Skip to main content

Zusammenfassung

Das Spektrum der Lebererkrankungen nach einer Infektion mit hepatotropen Viren reicht von einem klinisch vollkommen blanden über einen cholestatischen Verlauf bis zum akuten Leberversagen. Die Erkrankungen sind selten und können teilweise durch eine zeitgerechte und adäquate Prävention oder postpartale Überwachung vermieden oder zumindest angemessen eingeschätzt werden. Die klassischen Hepatitisviren umfassen die Hepatitiden A bis E (Tab. 12.1). Darüber hinaus wurden in neuerer Zeit das Hepatitis-G-Virus und das TT-Virus charakterisiert. In Tab. 12.2 sind die in Europa relevanten hepatotropen Viren mit möglichem Krankheitswert dargestellt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Weiterführende Literatur

Hepatitis A (HAV)

  • Beniwal M, Kumar A, Kar P et al (2003) Prevalence and severity of acute viral hepatitis and fulminant hepatitis during pregnancy: a prospective study from north India. Indian J Med Microbiol 21:184–185

    PubMed  CAS  Google Scholar 

  • Duff P (1998) Hepatitis in pregnancy. Semin Perinatol 22:277–283

    Article  PubMed  CAS  Google Scholar 

  • Duff B, Duff P (1998) Hepatitis A vaccine: ready for prime time. Obstet Gynecol 91:468–471

    Article  PubMed  CAS  Google Scholar 

  • Elinav E, Ben-Dov IZ, Shapira Y et al (2006) Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. Gastroenterology 130:1129–1134

    Article  PubMed  Google Scholar 

  • Erkan T, Kutlu T, Cullu F et al (1998) A case of vertical transmission of hepatitis A virus infection. Acta Paediatr 87:1008–1009

    Article  PubMed  CAS  Google Scholar 

  • Fagan EA, Hadzic N, Saxena R et al (1999) Symptomatic neonatal hepatitis A disease from a virus variant acquired in utero. Pediatr Infect Dis J 18:389–391

    Article  PubMed  CAS  Google Scholar 

  • Friese K, Schäfer A, Hof H (2003) Infektionskrankheiten in Gynäkologie und Geburtshilfe. Springer, Berlin

    Google Scholar 

  • Hallam A, Kerlin P (1991) Viral hepatitis A to E. An update. Aust Fam Physician 20:760 (762–763, 766–770)

    PubMed  CAS  Google Scholar 

  • Leikin E, Lysikiewicz A, Garry D et al (1996) Intrauterine transmission of hepatitis A virus. Obstet Gynecol 88:690–691

    Article  PubMed  CAS  Google Scholar 

  • Mcduffie Jr. RS, Bader T (1999) Fetal meconium peritonitis after maternal hepatitis A. Am J Obstet Gynecol 180:1031–1032

    Article  PubMed  Google Scholar 

  • Motte A, Blanc J, Minodier P et al (2009) Acute hepatitis A in a pregnant woman at delivery. Int J Infect Dis 13:e49–51

    Article  PubMed  Google Scholar 

  • Mylonas I, Friese K (2009) Infektionen in der Gynäkologie und Geburtshilfe. Elsevier Urban, München

    Google Scholar 

  • Mylonas I, Friese K (2010) Infektionen in der Geburtshilfe. In: Schneider H, Husslein P, Schneider KTM (Hrsg) Die Geburtshilfe. Springer, Heidelberg, S 379–434

    Google Scholar 

  • Mylonas I, Bauerfeind I, Friese K (2005) Impfungen in der Schwangerschaft. Der Gynäkologe 38:771–779

    Article  Google Scholar 

  • Mylonas I, Gingelmaier A, Friese K (2006) Systemische Infektionen in der Geburtshilfe. Der Gynäkologe 39:223–232

    Article  Google Scholar 

  • Renge RL, Dani VS, Chitambar SD et al (2002) Vertical transmission of hepatitis A. Indian J Pediatr 69:535–536

