Abstract
Everyone interested in neuroanaesthesia talks about intracranial pressure (ICP), but in daily clinical practice nobody measures it during craniotomy. This was the thesis that started this work more than ten years ago. A method for easy monitoring of ICP during surgery, but before opening of dura, was devised and the method was introduced in our daily clinical practice. In this chapter indications for ICP measurement, critical levels of ICP and regional differences in ICP are described. Medical approaches to ICP control are considered, including body position, hyperventilation, hypothermia and administration of barbiturate. The effect of suctioning, positive end-expiratory pressure, sedatives and analgetics are discussed as well as the use of mannitol and hypertonic saline.
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References
Abou-Madi M, Trop D, Ravussin P (1993) The early role of mannitol-induced haemodynamic changes in the control of intracranial hypertension. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 601–604
Abramson NS, Safar P, Detre K et al (1983) Results of a randomized clinical trial of brain resuscitation with thiopental. Anesthesiology 59:A101
Albeck MJ, Skak C, Nielsen PR et al (1998) Age dependency of resistance to cerebrospinal fluid outflow. J Neurosurg 89:275–278
Albrecht RF, Ruttle M (1987) Cerebral effect of extended hyperventilation in anaesthetized goats. Stroke 18:649–655
Alexander SC, Smith TC, Strobel G et al (1968) Cerebral carbohydrate metabolism of man during respiratory and metabolic alkalosis. J Appl Physiol 24:66–72
Altura BT, Altura BM (1975) Pentobarbital and contraction of vascular smooth muscle. Am J Physiol 229:1635–1640
Andersen AR, Tfeft-Hansen P, Lassen NA (1987) The effect of ergotamine and dihydroergotamine on cerebral blood flow in man. Stroke 18:120–123
Andrews PJD, Citerio G (2006) Lund therapy: pathophysiology-based therapy or contrived over-interpretation of limited data? Intensive Care Med 32:1461–1464
Andrews RJ, Muto RP(1992) Retraction brain ischaemia: mannitol plus nimodipine preserves both cerebral blood flow and evoked potentials during normoventilation and hyperventilation. Neurol Res 14:19–25
Andrews PJD, Dearden NM, Miller JD (1993) Comparison of thiopentone and propofol at two rates of intravenous administration in severely head injured patients. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 623–628
Artru AA (1987) Reduction of cerebrospinal fluid pressure by hypocapnia: changes in cerebral blood volume, cerebrospinal fluid volume, and brain tissue water and electrolytes. J Cereb Blood Flow Metab 7:471–479
Artru AA, Hornbein TF (1987) Prolonged hypocapnia does not alter the rate of CSF production in dogs during halothane anaesthesia or sedation with nitrous oxide. Anesthesiology 67:66–71
Artru AA, Nugent M, Michenfelder JD (1981) Anesthetics affect the cerebral metabolic response to circulatory catecholamine. J Neurochem 36:1941–1946
Asgeirsson B, Grände PO, Nordström C-H (1994) A new therapy of posttrauma brain oedema based on haemodynamic principles for brain volume regulation. Intensive Care Med 20:260–267
Asgeirsson B, Grände PO, Nordström C-H et al (1995) Cerebral haemodynamic effects of dihydroergotamine in patients with severe traumatic brain lesions. Acta Anesthesiol Scand 39:922–930
Aucoin PJ, Kotilainen HR, Gantz NM et al (1986) Intracranial pressure monitors. Epidemiologic study of risk factors and infections. Am J Med 80:369–376
Auer LM, Haselsberger K (1987) Effect of intravenous mannitol on cat pial arteries and veins during normal and elevated intracranial pressure. Neurosurgery 21:142–146
Awad I, Little JR, Lucas F et al (1983) Modification of focal cerebral ischemia by prostacyclin and indomethacin. J Neurosurg 58:714–719
Battison C, Peter H, Andrews JD et al (2005) Randomized, controlled trial on the effect of 20% mannitol solution and a 7.5% saline/6% dextran solution on increased intracranial pressure after brain injury. Crit Care Med 33:196–202
Bereczki D, Liu M, do Prado GF et al (2001) Mannitol for acute stroke. Cochrane Database Syst Rev 1:CD001153
Berger S, Schürer L, Härtl R et al (1995) Reduction of posttraumatic intracranial hypertension by hypertonic/hyperoncotic saline/dextran and hypertonic mannitol. Neurosurgery 37:98–108
Berntman L, Dahlgren N, Siesjö BK (1978) Influence of intravenously administered catecholamine on cerebral oxygen consumption and blood flow in the rat. Acta Physiol Scand 104:101–108
Biestro A, Alberti R, Galli R et al (1997) Osmotherapy for increased intracranial pressure: comparison between mannitol and glycerol. Acta Neurochir 139:725–733
Bloomfield GL, Ridings PC, Blockers CR et al (1997) A proposed relationship between increased intraabdominal, intrathoracic, and intracranial pressure. Crit Care Med 25:496–503
Bouma GJ, Muizlaar JP, Choi SC et al (1991) Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia. J Neurosurg 75:685–693
Bouma GJ, Muizelaar JP, Stringer WA et al (1992) Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography. J Neurosurg 77:360–368
Bowie RA, O’Conner PJ, Hardman JG et al (2001) The effect of continuous positive airway pressure on cerebral blood flow velocity in awake volunteers. Anesth Analg 92:415–417
Bozza MM, Maspes PE, Rossanda M (1961) The control of brain volume and tension during intracranial operations. Br J Anaesth 33:132–147
Braakman R, Schouten HJA et al (1983) Megadose steroids in severe head injury. J Neurosurg 58:326–330
Bracken MB, Shepard MJ, Collins WF et al (1985) A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the National Acute Spinal Cord Injury Study. J Neurosurg 63:704–713
Bracken MB, Shepard MJ, Collins WF et al (1990) A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N Engl J Med 322:1405–1411
Brawley BW, Strandness DE, Kelly WA (1967) The physiologic response to therapy in experimental cerebral ischaemia. Arch Neurol 17:180–187
Broaddus WC, Pendleton GA, Delashaw SB et al (1989) Differential intracranial pressure recordings in patients with dual ipsilateral monitors. In: Hoff JH, Betz AL (eds) Intracranial pressure VII. Springer, Berlin, pp 41–44
Brown SC, Lam AM, Manninen PH (1986) Haemodynamic effects of high-dose mannitol in man. Can Anaesth Soc J 33:S92–S93
Bruce DA, Langfitt TW, Miller JD et al (1973) Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J Neurosurg 38:131–145
Bruce DA, Raphaely RC, Goldberg AI et al (1979) Pathophysiology, treatment and outcome following severe head injury in children. Childs Brain 5:174–191
Bundgaard H, Cold GE (2000) Studies of regional subdural pressure gradients during craniotomy. Br J Neurosurg 14:229–234
Bundgaard H, Jensen K, Cold GE et al (1996) Effects of perioperative indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients subjected to craniotomy for cerebral tumours. J Neurosurg Anesthesiol 8:273–279
Bundgaard H, Landsfeldt U, Cold GE (1998) Subdural monitoring of ICP during craniotomy: thresholds of cerebral swelling/herniation. Acta Neurchir Suppl 71:276–278
Bundgaard H, von Oettingen G, Jørgensen H et al (2001) The effects of dihydroergotamine on intracranial pressure, cerebral blood flow and cerebral metabolism in patients subjected to craniotomy for brain tumours. J Neurosurg Anesthesiol 13:195–201
Burke AM, Quest DO, Chien S et al (1981) The effects of mannitol on blood viscosity. J Neurosurg 55:550–553
Busto R, Globus MYT, Dietrich WD et al (1989) Effect of mild hypothermia on ischemic-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20:904–910
Cain SM (1963) An attempt to demonstrate cerebral anoxia during hyperventilation of anaesthetized dogs. Am J Physiol 204:323–326
Carey BJ, Manktelow BN, Panerai RB et al (2001) Cerebral autoregulation responses to head-up tilt in normal subjects and patients with recurrent vasovagal syncope. Circulation 21:898–902
Carlsson C, Hägerdal M, Siesjö BK (1976) Protective effect of hypothermia in cerebral oxygen deficiency caused by arterial hypoxia. Anesthesiology 44:27–34
Carmona Suazo JA, Maas AIR, van den Brink WA (2000) CO2 reactivity and brain oxygen pressure monitoring in severe head injury. Crit Care Med 28:3268–3274
Chambers IR, Kane PJ, Signorini DF et al (1998) Bilateral ICP monitoring: its importance in detecting the severity of secondary insults. Acta Neurochir Suppl 71:42–43
Chambers IR, Banister K, Mendelow AD (2001) Intracranial pressure within a developing intracerebral haemorrhage. Br J Neurosurg 15:140–141
Changaris DG, McGraw CP, Richardson JD et al (1987) Correlation of cerebral perfusion pressure and Glasgow coma scale to outcome. J Trauma 27:1007–1012
Chi OZ, Lu X, Wei HM et al (1996) Hydroxyethyl starch solution attenuates blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Anesth Analg 83:226–341
Chopp M, Knight R, Tidwell CD et al (1989) The metabolic effects of mild hypothermia on global cerebral ischemia and recirculation in the cat: comparison to normothermia and hyperthermia. J Cereb Blood Flow Metab 9:141–148
Christensen MS (1974) Acid-base changes in cerebrospinal fluid and blood, and blood volume changes following prolonged hyperventilation in man. Br J Anaesth 46:348–357
Chung C, Gottstein J, Blei AT (2001) Indomethacin prevents the development of experimental ammonia-induced brain edema in rats after portacaval anastomosis. Hepatology 34:249–254
Clemmesen JO, Hansen BA, Larsen FS (1997) Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. Hepatology 26:1423–1425
Clifton GL, Jiang JY, Lyeth BG et al (1991) Marked protection by moderate hypothermia after experimental traumatic brain injury. J Cereb Blood Flow Metab 11:114–121
Clifton GL, Allen S, Barrodale P et al (1993) A phase II study of moderate hypothermia in severe brain injury. J Neurotrauma 10:263–271
Cohen PJ (1981) To dream the impossible dream (editorial view). Anesthesiology 55: 491–493
Cold GE (1978) Cerebral metabolic rate of oxygen (CMR O2) in the acute phase of brain injury. Acta Anaesthesiol Scand 22:249–256
Cold GE (1989a) Measurement of CO2 reactivity and barbiturate reactivity in patients with severe head injury. Acta Neurochir 98:153–163
Cold GE (1989b) Does acute hyperventilation provoke cerebral oligaemia in comatose patients after acute head injury? Acta Neurochir (Wien) 96:100–106
Cold GE, Felding M (1993) Even small doses of morphine might provoke “luxury perfusion” in the postoperative period after craniotomy. Neurosurgery 32:327
Cold GE, Enevoldsen EM, Malmros R (1975) The prognostic value of continuous intraventricular pressure recording in unconscious brain-injured patients under controlled ventilation. In: Lundberg N, Pontén U, Brock M (eds) Intracranial pressure II. Springer, Berlin, pp 517–521
Cold GE, Jensen FT, Malmros R (1977a). The cerebrovascular CO2 reactivity during the acute phase of brain injury. Acta Anaesthesiol Scand 21:222–231
Cold GE, Jensen FT, Malmros R (1977b). The effects of Pa CO2 reduction on regional cerebral blood flow in the acute phase of brain injury. Acta Anaesth Scand 21:359–367
Cold GE, Eskesen V, Eriksen H et al (1986) Changes in CMR O2, EEG and concentration of etomidate in serum and brain tissue during craniotomy with continuous etomidate supplemented with N2O and fentanyl. Acta Anaesthesiol Scand 30:159–163
Cold GE, Tange M, Jensen TM et al (1996) Subdural pressure measurement during craniotomy. Correlation with tactile estimation of dura tension and brain herniation after opening of dura. Br J Neurosurg 10:69–75
Coles JP, Minhas PS, Fryer TD et al (2002) Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates. Crit Care Med 30:1950–1959
Connolly JE, Boyd RJ, Calvin JW (1962) The protective effect of hypothermia in cerebral ischaemia. Experimental and clinical application by selective brain cooling in the human. Surgery 52:15–24
Constantini S, Cotev S, Rappaport H et al (1988) Intracranial pressure monitoring after elective intracranial surgery. J Neurosurg 69:540–544
Cooper PR, Moody S, Clark WK et al (1979) Dexamethasone and severe head injury. A prospective double-blind study. J Neurosurg 51:307–316
Cooper DJ, Myles PS, McDermott FT et al (2004). Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial. JAMA 291:1350–1357
Cottrell JE, Robustelli A, Post K et al (1977) Furosemide- and mannitol-induced changes in intracranial pressure and serum osmolality and electrolytes. Anesthesiology 47:28–30
Cottrell JE, Hartung J, Giffin JP et al (1983) Intracranial and hemodynamic changes after succinyl administration in cats. Anesth Analg 62:1006–1009
CRASH trial collaboration (2004) Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomized placebo-controlled trial. Lancet 364:1321–1328
Cruz J (1993) Combined continuous monitoring of systemic and cerebral oxygenation in acute brain injury: preliminary observations. Crit Care Med 21:1225–1232
Cruz J (1998) The first decade of continuous monitoring of jugular bulb oxyhaemoglobin saturation: management strategies and clinical outcome. Crit Care Med 26:344–351
Cruz J, Jaggi JL, Hoffstad OJ (1995) Cerebral blood flow, vascular resistance, and oxygen metabolism in acute brain trauma: redefining the role of cerebral perfusion pressure? Crit Care Med 23:1412–1417
Cruz J, Minoja G, Okuchi K (2001) Improving clinical outcomes from acute subdural haematomas with the emergency preoperative administration of high doses of mannitol: a randomized trial. Neurosurgery 49:864–871
Cruz J, Minoja G, Okuchi K (2002) Major clinical and physiological benefits of early high doses of mannitol for intraparenchymal temporal hemorrhages with abnormal pupillary widening: a randomized study. Neurosurgery 51:628–637
Cruz J, Minoja G, Okuchi K et al (2004) Successful use of the new high-dose mannitol treatment in patients with Glasgow Coma Scale scores of 3 and bilateral abnormal papillary widening: a randomized trial. J Neurosurg 100:376–383
Cushing H (1903) The blood pressure reaction of acute cerebral compression, illustrated by cases of intracranial hemorrhage. Am J Med Sci 125:1017–1044
Czosnyka M, Pickard JD (2004) Monitoring and interpretation of intracranial pressure. J Neurol Neurosurg Psychiatry 75:813–821
Czosnyka M, Price DJ, Williamson M (1994) Monitoring of cerebrospinal dynamics using continuous analysis of intracranial pressure and cerebral perfusion pressure in head injury. Acta Neurochir (Wien) 126:113–119
Dahl B, Jensen K, Cold GE et al (1991) Studies of barbiturate reactivity in patients with severe head injury. Acta Anaesthesiol Scand Suppl 96:201
Dahl B, Bergholt B, Kjærgaard JO et al (1996) The correlation between CO2 and indomethacin reactivity in severe head injury. Acta Neurochir 138:265–273
Dahlgren N, Nilsson B, Sakabe T et al (1981) The effect of indomethacin on cerebral blood flow and oxygen consumption in the rat at normal and increased carbon dioxide tensions. Acta Physiol Scand 111:475–485
