Abstract
Traditionally, chronic obstructive pulmonary disease (COPD) includes pulmonary emphysema and chronic bronchitis. This definition of COPD has been recently modified by the Global Initiative for Chronic Obstructive Lung Disease, which has defined it as a disease state characterized by airflow limitation that is not fully reversible. Pathologically, the chronic airflow limitation characteristic of COPD is caused by a mixture of small airway disease and parenchymal lung destruction. Computed tomography (CT) is superior to chest radiography in the detection of emphysema and in the assessment of its distribution and extent. The introduction of multidetector CT (MDCT) allows acquisition of high-resolution scans in a volumetric manner over the entire lung, and this approach has been shown to be suitable for the assessment of emphysema. The inherent limitations of subjective visual scoring, the characteristic CT morphology of emphysema, and the digital nature of the CT dataset have fostered considerable interest in the use of CT as an objective quantification tool for pulmonary emphysema. The evaluation of the airways on chest radiograph is limited, but it provides an ideal contrast in composition for CT image analysis. MDCT now allows for the acquisition of a contiguous thin section. The current techniques for evaluation of COPD increase the importance of MDCT beyond the clinical context toward its truly experimental and preclinical research modality.
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References
Bankier AA, De Maertelaer V, Keyzer C, Gevenois PA (1999) Pulmonary emphysema: subjective visual grading versus objective quantification with macroscopic morphometry and thin-section CT densitometry. Radiology 211:851–858
Boushy SF, Aboumrad MH, North LB, Helgason AH (1971) Lung recoil pressure, airway resistance, and forced flows related to morphologic emphysema. Am Rev Respir Dis 104:551–561
Calverley PM (2004) The GOLD classification has advanced understanding of COPD. Am J Respir Crit Care Med 170:211–212, discussion 214
Chabat F, Yang GZ, Hansell DM (2003) Obstructive lung diseases: texture classification for differentiation at CT. Radiology 228:871–877
Coxson HO (2008) Quantitative computed tomography assessment of airway wall dimensions: current status and potential applications for phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc 5:940–945
Coxson HO, Rogers RM, Whittall KP, D’yachkova Y, Paré PD, Sciurba FC, Hogg JC (1999) A quantification of the lung surface area in emphysema using computed tomography. Am J Respir Crit Care Med 159:851–856
Desai SR, Hansel DM, Walker A, Macdonald SL, Chabat F, Wells AU (2007) Quantification of emphysema: a composite physiologic index derived from CT estimation of disease extent. Eur Radiol 17:911–918
Dunnill MS (1982) The problem of lung growth. Thorax 37:561–563
Gelb AF, Zamel N, Hogg JC, Müller NL, Schein MJ (1998) Pseudophysiologic emphysema resulting from severe small-airways disease. Am J Respir Crit Care Med 158:815–819
Gevenois PA, Yernault JC (1995) Can computed tomography quantify pulmonary emphysema? Eur Respir J 8:843–848
Gevenois PA, de Maertelaer V, De Vuyst P, Zanen J, Yernault JC (1995) Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 152:653–657
Gevenois PA, Scilla P, de Maertelaer V, Michils A, De Vuyst P, Yernault JC (1996a) The effects of age, sex, lung size, and hyperinflation on CT lung densitometry. AJR Am J Roentgenol 167:1169–1173
Gevenois PA, Scillia P, de Maertelaer V, Zanen J, Jacobovitz D, Cosio MG, Yernault JC (1996b) Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 154:187–192
Gillooly M, Lamb D (1993) Airspace size in lungs of lifelong non-smokers: effect of age and sex. Thorax 48:39–43
Gough J, Wentworth JE (1949) The use of thin sections of entire organs in morbid anatomical studies. J R Microsc Soc 69:231–235
Gould GA, MacNee W, McLean A, Warren PM, Redpath A, Best JJ, Lamb D, Flenley DC (1988) CT measurements of lung density in life can quantitate distal airspace enlargement – an essential defining feature of human emphysema. Am Rev Respir Dis 137:380–392