    Article  PubMed  Google Scholar 

  • Siegl G (2004) Hepatitis A and E enterically transmitted virus infections of the liver. Ther Umsch 61:481–448

    Article  PubMed  CAS  Google Scholar 

  • Thomas HC, Lemon S, Zuckerman AJ (2005) Viral Hepatitis, 3. Aufl. Blackwell Publishing, Ltd

    Book  Google Scholar 

  • Urganci N, Arapoglu M, Akyildiz B, Nuhoglu A (2003) Neonatal cholestasis resulting from vertical transmission of hepatitis A infection. Pediatr Infect Dis J 22:381–382

    PubMed  Google Scholar 

  • Victor JC, Monto AS, Surdina TY (2007) Hepatitis A vaccine versus immune globulin for postexposure prophylaxis. N Engl J Med 357:1685–1694

    Article  PubMed  CAS  Google Scholar 

  • Watson JC, Fleming DW, Borella AJ et al (1993) Vertical transmission of hepatitis A resulting in an outbreak in a neonatal intensive care unit. J Infect Dis 167:567–571

    Article  PubMed  CAS  Google Scholar 

  • Zhu SS, Zhang HF, Yang XJ, Tang HM, Wu SX (2003) Clinical features of hepatitis A in 1,629 children. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 17:91–93

    PubMed  Google Scholar 

Hepatitis B (HBV)

  • American College of Obstetricians and Gynecologists (ACOG) (2007) Viral Hepatitis in Pregnancy. ACOG Practice Bulletin, number 86

    Google Scholar 

  • Bortolotti F, Guido M, Bartolacci S, Cadrobbi P, Morsica G, Noventa F, Crivellaro C et al (2006) Chronic hepatitis B in children after e antigen seroclearance: final report of a 29-year longitudinal study. Hepatology 43:556–562

    Article  PubMed  Google Scholar 

  • Bundesamt für Gesundheit (2011) Übertragbare Krankheiten. Bulletin 10/11:196–204

    Google Scholar 

  • Chu CM, Hung SJ, Lin J, Tai DI, Liaw YF (2004) Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med 116:829–834

    Article  PubMed  CAS  Google Scholar 

  • Cornberg M, Manns MP (2011) Prävention der Virushepatitis A bis E. Internist 52:250–264

    Article  PubMed  CAS  Google Scholar 

  • Cornberg M, Protzer U, Dollinger MM et al (2007) Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virus(HBV-)Infektion. „Upgrade“ der Leitlinie, AWMF-Register-Nr. 021/011. Z Gastroenterol 45:1–50

    Google Scholar 

  • Ferenci P (2009) Hepatitis B und Schwangerschaft. J Gastroenterol Hepatol Erkr 7:26–29

    Google Scholar 

  • Friese K, Schäfer A, Hof H (2003) Infektionskrankheiten in Gynäkologie und Geburtshilfe. Springer, Berlin

    Google Scholar 

  • Hsu HY, Chang MH, Lee CY, Chen JS, Hsu HC, Chen DS (1992) Spontaneous loss of HBsAg in children with chronic hepatitis B virus infection. Hepatology 15:382–386

    Article  PubMed  CAS  Google Scholar 

  • Jonas MM, Mizerski J, Badia IB, Areias JA, Greensmith MJ, Little NR, Schwarz KB et al (2002) Clinical trial of lamivudine in children with chronic hepatitis B. N Engl J Med 346:1706–1713

    Article  PubMed  CAS  Google Scholar 

  • Krause G (2007) Meldepflicht für Infektionskrankheiten. Dtsch Arztebl 104:A2811–2820

    Google Scholar 

  • Laubscher B, Gehri M, Roulet M, Wirth S, Gerner P (2005) Survival of infantile fulminant hepatitis B and treatment with Lamivudine. J Pediatr Gastroenterol Nutr 40:518–520

