Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Waring GO 3rd, Bourne WM, Edelhauser HF et al (1982) The corneal endothelium: normal and pathologic structure and function. Ophthalmology 89:531–590
Kreutziger GO (1976) Lateral membrane morphology and gap junction structure in rabbit corneal endothelium. Exp Eye Res 23:285–293
Barry PA, Petroll WM, Andrews PM et al (1995) The spatial organization of corneal endothelial cytoskeletal proteins and their relationship to the apical junctional complex. Invest Ophthalmol Vis Sci 36:1115–1124
Petroll WM, Hsu JK, Bean J et al (1999) The spatial organization of apical junctional complex-associated proteins in feline and human corneal endothelium. Curr Eye Res 18:10–19
Ottersen OP, Vegge T (1977) Ultrastructure and distribution of intercellular junctions in corneal endothelium. Acta Ophthalmol (Copenh) 55:69–78
Mandell KJ, Berglin L, Severson EA et al (2007) Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function. Invest Ophthalmol Vis Sci 48:3928–3936
Valtink M, Gruschwitz R, Funk RH et al (2008) Two clonal cell lines of immortalized human corneal endothelial cells show either differentiated or precursor cell characteristics. Cells Tissues Organs 187:286–294
Leuenberger PM (1973) Lanthanum hydroxide tracer studies on rat corneal endothelium. Exp Eye Res 15:85–91
Williams K, Watsky M (2002) Gap junctional communication in the human corneal endothelium and epithelium. Curr Eye Res 25:29–36
Kaye GI, Mishima S, Cole JD et al (1968) Studies on the cornea. VII. Effects of perfusion with a Ca++-free medium on the endothelium. Invest Ophthalmol Vis Sci 7:53–66
Stiemke MM, McCartney MC, Cantu-Crouch D et al (1991) Maturation of the corneal endothelial tight junction. Invest Ophthalmol Vis Sci 32:2757–2765
Maurice DM (1972) The location of the fluid pump in the cornea. J Physiol 221:43–54
Hamann S, Zeuthen T, La Cour M et al (1998) Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye. Am J Physiol 274:C1332–C1345
Tiagarajah JR, Verkman AS (2002) Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency af er swelling. J Biol Chem 277:19139–19144
Laing RA, Sandstrom MM, Berrospi AR et al (1976) Changes in the corneal endothelium as a function of age. Exp Eye Res 22:587–594
Honda H, Ogita Y, Higuchi S et al (1982) Cell movements in a living mammalian tissue: long-term observation of individual cells in wounded corneal endothelial of cats. J Morphol 174:25–39
Matsuda M, Sawa M, Edelhauser HF et al (1985) Cellular migration and morphology in corneal endothelial wound repair. Invest Ophthalmol Vis Sci 26:443–449
Laing RA, Neubauer L, Oak SS et al (1984) Evidence of mitosis in the adult corneal endothelium. Ophthalmology 91:1129–1134
Joyce NC, Meklir B, Joyce SJ et al (1996) Cell cycle protein expression and proliferative status in human corneal cells. Invest Ophthalmol Vis Sci 37:645–655
Joyce NC, Navon SE, Roy S et al (1996) Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ. Invest Ophthalmol Vis Sci 37:1566–1575
Joyce NC, Zhu CC, Harris DL (2009) Relationship between oxidative stress, DNA damage, and proliferative capacity in human corneal endothelium. Invest Ophthalmol Vis Sci 50(5):2116–2122
Senoo T, Joyce NC (2000) Cell cycle kinetics in corneal endothelium from old and young donors. Invest Ophthalmol Vis Sci 41:660–667
Senoo T, Obara Y, Joyce NC (2000) EDTA: a promoter of proliferation in human corneal endothelium. Invest Ophthalmol Vis Sci 41:2930–2935
Baum JL, Niedra R, Davis C et al (1979) Mass culture of human corneal endothelial cells. Arch Ophthalmol 97:1136–1140
Chen KH, Azar D, Joyce NC (2001) Transplantation of adult human corneal endothelium ex vivo. Cornea 20:731–737