Hasegawa M, Nasuhara Y, Onodera Y, Makita H, Nagai K, Fuke S, Ito Y, Betsuyaku T, Nishimura M (2006) Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 173:1309–1315
Hayhurst MD, MacNee W, Flenley DC, Wright D, McLean A, Lamb D, Wightman AJ, Best J (1984) Diagnosis of pulmonary emphysema by computerised tomography. Lancet 2:320–322
Hoffman EA, McLennan G (1997) Assessment of the pulmonary structure-function relationship and clinical outcomes measures: quantitative volumetric CT of the lung. Acad Radiol 4:758–776
Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, Pare PD (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350:2645–2653
Hruban RH, Meziane MA, Zerhouni EA, Khouri NF, Fishman EK, Wheeler PS, Dumler JS, Hutchins GM (1987) High resolution computed tomography of inflation-fixed lungs. Pathologic-radiologic correlation of centrilobular emphysema. Am Rev Respir Dis 136:935–940
Kalender WA, Fichte H, Bautz W, Skalej M (1991) Semiautomatic evaluation procedures for quantitative CT of the lung. J Comput Assist Tomogr 15:248–255
Knudson RJ, Standen JR, Kaltenborn WT, Knudson DE, Rehm K, Habib MP, Newell JD (1991) Expiratory computed tomography for assessment of suspected pulmonary emphysema. Chest 99:1357–1366
Kuwano KM, Matsuba K, Ikeda T, Murakami J, Araki A, Nishitani H, Ishida T, Yasumoto K, Shigematsu N (1990) The diagnosis of mild emphysema. Correlation of computed tomography and pathology scores. Am Rev Respir Dis 141:169–178
Lee EY, Litmanovich D, Boiselle PM (2009) Multidetector CT in evaluation of tracheobronchomalacia. Radiol Clin North Am 47:261–269
Madani A, Keyzer C, Gevenois PA (2001) Quantitative computed tomography assessment of lung structure and function in pulmonary emphysema. Eur Respir J 18:720–730
Madani A, Zanen J, de Maertelaer V, Gevenois PA (2006) Pulmonary emphysema: objective quantification at multi-detector row CT – comparison with macroscopic and microscopic morphometry. Radiology 238:1036–1043
Madani A, De Maertelaer V, Zanen J, Gevenois PA (2007) Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification – comparison with macroscopic and microscopic morphometry. Radiology 243:250–257
Madani A, Van Muylem A, de Maertelaer V, Zanen J, Gevenois PA (2008) Pulmonary emphysema: size distribution of emphysematous spaces on multidetector CT images – comparison with macroscopic and microscopic morphometry. Radiology 248:1036–1041
Mayo JR, Aldrich J, Muller NL (2003) Radiation exposure at chest CT: a statement of the Fleischner Society. Radiology 228:15–21
McLean A, Warren PM, Gillooly M, MacNee W, Lamb D (1992) Microscopic and macroscopic measurements of emphysema: relation to carbon monoxide gas transfer. Thorax 47:144–149
Miller RR, Muller NL, Vedal S, Morrison NJ, Staples CA (1989) Limitations of computed tomography in the assessment of emphysema. Am Rev Respir Dis 139:980–983
Mishima M, Hirai T, Itoh H, Nakano Y, Sakai H, Muro S, Nishimura K, Oku Y, Chin K, Ohi M, Nakamura T, Bates JH, Alencar AM, Suki B (1999a) Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 96:8829–8834
Mishima M, Itoh H, Sakai H, Nakano Y, Muro S, Hirai T, Takubo Y, Chin K, Ohi M, Nishimura K, Yamaguchi K, Nakamura T (1999b) Optimized scanning conditions of high resolution CT in the follow-up of pulmonary emphysema. J Comput Assist Tomogr 23:380–384
Mori K, Hasegawa J, Suenaga Y, Toriwaki J (2000) Automated anatomical labeling of the bronchial branch and its application to the virtual bronchoscopy system. IEEE Trans Med Imaging 19:103–114
Müller NL, Coxson H (2002) Chronic obstructive pulmonary disease. 4: imaging the lungs in patients with chronic obstructive pulmonary disease. Thorax 57:982–985
Müller NL, Staples CA, Miller RR, Abboud RT (1988) “Density mask”. An objective method to quantitate emphysema using computed tomography. Chest 94:782–787
Murata K, Itoh H, Todo G, Kanaoka M, Noma S, Itoh T, Furuta M, Asamoto H, Torizuka K (1986) Centrilobular lesions of the lung: demonstration by high-resolution CT and pathologic correlation. Radiology 161:641–645
Murata K, Khan A, Herman PG (1989) Pulmonary parenchymal disease: evaluation with high-resolution CT. Radiology 170:629–635
Nakano Y, Muro S, Sakai H, Hirai T, Chin K, Tsukino M, Nishimura K, Itoh H, Pare PD, Hogg JC, Mishima M (2000) Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function. Am J Respir Crit Care Med 162:1102–1108
Nakano Y, Wong JC, de Jong PA, Buzatu L, Nagao T, Coxson HO, Elliott WM, Hogg JC, Pare PD (2005) The prediction of small airway dimensions using computed tomography. Am J Respir Crit Care Med 171:142–146
Nishimura K, Murata K, Yamagishi M, Itoh H, Ikeda A, Tsukino M, Koyama H, Sakai N, Mishima M, Izumi T (1998) Comparison of different computed tomography scanning methods for quantifying emphysema. J Thorac Imaging 13:193–198
Orlandi I, Moroni C, Camiciottoli G, Bartolucci M, Pistolesi M, Villari N, Mascalchi M (2005) Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology 234: 604–610
Patel BD, Coxson HO, Pillai SG, Agusti AG, Calverley PM, Donner CF, Make BJ, Muller NL, Rennard SI, Vestbo J, Wouters EF, Hiorns MP, Nakano Y, Camp PG, Nasute Fauerbach PV, Screaton NJ, Campbell EJ, Anderson WH, Pare PD, Levy RD, Lake SL, Silverman EK, Lomas DA (2008) Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 178:500–505
Pauwels RA, Buist AS, Ma P, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. Respir Care 46: 798–825
Pugatch RD (1983) The radiology of emphysema. Clin Chest Med 4:433–442
Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176:532–555
Remy-Jardin M, Remy J, Gosselin BC, Copin MC, Wurtz A, Duhamel A (1996) Sliding thin slab, minimum intensity projection technique in the diagnosis of emphysema: histopathologic-CT correlation. Radiology 200:665–671
Snider GL, Kleinerman JL, Thurlbeck WM, Bengali ZH (1985) The definition of emphysema: report of a National Heart, Lung, and Blood Institute, Division of Lung Disease Workshop. Am Rev Respir Dis 132:182–183
Soejima K, Yamaguchi K, Kohda E, Takeshita K, Ito Y, Mastubara H, Oguma T, Inoue T, Okubo Y, Amakawa K, Tateno H, Shiomi T (2000) Longitudinal follow-up study of smoking-induced lung density changes by high-resolution computed tomography. Am J Respir Crit Care Med 161:1264–1273
Sutinen S, Christoforidis AJ, Klugh GA, Pratt PC (1965) Roentgenologic criteria for the recognition of nonsymptomatic pulmonary emphysema. Correlation between roentgenologic findings and pulmonary pathology. Am Rev Respir Dis 91:69–76
Thurlbeck WM (1967) The internal surface area of nonemphysematous lungs. Am Rev Respir Dis 95:765–773
Thurlbeck WM, Müller NL (1994) Emphysema: definition, imaging, and quantification. AJR Am J Roentgenol 163:1017–1025
Thurlbeck WM, Simon G (1978) Radiographic appearance of the chest in emphysema. AJR Am J Roentgenol 130:429–440
Thurlbeck WM, Dunnill MS, Hartung W, Heard BE, Heppleston AG, Ryder RC (1970) A comparison of three methods of measuring emphysema. Hum Pathol 1:215–226
Tiddens HA, Pare PD, Hogg JC, Hop WC, Lambert R, de Jongste JC (1995) Cartilaginous airway dimensions and airflow obstruction in human lungs. Am J Respir Crit Care Med 152:260–266
Tschirren J, Hoffman EA, McLennan G, Sonka M (2005) Intrathoracic airway trees: segmentation and airway morphology analysis from low-dose CT scans. IEEE Trans Med Imaging 24:1529–1539
Turner P, Whimster WF (1981) Volume of emphysema. Thorax 36:932–937
Uppaluri R, Mitsa T, Sonka M, Hoffman EA, McLennan G (1997) Quantification of pulmonary emphysema from lung computed tomography images. Am J Respir Crit Care Med 156:248–254
Webb WR, Stein MG, Finkbeiner WE, Im JG, Lynch D, Gamsu G (1988) Normal and diseased isolated lungs: high-resolution CT. Radiology 166:81–87
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Litmanovich, D., Bankier, A.A., Gevenois, P.A. (2011). Chronic Obstructive Pulmonary Disease: Comparison Between Conventional Radiography and Computed Tomography. In: Coche, E., Ghaye, B., de Mey, J., Duyck, P. (eds) Comparative Interpretation of CT and Standard Radiography of the Chest. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79942-9_14
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