Daley ML, Han S, Leffler C (2002) Cyclic variation of cerebral pial arteriolar diameter synchronized with positive pressure inhalation. Acta Neurochir Suppl 81:143–145
Darby JM, Yonas H, Marion DW et al (1988) Local inverse steal induced by hyperventilation in head injury. Neurosurgery 23:84–88
Dearden NM, Gibson SJ, McDowall DG et al (1986) Effect of high-dose dexamethasone on outcome from severe head injury. J Neurosurg 64:81–88
Dempsey RJ, Roy MW, Meyer KL et al (1985) Indomethacin-mediated improvement following middle cerebral artery occlusion in cats. Effects of anesthesia. J Neurosurg 62:874–881
De Reuck JL (1984) Cerebral argioarchitecture and perinatal brain lesions in premature and full-term infants. Acta Neurol Scand 70:391–395
DeWitt DS, Prough DS, Deal DD et al (1996) Hypertonic saline does not improve cerebral oxygen delivery after head injury and mild hemorrhage in cats. Crit Care Med 24:109–117
Dieterich H-J, Reutershan J, Felbinger TW et al (2003) Penetration of intravenous hydroxyethyl starch into the cerebrospinal fluid in patients with impaired blood-brain barrier. Anesth Analg 96:1150–1154
Dietrich WD, Busto R, Valdes I et al (1990) Effects of normothermic versus mild hyperthermic forebrain ischemia in rats. Stroke 21:1318–1325
Dings J, Meixenberger J, Amschler J et al (1996) Brain tissue p O2 in relation to cerebral perfusion pressure, TCD findings and CO2 reactivity after severe head injury. Acta Neurochir 138:425–434
duCailar J, Rioux J, Groleau D et al (1964) Hypothermie au dessous de 25 par refrigeration externe et sans circulation extra-corporelle. Ann Anesth Franc 4:781–800
Ducey JP, Lamiell JM, Gueller GE (1990) Cerebral electrophysiological effects of resuscitation with hypertonic saline-dextran after hemorrhage. Crit Care Med 18:744–749
Dunn LT (2002) Raised intracranial pressure. J Neurol Neurosurg Psychiatry 73 (suppl 1):i23–i27
Durwald QJ, Del Maestro RF, Amacher AL et al (1983) The influence of systemic arterial pressure and intracranial pressure on the development of cerebral vasogenic edema. J Neurosurg 59:803–809
Edvinsson L, McCulloch J (1981) Effects of pentobarbital on contractile responses of feline cerebral arteries. J Cereb Blood Flow Metab 1:437–440
Edwards P, Arango M, Balica L et al (2005) Final results of MRC CRASH, a randomized placebo-controlled trial of intravenous corticosteroid in adults with head injury: outcomes at 6 months. Lancet 365:1957–1959
Eide PK (2003) The relationship between intracranial pressure and size of cerebral ventricles assessed by computed tomography. Acta Neurochir 145:171–179
Eisenberg HM, Frankowski RF, Contant CF et al (1988) High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg 69:15–23
Ellingsen I, Hauge A, Nicolaysen G et al (1987) Changes in human cerebral blood flow due to step changes in PaO2 and PaCO2. Acta Physiol Scand 129:157–163
Este-McDonald JR, Josephs LG, Birkett DH et al (1995) Changes in intracranial pressure associated with apneumic retractors. Arch Surg 130:362–365
Famularo G (1999) The puzzle of neuronal death and life: is mannitol the right drug for the treatment of brain oedema associated with ischemic stroke? Eur J Emerg Med 6:363–368
Fandino J, Stocker R, Prokop S et al (1999) Correlation between jugular bulb oxygen saturation and partial pressure of brain tissue oxygen during CO2 and O2 reactivity tests in severely head-injured patients. Acta Neurochir 141:825–834
Faupel G, Reulen HJ, Muller D et al (1976) Double-blind study on the effects of steroids on severe closed head injury. In: Pappius HM, Feindal W (eds) Dynamics of brain edema. Springer, Berlin, pp 337–343
Feldman Z, Kanter MJ, Robertson CS et al (1992) Effect of head elevation on intracranial pressure, cerebral perfusion pressure, and cerebral blood flow in head-injured patients. J Neurosurg 76:207–211
Feldman Z, Roberson CS, Contant CSF et al (1997) Positive end-expiratory pressure reduces intracranial compliance in the rabbit. J Neurosurg Anesthesiol 9:175–179
Fieschi C, Battistini N, Beduschi A et al (1974) Regional cerebral blood flow and intraventricular pressure in acute head injuries. J Neurol Neurosurg Psychiatry 37:1378–1388
Filipo V, Butterworth RF (2002) Neurobiology of ammonia. Prog Neurobiol 67:259–279
Fisher B, Thomas D, Peterson B (1992) Hypertonic saline lowers raised intracranial pressure in children after head trauma. J Neurosurg Anesthesiol 4:4–10
Fortune JB, Feustel PJ, Graca L et al (1995) Effect of hyperventilation, mannitol, and ventriculostomy drainage on cerebral blood flow after head injury. J Trauma 39:1091–1097
French LA, Galicich JH (1964) The use of steroids for control of cerebral edema. Clin Neurosurg 10:212–223
Frost EA (1977) Effects of positive end-expiratory pressure on intracranial pressure and compliance in brain-injured patients. J Neurosurg 47:195–200
Ganz JC, Hall C, Zwernow NN (1995) Cerebral blood flow during experimental epidural bleeding in swine. Acta Neurochir 103:148–157
Gaudet RJ, Alam I, Levine L (1980) Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J Neurochem 35:653–658
Gemma M, Tommasino C, Cerri M et al (2002) Intracranial effects of endotracheal suctioning in the acute phase of head injury. J Neurosurg Anesthesiol 14:50–54
Georgiadis D, Schwartz S, Baumgartner RW et al (2001) Influence of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure in patients with acute stroke. Stroke 32:2088–2092
Giffin JP, Hartung J, Cottrell et al (1986) Effect of vecuronium on intracranial pressure, mean arterial pressure and heart rate in cats. Br J Anesth 58:441–443
Gilles FH, Leviton A, Kerr CS (1976) Endotoxin leucoencephalopathy in the telencephalon of the newborn kitten. J Neurol Sci 27:183–191
Glaser N, Barnett P, McCaslin I et al (2001) Risk factors for cerebral oedema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med 344:264–269
Gleason CA, Short BL, Jones MD Jr (1989) Cerebral blood flow and metabolism during and after prolonged hypocapnia in newborn lambs. J Pediatr 115:309–314
Gobiet W, Bock WJ, Liesgang J et al (1976) Treatment of acute cerebral edema with high dose of dexamethasone. In: Beks JWF et al (eds) Intracranial pressure III. Springer, Berlin, pp 231–235
Gopinath SP, Valadka AB, Uzura M et al (1999) Comparison of jugular venous oxygen saturation and brain tissue P O2 as monitors of cerebral ischaemia after head injury. Crit Care Med 27:2337–2345
Gordon E (1970) The action of drugs on intracranial contents. In: Boulton TB, Bryce-Smith R et al (eds) Progress in anaesthesiology. Excerpta Medica, Amsterdam, p 60
Gotoh F, Meyer JS, Takagi Y (1965) Cerebral effects of hyperventilation in man. Arch Neurol 12:410–423
Graham EM, Apostolou M, Mishra OP et al (1996) Modification of the N-methyl-D- Aspartate (NMDA) receptor in the brain of newborn piglets following hyperventilation induced ischemia. Neurosci Lett 218:29–32
Grände P-O (1989) The effects of dihydroergotamine in patients with head injury and raised intracranial pressure. Intensive Care Med 15:523–527
Grände P-O (2006) The “Lund Concept” for the treatment of severe head trauma: physiological principles and clinical application. Intensive Care Med 32:1475–1484
Greenberg JH, Alavi A, Reivich M et al (1978) Local cerebral blood volume response to carbon dioxide in man. Circ Res 43:324–331
Greenwood J, Luthert PJ, Pratt OE et al (1988) Hyperosmolar opening of the blood-brain barrier in energy-depleted rat brain. Part I. Permeability studies. J Cereb Blood Flow Metab 8:9–15
Greisen G, Munck H, Lou H (1987) Severe hypocapnia in preterm infants and neurodevelopmental deficit. Acta Paediatr Scand 76:401–404
Gross CE, Abel PW (1985) Contraction and relaxation of rabbit basilar artery by thiopental. Neurosurgery 17:433–435
Grubb RL, Raichle ME, Eichling JO et al (1974) The effects of changes in Pa CO2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5:630–638
Grubb RL, Raichle ME, Eichling JO et al (1977) Effects of subarachnoid hemorrhage on cerebral blood volume, blood flow and oxygen utilization in humans. J Neurosurg 46:446–453
Gudeman SK, Miller JD, Becker DP (1979) Failure of high-dose steroid therapy to influence intracranial pressure in patients with severe head injury. J Neurosurg 51:301–306
Guieu JD, Lapierre M, Blond S et al (1979) Correlations between intracranial pressure variations and EEG changes in patients with cranial trauma (translated). Rev Electroencephalogr Neurophysiol Clin 9:194–201
Haddad GG, Jiang C (1997) O2-sensing mechanisms in excitable cells: role of plasma membrane K+ channels. Annu Rev Physiol 59:23–42
Hallenbeck JM, Furlow TW (1979) Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog. Stroke 10:629–637
Halverson A, Buchanan R, Jacobs L et al (1998) Evaluation of mechanism of increased intracranial pressure with insufflation. Surg Endosc 12:266–269
Haring HP, Hormann C, Schalow S et al (1994) Continuous positive airway pres- sure breathing increases cerebral blood flow velocity in humans. Anesth Analg 79: 883–885
Hariri RJ, Firlich AD, Shepard SR et al (1993) Traumatic brain injury, hemorrhagic shock, and fluid resuscitation: effects on intracranial pressure and brain compliance. J Neurosurg 79:421–427
Harp JR, Wollman H (1973) Cerebral metabolic effects of hyperventilation and deliberate hypotension. Br J Anaesth 45:256–262
Harris RJ, Bayhan M, Branston NM et al (1982) Modulation of the pathophysiology of primate focal cerebral ischaemia by indomethacin. Stroke 13:17–24
Härtl R, Schürer L, Dautermann C et al (1993) Effect of hypertonic-hyperoncotic solutions (HHS) on increased intracranial pressure after a focal brain lesion and inflation of an epidural balloon. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 612–614
Härtl R, Medary MB, Ruge M et al (1997) Early white blood cell dynamics after traumatic brain injury: effects on cerebral microcirculation. J Cereb Blood Flow Metab 17:1210–1220
Haure P, Cold GE, Hansen TM et al (2003) The ICP-lowering effect of 10° reverse Trendelenburg position during craniotomy is stable during a 10-minute period. J Neurosurg Anesthesiol 15:297–301
Havill JH (1984) Prolonged hyperventilation and intracranial pressure. Crit Care Med 12:72–74
Haxhiu MA, van Lunteren E, Deal EC et al (1989) Role of the ventral surface of medulla in the generation of Mayer waves. Am J Physiol 257:R804–R809
Hering R, Wrigge H, Vorwerk R et al (2001) The effects of prone positioning in intraabdominal pressure and cardiovascular and renal function in patients with acute lung injury. Anesth Analg 92:1226–1231
Himmelseher S, Pfenninger E, Morin P et al (2001) Hypertonic-hyperoncotic saline differentially affects healthy and glutamate-injured primary rat hippocampus neurons and cerebral astrocytes. J Neurosurg Anesthesiol 13:120–130
Hochwald GM, Wald A, Malhan C (1976) The sink action of cerebrospinal fluid volume flow. Arch Neurol 33:339–344
Hoffman WE, Werner C, Baughman VL et al (1991) Postischemic treatment with hypothermia improves outcome from incomplete cerebral ischemia in rats. J Neurosurg Anesthesiol 3:34–38
Hörmann C, Mohsenipour I, Gottardis M et al (1994) Response of cerebrospinal fluid pressure to continuous positive airway pressure in volunteers. Anesth Analg 78:54–57
Howells T, Elf K, Jones PA et al (2005) Pressure reactivity as a guide in the treatment of cerebral perfusion pressure in patients with brain trauma. J Neurosurg 102:311–317
Hulme A, Cooper R (1976) The effects of head position and jugular vein compression on intracranial pressure. A clinical study. In: Beks JWF, Bosch DA, Brock M (eds) Intracranial pressure III. Springer, Berlin, pp 259–263
Hung OR, Hare GM, Brien S (2000) Head elevation reduces head-rotation associated increased ICP in patients with intracranial tumours. Can J Anaesth 47:415–420
Hunter AR (1972) Thiopentone supplemented anaesthesia for neurosurgery. Br J Anaesth 44:506–510
Imberti R, Ciceri M, Bellinzona G et al (2000) The use of hyperventilation in the treatment of plateau waves in two patients with severe traumatic brain injury: contrasting effects on cerebral oxygenation. J Neurosurg Anesthesiol 12:124–127
Imberti R, Bellinzona G, Langer M (2002) Cerebral tissue P O2 and Sjv O2 changes during moderate hyperventilation in patients with severe traumatic brain injury. J Neurosurg 96:97–102
Ito U, Ohno K, Nakamura R et al (1979) Brain edema during ischemia after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability. Stroke 10:542–547
Jafar JJ, Johns LM, Mullan SF (1986) The effect of mannitol on cerebral blood flow. J Neurosurg 64:754–759
Jaggi JL, Obrist WD, Gennarelli TA et al (1990) Relationship of early cerebral blood flow and metabolism to outcome in acute head injury. J Neurosurg 72:176–182
James HE (1978) Cytotoxic edema produced by 6-aminonicotinamide and its response to therapy. Neurosurgery 3:196–200
James HE (1980) Methodology for the control of intracranial pressure with hypertonic mannitol. Acta Neurochir (Wien) 51:161–172
Jennett WB, Teasdale C (1981) Management of head injuries in the acute state. Davis, Philadelphia, pp 240–241
Jensen K, Öhrström J, Cold GE et al (1991) The effects of indomethacin on intracranial pressure, cerebral blood flow, and cerebral metabolism in patients with severe head injury and intracranial hypertension. Acta Neurochir (Wien) 108:116–121
Jensen K, Freundlich M, Bünemann L et al (1993) The effect of indomethacin upon cerebral blood flow in healthy volunteers. The influence of moderate hypoxia and hypercapnia. Acta Neurochir (Wien) 124:114–119
Jensen K, Kjaergaard S, Malte E et al (1996) Effect of graduated intravenous and standard rectal doses of indomethacin on cerebral blood flow in healthy volunteers. J Neurosurg Anesthesiol 8:111–116
Johnston AJ, Steiner LA, Balestreri M et al (2003) Hyperoxia and cerebral haemodynamic responses to moderate hyperventilation. Acta Anaesthesiol Scand 47:391–396
Johnstone IH, Harper AM (1973) The effect of mannitol on cerebral blood flow. An experimental study. J Neurosurg 38:461–471
Jones SJ, Dinsmore J (2002) Effect of diclofenac on cerebral blood flow velocity in patients with supratentorial tumours. Br J Anaesth 89:762–764
Jørgensen HA, Bundgaard H, Cold GE (1999) Subdural pressure measurement during fossa posterior surgery. Br J Neurosurg 13:449–453
Josephs LG, Este-McDonald E, Birkett DH et al (1994) Diagnostic laparoscopy increases intracranial pressure. J Trauma 36:815–818
Kalmar AF, van Aken J, Caemaert J et al (2005) Value of Cushing reflex as warning sign for brain ischaemia during neuroendoscopy. Br J Anaesth 94:791–799
Kanter MJ, Robertson CS, Sheinberg MA et al (1993) Changes in cerebral haemodynamics with head elevated vs. head flat. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, p 79
Kassell NF, Hitchon PW, Gerk MK et al (1980) Alterations in cerebral blood flow, oxygen metabolism, and electrical activity produced by high dose sodium thiopental. Neurosurgery 7:598–603
Kassell NF, Baumann KW, Hitchon PW et al (1982) The effects of high dose mannitol on cerebral blood flow in dogs with normal intracranial pressure. Stroke 13:59–61
Kaufmann AM, Cardoso ER (1992) Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg 77:584–589
Kazan S, Karasoy M, Baloglu H et al (1999) The effect of mild hypothermia, mannitol and insulin-induced hypoglycaemia on ischemic infarct volume in the early period after permanent middle cerebral artery occlusion in the rat. Acta Neurochir 141:979–987
Kellie G (1824) An account of the appearances observed in the dissection of two of the three individuals presumed to have perished in the storm of the 3rd, and whose bodies were discovered in the vicinity of Leith on the morning of the 4th November 1921 with some reflections on the pathology of the brain. Trans Med Chir Sci, Edinburgh, 1:84–169
Kempski O, Obert C, Mainka T et al (1996) “Small volume resuscitation” as treatment of cerebral blood flow disturbances and increased ICP in trauma and ischemia. Acta Neurochir Suppl 66:114–117
Kenning JA, Toutant SM, Saunders RL (1981) Upright patient positioning in the management of intracranial hypertension. Surg Neurol 15:148–152
Khanna S, Davis D, Peterson B et al (2000) Use of hypertonic saline in the treatment of severe refractory posttraumatic intracranial hypertension in pediatric traumatic brain injury. Crit Care Med 28:4:1144–1151
Kien RD, Reitan JA, White DA et al (1991a) Cardiac contractility and blood flow distribution following resuscitation with 7.5% hypertonic saline in anesthetized dogs. Circ Shock 35:109–116
Kien ND, Kramer GC, White DA (1991b) Acute hypotension caused by rapid hypertonic saline infusion in anesthetized dogs. Anesth Analg 73:597–602
Kiening KL, Schoening WN, Lanksch WR et al (2002) Intracranial compliance as bed-side monitoring technique in severely head-injured patients. Acta Neurochir Suppl 81:177–180
Kim B, Feldman EL (2002) Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem 26:27393–27400
Kim HJ, Levasseur JE, Patterson JL et al (1989) Effect of indomethacin pretreatment on acute mortality in experimental brain injury. J Neurosurg 71:565–572
Kim W, Moon SO, Sung MJ et al (2002) Protective effect of adrenomedullin in mannitol-induced apoptosis. Apoptosis 7:527–536
Kitagawa K, Matsumoto M, Tagaya M et al (1991) Hyperthermia-induced neuronal protection against ischemic injury in gerbils. J Cereb Blood Flow Metab 11:449–452
Kitahata LM, Galicich JM, Sato I (1971) The effect of passive hyperventilation on intracranial pressure. J Neurosurg 34:185–193
Koide T, Wieloch TW, Siesjö BK (1986) Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. J Cereb Blood Flow Metab 6:395–404
Kojima T, Iwat K, Tamai K (1993) Change of cerebral electrophysiological activity, regional cerebral blood flow and regional cerebral blood volume in acute intracranial hypertension. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 249–252
Kolbitsch C, Lorenz IH, Hoermann C et al (2000) The influence of increased intrathoracic pressure on cerebral compliance in humans. Proc XI ICP Symp, Cambridge P17-8, p 286
Kolbitsch C, Lorenz ICH, Hörmann C et al (2002) The impact of hypercapnia on systolic cerebrospinal fluid peak velocity in the aqueduct of Sylvius. Anesth Analg 95:1049–1051
Korenkov AI, Pahnke J, Frei K et al (2000) Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following cerebral ischemia. Neurosurg Rev 23:145–150
Kramer GC, Perron PR, Lindsey DC et al (1986) Small-volume resuscitation with hypertonic saline dextran solution. Surgery 100:239–247
Kuchiwaki H, Misu N, Takada S et al (1992) Measurement of local directional pressures in the brain with mass. Neurosurgery 31:731–738
Laffey JG, Kavanagh BP (2002) Hypocapnia. N Engl J Med 347:43–53
Langfitt TW, Weinstein JD, Kassell NF et al (1964) Transmission of increased intracranial pressure within the craniospinal axis. J Neurosurg 21:989–997
Lanier WL, Milde JH, Michenfelder JD (1985) The cerebral effects of pancuronium and atracurium in halothane-anesthetized dogs. Anesthesiology 63:589–597
Lanier WL, Milde JH, Michenfelder JD (1986) Cerebral stimulation following succinylcholine in dogs Anesthesiology 64:551–559
Lanier WL, Iaizzo PA, Milde JH (1989) Cerebral function and muscle afferent activity following intravenous succinylcholine in dogs anesthetized with halothane: the effects of pretreatment with a defasciculating dose of pancuronium. Anesthesiology 71:87–95
Larsen R, Hilfiker O, Radle J et al (1981) Midazolam: Wirkung auf allgemeine Hämodynamik, Hirndurchblutung und Cerebralen Sauerstoffverbrauch bei Neurochirurgischen Patienten. Anesthetist 30:18–21
Larsen JR, Haure P, Cold GE (2002) Reverse Trendelenburg position reduces intracranial pressure during craniotomy. J Neurosurg Anesthesiol 14:16–21
Lee ST (1989) Intracranial pressure changes during positioning of patients with severe head injury. Heart Lung 18:411–414
Lescot T, Naccache L, Bonnet MP et al (2005) The relationship of intracranial pressure Lundberg waves to electroencephalograph fluctuations in patients with severe head trauma. Acta Neurochir 147:125–129
Little JR (1978) Modification of acute focal ischaemia by treatment with mannitol. Stroke 9:4–9
Lodrini S, Montolivo M, Pluchino F et al (1989) Positive end-expiratory pressure in supine and sitting positions: its effects on intrathoracic and intracranial pressures. Neurosurgery 24:873–877
Long DM, Maxwell R, Choi KS (1976) A new therapy regimen for brain edema. In: Pappius HM, Feidal W (eds) Dynamics of brain edema. Springer, Berlin, pp 293–300
Lukins MB, Manninen PH (2005) Hyperglycemia in patients administered dexamethasone for craniotomy. Anesth Analg 100:1129–1133
Lundberg N (1960) Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Scand 36(suppl 149):1–193
Lundberg N, Kjällquist A, Bien C (1959) Reduction of increased intracranial pressure by hyperventilation. Acta Psychiatr Neurol Scand 34(suppl 139)
Maas AIR, Fleckenstein W, deJong DA et al (1993) Effect of increased ICP and decreased cerebral perfusion pressure on brain tissue and cerebrospinal fluid oxygen tension. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 233–237
Maas AIR, Dearden M, Teasdale GM et al (1997) EBIC guidelines for management of severe head injury in adults. Acta Neurochir 139:286–294
MacDonald JT, Uden DL (1982) Intravenous glycerol and mannitol therapy in children with intracranial hypertension. Neurology 32:437–440
MacKenzie ET, McCullock J, O’Keane M et al (1976) Cerebral circulation and norepinephrine: relevance of the blood-brain barrier. Am J Physiol 231:483–488
Maeda M, Miyazaki M (1998) Control of ICP and cerebrovascular bed by the cholinergic basal forebrain. Acta Neurochir Suppl 71:293–296
Maeda M, Miyazaki M, Ishii S (1989) The role of the mutual interaction between the locus coeruleus complex and the cholinoceptive pontine area in the plateau wave. In: Hoff JT, Betz AL (eds) Intracranial pressure VII. Springer, Berlin, pp 228–231
Maeda M, Miyazaki M, Ishii S (1993) Control of ICP by the medullary reticular formation. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 207–213
Maioriello A, Chaljub G, Nauta HJW et al (2002). Chemical shift imaging of mannitol in acute cerebral ischemia. J Neurosurg 87:687–691
Mak S, Egri Z, Tanna G et al (2002) Vitamin C prevents hyperoxia-mediated vasoconstriction and impairment of endothelium-dependent vasodilatation. Am J Physiol Heart Circ Physiol 282:H2414–H2421
Malek AM, Goss GG, Jiang L et al (1998) Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke 29:2631–2640
Manninen PH, Lam AM, Gelb AW et al (1987) The effect of high-dose mannitol on serum and urine electrolytes and osmolality in neurosurgical patients. Can J Anaesth 34:442–446
Manno EM, Adams RE, Derdeyn CP et al (1999) The effects of mannitol on cerebral edema after large hemispheric cerebral infarct. Neurology 52:583–587
March Ml, Dunlop BJ, Shapiro HM et al (1980) Succinylcholine-intracranial pressure effects in neurosurgical patients. Anesth Analg 59:550–551
Marin J, Lobato RD, Rico ML et al (1981) Effect of pentobarbital on the reactivity of isolated human cerebral arteries. J Neurosurg 54:521–524
Marion DW, Obrist WD, Carlien PM et al (1993) The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report. J Neurosurg 79:354–362
Marion DW, Penrod LE, Kelsey SF et al (1997) Treatment of traumatic brain injury with moderate hypothermia. New Engl J Med 336:540–545
Marshall LF, Smith RW, Rauscher LA et al (1978) Mannitol dose requirements in brain-injured patients. J Neurosurg 48:169–172
Marshall WK, Page RB, Milchak MA (1982) Furosemide reduces brain water in cerebral injury in dogs. Anesthesiology 57:A308
Marshall LF, Zovickian J, Ostrup R et al (1986) Multiple simultaneous recordings of ICP in patients with acute mass lesions. In: Miller JD, Teasdale GM, Rowan JO et al (eds) Intracranial pressure VI. Springer, Berlin, pp 184–186
Martins AN, Doyle TF, Newby N (1976) PaCO2 and rate of formation of cerebrospinal fluid in the monkey. Am J Physiol 231:127–131
Marx W, Shah N, Long C et al (1989) Sufentanil, alfentanil, and fentanyl: impact on cerebrospinal fluid pressure in patients with brain tumors. J Neurosurg Anesthesiol 1:3–7
Mascia L, Grasso S, Puntillo F et al (2000) The effects of PEEP on cerebral haemodynamics in severe brain injured patients with acute lung injury. Intensive Care Med 123
Mascia L, Grasso S, Fiore T et al (2005) Cerebro-pulmonary interactions during the application of low levels of positive end-expiratory pressure. Intensive Care Med 31:373–379
Mavrocordatos P, Bissonnette P, Ravussion P (2000) Effects of neck position and head elevation on intracranial pressure in anaesthetized neurosurgical patients: preliminary results. J Neurosurg Anesthesiol 12:10–14
Mayhall CG, Archer NH, Lamb VA et al (1984) Ventriculostomy-related infections. A prospective epidemiological study. N Eng J Med 310:553–559
Mayzler O, Leon A, Eilig I et al (2006) The effect of hypertonic (3%) saline with and without furosemide on plasma osmolality, sodium concentration, and brain water content after closed head trauma in rats. J Neurosurg Anesthesiol 18:24–31
Mazzoni MC, Borgstrom P, Arfors KE et al (1988) Dynamic fluid redistribution in hyperosmotic resuscitation of hypovolemic hemorrhage. Am J Physiol 255:H629–H637
McGuire G, Crossley D, Richards J et al (1997) Effects of varying levels of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure. Crit Care Med 25:1059–1062
Mchedlishvili G (1988) Pathogenetic role of circulatory factors in brain oedema development. Neursurg Rev 11:7–13
McHenry LC Jr, Jaffe ME, West JW et al (1972) Regional cerebral blood flow and cardiovascular effects of hexobendine in stroke patients. Neurology (Minneap) 22:217–223
McLaughlin MR, Marion DW (1996) Cerebral blood flow and vasoresponsivity within and around cerebral contusions. J Neurosurg 85:871–876
McQueen JD, Jeanes LD (1964) Dehydration and rehydration of the brain with hypertonic urea and mannitol. J Neurosurg 11:118–128
Meixensberger J, Brawanski A, Danhauser-Leistner I et al (1993) Is there a risk to induce ischemia by hyperventilation therapy? In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 589–591
Meixensberger J, Baunach S, Amschler J et al (1997) Influence of body position on tissue-p O2, cerebral perfusion pressure and intracranial pressure in patients with acute brain injury. Neurol Res 19:249–253
Meixensberger J, Jager A, Dings J et al (1998) Multimodal haemodynamic neuromonitoring: quality and consequences for therapy of severely head injured patients. Acta Neurochir Suppl 71:260–262
Mellander S, Nordenfelt I (1970) Comparative effects of dihydroergotamine and noradrenalin on resistance exchange and capacitance functions in the peripheral circulation. Clin Sci 39:183–201
Merlo F, Demo P, Moreth T et al (1993) Propofol vs. thiopental for the control of elevated ICP in head injured patients. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 629–631
Messeter K, Nordström C-H, Sundbärg G et al (1986) Cerebral haemodynamics in patients with severe head trauma. J Neurosurg 64:231–237
Metz C, Holzschuh M, Bein T et al (1996) Moderate hypothermia in patients with severe head injury: Cerebral and extracerebral effects. J Neurosurg 85:533–541
Meyer FB, Anderson RE, Sundt TM et al (1987) Treatment of experimental focal cerebral ischaemia with mannitol. J Neurosurg 66:109–115
Michenfelder JD (1974) The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 41:231–236
Michenfelder JD, Milde JH (1977) Failure of prolonged hypocapnia, hypothermia or hypertension to favourably alter acute stroke in primates. Stroke 8:87–91
Michenfelder JD, Milde JH (1991) The relationship among canine brain temperature, metabolism, and function during hypocapnia. Anesthesiology 75:130–136
Michenfelder JD, Sundt TM (1973) The effect of Pa CO2 on the metabolism of ischemic brain in squirrel monkeys. Anesthesiology 38:445–453
Milde LN, Milde JH, Michenfelder JD (1985) Cerebral functional, metabolic, and haemodynamic effects of etomidate in dogs. Anesthesiology 63:371–377
Milde LN, Milde JH, Gallagher W (1990) Effects of sufentanil on cerebral circulation and metabolism in dogs. Anesth Analg 70:138–146
Miller JD, Leech P (1975) Effects of mannitol and steroid therapy on intracranial volume-pressure relationships in patients. J Neurosurg 42:274–281
Miller JD, Becker DP, Ward JD et al (1977) Significance of intracranial hypertension in severe head injury. J Neurosurg 47:503–513
Miller JD, Wilkinson HA, Rosenfeld SA et al (1986) Intracranial hypertension and cerebrospinal fluid production in dogs: effects of furosemide. Exp Neurol 94:66–80
Miller JD, Peeler DF, Pattisapu J et al (1987) Supratentorial pressure. Part 1: differential intracranial pressure. Neurol Res 9:16–26
Minchenko A, Leshchinsky I, Opentanova I et al (2002) Hypoxia inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 277:6183–6187
Mindermann T, Gratzl O (1998) Interhemispheric pressure gradients in severe head trauma in humans. Acta Neurochir Suppl 71:56–58
Mirski AM, Denchev ID, Schnitzer SM et al (2000) Comparison between hypertonic saline and mannitol in the reduction of elevated intracranial pressure in a rodent model of acute cerebral injury. J Neurosurg Anesthesiol 12:334–344
Mittlmeier T, Vollmar B, Menger MD et al (2003) Small volume hypertonic hydroxyethyl starch reduces acute microvascular dysfunction after closed soft-tissue trauma. J Bone Joint Surg Br 85:126–132
Monro A (1823) Observations of the structure and function of the nervous system. Creech and Johnson, Edinburgh, p 5
Moon PF, Kramer GC (1995) Hypertonic saline/dextran resuscitation from hemorrhagic shock induces transient acidosis. Crit Care Med 23:323–331