Zhu CC, Joyce NC (2004) Proliferative response of corneal endothelial cells from young and older donors. Invest Ophthalmol Vis Sci 45:1743–1751
Leone G, DeGregori J, Jakoi L et al (1999) Collaborative role of E2F transcriptional activity and G1 cyclin dependent kinase activity in the induction of S phase. Proc Natl Acad Sci USA 96:6626–6631
Sherr CJ (1993) Mammalian G1 cyclins. Cell 73:1059–1065
Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704–707
Harper JW, Adami GF, Wei N et al (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1-cyclin-dependent kinases. Cell 75:805–816
Polyak K, Kato JY, Solomon MJ et al (1994) P27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor- β and contact inhibition to cell cycle arrest. Genes Dev 8:9–22
Helton ES, Chen X (2007) p53 modulation of the DNA damage response. J Cell Biochem 100:883–896
Joyce NC, Harris DL, Zieske JD (1998) Mitotic inhibition of corneal endothelium in neonatal rats. Invest Ophthalmol Vis Sci 39:2572–2583
Joyce NC, Harris DL, Mello DM (2002) Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-β2. Invest Ophthalmol Vis Sci 43:2152–2159
Joyce NC (2003) Proliferative capacity of corneal endothe-lium. Prog Retin Eye Res 22:359–389
Gospodarowicz D, Delgado D, Vlodavsky I (1980) Permissive effect of the extracellular matrix on cell proliferation in vitro. Proc Natl Acad Sci USA 77:4094–4098
Wilson SE, Schultz GF, Chegini N et al (1994) Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res 59:63–71
Schultz-Cherry S, Lawler J, Murphy-Ullrich JE (1994) The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J Biol Chem 269:26783–26788
Joyce NC, Zieske JD (1997) Transforming growth factor-beta receptor expression in human cornea. Invest Ophthalmol Vis Sci 38:1922–1928
Harris DL, Joyce NC (1999) Transforming growth factor-beta suppresses proliferation of rabbit corneal endothelial cells in vitro. J Interferon Cytokine Res 19:327–334
Chen KH, Harris DL, Joyce NC (1999) TGF-beta2 in aqueous humor suppresses S-phase entry in cultured corneal endothelial cells. Invest Ophthalmol Vis Sci 40:2513–2519
Kim T Y, Kim WI, Smith RE et al (2001) Role of p27(Kip1) in cAMP- and TGF-beta2-mediated antiproliferation in rabbit corneal endothelial cells. Invest Ophthalmol Vis Sci 42:3142–3149
Chen KH, Hsu WM, Chiang CC et al (2003) Transforming growth factor-beta2 inhibition of corneal endothelial proliferation mediated by prostaglandin. Curr Eye Res 26:363–370
Joyce NC (2005) Cell cycle status in human corneal endothelium. Exp Eye Res 81:629–638
Joyce NC, Zhu CC (2004) Human corneal endothelial cell proliferation: potential for use in regenerative medicine. Cornea 23:S8–S19
Enomoto K, Mimura T, Harris DL et al (2006) Age-related differences in cyclin-dependent kinase inhibitor expression and retinoblastoma hyperphosphorylation in human corneal endothelial cells. Invest Ophthalmol Vis Sci 47:4330–4340
Stoeber K, Tlsty TD, Happerfield I et al (2001) DNA replication licensing and human cell proliferation. J Cell Sci 114:2027–2041
Wharton SB, Chan KK, Anderson JR et al (2001) Replicative Mcm2 protein as a novel proliferation marker in oligo-dendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis. Neuropathol Appl Neurobiol 27:305–313
Mimura T, Joyce NC (2006) Replication competence and senescence in central and peripheral human corneal endothelium. Invest Ophthalmol Vis Sci 47:1387–1396
Quereda V, Martinalbo J, Dubus P et al (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26:7665–7674
Wilson SE, Weng J, Blair S et al (1995) Expression of E6/E7 or SV40 large T antigen-coding oncogenes in human cor-neal endothelial cells indicates regulated high-proliferative capacity. Invest Ophthalmol Vis Sci 36:32–40
Wilson SE, Lloyd SA, He YG et al (1993) Extended life of human corneal endothelial cells transfected with the SV40 large T antigen. Invest Ophthalmol Vis Sci 34:2112–2123
Kikuchi M, Zhu C, Senoo Thet al (2006) p27kip1 siRNA induces proliferation in corneal endothelial cells from young, but not older donors. Invest Ophthalmol Vis Sci 47:4803–4809
McAlister JC, Joyce NC, Harris DL et al (2005) Induction of replication in human corneal endothelial cells by E2F2 transcription factor cDNA transfer. Invest Ophthalmol Vis Sci 46:3597–3603
DeGregori J, Leone G, Miron A et al (1997) Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 94:7245–7250
Amann J, Holley G P, Lee SB et al (2003) Increased endothelial cell density in the paracentral and peripheral regions of the human cornea. Am J Ophthalmol 135:584–590
Bednarz J, Rodokanaki-von Schrenck A, Engelmann K (1998) Different characteristics of endothelial cells from central and peripheral human cornea in primary culture and af er subculture. In Vitro Cell Dev Biol Anim 34:149–153
Campisi J (1996) Replicative senescence: an old lives' tale? Cell 84:497–500
Cristofalo VJ (1988) Cellular biomarkers of aging. Exp Gerontol 23:297–305
Dimri G P, Lee X, Basile G et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363–9367
Hjelmeland LM, Cristofalo VJ, Funk W et al (1999) Senescence of the retinal pigment epithelium. Mol Vis 5:33
Chylack LT Jr (1984) Mechanisms of senile cataract formation. Ophthalmology 91:596–602
Burke JM, Soref C (1988) Topographical variation in growth in cultured bovine retinal pigment epithelium. Invest Ophthalmol Vis Sci 29:1784–1788
Wright WE, Shay JW (1992) Telomere positional effects and the regulation of cellular senescence. Trends Genet 8:193–197
Ben-Porath I, Weinberg RA (2005) The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37:961–976
Egan CA, Savre-Train I, Shay JW et al (1998) Analysis of telomere lengths in human corneal endothelial cells from donors of different ages. Invest Ophthalmol Vis Sci 39:648–653
Konomi K, Joyce NC (2007) Age and topographical comparison of telomere lengths in human corneal endothelial cells. Mol Vis 13:1251–1258
Toussaint O, Medrano EE, von Zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and mel-anocytes. Exp Gerontol 35:927–945
Melov S (2000) Mitochondrial oxidative stress: physiologic consequences and potential for a role in aging. Ann NY Acad Sci 908:219–225
Van der Zee J, Krootjes BBH, Chignell CF et al (1993) Hydroxyl radical generation by a light-dependent Fenton reaction. Free Radic Biol Med 14:105–113
Lombard DB, Chua KF, Mostoslavsky R et al (2005) DNA repair, genome stability, and aging. Cell 120:497–512
Beckman KB, Ames BN (1997) Oxidative decay of DNA. J Biol Chem 272:19633–19636
Von Zglinicki T, Saretzki G, LadhoffJ et al (2005) Human cell senescence as a DNA damage response. Mech Ageing Dev 126:111–117
Lou Z, Chen J (2006) Cellular senescence and DNA repair. Exp Cell Res 312:2641–2646
Chen JH, Stoeber K, Kinsgbury S et al (2004) Loss of pro-liferative capacity and induction of senescence in oxida-tively stressed human fibroblasts. J Biol Chem 279:49439–49446
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Joyce, N.C. (2010). Cell Cycle Control and Replication in Corneal Endothelium. In: Reinhard, T., Larkin, F. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85544-6_6
Download citation
DOI: https://doi.org/10.1007/978-3-540-85544-6_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-85543-9
Online ISBN: 978-3-540-85544-6
eBook Packages: MedicineMedicine (R0)