Skip to main content
SpringerLink
Log in

Histopathology of Skin Cancer

  • Chapter
Managing Skin Cancer

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. 1. Röwert-Huber J, Patel MJ, Forschner T, Ulrich C, Eberle J, Kerl H, Sterry W, Stockfleth E (2007) Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclas-sification. Br J Dermatol 156(Suppl 3):8–12

    Article  PubMed  Google Scholar 

  2. 1. Kanitakis J, Euvrard S, Chouvet B et al (2006) Merkel cell carcinoma in organ-transplant recipients: report of two cases with unusual histological features and literature review. J Cutan Pathol 33:686–694

    Article  PubMed  Google Scholar 

  3. 2. Ratner D, Nelson BR, Brown MD, et al (1993) Merkel cell carcinoma. Journal of the American Academy of Dermatology 29(2 part 1):143–156

    Article  PubMed  CAS  Google Scholar 

  4. Walsh JS, Perniciaro C, Randle HW (1999) Calcifying basal cell carcinomas. Dermatol Surg 25(1):49–51

    Article  PubMed  CAS  Google Scholar 

  5. Crowson, AN (2006) Basal cell carcinoma: biology, morphology and clinical implications. Mod Pathol 19(Suppl 2):S127–S147

    Article  PubMed  Google Scholar 

  6. Crowson AN, Magro CM, Kadin M et al (1996) Differential expression of bcl-2 oncogene in human basal cell carcinoma. Hum Pathol 27:355–359

    Article  PubMed  CAS  Google Scholar 

  7. Jones CC, Ansari SJ, Tschen JA (1991) Cystic fibroepithe-lioma of Pinkus. J Cutan Pathol 18:220–222

    Article  PubMed  CAS  Google Scholar 

  8. Spoonemore K, Crowson AN (2004) Eccrine syringofi-broadenoma in a patient with chronic graft-versus-host disease (Abstract). J Cutan Pathol 1:128–129

    Google Scholar 

  9. Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H (1990) Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial. J Clin Pathol 43:213

    Article  PubMed  CAS  Google Scholar 

  10. Tellechea O, Reis JP, Domingues JC, Baptista AP (1993) Monoclonal antibody Ber EP4 distinguishes basal-cell carcinoma from squamous-cell carcinoma of the skin. Am J Dermatopathol 15:452

    Article  PubMed  CAS  Google Scholar 

  11. Jones MS, Helm KF, Maloney ME (1997) The immunohis-tochemical characteristics of the basosquamous cell carcinoma. Dermatol Surg 23:181

    Article  PubMed  CAS  Google Scholar 

  12. Beer TW, Shepherd P, Theaker JM (2000) Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin. Histopathology 37:218

    Article  PubMed  CAS  Google Scholar 

  13. Rossen K, Thomsen HK (2001) Ber-EP4 immunoreactivity depends on the germ layer origin and maturity of the squamous epithelium. Histopathology 39:386

    Article  PubMed  CAS  Google Scholar 

  14. Krahl D, Sellheyer K (2007) Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma. J Cutan Pathol Oct; 34(10):782–787

    Article  Google Scholar 

  15. Ackerman AB (1980) Malignant melanoma: a unifying concept. Hum Pathol 11(6):591–595

    Article  PubMed  CAS  Google Scholar 

  16. Elder DE (2006) Pathology of melanoma. Clin Cancer Res 12(7 Pt 2):2308s–2311s

    Article  PubMed  CAS  Google Scholar 

  17. Clark WH et al (1989) Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst 81(24):1893–1904

    Article  PubMed  Google Scholar 

  18. Weyers W, Bonczkowitz M, Weyers I, Bittinger A, Schill WB (1996) Melanoma in situ versus melanocytic hyperpla-sia in sun-damaged skin. Assessment of the significance of histopathologic criteria for differential diagnosis. Am J Dermatopathol Dec;18(6):560–566

    Article  CAS  Google Scholar 

  19. Flotte TJ, Mihm MC Jr (1999) Lentigo maligna and malignant melanoma in situ, lentigo maligna type. Hum Pathol 30(5):533–536

    Article  PubMed  CAS  Google Scholar 

  20. Kuchelmeister C, Schaumburg-Lever G, Garbe C (2000) Acral cutaneous melanoma in caucasians: clinical features, histopathology and prognosis in 112 patients. Br J Dermatol Aug 143(2):275–280

    Article  CAS  Google Scholar 

  21. Thelmo MC, Sagebiel RW, Treseler PA, Morita ET, Nguyen LH, Kashani-Sabet M, Leong SP (2001) Evaluation of sentinel lymph node status in spindle cell melanomas. J Am Acad Dermatol 44(3):451–455

    Article  PubMed  CAS  Google Scholar 

  22. Carlson JA, Dickersin GR, Sober AJ, Barnhill RL (1995) Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases. Cancer 75(2):478–494

    Article  PubMed  CAS  Google Scholar 

  23. Leu HJ, Odermatt B (1985) Multicentric angiosarcoma (Kaposi's sarcoma). Light and electron microscopic and immu-nohistological findings of idiopathic cases in Europe and Africa and of cases associated with AIDS are histologically identical. Virchows Arch A Pathol Anat Histopathol 408(1):29–41

