Transport of sugars represents an important step in sugar metabolism of bacteria, and is often a limiting step for control of metabolism. Little is known about sugar transport in most lactic acid bacteria (LAB), in particular in heterofermentative strains. In the recent years, important information was obtained from genome sequences of lactic acid bacteria. Here, the annotated genomes of Oenococcus oeni PSU-1 and other wine related LAB, Pediococcus pentosaceus ATCC 25745, Leuconostoc mesenteroides ATCC 8293, Lactobacillus plantarum WCFS1 and Lactococcus lactis ssp. lactis IL1403 were screened for genes which are associated with uptake of sugars. In the homo- and heterofermentative LAB secondary carriers, phosphotransferase systems and ABC transporters are found which are candidates for the uptake of sugars and sugar alcohols.
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References
Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S (2003) Structure and mechanism of the lactose permease of Escherichia coli. Science 301:610–615
Ajdic C, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ (2002) Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A 99(22):14434–14439
Axelsson L (2004) Lactic acid bacteria: classification and physiology. In: Salminen S, Von Wright A (eds.) Lactic Acid Bacteria: Microbiology and Functional Aspects, 3rd edn. Marcel Deker, New York, pp. 1–72
Beelman RB, Gavin A, Keen RN (1977) A new strain of Leuconostoc oenos for induced malo-lactic fermentation in eastern wines. Am J Enol Vit 28(3):159–170
Benthin S, Nielsen J, Villadsen J (1993) Two uptake systems for fructose in Lactococcus lactis subsp. cremoris FD1 produce glycolytic and gluconeogenetic fructose phosphates and induce oscillation in growth and lactic acid formation. Appl Environ Microbiol 59 (10):3206–3211
Blickstad E, Molin G (1981) Growth and lactic acid production of Pediococcus pentosaceus at different gas environments, temperatures, pH values and nitrite concentrations. Eur J Appl Microbiol Biotechnol 13:170–174
Boekhorst J, Siezen RJ, Zwahlen MC, Vilanova D, Pridmore RD, Mercenier A, Kleerebezem M, De Vos WM, Brüssow H, Desiere F (2004) The complete genomes of Lactobacillus plantarum and Lactobacillus johnsonii reveal extensive differences in chromosome organisation and gene content. Microbiology 150:3601–3611
Bolotin A, Wincker P, Mauger S, Jaillon O, Malarme K, Weissenbach J, Ehrlich SD, Sorokin A (2001) The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403. Genome Res 11(5):731–753
Boos W, Lucht JM (1996) Periplasmic binding protein-dependent ABC transporters. In: Neidhardt FC (ed.) Escherichia coli and Salmonella, Cellular and Molecular Biology, 2nd edn. vol 1. ASM Press, Washington, DC, pp. 1175–1209
Chaillou S, Postma PW, Pouwels PH (1998) Functional expression in Lactobacillus plantarum of xylP encoding the isoprimeverose transporter of Lactobacillus pentosus. J Bacteriol 180:4011–4014
Chaillou S, Pouwels PH, Postma PW (1999) Transport of d-Xylose in Lactobacillus pentoses, Lactobacillus casei, and Lactobacillus plantarum: evidence for mechanism of facilitated diffusion via the phosphoenolpyruvate:mannose phosphotransferase system. J Bacteriol 181(16):4768–4773
Cocaign-Bousquet M, Garrigues C, Loubiere P, Lindley ND (1996) Physiology of pyruvate metabolism in Lactococcus lactis. Antonie van Leeuwenhoek 70:253–267
Deutscher J, Francke C, Postma PW (2006) How phosphotransferase system-related protein phos-phorylation regulates carbohydrate metabolism in bacteria. Microbiol Mol Biol Rev 70(4):939–1031
Finn RD, Mistry J, Schuster-Böckler B, Griffiths-Jones S, Hollich V, Lassmann T, Moxon S, Marshall M, Khanna A, Durbin R, Eddy SR, Sonnhammer ELL, Batemann A (2006) Pfam: clans, web tools and services. Nucleic Acids Res 34(database issue):D247–D251
Garrigues C, Loubiere P, Lindley ND, Cocaign-Bousquet M (1997) Control of the shift from homolactic acid to mixed-acid fermentation in Lactococcus lactis: predominant role of the NADH/NAD+; ratio. J Bacteriol 179(17):5282–5287
Garvie EI (1986a) Genus Pediococcus. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG (eds.) Bergey's Manual of Systematic Bacteriology, vol II. Williams & Wilkins, Baltimore, MD, pp. 1075–1079
Garvie EI (1986b) Genus Leuconostoc van Tieghem 1878, 198AL emend mut. char. Hucker and Pederson 1930, 66AL. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG (eds.) Bergey's Manual of Systematic Bacteriology, vol II. Williams&Wilkins, Baltimore, MD, pp. 1071–1074
Grossiord BP, Luesink EJ, Vaugan EE, Arnaud A, De Vos WM (2003) Characterization, expression, and mutation of the Lactococcus lactis galPMKTE genes, involved in galactose utilization via the Leloir pathway. J Bacteriol 185:870–878
Heuberger EH, Smits E, Poolman B (2001) Xyloside transport by XylP, a member of the galacto-side-pentoside-hexuronide family. J Biol Chem 276:34465–34472
Huang Y, Lemieux MJ, Song J, Auer M, Wang DN (2003) Structure and mechanism of the glyc-erol-3-phosphate transporter from Escherichia coli. Science 301(5633):616–620
Huber F, Erni B (1996) Membrane topology of the mannose transporter of Escherichia coli K12. Eur J Biochem 239:810–817
Kandler O (1983) Carbohydrate metabolism in lactic acid bacteria. Antonie van Leeuwenhoek 49:209–224
Kandler O, Weiss N (1986) Genus Lactobacillus. In: Sneath PHA, Mair NS, Sharpe ME, Holt JG (eds.) Bergey's Manual of Systematic Bacteriology, vol II. Williams&Wilkins, Baltimore, MD, pp. 1209–1234
Klaenhammer T, Altermann E, Arigoni F, Bolotin A, Breidt F, Broadbent J, Cano R, Chaillou S, Deutscher J, Gasson M, Van De Guchte M, Guzzo J, Hartke A, Hawkins T, Hols P, Hutkins R, Kleerebezem M, Kok J, Kuipers O, Lubbers M, Maguin E, McKay L, Mills D, Nauta A, Overbeek R, Pel H, Pridmire D, Saier M, Van Sinderen A, Steele J, O'Sullivan D, De Vo s W, Weimer B, Zagorec M, Siezen R (2002) Discovering lactic acid bacteria by genomics. Antonie van Leeuwenhoek 82:29–58
Kleerebezem M, Boekhorst J, van Kranenburg R, Molenaar D, Kuipers OP, Leer R, Tarchini R, Peters SA, Sandbrink HM, Fiers MWEJ, Stiekema W, Klein Lankhorst RM, Bron PA, Hoffer SM, Nierop Groot MN, Kerkhoven R, De Vries M, Ursing B, De Vos WM, Siezen RJ (2003) Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci U S A 100(4):1990–1995
Konings WN (2002) The cell membrane and the struggle for life of lactic acid bacteria. Antonie van Leeuwenhoek 82:3–27
Kundig W, Ghosh S, Roseman S (1964) Phosphate bound to histidine in a protein as an intermediate in a novel phosphor-transferase system. Proc Natl Acad Sci U S A 52:1067–1074
Law J, Buist G, Haandrikman A, Kok J, Venema G, Leenhouts K (1995) A system to generate chromosomal mutations in Lactococcus lactis which allows fast analysis of targeted genes. J Bacteriol 177(24):7011–7018
Lengeler JW, Jahreis K (1996) Phosphotransferase systems or PTS as carbohydrate transport and as signal transduction systems. In: Konings WN, Kaback HR, Lolkema JS (eds.) Handbook of Biological Physics, vol 2. Elsevier, Amsterdam, pp. 573–598
MacPherson AJ, Jones-Mortimer MC, Henderson PJ (1981) Identification of the AraE transport protein of Escherichia coli. Biochem J 196(1):269–283
Markowitz VM, Korzeniewski F, Palaniappan K, Szeto E, Werner G, Padki A, Zhao X, Dubchak I, Hugenholtz P, Anderson I, Lykidis A, Mavromatis K, Ivanova N, Kyrpides N (2006) The integrated microbial genomes (IMG) system. Nulceic Acids Res 34(database issue):D344–D348
Melchiorsen CR, Jokumsen KV, Villadsen J, Isrealsen H, Arnau J (2002) The level of pyruvate-formate lyase controls the shift from homolactic to mixed acid product formation in Lactococcus lactis. Appl Microbiol Biotechnol 58(3):338–344
Mills DA, Rawsthorne H, Parker C, Tamir D, Makarova K (2005) Genomic analysis of Oenococcus oeni PSU-1 and its relevance to winemaking. FEMS Microbiol Rev 29:465–475
Nagasaki H, Ito K, Matsuzaki S, Tanaka S (1992) Existence of phosphoenolpyruvate: carbohydrate phosphotransferase systems in Lactobacillus fermentum, an obligate heterofermenter. Microbiol Immunol 36 (5):553–558
Neves AR, Pool WA, Kok J, Kuipers OP, Santos H (2005) Overview on sugar metabolism and its control in Lactococcus lactis – the input from in vivo NMR. FEMS Microbiol Rev 29:531–554
Palmfeldt J, Paese M, Hahn-Hägerdal B, van Niel EWJ (2004) The pool of ADP and ATP regulates anaerobic product formation in resting cells of Lactococcus lactis. Appl Environ Mircobiol 70(9):5477–5484
Pao SS, Paulsen IT, Saier MH Jr (1998) Major facilitator superfamily. Microbiol Mol Biol Rev 62 (1):1–34
Papagianni M, Avramidis N, Filiousis G (2007) Glycolysis and the regulation of glucose transport in Lactococcus lactis spp. lactis in batch and fed-batch culture. Microb Cell Fact 6:16
Poolman B, Knol J, Van Der Does C, Henderson PJF, Liang WJ, Leblanc G, Pourcher T, Mus-Veteau I (1996) Cation and sugar selectivity determinants in a novel family of transpor proteins. Mol Microbiol 19(5):911–922
Postma PW, Lengeler JW, Jacobson GR (1993) Phosphoenolpyruvate: carbohydrate phospho-transferase systems of bacteria. Microbiol Rev 57(3):543–594
Reizer J, Saier MH Jr, Deutscher J, Grenier F, Thompson J, Hengstenberg W (1988) The phos-phoenolpyruvate:sugar phosphotransferase system in gram-positive bacteria: properties, mechanism, and regulation. Crit Rev Microbial 15(4):297–338
Romano AH, Trifone JD, Brustolon M (1979) Distribution of the phosphoenolpyruvate: glucose phosphotransferase system in fermentative bacteria. J Bacteriol 139(1):93–97
Saier MH Jr (2000) Families of transmembrane sugar transport proteins. Mol Microbiol 35(4):699–710
Saier MH Jr, Ye JJ, Klinke S, Nino E (1996) Identification of an anaerobically induced phosphoe-nolpyruvate-dependent fructose-specific phosphotransferase system and evidence for Embden—Meyerhof glycolytic pathway in the heterofermentative bacterium Lactobacillus brevis. J Bacteriol 178(1):314–316
Saier MH Jr, Tran C V, Barabote RD (2006) TCDB: the transporter classification database for membrane transport protein analyses and information. Nucleic Acids Res(34 database issue): D181–D186
Saulnier DMA, Molenaar D, De Vos WM, Gibson GR, Kolida S (2007) Identification of prebiotic fructooligosaccharide metabolism in Lactobacillus plantarum WCF1 through microarrays. Appl Environ Microbiol 73(6):1753–1765
Saurin W, Hofnung M, Dassa E (1999) Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. J Mol Evol 48(1):22–41
Schleifer KH, Kraus J, Dvorak C, Kilpper-Bälz R, Collins MD, Fischer W (1985) Transfer of Streptococcus lactis and related streptococci to the genus Lactococcus gen. nov. Syst Appl Microbiol 6:183–195
Schneider E, Hunke S (1998) ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains. FEMS Microbiol Rev 22(1):1–20
Sjöberg A, Hahn-Hägerdal B (1989) β-Glucose-1-phosphate, a possible mediator for polysaccharide formation in maltose-assimilating Lactococcus lactis. Appl Environ Microbiol 55(6):1549–1554
Stolz P, Vogel RF, Hammes WP (1995) Utilization of electron acceptors by lactobacilli isolated from sour dough. Z Lebensm Unters Forsch 201:402–410
Tatusov RL, Koonin EV, Lipman DJ (1997) A Genomic perspective on protein families. Science 278:631–637
Teuber M, Geis A (1981) The Family Streptococcaceae (Nonmedical Aspects). In: Starr MP, Stolp H, Trüper HW, Balows A, Schlegel HG (eds.) The Procaryotes, A Handbook on Habitats, Isolation, and Identification of Bacteria. Springer, Berlin, pp. 1614–1630
Thompson J (1980) Galactose transport systems in Streptococcus lactis. J Bacteriol 144(2):683–691
Thompson J (1987) Sugar transport in the lactic acid bacteria. In: Reizer J, Peterskofky A (eds.) Sugar Transport and Metabolism in Gram-positive Bacteria. Ellis Horwood Limited, Chichester, pp. 13–38
Thompson J, Chassy BM (1981) Uptake and metabolism of sucrose by Streptococcus lactis. J Bacteriol 147(2):543–551
Thompson J, Chassy BM (1985) Intracellular phosphorylation of glucose analogs via the phos-phoenolpyruvate:mannose-phosphotransferase system in Streptococcus lactis. J Bacteriol 162(1):224–234
Unden G, Zaunmüller T (2008) Metabolism of sugars and organic acids by lactic acid bacteria from wine and must. Chap. 7, this volume
Veiga-Da-Cunha M, Santos H, van Schaftingen E (1993) Pathway and regulation of erythritol formation in Leucocnostoc oenos. J Bacteriol 175:3941–3948
Yazyu H, Shiota-Niiya S, Shimamoto T, Kanazawa H, Futai M, Tsuchiya T (1984) Nucleotide sequence of the melB gene and characteristics of deduced amino acid sequence of the melibi-ose carrier in Escherichia coli. J Biol Chem 259:4320–4326
Zaunmüller T, Eichert M, Richter H, Unden G (2006) Variations in the energy metabolism of bio-tecgnologically relevant heterofermentative lactic acid bacteria during growth on sugars and organic acids. Appl Microbiol Biotechnol 72(3):421–429
Zhang DS, Lovitt RW (2005) Studies on growth and metabolism of Oenococcus oeni on sugars and sugar mixtures. J Appl Microbiol 99:565–572
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Zaunmüller, T., Unden, G. (2009). Transport of Sugars and Sugar Alcohols by Lactic Acid Bacteria. In: König, H., Unden, G., Fröhlich, J. (eds) Biology of Microorganisms on Grapes, in Must and in Wine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85463-0_8
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