    Article  PubMed  CAS  Google Scholar 

  • Lee PI, Lee CY, Huang LM, Chang MH (1995) Long-term efficacy of recombinant hepatitis B vaccine and risk of natural infection in infants born to mothers with hepatitis B e antigen. J Pediatr 126:716–721

    Article  PubMed  CAS  Google Scholar 

  • López M, Coll O (2010) Chronic viral infections and invasive procedures: risk of vertical transmission and current recommendations. Fetal Diagn Ther 28:1–8

    Article  PubMed  Google Scholar 

  • Mylonas I, Friese K (2009) Infektionen in der Gynäkologie und Geburtshilfe. Elsevier, Urban, München

    Google Scholar 

  • Robert-Koch-Institut (2010) Zur Situation bei wichtigen Infektionskrankheiten in Deutschland. Virushepatitis B, C und D im Jahr 2009. Epid Bull 20:177–190

    Google Scholar 

  • Schrag SJ, Arnold KE, Mohle-Boetani JC et al (2003) Prenatal screening for infectious diseases and opportunities for prevention. Obstet Gynecol 102:753–760

    Article  PubMed  Google Scholar 

  • Sokal EM, Kelly DA, Mizerski J, Badia IB, Vegnente A, Schwarz KB, Areias JA et al (2006) Long-term lamivudine therapy for children with HBeAg-positive chronic hepatitis B. Hepatology 43:225–232

    Article  PubMed  CAS  Google Scholar 

  • Thierfelder W, Hellenbrand W, Meisel H et al (2001) Prevalence of markers for hepatitis A, B and C in the German population. Results of the German National Health Interview and Examination Survey 1998. Eur J Epidemiol 17:429–435

    Article  PubMed  CAS  Google Scholar 

  • Tran TT (2009) Management of hepatitis B in pregnancy: weighing the options. Clev Clin J Med 76(Suppl 3):S25–S29

    Article  Google Scholar 

Hepatitis C (HCV)

  • Alter MJ (2007) Epidemiology of hepatitis C virus infection. World J Gastroenterol 13:2436–2441

    PubMed  Google Scholar 

  • Bhola K, McGuire W (2007) Does avoidance of breast feeding reduce mother-to-infant transmission of hepatitis C virus infection? Arch Dis Child 92:365–366

    Article  PubMed  CAS  Google Scholar 

  • Bortolotti F, Verucchi G, Camma C, Cabibbo G, Giacchino R, Indolfi G, Zancan L et al (2008) Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease. Gastroenterology 134(7):1900–1907

    Article  PubMed  Google Scholar 

  • Bourlet T, Levy R, Maertens A, Tardy JC, Grattard F, Cordonier H, Laurent JL, Guerin JF, Pozzetto B (2002) Detection and characterization of hepatitis C virus RNA in seminal plasma and spermatozoon fractions of semen from patients attempting medically assisted conception. J Clin Microbiol 40:3252–3255

    Article  PubMed  CAS  Google Scholar 

  • Boxall E, Baumann K, Price N, Sira J, Brown M, Kelly D (2007) Discordant outcome of perinatal transmission of hepatitis C in twin pregnancies. J Clin Virol 38:91–95

    Article  PubMed  Google Scholar 

  • Cacciola I, Pollicino T, Squadrito G, Cerenzia G, Orlando ME, Raimondo G (1999) Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 341:22–26

    Article  PubMed  CAS  Google Scholar 

  • Ceci O, Margiotta M, Marello F, Francavilla R, Loizzi P, Francavilla A, Mautone A, Impedovo L, Ierardi E, Mastroianni M, Bettocchi S, Selvaggi L (2001) Vertical transmission of hepatitis C virus in a cohort of 2,447 HIV-seronegative pregnant women: a 24-month prospective study. J Pediatr Gastroenterol Nutr 33:570–575

    Article  PubMed  CAS  Google Scholar 

  • Conte D, Fraquelli M, Prati D, Colucci A, Minola E (2000) Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women. Hepatology 31:751–755

    Article  PubMed  CAS  Google Scholar 

  • Dal Molin G, D’Agaro P, Ansaldi F, Ciana G, Fertz C, Alberico S, Campello C (2002) Mother-to-infant transmission of hepatitis C virus: rate of infection and assessment of viral load and IgM anti-HCV as risk factors. J Med Virol 67:137–142

    Article  Google Scholar 

  • England K, Pembrey L, Tovo PA, Newell ML (2005) Excluding hepatitis C virus (HCV) infection by serology in young infants of HCV-infected mothers. Acta Paediatr 94:444–450

    Article  PubMed  Google Scholar 

  • European Paediatric Hepatitis C Virus Network (2001) Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. BJOG 108:371–377

    Article  Google Scholar 

  • Friese K, Schäfer A, Hof H (2003) Infektionskrankheiten in Gynäkologie und Geburtshilfe. Springer, Berlin

    Google Scholar 

  • Friese K, Mörike K, Neumann G, Windorfer A (2009) Arzneimittel in der Schwangerschaft und Stillzeit: Ein Leitfaden für Ärzte und Apotheker. Wissenschaftliche Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Gibb DM, Goodall RL, Dunn DT, Healy M, Neave P, Cafferkey M, Butler K (2000) Mother-to-child transmission of hepatitis C virus: evidence for preventable peripartum transmission. Lancet 356:904–907

    Article  PubMed  CAS  Google Scholar 

  • Hayashida A, Inaba N, Oshima K, Nishikawa M, Negishi M, Hayashida S, Shoda A et al (2007) Re-evaluation of the true rate of hepatitis C virus mother-to-child transmission and its novel risk factors based on our two prospective studies. J Obstet Gynaecol Res 33:417–422

    Article  PubMed  Google Scholar 

  • Jara P, Hierro L, de la Vega A, Diaz C, Minos-Bartolo G, Frauca E, Camarena C et al (2008) Efficacy and safety of peginterferon-alpha2b and ribavirin combination therapy in children with chronic hepatitis C infection. Pediatr Infect Dis J 27:142–148

    PubMed  Google Scholar 

  • Maheshwari A, Ray S, Thuluvath PJ (2008) Acute hepatitis C. Lancet 372:321–332

    Article  PubMed  Google Scholar 

  • Marine-Barjoan E, Berrebi A, Giordanengo V, Favre SF, Haas H, Moreigne M, Izopet J, Tricoire J, Tran A, Pradier C, Bongain A (2007) HCV/HIV co-infection, HCV viral load and mode of delivery: risk factors for mother-to-child transmission of hepatitis C virus? AIDS 21:1811–1815

    Article  PubMed  Google Scholar 

  • Mast EE, Hwang LY, Seto DS, Nolte FS, Nainan OV, Wurtzel H, Alter MJ (2005) Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy. J Infect Dis 192:1880–1889

    Article  PubMed  Google Scholar 

  • Mylonas I, Friese K (2009) Infektionen in der Gynäkologie und Geburtshilfe. Elsevier, Urban, München

    Google Scholar 

  • Nakashima K, Ikematsu H, Hayashi J, Kishihara Y, Mutsutake A, Kashiwagi S (1995) Intrafamilial transmission of hepatitis-C virus among the population of an endemic area of Japan. JAMA 274:1459–1461

    Article  PubMed  CAS  Google Scholar 

  • Ohto H, Terazawa S, Sasaki N, Hino K, Ishiwata C, Matsui A, Ujiie N, Endo C, Kako M et al (1994) Transmission of hepatitis C virus from mothers to infants. The Vertical Transmission of Hepatitis C Virus Collaborative Study Group. N Engl J Med 330:744–750

    Article  PubMed  CAS  Google Scholar 

  • Polywka S, Schroter M, Feucht HH, Zollner B, Laufs R (1999) Low risk of vertical transmission of hepatitis C virus by breast milk. Clin Infect Dis 29:1327–1329

    Article  PubMed  CAS  Google Scholar 

  • Polywka S, Feucht H, Laufs R (2003) Die chronische Hepatitis C der Mutter ist keine Kontraindikation für das Stillen. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 46:739–743

    Article  Google Scholar 

  • Polywka S, Pembrey L, Tovo PA, Newell ML (2006) Accuracy of HCV-RNA PCR tests for diagnosis or exclusion of vertically acquired HCV infection. J Med Virol 78:305–310

    Article  PubMed  CAS  Google Scholar 

  • Resti M, Azzari C, Galli L, Zuin G, Giacchino R, Bortolotti F, Marcellini M, Moriondo M, de Martino M, Vierucci A (2002) Maternal drug use is a preeminent risk factor for mother-to-child hepatitis C virus transmission: results from a multicenter study of 1372 mother-infant pairs. J Infect Dis 185:567–572

    Article  PubMed  Google Scholar 

  • Sarrazin C, Berg T, Ross RS et al (2010) Update der S3-Leitlinie Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV-)Infektion. „Upgrade“ der Leitlinie, AWMF-Register-Nr. 021/012. Z Gastroenterol 48:289–351

    Article  PubMed  CAS  Google Scholar 

  • Steininger C, Kundi M, Jatzko G, Kiss H, Lischka A, Holzmann H (2003) Increased risk of mother-to-infant transmission of hepatitis C virus by intrapartum infantile exposure to maternal blood. J Infect Dis 187:345–351

    Article  PubMed  Google Scholar 

  • Tovo PA, Palomba E, Ferraris G, Principi N, Ruga E, Dallacasa P, Maccabruni A (1997) Increased risk of maternal-infant hepatitis C virus transmission for women coinfected with human immunodeficiency virus type 1. Italian Study Group for HCV Infection in Children. Clin Infect Dis 25:1121–1124

    Article  PubMed  CAS  Google Scholar 

  • Wiegand J, Buggisch P, Boecher W, Zeuzem S, Gelbmann CM, Berg T, Kauffmann W, Kallinowski B, Cornberg M, Jaeckel E, Wedemeyer H, Manns MP (2006) Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: the HEP-NET acute-HCV-II study. Hepatology 43:250–256

    Article  PubMed  CAS  Google Scholar 

  • Wirth S, Pieper-Boustani H, Lang T, Ballauff A, Wintermeyer P, Gerner P, Kullmer U et al (2005) Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C. Hepatology 41:1013–1018

    Article  PubMed  CAS  Google Scholar 

  • Zanetti AR, Tanzi E, Paccagnini S, Principi N, Pizzocolo G, Caccamo ML, D’Amico E, Cambie G, Vecchi L (1995) Mother-to-infant transmission of hepatitis C virus. Lombardy Study Group on Vertical HCV Transmission. Lancet 345:289–291

    Article  PubMed  CAS  Google Scholar 

  • Zanetti AR, Tanzi E, Romano L, Principi N, Zuin G, Minola E, Hunt J, Palmieri M, Marini A, Ghisotti D, Friedman P, Zapparoli B et al (1998) Multicenter trial on mother-to-infant transmission of GBV-C virus. The Lombardy Study Group on Vertical/Perinatal Hepatitis Viruses Transmission. J Med Virol 54:107–112

    Article  PubMed  CAS  Google Scholar 

Hepatitis D (HDV)

  • Bart PA, Jacquier P, Zuber PL et al (1996) Seroprevalence of HBV (anti-HBc, HBsAg and anti-HBs) and HDV infections among 9006 women at delivery. Liver 16:110–116

    PubMed  CAS  Google Scholar 

  • Castelnau C, Le Gal F, Ripault MP et al (2006) Efficacy of peginterferon alpha-2b in chronic hepatitis delta: relevance of quantitative RT-PCR for follow-up. Hepatology 44:728–735

    Article  PubMed  CAS  Google Scholar 

  • Erhardt A, Gerlich W, Starke C et al (2006) Treatment of chronic hepatitis delta with pegylated interferon-alpha2b. Liver Int 26:805–810

    Article  PubMed  CAS  Google Scholar 

  • Flores R, Grubb D, Elleuch A et al (2011) Rolling-circle replication of viroids, viroid-like satellite RNAs and hepatitis delta virus: Variations on a theme. RNA Biol 8(2):200–206

    Article  PubMed  CAS  Google Scholar 

  • Huang YH, Wu JC, Lu SN, Chiang TY, Chang FY, Lee SD (1999) Phylogenetic analysis to document a common source of hepatitis D virus infection in a mother and her child. Zhonghua Yi Xue Za Zhi (Taipei) 62:28–32

    CAS  Google Scholar 

  • Lau JY, Smith HM, Chaggar K et al (1991) Significance of IgM anti-hepatitis D virus (HDV) in chronic HDV infection. J Med Virol 33:273–276

    Article  PubMed  CAS  Google Scholar 

  • Le Gal F, Gordien E, Affolabi D et al (2005) Quantification of hepatitis delta virus RNA in serum by consensus real-time PCR indicates different patterns of virological response to interferon therapy in chronically infected patients. J Clin Microbiol 43:2363–2369

    Article  PubMed  CAS  Google Scholar 

  • Mansour W, Ducancelle A, Le Gal F et al (2010) Resolution of chronic hepatitis Delta after 1 year of combined therapy with pegylated interferon, tenofovir and emtricitabine. J Clin Virol 47:97–99

    Article  PubMed  CAS  Google Scholar 

  • Pascarella S, Negro F (2011) Hepatitis D virus: an update. Liver Int 31:7–21

    Article  PubMed  CAS  Google Scholar 

  • Ramia S, Bahakim H (1988) Perinatal transmission of hepatitis B virus-associated hepatitis D virus. Ann Inst Pasteur Virol 139:285–290

    Article  PubMed  CAS  Google Scholar 

  • Rizzetto M (2010) Hepatitis D: clinical features and therapy. Dig Dis 28:139–143

    Article  PubMed  CAS  Google Scholar 

  • Shattock AG, Morris MC (1991) Evaluation of commercial enzyme immunoassays for detection of hepatitis delta antigen and anti-hepatitis delta virus (HDV) and immunoglobulin M anti-HDV antibodies. J Clin Microbiol 29:1873–1876

    PubMed  CAS  Google Scholar 

  • Sureau C (2010) The use of hepatocytes to investigate HDV infection: the HDV/HepaRG model. Methods Mol Biol 640:463–473

    Article  PubMed  CAS  Google Scholar 

  • Tang JR, Cova L, Lamelin JP et al (1994) Clinical relevance of the detection of hepatitis delta virus RNA in serum by RNA hybridization and polymerase chain reaction. J Hepatol 21:953–960

    Article  PubMed  CAS  Google Scholar 

Hepatitis E (HEV)

  • Aboulata AA, Ahmad MS, Shaban MM, Zayd KM, Abd El-Moktader AM (2005) Prevalence of hepatitis E virus in Egyptian children presented with minor hepatic disorders. Egypt J Immunol 12:71–76

    PubMed  Google Scholar 

  • Beniwal M, Kumar A, Kar P et al (2003) Prevalence and severity of acute viral hepatitis and fulminant hepatitis during pregnancy: a prospective study from north India. Indian J Med Microbiol 21:184–185

    PubMed  CAS  Google Scholar 

  • Bi SL, Purdy MA, Mccaustland KA et al (1993) The sequence of hepatitis E virus isolated directly from a single source during an outbreak in China. Virus Res 28:233–247

    Article  PubMed  CAS  Google Scholar 

  • Bose PD, Das BC, Kumar A et al (2010) High viral load and deregulation of the progesterone receptor signaling pathway: Association with Hepatitis E-related poor pregnancy outcome. J Hepatol 54(6):1107–1113

    Article  PubMed  CAS  Google Scholar 

  • Buti M, Plans P, Dominguez A, Jardi R, Salleras L, Esteban R, Rodriguez Frias F et al (2008) Prevalence of hepatitis E virus infection in children in the northeast of Spain. Clin Vaccine Immunol 15:732–734

    Article  PubMed  CAS  Google Scholar 

  • Chibber RM, Usmani MA, Al-Sibai MH (2004) Should HEV infected mothers breast feed? Arch Gynecol Obstet 270:15–20

    Article  PubMed  Google Scholar 

  • Dalton HR, Fellows HJ, Stableforth W et al (2007) The role of hepatitis E virus testing in drug-induced liver injury. Aliment Pharmacol Ther 26:1429–1435

    Article  PubMed  CAS  Google Scholar 

  • Dalton HR, Bendall RP, Keane FE et al (2009) Persistent carriage of hepatitis E virus in patients with HIV infection. N Engl J Med 361:1025–1027

    Article  PubMed  CAS  Google Scholar 

  • Favorov MO, Fields HA, Purdy MA et al (1992) Serologic identification of hepatitis E virus infections in epidemic and endemic settings. J Med Virol 36:246–250

    Article  PubMed  CAS  Google Scholar 

  • Gerolami R, Moal V, Picard C et al (2009) Hepatitis E virus as an emerging cause of chronic liver disease in organ transplant recipients. J Hepatol 50:622–624

    Article  PubMed  Google Scholar 

  • Green KY, Ando T, Balayan MS et al (2000) Taxonomy of the caliciviruses. J Infect Dis 181(Suppl 2):322–330

    Article  Google Scholar 

  • Haagsma EB, Niesters HG, Van Den Berg AP et al (2009) Prevalence of hepatitis E virus infection in liver transplant recipients. Liver Transpl 15:1225–1228

    Article  PubMed  Google Scholar 

  • Khuroo MS, Teli MR, Skidmore S et al (1981) Incidence and severity of viral hepatitis in pregnancy. Am J Med 70:252–255

    Article  PubMed  CAS  Google Scholar 

  • Khuroo MS, Kamili S, Jameel S (1995) Vertical transmission of hepatitis E virus. Lancet 345:1025–1026

    Article  PubMed  CAS  Google Scholar 

  • Khuroo MS, Kamili S, Yattoo GN (2004) Hepatitis E virus infection may be transmitted through blood transfusions in an endemic area. J Gastroenterol Hepatol 19:778–784

    Article  PubMed  Google Scholar 

  • Kumar A, Beniwal M, Kar P et al (2004) Hepatitis E in pregnancy. Int J Gynaecol Obstet 85:240–244

    Article  PubMed  CAS  Google Scholar 

  • Matsubayashi K, Nagaoka Y, Sakata H et al (2004) Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion 44:934–940

    Article  PubMed  Google Scholar 

  • Naidu SS, Viswanathan R (1957) Infectious hepatitis in pregnancy during Delhi epidemic. Indian J Med Res 45:71–76

    PubMed  CAS  Google Scholar 

  • Naik SR, Aggarwal R, Salunke PN et al (1992) A large waterborne viral hepatitis E epidemic in Kanpur, India. Bull World Health Organ 70:597–604

    PubMed  CAS  Google Scholar 

  • Ollier L, Tieulie N, Sanderson F et al (2009) Chronic hepatitis after hepatitis E virus infection in a patient with non-Hodgkin lymphoma taking rituximab. Ann Intern Med 150:430–431

    Article  PubMed  Google Scholar 

  • Ramalingaswami V, Purcell RH (1988) Waterborne non-A, non-B hepatitis. Lancet 1:571–573

    Article  PubMed  CAS  Google Scholar 

  • Shukla P, Chauhan UK, Naik S et al (2007) Hepatitis E virus infection among animals in northern India: an unlikely source of human disease. J Viral Hepat 14:310–317

    Article  PubMed  CAS  Google Scholar 

  • Stoszek SK, Abdel-Hamid M, Saleh DA et al (2006) High prevalence of hepatitis E antibodies in pregnant Egyptian women. Trans R Soc Trop Med Hyg 100:95–101

    Article  PubMed  Google Scholar 

  • Teshale EH, Grytdal SP, Howard C et al (2010) Evidence of person-to-person transmission of hepatitis E virus during a large outbreak in Northern Uganda. Clin Infect Dis 50:1006–1010

    Article  PubMed  Google Scholar 

  • Teshale EH, Hu DJ, Holmberg SD (2010) The two faces of hepatitis E virus. Clin Infect Dis 51:328–334

    Article  PubMed  Google Scholar 

  • Tsega E, Krawczynski K, Hansson BG et al (1993) Hepatitis E virus infection in pregnancy in Ethiopia. Ethiop Med J 31:173–181

    PubMed  CAS  Google Scholar 

  • Viswanathan R (1957) Infectious hepatitis in Delhi (1955–1956). A critical study: epidemiology. Indian J Med Res 45:49–58

    PubMed  CAS  Google Scholar 

  • Zhu FC, Zhang J, Zhang XF et al (2010) Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 376:895–902

    Article  PubMed  CAS  Google Scholar 

  • Zhuang H, Cao XY, Liu CB et al (1991) Epidemiology of hepatitis E in China. Gastroenterol Jpn 26(Suppl 3):135–138

    PubMed  Google Scholar 

Resümee

  • American College of Obstetricians and Gynecologists (2007) ACOG Practice Bulletin No. 86: Viral hepatitis in pregnancy. Obstet Gynecol 110(4):941–956

    Article  Google Scholar 

  • Bundesamt für Gesundheit (2011) Übertragbare Krankheiten. Bulletin 10/11:196–204

    Google Scholar 

  • Cornberg M, Manns MP (2011) Prävention der Virushepatitis A bis E. Internist 52:250–264

    Article  PubMed  CAS  Google Scholar 

  • Krause G (2007) Meldepflicht für Infektionskrankheiten. Dt Ärztebl 104:A2811–2820

    Google Scholar 

  • López M, Coll O (2010) Chronic viral infections and invasive procedures: risk of vertical transmission and current recommendations. Fetal Diagn Ther 28:1–8

    Article  PubMed  Google Scholar 

  • Robert-Koch-Institut (2008) Zur Situation der Hepatitis A in Deutschland im Jahr 2007. Epid Bull 44:379–384

    Google Scholar 

  • Robert-Koch-Institut (2008) Hepatitis E – Epidemiologie und Risikofaktoren in Deutschland. Epid Bull 49:435–446

    Google Scholar 

  • Robert-Koch-Institut (2010) Zur Situation bei wichtigen Infektionskrankheiten in Deutschland. Virushepatitis B, C und D im Jahr 2009. Epid Bull 20:177–190

    Google Scholar 

  • Schrag SJ, Arnold KE, Mohle-Boetani JC et al (2003) Prenatal screening for infectious diseases and opportunities for prevention. Obstet Gynecol 102:753–760

    Article  PubMed  Google Scholar 

  • Thierfelder W, Hellenbrand W, Meisel H et al (2001) Prevalence of markers for hepatitis A, B and C in the German population. Results of the German National Health Interview and Examination Survey 1998. Eur J Epidemiol 17:429–435

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mylonas, I., Wirth, S. (2013). Hepatitisviren. In: Friese, K., Mylonas, I., Schulze, A. (eds) Infektionserkrankungen der Schwangeren und des Neugeborenen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78325-1_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-78325-1_12

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78324-4

  • Online ISBN: 978-3-540-78325-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics