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Renal Cystic Disease

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Radiological Imaging of the Kidney

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Renal cystic disease is a heterogeneous entity including developmental (simple and complex cysts, localized cystic diseases, extraparenchymal sinus cysts, medullary sponge kidney and multicystic dysplastic kidney), acquired (acquired cystic kidney disease) and heritable (autosomal dominant polycsystic kidney disease, autosomal recessive polycystic kidney disease, tuberous sclerosis complex, von Hippel–Lindau disease) disorders. Various imaging modalities are used for the diagnosis and clinical evaluation of renal cystic diseases. While ultrasound is more commonly used as a screening modality, CT and MR imaging are more widely used in clinical settings for characterizing renal cystic lesions, assessing cysts complications and differentiating benign from malignant cystic lesions. The diagnosis of a specific renal cystic disease can be made by a review of the patient’s clinical history in conjunction with radiographic findings. Key imaging features useful for the diagnosis of renal cystic disease include the location, distribution, size, and composition of renal cysts as well as other coexisting noncystic renal lesions and characteristic extrarenal findings.

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References

  • Amis ES Jr, Cronan JJ (1988). The renal sinus: an imaging review and proposed nomenclature for sinus cysts. J Urol 139(6):1151–1159

    Google Scholar 

  • Bae KT, Heiken JP, Siegel CL et al. (2000) Renal cysts: is attenuation artifactually increased on contrast-enhanced CT images? Radiology 216(3):792–796

    Google Scholar 

  • Bae KT, Zhu F, Chapman AB et al. (2006) Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. Clin J Am Soc Nephrol 1(1):64–69

    Google Scholar 

  • Bakir AA, Hasnain M, Young S et al. (1999) Dialysis-associated renal cystic disease resembling autosomal dominant polycystic kidney disease: a report of two cases. Am J Nephrol 19(4):519–522

    Google Scholar 

  • Bernstein J (1976) A classification of renal cysts. Perspect Nephrol Hypertens 4:7–30

    Google Scholar 

  • Birnbaum BA, Hindman N, Lee J et al. (2007) Renal cyst pseudoenhancement: influence of multidetector CT reconstruction algorithm and scanner type in phantom model. Radiology 244(3):767–775

    Google Scholar 

  • Boal DK, Teele RL (1980) Sonography of infantile polycystic kidney disease. AJR Am J Roentgenol 135(3):575–580

    Google Scholar 

  • Bosniak MA (1986) The current radiological approach to renal cysts. Radiology 158(1):1–10

    Google Scholar 

  • Boton R, Gaviria M, Batlle DC (1987) Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis 10(5):329–345

    Google Scholar 

  • Brenner BM, Rector FC (2008) Brenner & Rector’s the kidney, 8th edn. Saunders Elsevier, Philadelphia

    Google Scholar 

  • Brown ED, Semelka RC (1995) Magnetic resonance imaging of the adrenal gland and kidney. Top Magn Reson Imaging 7(2):90–101

    Google Scholar 

  • Casper KA, Donnelly LF, Chen B et al. (2002) Tuberous sclerosis complex: renal imaging findings. Radiology 225(2): 451–456

    Google Scholar 

  • Chapman AB (2008) Approaches to testing new treatments in autosomal dominant polycystic kidney disease: insights from the CRISP and HALT-PKD studies. Clin J Am Soc Nephrol 3(4):1197–1204 (CJN.00060108)

    Google Scholar 

  • Chapman AB, Guay-Woodford LM, Grantham JJ et al. (2003) Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. Kidney Int 64(3):1035–1045

    Google Scholar 

  • Chilton SJ, Cremin BJ (1981) The spectrum of polycystic disease in children. Pediatr Radiol 11(1):9–15

    Google Scholar 

  • Choyke PL (2000) Acquired cystic kidney disease. Eur Radiol 10(11):1716–1721

    Google Scholar 

  • Choyke PL, Filling-Katz MR, Shawker TH et al. (1990) von Hippel-Lindau disease: radiologic screening for visceral manifestations. Radiology 174(3 pt 1):815–820