    Article  PubMed  CAS  Google Scholar 

  24. Chow JW, Lucas SB (1990) Endemic and atypical Kaposi's sarcoma in Africa –histopathological aspects. Clin Exp Dermatol 15(4):253–259

    Article  PubMed  CAS  Google Scholar 

  25. Cottoni F, Montesu MA (1996) Kaposi's sarcoma classification: a problem not yet defined. Int J Dermatol 35(7):480–483

    Article  PubMed  CAS  Google Scholar 

  26. Olsen SJ, Moore PS (1998) Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) and the etiology of KS. In: Medveczky P, Friedman H, Bendinelli M (eds) Herpesviruses and immunity. Plenum, New York

    Google Scholar 

  27. Robin YM et al (2004) Human herpesvirus 8 immunostain-ing: a sensitive and specific method for diagnosing Kaposi sarcoma in paraffin-embedded sections. Am J Clin Pathol 121:330–334

    Article  PubMed  Google Scholar 

  28. Shimizu A, O'Brien KP, Sjöblom T et al (1999) The der-matofibrosarcoma protuberans-associated collagen type I1/ platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res 59:3719–3723

    PubMed  CAS  Google Scholar 

  29. Weiss SW, JR Goldblum (2001) Fibrohistiocytic tumors of intermediate malignancy. In: SW Weiss, JR Goldblum (eds) Enzinger and Weiss's soft tissue tumors, 4th edn. Mosby, St Louis, pp 491–534

    Google Scholar 

  30. Weiss SW, Nickoloff BJ (1993) CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 17:1039–1045

    Article  PubMed  CAS  Google Scholar 

  31. Terrier-Lacombe MJ, Guillou L, Maire G, Terrier P, Vince DR, de Saint Aubain Somerhausen N, Collin F, Pedeutour F, Coindre JM (2003) Dermatofibrosarcoma pro-tuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data — a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 27(1):27–39

    Article  PubMed  Google Scholar 

  32. Kanitakis J, Bourchany D, Claudy A (2000) Expression of the CD10 antigen (neutral endopeptidase) by mesenchymal tumors of the skin. Anticancer Res 20(5B):3539–3544

    PubMed  CAS  Google Scholar 

  33. Dettrick A, Geoff S (2006) Atypical fibroxanthoma with perineural or intraneural invasion: report of two cases. J Cutan Pathol 33:318–322

    Article  PubMed  Google Scholar 

  34. Weedon D, Williamson R, Mirza B (2005) CD10, a useful marker for atypical fibroxanthomas. Am J Dermatopathol 27(2):181

    Article  PubMed  Google Scholar 

  35. Jensen K, Wilkinson B, Wines N, Kossard S (2004) Procollagen 1 expression in atypical fibroxanthoma and other tumors. J Cutan Pathol 31(1):57–61

    Article  PubMed  Google Scholar 

  36. Fletcher CD (2006) The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 48(1):3–12

    Article  PubMed  CAS  Google Scholar 

  37. Derré J, Lagace R, Nicolas A et al (2001) Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas. Lab Invest 81:211–215

    Article  PubMed  Google Scholar 

  38. Chibon F, Mariani O, Mairal A et al (2003) The use of clustering software for the classification of comparative genomic hybridization data. An analysis of 109 malignant fibrous histiocytomas. Cancer Genet Cytogenet 141:75–78

    Article  PubMed  CAS  Google Scholar 

  39. Iwasaki H, Isayama T, Johzaki H, Kikuchi M (1987) Malignant fibrous histiocytoma. Evidence of perivascular mesenchymal cell origin immunocytochemical studies with monoclonal anti-MFH antibodies. Am J Pathol 128(3):528–537

    CAS  Google Scholar 

  40. Lazova R, Moynes R, May D, Scott G (1997) LN-2 (CD74) A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer 79(11):2115–2124

    Article  PubMed  CAS  Google Scholar 

  41. Smith ME, Costa MJ, Weiss SW (1991) Evaluation of CD68 and other histiocytic antigens in angiomatoid malignant fibrous histiocytoma. Am J Surg Pathol 15(8):757–763

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Director of the Dermatology Faculty Practice, Mt Sinai School of Medicine, 5 East 98th Street 5th Floor, NY, NY 10029

    G. Goldenberg (Assistant Professor)

Authors
  1. G. Goldenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. E. Golitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Fitzpatrick
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Goldenberg .

Editor information

Editors and Affiliations

  1. Skin Cancer Center Charité, Department of Dermatology, Charité University Medicine Berlin, Charitéplatz 1, Berlin, 10117, Germany

    Eggert Stockfleth

  2. Department of Dermatology, 6620 Main Street, Suite 1425, Houston, TX, 77030, USA

    Theodore Rosen (Chief of VA Dermatology Clinic Professor) (Chief of VA Dermatology Clinic Professor)

  3. Ground Floor, 225 Macquarie Street, Sydney, NSW, 2000, Australia

    Stephen Shumack

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Goldenberg, G., Golitz, L.E., Fitzpatrick, J. (2010). Histopathology of Skin Cancer. In: Stockfleth, E., Rosen, T., Shumack, S. (eds) Managing Skin Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79347-2_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-79347-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-79346-5

  • Online ISBN: 978-3-540-79347-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation