Skip to main content

Cell Cycle Control and Replication in Corneal Endothelium

  • Chapter
Cornea and External Eye Disease

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Waring GO 3rd, Bourne WM, Edelhauser HF et al (1982) The corneal endothelium: normal and pathologic structure and function. Ophthalmology 89:531–590

    PubMed  Google Scholar 

  2. Kreutziger GO (1976) Lateral membrane morphology and gap junction structure in rabbit corneal endothelium. Exp Eye Res 23:285–293

    Article  PubMed  CAS  Google Scholar 

  3. Barry PA, Petroll WM, Andrews PM et al (1995) The spatial organization of corneal endothelial cytoskeletal proteins and their relationship to the apical junctional complex. Invest Ophthalmol Vis Sci 36:1115–1124

    PubMed  CAS  Google Scholar 

  4. Petroll WM, Hsu JK, Bean J et al (1999) The spatial organization of apical junctional complex-associated proteins in feline and human corneal endothelium. Curr Eye Res 18:10–19

    Article  PubMed  CAS  Google Scholar 

  5. Ottersen OP, Vegge T (1977) Ultrastructure and distribution of intercellular junctions in corneal endothelium. Acta Ophthalmol (Copenh) 55:69–78

    Article  CAS  Google Scholar 

  6. Mandell KJ, Berglin L, Severson EA et al (2007) Expression of JAM-A in the human corneal endothelium and retinal pigment epithelium: localization and evidence for role in barrier function. Invest Ophthalmol Vis Sci 48:3928–3936

    Article  PubMed  Google Scholar 

  7. Valtink M, Gruschwitz R, Funk RH et al (2008) Two clonal cell lines of immortalized human corneal endothelial cells show either differentiated or precursor cell characteristics. Cells Tissues Organs 187:286–294

    Article  PubMed  Google Scholar 

  8. Leuenberger PM (1973) Lanthanum hydroxide tracer studies on rat corneal endothelium. Exp Eye Res 15:85–91

    Article  PubMed  CAS  Google Scholar 

  9. Williams K, Watsky M (2002) Gap junctional communication in the human corneal endothelium and epithelium. Curr Eye Res 25:29–36

    Article  PubMed  Google Scholar 

  10. Kaye GI, Mishima S, Cole JD et al (1968) Studies on the cornea. VII. Effects of perfusion with a Ca++-free medium on the endothelium. Invest Ophthalmol Vis Sci 7:53–66

    CAS  Google Scholar 

  11. Stiemke MM, McCartney MC, Cantu-Crouch D et al (1991) Maturation of the corneal endothelial tight junction. Invest Ophthalmol Vis Sci 32:2757–2765

    PubMed  CAS  Google Scholar 

  12. Maurice DM (1972) The location of the fluid pump in the cornea. J Physiol 221:43–54

    PubMed  CAS  Google Scholar 

  13. Hamann S, Zeuthen T, La Cour M et al (1998) Aquaporins in complex tissues: distribution of aquaporins 1–5 in human and rat eye. Am J Physiol 274:C1332–C1345

    PubMed  CAS  Google Scholar 

  14. Tiagarajah JR, Verkman AS (2002) Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency af er swelling. J Biol Chem 277:19139–19144

    Article  CAS  Google Scholar 

  15. Laing RA, Sandstrom MM, Berrospi AR et al (1976) Changes in the corneal endothelium as a function of age. Exp Eye Res 22:587–594

    Article  PubMed  CAS  Google Scholar 

  16. Honda H, Ogita Y, Higuchi S et al (1982) Cell movements in a living mammalian tissue: long-term observation of individual cells in wounded corneal endothelial of cats. J Morphol 174:25–39

    Article  PubMed  CAS  Google Scholar 

  17. Matsuda M, Sawa M, Edelhauser HF et al (1985) Cellular migration and morphology in corneal endothelial wound repair. Invest Ophthalmol Vis Sci 26:443–449

    PubMed  CAS  Google Scholar 

  18. Laing RA, Neubauer L, Oak SS et al (1984) Evidence of mitosis in the adult corneal endothelium. Ophthalmology 91:1129–1134

    PubMed  CAS  Google Scholar 

  19. Joyce NC, Meklir B, Joyce SJ et al (1996) Cell cycle protein expression and proliferative status in human corneal cells. Invest Ophthalmol Vis Sci 37:645–655

    PubMed  CAS  Google Scholar 

  20. Joyce NC, Navon SE, Roy S et al (1996) Expression of cell cycle-associated proteins in human and rabbit corneal endothelium in situ. Invest Ophthalmol Vis Sci 37:1566–1575

    PubMed  CAS  Google Scholar 

  21. Joyce NC, Zhu CC, Harris DL (2009) Relationship between oxidative stress, DNA damage, and proliferative capacity in human corneal endothelium. Invest Ophthalmol Vis Sci 50(5):2116–2122

    Article  PubMed  Google Scholar 

  22. Senoo T, Joyce NC (2000) Cell cycle kinetics in corneal endothelium from old and young donors. Invest Ophthalmol Vis Sci 41:660–667

    PubMed  CAS  Google Scholar 

  23. Senoo T, Obara Y, Joyce NC (2000) EDTA: a promoter of proliferation in human corneal endothelium. Invest Ophthalmol Vis Sci 41:2930–2935

    PubMed  CAS  Google Scholar 

  24. Baum JL, Niedra R, Davis C et al (1979) Mass culture of human corneal endothelial cells. Arch Ophthalmol 97:1136–1140

    PubMed  CAS  Google Scholar 

  25. Chen KH, Azar D, Joyce NC (2001) Transplantation of adult human corneal endothelium ex vivo. Cornea 20:731–737

    Article  PubMed  CAS  Google Scholar 

  26. Zhu CC, Joyce NC (2004) Proliferative response of corneal endothelial cells from young and older donors. Invest Ophthalmol Vis Sci 45:1743–1751

    Article  PubMed  Google Scholar 

  27. Leone G, DeGregori J, Jakoi L et al (1999) Collaborative role of E2F transcriptional activity and G1 cyclin dependent kinase activity in the induction of S phase. Proc Natl Acad Sci USA 96:6626–6631

    Article  PubMed  CAS  Google Scholar 

  28. Sherr CJ (1993) Mammalian G1 cyclins. Cell 73:1059–1065

    Article  PubMed  CAS  Google Scholar 

  29. Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704–707

    Article  PubMed  CAS  Google Scholar 

  30. Harper JW, Adami GF, Wei N et al (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1-cyclin-dependent kinases. Cell 75:805–816

    Article  PubMed  CAS  Google Scholar 

  31. Polyak K, Kato JY, Solomon MJ et al (1994) P27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor- β and contact inhibition to cell cycle arrest. Genes Dev 8:9–22

    Article  PubMed  CAS  Google Scholar 

  32. Helton ES, Chen X (2007) p53 modulation of the DNA damage response. J Cell Biochem 100:883–896

    Article  PubMed  CAS  Google Scholar 

  33. Joyce NC, Harris DL, Zieske JD (1998) Mitotic inhibition of corneal endothelium in neonatal rats. Invest Ophthalmol Vis Sci 39:2572–2583

    PubMed  CAS  Google Scholar 

  34. Joyce NC, Harris DL, Mello DM (2002) Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-β2. Invest Ophthalmol Vis Sci 43:2152–2159

    PubMed  Google Scholar 

  35. Joyce NC (2003) Proliferative capacity of corneal endothe-lium. Prog Retin Eye Res 22:359–389

    Article  PubMed  CAS  Google Scholar 

  36. Gospodarowicz D, Delgado D, Vlodavsky I (1980) Permissive effect of the extracellular matrix on cell proliferation in vitro. Proc Natl Acad Sci USA 77:4094–4098

    Article  PubMed  CAS  Google Scholar 

  37. Wilson SE, Schultz GF, Chegini N et al (1994) Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res 59:63–71

    Article  PubMed  CAS  Google Scholar 

  38. Schultz-Cherry S, Lawler J, Murphy-Ullrich JE (1994) The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J Biol Chem 269:26783–26788

    PubMed  CAS  Google Scholar 

  39. Joyce NC, Zieske JD (1997) Transforming growth factor-beta receptor expression in human cornea. Invest Ophthalmol Vis Sci 38:1922–1928

    PubMed  CAS  Google Scholar 

  40. Harris DL, Joyce NC (1999) Transforming growth factor-beta suppresses proliferation of rabbit corneal endothelial cells in vitro. J Interferon Cytokine Res 19:327–334

    Article  PubMed  CAS  Google Scholar 

  41. Chen KH, Harris DL, Joyce NC (1999) TGF-beta2 in aqueous humor suppresses S-phase entry in cultured corneal endothelial cells. Invest Ophthalmol Vis Sci 40:2513–2519

    PubMed  CAS  Google Scholar 

  42. Kim T Y, Kim WI, Smith RE et al (2001) Role of p27(Kip1) in cAMP- and TGF-beta2-mediated antiproliferation in rabbit corneal endothelial cells. Invest Ophthalmol Vis Sci 42:3142–3149

    PubMed  CAS  Google Scholar 

  43. Chen KH, Hsu WM, Chiang CC et al (2003) Transforming growth factor-beta2 inhibition of corneal endothelial proliferation mediated by prostaglandin. Curr Eye Res 26:363–370

    Article  PubMed  Google Scholar 

  44. Joyce NC (2005) Cell cycle status in human corneal endothelium. Exp Eye Res 81:629–638

    Article  PubMed  CAS  Google Scholar 

  45. Joyce NC, Zhu CC (2004) Human corneal endothelial cell proliferation: potential for use in regenerative medicine. Cornea 23:S8–S19

    Article  PubMed  Google Scholar 

  46. Enomoto K, Mimura T, Harris DL et al (2006) Age-related differences in cyclin-dependent kinase inhibitor expression and retinoblastoma hyperphosphorylation in human corneal endothelial cells. Invest Ophthalmol Vis Sci 47:4330–4340

    Article  PubMed  Google Scholar 

  47. Stoeber K, Tlsty TD, Happerfield I et al (2001) DNA replication licensing and human cell proliferation. J Cell Sci 114:2027–2041

    PubMed  CAS  Google Scholar 

  48. Wharton SB, Chan KK, Anderson JR et al (2001) Replicative Mcm2 protein as a novel proliferation marker in oligo-dendrogliomas and its relationship to Ki67 labelling index, histological grade and prognosis. Neuropathol Appl Neurobiol 27:305–313

    Article  PubMed  CAS  Google Scholar 

  49. Mimura T, Joyce NC (2006) Replication competence and senescence in central and peripheral human corneal endothelium. Invest Ophthalmol Vis Sci 47:1387–1396

    Article  PubMed  Google Scholar 

  50. Quereda V, Martinalbo J, Dubus P et al (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26:7665–7674

    Article  PubMed  CAS  Google Scholar 

  51. Wilson SE, Weng J, Blair S et al (1995) Expression of E6/E7 or SV40 large T antigen-coding oncogenes in human cor-neal endothelial cells indicates regulated high-proliferative capacity. Invest Ophthalmol Vis Sci 36:32–40

    PubMed  CAS  Google Scholar 

  52. Wilson SE, Lloyd SA, He YG et al (1993) Extended life of human corneal endothelial cells transfected with the SV40 large T antigen. Invest Ophthalmol Vis Sci 34:2112–2123

    PubMed  CAS  Google Scholar 

  53. Kikuchi M, Zhu C, Senoo Thet al (2006) p27kip1 siRNA induces proliferation in corneal endothelial cells from young, but not older donors. Invest Ophthalmol Vis Sci 47:4803–4809

    Article  PubMed  Google Scholar 

  54. McAlister JC, Joyce NC, Harris DL et al (2005) Induction of replication in human corneal endothelial cells by E2F2 transcription factor cDNA transfer. Invest Ophthalmol Vis Sci 46:3597–3603

    Article  PubMed  Google Scholar 

  55. DeGregori J, Leone G, Miron A et al (1997) Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 94:7245–7250

    Article  PubMed  CAS  Google Scholar 

  56. Amann J, Holley G P, Lee SB et al (2003) Increased endothelial cell density in the paracentral and peripheral regions of the human cornea. Am J Ophthalmol 135:584–590

    Article  PubMed  Google Scholar 

  57. Bednarz J, Rodokanaki-von Schrenck A, Engelmann K (1998) Different characteristics of endothelial cells from central and peripheral human cornea in primary culture and af er subculture. In Vitro Cell Dev Biol Anim 34:149–153

    Article  PubMed  CAS  Google Scholar 

  58. Campisi J (1996) Replicative senescence: an old lives' tale? Cell 84:497–500

    Article  PubMed  CAS  Google Scholar 

  59. Cristofalo VJ (1988) Cellular biomarkers of aging. Exp Gerontol 23:297–305

    Article  PubMed  CAS  Google Scholar 

  60. Dimri G P, Lee X, Basile G et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363–9367

    Article  PubMed  CAS  Google Scholar 

  61. Hjelmeland LM, Cristofalo VJ, Funk W et al (1999) Senescence of the retinal pigment epithelium. Mol Vis 5:33

    PubMed  CAS  Google Scholar 

  62. Chylack LT Jr (1984) Mechanisms of senile cataract formation. Ophthalmology 91:596–602

    PubMed  Google Scholar 

  63. Burke JM, Soref C (1988) Topographical variation in growth in cultured bovine retinal pigment epithelium. Invest Ophthalmol Vis Sci 29:1784–1788

    PubMed  CAS  Google Scholar 

  64. Wright WE, Shay JW (1992) Telomere positional effects and the regulation of cellular senescence. Trends Genet 8:193–197

    Article  PubMed  CAS  Google Scholar 

  65. Ben-Porath I, Weinberg RA (2005) The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37:961–976

    Article  PubMed  CAS  Google Scholar 

  66. Egan CA, Savre-Train I, Shay JW et al (1998) Analysis of telomere lengths in human corneal endothelial cells from donors of different ages. Invest Ophthalmol Vis Sci 39:648–653

    PubMed  CAS  Google Scholar 

  67. Konomi K, Joyce NC (2007) Age and topographical comparison of telomere lengths in human corneal endothelial cells. Mol Vis 13:1251–1258

    PubMed  CAS  Google Scholar 

  68. Toussaint O, Medrano EE, von Zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and mel-anocytes. Exp Gerontol 35:927–945

    Article  PubMed  CAS  Google Scholar 

  69. Melov S (2000) Mitochondrial oxidative stress: physiologic consequences and potential for a role in aging. Ann NY Acad Sci 908:219–225

    Article  PubMed  CAS  Google Scholar 

  70. Van der Zee J, Krootjes BBH, Chignell CF et al (1993) Hydroxyl radical generation by a light-dependent Fenton reaction. Free Radic Biol Med 14:105–113

    Article  PubMed  Google Scholar 

  71. Lombard DB, Chua KF, Mostoslavsky R et al (2005) DNA repair, genome stability, and aging. Cell 120:497–512

    Article  PubMed  CAS  Google Scholar 

  72. Beckman KB, Ames BN (1997) Oxidative decay of DNA. J Biol Chem 272:19633–19636

    Article  PubMed  CAS  Google Scholar 

  73. Von Zglinicki T, Saretzki G, LadhoffJ et al (2005) Human cell senescence as a DNA damage response. Mech Ageing Dev 126:111–117

    Article  CAS  Google Scholar 

  74. Lou Z, Chen J (2006) Cellular senescence and DNA repair. Exp Cell Res 312:2641–2646

    Article  PubMed  CAS  Google Scholar 

  75. Chen JH, Stoeber K, Kinsgbury S et al (2004) Loss of pro-liferative capacity and induction of senescence in oxida-tively stressed human fibroblasts. J Biol Chem 279:49439–49446

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Joyce, N.C. (2010). Cell Cycle Control and Replication in Corneal Endothelium. In: Reinhard, T., Larkin, F. (eds) Cornea and External Eye Disease. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85544-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-85544-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85543-9

  • Online ISBN: 978-3-540-85544-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics