara T, et al (1999) Molecular aspects of organic compound transport across the plasma membrane of hepatocytes. J Gastroenterol Hepatol 14: 405–12

    Article  CAS  PubMed  Google Scholar 

  7. König J, Cui Y, Nies AT, et al (2000) A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol 278: G156–64

    Google Scholar 

  8. Kubitz R, Huth C, Schmitt M, et al (2001) Protein kinase C — dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. Hepatology 34: 340–50

    Article  CAS  PubMed  Google Scholar 

  9. Kubitz R, Sutfels G, Kuhlkamp T, et al (2004) Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38MAP kinase. Gastroen-terology 126: 541–53

    Article  CAS  Google Scholar 

  10. Kullak-Ublick GA (1999) Regulation of organic anion and drug transporters of the sinusoidal membrane. J Hepatol 31: 563–73

    Article  CAS  PubMed  Google Scholar 

  11. Kullak-Ublick GA, Stieger B, Meier PJ (2004) Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126: 322–42

    Article  CAS  PubMed  Google Scholar 

  12. Löffler G, Petrides PE (1998) Biochemie und Pathobiochemie. 6. Auflage. Springer, Berlin

    Google Scholar 

  13. Lomri N, Fitz JG, Scharschmidt BF (1996) Hepatocellular transport: role of ATP-binding cassette proteins. Semin Liv Dis 16: 201–10

    Article  CAS  Google Scholar 

  14. Marinelli RA, LaRusso NF (1997) Aquaporin water channels in liver: their significance in bile formation. Hepatology 26: 1081–4

    Article  CAS  PubMed  Google Scholar 

  15. Marinelli RA, Tietz PS, LaRusso NF (2005) Regulated vesicle trafficking of membrane transporters in hepatic epithe-lia. J Hepatology 42: 592–603

    Article  CAS  Google Scholar 

  16. Masyuk AI, LaRusso NF (2006) Aquaporins in the hepato-biliary system. Hepatology 43: S75–81

    Article  CAS  PubMed  Google Scholar 

  17. Meier PJ, Eckhardt U, Schroeder A, et al (1997) Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26: 1667–77

    Article  CAS  PubMed  Google Scholar 

  18. Müller M, Jansen PLM (1998) The secretory function of the liver: new aspects of hepatobiliary transport. J Hepatol 28: 344–54

    Article  PubMed  Google Scholar 

  19. Olkkonen VM, Ikonen E (2000) Genetic defects of intracel-lular-membrane transport. N Engl J Med 343: 1095–104

    Article  CAS  PubMed  Google Scholar 

  20. Pauli-Magnus C, Meier PJ (2003) Pharmacogenetics of hepatocellular transporters. Pharmacogenetics 13: 189–98

    Article  CAS  PubMed  Google Scholar 

  21. Pauli-Magnus C, Meier PJ (2006) Hepatobiliary transporters and drug-induced cholestasis. Hepatology 44: 778–87

    Article  CAS  PubMed  Google Scholar 

  22. Portincasa P, Moschetta A, Mazzone A, et al (2003) Water handling and aquaporins in bile formation: recent advances and research trends. J Hepatol 39: 864–74

    Article  CAS  PubMed  Google Scholar 

  23. Shin HJ, Anzai N, Enomoto A, et al (2007) Novel liver-spe-cific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology 45: 1046–55

    Article  CAS  PubMed  Google Scholar 

  24. Strazzabosco M, Boyer JL (1996) Regulation of intracellular pH in the hepatocyte. Mechanisms and physiological implications. J Hepatol 24: 631–44

    Article  CAS  PubMed  Google Scholar 

  25. Trauner M, Boyer JL (2003) Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 83: 633–71

    CAS  PubMed  Google Scholar 

  26. Wehner F, Kinne RKH, Petzinger E (1996) Second international Ringberg conference: “Cell biology and molecular basis of liver transport”. Hepatology 24: 259–67

    CAS  PubMed  Google Scholar 

  27. Wolkoff AW (1996) Hepatocellular sinusoidal membrane organic anion transport and transporters. Semin Liver Dis 16: 121–7

    Article  CAS  PubMed  Google Scholar 

  28. Wolkoff AW, Suchy FJ, Moseley RH, et al (1998) Advances in hepatic transport: molecular mechanisms, genetic disorders, and treatment. A summary of the 1998 AASLD single topic conference. Hepatology 28: 1713–9

    Article  CAS  PubMed  Google Scholar 

  29. Zhang L, Dresser MJ, Gray AT, et al (1997) Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 51: 913–21

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Chair, Department of Medicine II, Klinikum Offenbach, Goethe University Frankfurt/Main, Starkenburgring 66, Offenbach, 63069, Germany

    Henryk Dancygier (Professor of Medicine)

  2. Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY, USA

    Henryk Dancygier (Professor of Medicine)

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  1. Henryk Dancygier
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Dancygier, H. (2010). Hepatocellular Transport. In: Clinical Hepatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-93842-2_5

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  • DOI: https://doi.org/10.1007/978-3-540-93842-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

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