Cholera Toxin (CT): Immune Response of the Host and Vaccine Production

Cholera toxin (CT) is also a potent immunomodulator, and it exhibits both mucosal and systemic adjuvant activities. The mechanism by which CT exhibits its adjuvant effect has still remained largely unknown. CT or its component (particularly CTB) also plays a significant role in the preparation of different types of cholera vaccines. While summarizing the important observations that are likely to act as guiding factors in the preparation of vaccines, this chapter presents a brief account of the construction and actions of different killed or live oral cholera vaccines with a short concluding note on the current status of cholera vaccine.