    Google Scholar 

  • Choyke PL, Glenn GM, Walther MM et al. (1995) von Hippel-Lindau disease: genetic, clinical, and imaging features. Radiology 194(3):629–642

    Google Scholar 

  • Churchill DN, Bear JC, Morgan J et al. (1984) Prognosis of adult onset polycystic kidney disease re-evaluated. Kidney Int 26(2):190–193

    Google Scholar 

  • Churg J, World Health Organization. Collaborating Centre for the Histological Classification of Renal Diseases (1987) Renal disease: classification and atlas, 1st edn. Igaku-Shoin, New York

    Google Scholar 

  • Coulam CH, Sheafor DH, Leder RA et al. (2000) Evaluation of pseudoenhancement of renal cysts during contrast-enhanced CT. AJR Am J Roentgenol 174(2):493–498

    Google Scholar 

  • Dalgaard OZ (1957) Bilateral polycystic disease of the kidneys: a follow-up of two hundred eighty-four patients and their families. Acta Med Scand 328(suppl):1–233

    Google Scholar 

  • Davidson Alan J (1985) Radiology of the kidney. Saunders, Philadelphia

    Google Scholar 

  • Davis F, Coles GA, Harper PS et al. (1991) Polycystic kidney disease re-evaluated: a population-based study. Q J Med 79:477

    Google Scholar 

  • EL-Merhi FM, Bae KT (2004) Cystic renal disease. Magn Reson Imaging Clin N Am 12(3):449–467; vi

    Google Scholar 

  • Ewalt DH, Sheffield E, Sparagana SP et al. (1998) Renal lesion growth in children with tuberous sclerosis complex. J Urol 160(1):141–145

    Google Scholar 

  • Farres MT, Ronco P, Saadoun D et al. (2003) Chronic lithium nephropathy: MR imaging for diagnosis. Radiology 229(2): 570–574

    Google Scholar 

  • Forman HP, Middleton WD, Melson GL et al. (1993) Hyperechoic renal cell carcinomas: increase in detection at US. Radiology 188(2):431–434

    Google Scholar 

  • Gabow PA, Chapman AB, Johnson AM et al. (1990) Renal structure and hypertension in autosomal dominant polycystic kidney disease. Kidney Int 38(6):1177–1180

    Google Scholar 

  • Gardner KD Jr (1988) Cystic kidneys. Kidney Int 33(2):610–621

    Google Scholar 

  • Grantham JJ (2008) Clinical practice. Autosomal dominant polycystic kidney disease. N Engl J Med 359(14):1477–1485

    Google Scholar 

  • Grantham JJ, Chapman AB, Torres VE (2006a) Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes. Clin J Am Soc Nephrol 1(1):148–157

    Google Scholar 

  • Grantham JJ, Levine E (1985) Acquired cystic disease: replacing one kidney disease with another. Kidney Int 28(2):99–105

    Google Scholar 

  • Grantham JJ, Torres VE, Chapman AB et al. (2006b) Volume progression in polycystic kidney disease. N Engl J Med 354(20):2122–2130

    Google Scholar 

  • Greenbaum LA, Hidalgo G, Chand D et al. (2008) Obstacles to the prescribing of growth hormone in children with chronic kidney disease. Pediatr Nephrol 23(9):1531–1535

    Google Scholar 

  • Habif DV Jr, Berdon WE, Yeh MN (1982) Infantile polycystic kidney disease: in utero sonographic diagnosis. Radiology 142(2):475–477

    Google Scholar 

  • Harris PC, Bae KT, Rossetti S et al. (2006) Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 17(11):3013–3019

    Google Scholar 

  • Harrison AR, Rose GA (1979) Medullary sponge kidney. Urol Res 7(3):197–207

    Google Scholar 

  • Hartman DS, Choyke PL, Hartman MS (2004) From the RSNA refresher courses: a practical approach to the cystic renal mass. Radiographics 24(suppl 1):S101–S115

    Google Scholar 

  • Hartman DS, Davis CJ, Sanders RC et al. (1987) The multiloculated renal mass: considerations and differential features. Radiographics 7(1):29–52

    Google Scholar 

  • Hashimoto BE, Filly RA, Callen PW (1986) Multicystic dysplastic kidney in utero: changing appearance on US. Radiology 159(1):107–109

    Google Scholar 

  • Hecht EM, Israel GM, Krinsky GA et al. (2004) Renal masses: quantitative analysis of enhancement with signal intensity measurements versus qualitative analysis of enhancement with image subtraction for diagnosing malignancy at MR imaging. Radiology 232(2):373–378

    Google Scholar 

  • Hilpert PL, Friedman AC, Radecki PD et al. (1986) MRI of hemorrhagic renal cysts in polycystic kidney disease. AJR Am J Roentgenol 146(6):1167–1172

    Google Scholar 

  • Ho VB, Allen SF, Hood MN et al. (2002) Renal masses: quantitative assessment of enhancement with dynamic MR imaging. Radiology 224(3):695–700

    Google Scholar 

  • Huch Boni RA, Debatin JF, Krestin GP (1996) Contrast-enhanced MR imaging of the kidneys and adrenal glands. Magn Reson Imaging Clin North Am 4(1):101–131

    Google Scholar 

  • Ishikawa I (1985) Uremic acquired cystic disease of kidney. Urology 26(2):101–108

    Google Scholar 

  • Karmazyn B, Zerin JM (1997) Lower urinary tract abnormalities in children with multicystic dysplastic kidney. Radiology 203(1):223–226

    Google Scholar 

  • Kimberling WJ, Kumar S, Gabow PA et al. (1993) Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-123. Genomics 18:467–472

    Google Scholar 

  • Laucks SP Jr, McLachlan MS (1981) Aging and simple cysts of the kidney. Br J Radiol 54(637):12–14

    Google Scholar 

  • Lemaitre L, Robert Y, Dubrulle F et al. (1995) Renal angiomyolipoma: growth followed up with CT and/or US [comment]. Radiology 197(3):598–602

    Google Scholar 

  • Leung RS, Biswas SV, Duncan M et al. (2008) Imaging features of von Hippel-Lindau disease. Radiographics 28(1):65–79; quiz 323

    Google Scholar 

  • Levine E (1996) Acquired cystic kidney disease. Radiol Clin North Am 34(5):947–964

    Google Scholar 

  • Levine E, Collins DL, Horton WA et al. (1982) CT screening of the abdomen in von Hippel-Lindau disease. AJR Am J Roentgenol 139(3):505–510

    Google Scholar 

  • Levine E, Cook LT, Grantham JJ (1985) Liver cysts in autosomal-dominant polycystic kidney disease: clinical and computed tomographic study. AJR Am J Roentgenol 145(2): 229–233

    Google Scholar 

  • Levine E, Grantham JJ (1985) High-density renal cysts in autosomal dominant polycystic kidney disease demonstrated by CT. Radiology 154(2):477–482

    Google Scholar 

  • Levine E, Grantham JJ (1992). Calcified renal stones and cyst calcifications in autosomal dominant polycystic kidney disease: clinical and CT study in 84 patients. AJR Am J Roentgenol 159(1):77–81

    Google Scholar 

  • Levine E, Grantham JJ, Slusher SL et al. (1984) CT of acquired cystic kidney disease and renal tumors in long-term dialysis patients. AJR Am J Roentgenol 142(1):125–131

    Google Scholar 

  • Levine E, Hartman DS, Meilstrup JW et al. (1997) Current concepts and controversies in imaging of renal cystic diseases. Urol Clin North Am 24(3):523–543

    Google Scholar 

  • Levine E, Slusher SL, Grantham JJ et al. (1991) Natural history of acquired renal cystic disease in dialysis patients: a prospective longitudinal CT study. AJR Am J Roentgenol 156(3): 501–506

    Google Scholar 

  • Lonergan GJ, Rice RR, Suarez ES (2000) Autosomal recessive polycystic kidney disease: radiologic-pathologic correlation. Radiographics 20(3):837–855

    Google Scholar 

  • Maki DD, Birnbaum BA, Chakraborty DP et al. (1999) Renal cyst pseudoenhancement: beam-hardening effects on CT numbers. Radiology 213(2):468–472

    Google Scholar 

  • Markowitz GS, Radhakrishnan J, Kambham N et al. (2000) Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy. J Am Soc Nephrol 11(8):1439–1448

    Google Scholar 

  • Marotti M, Hricak H, Fritzsche P et al. (1987) Complex and simple renal cysts: comparative evaluation with MR imaging. Radiology 162(3):679–684

    Google Scholar 

  • Maw AM, Megibow AJ, Grasso M et al. (2007) Diagnosis of medullary sponge kidney by computed tomographic urography. Am J Kidney Dis 50(1):146–150

    Google Scholar 

  • Meier M, Beigel A, Schiffer L et al. (2007) Magnetic resonance imaging in a patient with chronic lithium nephropathy. Nephrol Dial Transplant 22(1):278–279

    Google Scholar 

  • Mindell HJ (1989). Imaging studies for screening native kidneys in long-term dialysis patients. AJR Am J Roentgenol 153(4): 768–769

    Google Scholar 

  • Mitnick JS, Bosniak MA, Hilton S et al. (1983) Cystic renal disease in tuberous sclerosis. Radiology 147(1):85–87

    Google Scholar 

  • Morag B, Rubinstein ZJ, Hertz M et al. (1983) Computed tomography in the diagnosis of renal parapelvic cysts. J Comput Assist Tomogr 7(5):833–836

    Google Scholar 

  • Nagata M, Shibata S, Shu Y (2002) Pathogenesis of dysplastic kidney associated with urinary tract obstruction in utero. Nephrol Dial Transplant 17(suppl 9):37–38

    Google Scholar 

  • Nahm AM, Ritz E (2000) The renal sinus cyst-the great imitator. Nephrol Dial Transplant 15(6):913–914

    Google Scholar 

  • Nascimento AB, Mitchell DG, Zhang XM et al. (2001) Rapid MR imaging detection of renal cysts: age-based standards. Radiology 221(3):628–632

    Google Scholar 

  • Nicolau C, Torra R, Badenas C et al. (1999) Autosomal dominant polycystic kidney disease types 1 and 2: assessment of US sensitivity for diagnosis. Radiology 213(1):273–276

    Google Scholar 

  • Parfrey PS, Bear JC, Morgan J et al. (1990) The diagnosis and prognosis of autosomal dominant polycystic kidney disease. N Engl J Med 323(16):1085–1090

    Google Scholar 

  • Pei Y, Obaji J, Dupuis A et al. (2009) Unified criteria for ultrasonographic diagnosis of ADPKD. J Am Soc Nephrol 20(1):205–212

    Google Scholar 

  • Pereira JM, Sirlin CB, Pinto PS et al. (2005) CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls. Radiographics 25(1):69–85

    Google Scholar 

  • Ravine D, Gibson RN, Walker RG et al. (1994) Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1. Lancet 343(8901):824–827

    Google Scholar 

  • Reichard EA, Roubidoux MA, Dunnick NR (1998) Renal neoplasms in patients with renal cystic diseases. Abdominal Imaging 23(3):237–248

    Google Scholar 

  • Rha SE, Byun JY, Jung SE et al. (2004) The renal sinus: pathologic spectrum and multimodality imaging approach. Radiographics 24(suppl 1):S117–S131

    Google Scholar 

  • Sagel SS, Stanley RJ, Levitt RG et al. (1977) Computed tomography of the kidney. Radiology 124(2):359–370

    Google Scholar 

  • Sanders RC, Hartman DS (1984) The sonographic distinction between neonatal multicystic kidney and hydronephrosis. Radiology 151(3):621–625

    Google Scholar 

  • Schwarz A, Lenz T, Klaen R et al. (1993) Hygroma renale: pararenal lymphatic cysts associated with renin-dependent hypertension (Page kidney). Case report on bilateral cysts and successful therapy by marsupialization. J Urol 150(3):953–957

    Google Scholar 

  • Schwarz A, Vatandaslar S, Merkel S et al. (2007) Renal cell carcinoma in transplant recipients with acquired cystic kidney disease. Clin J Am Soc Nephrol 2(4):750–756

    Google Scholar 

  • Semelka Richard C (2002) Abdominal-pelvic MRI. Wiley-Liss, New York, UK

    Google Scholar 

  • Silverman SG, Israel GM, Herts BR et al. (2008) Management of the incidental renal mass. Radiology 249(1):16–31

    Google Scholar 

  • Slywotzky CM, Bosniak MA (2001) Localized cystic disease of the kidney. AJR Am J Roentgenol 176(4):843–849

    Google Scholar 

  • Stapleton FB, Johnson D, Kaplan GW et al. (1980) The cystic renal lesion in tuberous sclerosis. J Pediatr 97(4):574–579

    Google Scholar 

  • Suh M, Coakley FV, Qayyum A et al. (2003) Distinction of renal cell carcinomas from high-attenuation renal cysts at portal venous phase contrast-enhanced CT. Radiology 228(2): 330–334

    Google Scholar 

  • Tada S, Yamagishi J, Kobayashi H et al. (1983) The incidence of simple renal cyst by computed tomography. Clin Radiol 34(4):437–439

    Google Scholar 

  • Takebayashi S, Hidai H, Chiba T et al. (1999) Using helical CT to evaluate renal cell carcinoma in patients undergoing hemodialysis: value of early enhanced images. AJR Am J Roentgenol 172(2):429–433

    Google Scholar 

  • Takebayashi S, Hidai H, Chiba T et al. (2000) Renal cell carcinoma in acquired cystic kidney disease: volume growth rate determined by helical computed tomography. Am J Kidney Dis 36(4):759–766

    Google Scholar 

  • Taouli B, Ghouadni M, Correas JM et al. (2003) Spectrum of abdominal imaging findings in von Hippel-Lindau disease. AJR Am J Roentgenol 181(4):1049–1054

    Google Scholar 

  • Taylor AJ, Cohen EP, Erickson SJ et al. (1989) Renal imaging in long-term dialysis patients: a comparison of CT and sonography. AJR Am J Roentgenol 153(4):765–767

    Google Scholar 

  • Thomsen HS, Levine E, Meilstrup JW et al. (1997) Renal cystic diseases. Eur Radiol 7(8):1267–1275

    Google Scholar 

  • Torres VE, Harris PC, Pirson Y (2007) Autosomal dominant polycystic kidney disease. Lancet 369(9569):1287–1301

    Google Scholar 

  • Turkbey B, Ocak I, Daryanani K et al. (2009) Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis (ARPKD/CHF). Pediatr Radiol 39(2):100–111

    Google Scholar 

  • Vester U, Kranz B, Hoyer PF (2010) The diagnostic value of ultrasound in cystic kidney diseases. Pediatr Nephrol 25(2):231–240

    Google Scholar 

  • Wang ZJ, Coakley FV, Fu Y et al. (2008) Renal cyst pseudoenhancement at multidetector CT: what are the effects of number of detectors and peak tube voltage? Radiology 248(3):910–916

    Google Scholar 

  • Winyard P, Chitty L (2001) Dysplastic and polycystic kidneys: diagnosis, associations and management. Prenat Diagn 21(11):924–935

    Google Scholar 

  • Zerres K, Rudnik-Schoneborn S, Steinkamm C et al. (1998) Autosomal recessive polycystic kidney disease. J Mol Med 76(5):303–309

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Pittsburgh, 3362 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Kyongtae T. Bae & Alessandro Furlan

  2. Department of Radiology, University of Texas, San Antonio, TX, USA

    Fadi M. El-Merhi

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  1. Kyongtae T. Bae
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  2. Alessandro Furlan
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  3. Fadi M. El-Merhi
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Correspondence to Kyongtae T. Bae .

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  1. Ospedale di Cattinara, Ist. Radiologia, Università Trieste, Strada di Fiume 447, Trieste, 34149, Italy

    Emilio Quaia

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Bae, K.T., Furlan, A., El-Merhi, F.M. (2010). Renal Cystic Disease. In: Quaia, E. (eds) Radiological Imaging of the Kidney. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87597-0_12

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