The target of the action of low temperatures is the water contained in large amounts in the biological objects, thus the phase transitions of water are of primary importance. A typical cryosurgery operation lasts between several minutes and an hour [838]. Cryoaction in medicine consists of a single or several (in cryosurgery) cycles “freezing—exposition—thawing” [346, 474, 745, 782,838]. The interval between the cycles in cryosurgery considerably increases the destruction of the living tissues, leaving the tissue for a longer time in the hypotonic state and providing the sufficient time needed for the blood microcirculation failure to develop [78,190].
Cryoaction could be modulated in time (the so-called “dynamic” cryo-surgery [822] or cryocycling [791]); as experiments show, the frequency of the temperature oscillations, caused by cryoprobe, is conserved throughout the entire region, while its amplitude decays with distance [791].
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© 2009 Springer-Verlag Berlin Heidelberg
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(2009). Ice Formation in Biological Medium. In: Zhmakin, A.I. (eds) Fundamentals of Cryobiology. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88785-0_2
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