Moraine J-J, Berré J, Mélot C (2000) Is cerebral perfusion pressure a major determinant of cerebral blood flow during head elevation in comatose patients with severe intracranial lesions? J Neurosurg 92:606–614
Morgan P, Ward B (1970) Hyperventilation and changes in the electroencephalogram and electroretinogram. Neurology 20:1009–1014
Muizelaar JP, Wei EP, Kontos HA et al (1983) Mannitol causes compensatory cerebral vasoconstriction and vasodilatation in response to blood viscosity changes J Neurosurg 59:822–828
Muizelaar JP, Lutz HA, Becker DP (1984) Effect of mannitol on ICP and CBF and correlation with pressure autoregulation in severely head-injured patients. J Neurosurg 61:700–706
Müller-Schweinitzer E, Rosenthaler J (1987) Dihydroergotamine: pharmacodynamics, and mechanism of venoconstrictor action in beagle dogs. J Cardiovasc Pharmacol 9:686–693
Munari C, Calbucci F (1979) Correlations between intracranial pressure (ICP) and EEG changes during traumatic coma. Rev Electroencephalogr Neurophysiol Clin 9:185–193
Nakamura T, Miyamoto O, Sumitani K et al (2003) Do rapid systemic changes of brain temperature have an influence on the brain? Acta Neurochir 145:301–307
Nath F, Galbraith S (1986) The effect of mannitol on cerebral white matter water content. J Neurosurg 65:41–43
Nekludov M, Bellander BM, Mure M (2006) Oxygenation and cerebral perfusion pressure improved in the prone position. Acta Anesthesiol Scand 50:932–936
Ng I, Lim J, Wong HB (2004) Effects of head posture on cerebral haemodynamics: its influence on intracranial pressure, cerebral perfusion pressure, and cerebral oxygenation. Neurosurgery 54:593–598
Nilsson F, Messeter K, Grände PO et al (1995) Effects of dihydroergotamine on cerebral circulation during experimental intracranial hypertension. Acta Anaesthesiol Scand 39:916–921
Nolte D, Bayer M, Lehr HA et al (1992) Attenuation of postischemic microvascular disturbances in striated muscle by hyperosmolar saline dextran. Am J Physiol 263:H1411–H1416
Noppens RR, Christ M, Brambrink AM et al (2006) An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia. Crit Care Med 34:2194–2200
Nordström C-H, Rehncrona S (1979) Reduction of cerebral blood flow and oxygen consumption with a combination of barbiturate anesthesia and induced hypothermia in the rat. Acta Anaesthesiol Scand 22:7–12
Nornes H, Magnäs B (1971) Supratentorial epidural pressure recording during posterior fossa surgery. J Neurosurg 35:541–549
Norris JW (1976) Steroid therapy in acute cerebral infarction. Arch Neurol 33:69–71
North JB, Reilly PL, Gorman D et al (1993) The effect of hypoxia on intracranial pressure and cerebral blood flow. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 238–243
Nunn JF (1987) Applied respiratory physiology, 3rd edn. Butterworth, Cambridge, UK
Obrist WD, Gennarelli TA, Segewa H et al (1979) Relation of cerebral blood flow to neurological status and outcome in head-injured patients. J Neurosurg 51:292–300
Obrist WD, Langfitt TW, Jaggi JL et al (1984) Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J Neurosurg 61:241–253
Oertel M, Kelly DF, Lee JH et al (2002) Is CPP therapy beneficial for all patients with high ICP? Acta Neurochir Suppl 81:67–68
Oka A, Belliveau MJ, Rosenberg PA et al (1993) Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci 13:1441–1453
Olafsson S, Gottstein J, Blei AT (1995) Brain edema and intracranial hypertension in rats after total hepatectomy. Gastroenterology 108:1097–1103
Olesen J, Skinhøj E (1972) Effects of ergot ankaloids (Hydergine) on cerebral haemodynamics in man. Acta Pharmacol 31:75–85
Onar M, Arik Z (1997) The evaluation of mannitol therapy in acute ischemic stroke patients by serial somatosensory evoked potentials. Electromyogr Clin Neurophysiol 37:213–218
Ott P, Larsen FS (2004) Blood-brain barrier permeability to ammonia in liver failure: a critical reappraisal. Neurochem Int 44:185–198
Paczynski RP, He YY, Diringer MN et al (1997) Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke 28:1437–1443
Palvölgyi R (1969) Regional cerebral blood flow in patients with intracranial tumours. J Neurosurg 31:149–163
Pappius HM, McCann WP (1969) Effects of steroids on cerebral edema in cats. Arch Neurol 20:207–216
Pasternak JJ, McGregor DG, Lanier WL (2004) Effect of single-dose dexamethasone on blood glucose concentration in patients undergoing craniotomy. J Neurosurg Anesthesiol 16:122–125
Patel J, Roberts I, Azzopardi D et al (2000) Randomized double-blind controlled trial comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatr Res 47:36–42
Paulson OB (1970) Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery. Neurology 20:63–77
Pena H, Gaines C, Suess D et al (1982) Effect of mannitol on experimental focal ischaemia in awake monkeys. Neurosurgery 11:477–481
Penn RD, Lee MC, Linninger AA et al (2005) Pressure gradients in the brain in an experimental model of hydrocephalus. J Neurosurg 102:1069–1075
Phelps ME, Grubb RL, Ter-Pogosian MM (1973) Correlation between Pa CO2 and regional cerebral blood volume by x-ray fluorescence. J Appl Physiol 35:274–280
Pichard JD, MacKenzie ET (1973) Inhibition of prostaglandin synthesis and the response of baboon cerebral circulation to carbon dioxide. Nat New Biol 245:187
Pierce EC, Lambertsen CJ, Deutsch S et al (1962) Cerebral circulation and metabolism during thiopental anesthesia and hyper-ventilation in man. J Clin Invest 41:1664–1671
Piper I, Spiegelberg A, Whittle I et al (1999) A comparative study of the Spiegelberg compliance devices with a manual volume-injection method: a clinical evaluation in patients with hydrocephalus. Br J Neurosurg 13:581–586
Pistolese GR, Faraglia V, Agnoli A et al (1972) Cerebral hemispheric “counter-steal” phenomenon during hyperventilation in cerebrovascular diseases. Stroke 3:456–461
Poca MA, Sahuquillo J, Topczewski T et al (2006) Posture-induced changes in intracranial pressure: a comparative study in patients with and without a cerebrospinal fluid block at the craniovertebral junction. Neurosurgery 58:899–906
Polderman KH, van de Kraats G, Dixon JM et al (2003) Increases in spinal fluid osmolarity induced by mannitol. Crit Care Med 31:584–590
Pollay M, Fullenwider C, Roberts A et al (1983) Effect of mannitol and furosemide on blood-brain osmotic gradient and intracranial pressure. J Neurosurg 59:945–950
Poon WS, Ng SC, Chan MT et al (2002) Neurochemical changes in ventilated head-injured patients with cerebral perfusion pressure treatment failure. Acta Neurochir 81:335–338
Portella G, Cormio M, Cierio G (2002) Continuous cerebral compliance monitoring in severe head injury. Its relationship with intracranial pressure and cerebral perfusion pressure. Acta Neurochir Suppl 81:173–175
Procaccio F, Menasce G, Sacchi L et al (1993) Ischemic insult due to manual ventilation in head injured patients with intracranial hypertension. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 583–588
Prough DS, Johnson JC, Poole GV et al (1985) Effects on intracranial pressure of resuscitation from hemorrhagic shock with hypertonic saline versus lactated Ringer’s solution. Crit Care Med 13:407–410
Prough DS, Withney JM, Taylor CL et al (1991) Regional cerebral blood flow following resuscitation from hemorrhagic shock with hypertonic saline. Anesthesiology 75:319–327
Quandt CM, Reyes RA (1984) Pharmacologic management of acute intracranial hypertension. Drug Intell Clin Pharm 18:105–112
Qureshi AI, Suarez JI (2000) Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med 28:3301–3313
Qureshi AI, Wilson DA, Traystman RJ (1999) Treatment of elevated intracranial pressure in experimental intracerebral hemorrhage: Comparison between mannitol and hypertonic saline. Neurosurgery 44:1055–1064
Qureshi AI, Wilson DA, Traystman RJ (2002) Treatment of transtentorial herniation unresponsive to hyperventilation using hypertonic saline in dogs: effect on cerebral blood flow and metabolism. J Neurosurg Anesthesiol 14:22–30
Raghavan M, Marik PE (2006) Therapy of intracranial hypertension in patients with fulminant hepatic failure. Neurocrit Care 4:179–189
Raichle ME, Posner JB, Plum F (1970) Cerebral blood flow during and after hyperventilation. Arch Neurol 23:394–403
Raphael JH, Chotai R (1994) Effects of cervical collar on cerebrospinal fluid pressure. Anaesthesia 49:437–439
Rasmussen M, Tankisi A, Cold GE (2004a) The effects of indomethacin on intracranial pressure and cerebral haemodynamics in patients undergoing craniotomy: a randomized prospective study. Anesthesia 59:229–236
Rasmussen M, Østergaard L, Juul N et al (2004b) Do indomethacin and propofol cause cerebral ischemic damage? Anesthesiology 101:872–878
Rasmussen M, Bundgaard H, Cold GE (2004c) Craniotomy for supratentorial brain tumours: risk factors for brain swelling after opening of dura mater. J Neurosurg 101:621–626
Rasmussen M, Upton RN, Grant C et al (2006) The effects of indomethacin on intracranial pressure and cerebral haemodynamics during isoflurane or propofol anesthesia in sheep with intracranial hypertension. Anesth Analg 102:1823–1829
Ravussin P, Archer DP, Tyler JL et al (1986a) Effects of rapid mannitol infusion on cerebral blood volume. J Neurosurg 64:104–113
Ravussin P, Chiolero R, Buchser E et al (1986b) CSF pressure changes following mannitol in patients undergoing craniotomy. Anesthesiology 65:A303
Reivich M, Cohen PJ, Greenbaum L (1966) Alterations in the electroencephalogram of awake man produced by hyperventilation: effects of 100% oxygen at 3 atmospheres (absolute) pressure. Neurology 16:304
Renaudin J, Fewer D, Wilson CB et al (1973) Dose dependency of Decadron in patients with partially excised brain tumors. J Neurosurg 39:302–305
Reulen HJ, Graham R, Spatz M et al (1977) Role of pressure gradients and bulk flow in dynamics of vasogenic edema. J Neurosurg 46:24–35
Risberg J, Lundberg N, Ingvar D (1969) Regional cerebral blood volume during acute transient rises of the intracranial pressure (plateau waves). J Neurosurg 31:303–310
Roberts PA, Pollay M, Engles C et al (1987) Effect on intracranial pressure of furosemide combined with varying doses and administration rates of mannitol. J Neurosurg 66:440–446
Rockoff MA, Marchall LF, Shapiro HM (1979) High-dose barbiturate therapy in humans: a clinical review of 60 patients. Ann Neurol 6:194–199
Rosa G, Orfie P, Sanfilippo M et al (1986) The effects of atracurium besylate (Tracium) on intracranial pressure and cerebral perfusion pressure. Anesth Analg 65:381–384
Rosenthal RJ, Hiatt JR, Phillips EH et al (1997) Intracranial pressure. Effect of pneumoperitoneum in a large-animal model. Surg Endosc 11:376–380
Rosenthal RJ, Friedman RL, Chidambaram A et al (1998) Effects of hyperventilation and hypoventilation on Pa CO2 and intracranial pressure during acute elevations of intraabdominal pressure with CO2 pneumoperitoneum: large animal observations. J Am Coll Surg 187:32–38
Rosenwasser RH, Kleiner LI, Krzeminski JP et al (1989) Intracranial pressure monitoring in the posterior fossa: a preliminary report. J Neurosurg 71:503–505
Rosner MJ, Becker DP (1984) Origin and evolution of plateau waves, experimental observations and a theoretical model. J Neurosurg 60:312–324
Rosner MJ, Coley IB (1986) Cerebral perfusion pressure, intracranial pressure, and head elevation. J Neurosurg 65:636–641
Rosner MJ, Coley I (1987) Cerebral perfusion pressure: a haemodynamic mechanism of mannitol and postmannitol hemogram. Neurosurgery 21:147–156
Rosomoff HL (1963) Distribution of intracranial contents with controlled hyperventilation: implications of neuroanaesthesia. Anesthesiology 24:640–645
Roux FX, Raggueneau JL, Geoerge B et al (1984) Pression epidurale locoregionale et pression intra-cranienne differentielle: interet de leur monitorage chez des patients porters dúe lesion intracerebrale unilaterale. Agressologie 25:559–561
Rudehill A, Lagerkranser M, Lindquist C et al (1983) Effects of mannitol on blood volume and central haemodynamics in patients undergoing cerebral aneurysm surgery. Anesth Analg 62:875–880
Ruta TS, Drummond JC, Cole DJ (1993) The effect of acute hypocapnia on local cerebral blood flow during middle cerebral artery occlusion in isoflurane anesthetized rats. Anesthesiology 78:134–140
Ryding E, Asgeirsson B, Bertman L et al (1990) Dihydroergotamine treatment of increased ICP following severe head injury. 5th Nordic CBF symposium, Lund 27
Sahuquillo J, Poca M-A, Arribas M et al (1999) Interhemispheric supratentorial intracranial pressure gradients in head-injured patients: are they clinically important. J Neurosurg 90:16–26
Sakabe T, Siesjö BK (1979) The effect of indomethacin on blood flow-metabolism couple in the brain under normal, hypercapnic and hypoxic conditions. Acta Physiol Scand 107:283–284
Sasaki T, Nakagomi T, Kirino et al (1988) Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA 1 sector. Stroke 19:1399–1403
Saul TG, Ducker TB (1982) Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. J Neurosurg 56:498–503
Scale TM, Meltz S, Yelon J et al (1994) Resuscitation of multiple trauma and head injury: role of crystalloid fluids and inotropes. Crit Care Med 22:1610–1615
Schaller B, Graf R (2005) Different compartments of intracranial pressure and its relationship to cerebral blood flow. J Trauma 59:1521–1531
Scheinberg P, Stead EA Jr (1949) The cerebral blood flow in male subjects as measured by the nitrous oxide technique. Normal values for blood flow, oxygen utilization, glucose utilization, and peripheral resistance, with observations on the effect of tilting and anxiety. J Clin Invest 28:1163–1171
Schell RM, Applegate RL, Cole DJ (1996) Salt, starch and water on the brain. Points of view. J Neurosurg Anesthesiol 8:178–182
Scheller MS, Zornow MH, Oh YS (1991) A comparison of the cerebral and haemodynamic effects of mannitol and hypertonic saline in a rabbit model of acute cryogenic brain injury. J Neurosurg Anesthesiol 3:291–296
Schenker S, McCandless DW, Brophy E et al (1967) Studies on the intracerebral toxicity of ammonia. J Clin Invest 46:838–848
Schettini A, Stahurski B, Young HF (1982) Osmotic and osmotic-loop diuresis in brain surgery. Effects on plasma and CSF electrolytes and ion excretion. J Neurosurg 56:679–684
Schierhout G, Robert I (2000) Mannitol for acute traumatic brain injury. Cochrane Database Syst Rev 2:CD001049
Schmoker JD, Zhuang J, Shackford SR (1991) Hypertonic fluid resuscitation improves cerebral oxygen delivery and reduces intracranial pressure after hemorrhagic shock. J Trauma 31:1607–1613
Schneider GH, von Helden GH, Franke R et al (1993) Influence of body position and cerebral perfusion pressure. Acta Neurochir 59:107–112
Schneider GH, Sarrafzadeh AS, Kiening KL et al (1998) Influence of hyperventilation on brain tissue: P O2, PaCO2, and pH in patients with intracranial hypertension. Acta Neurochir Suppl 71:62–65
Schreiber SJ, Lambert UKW, Doepp F et al (2002) Effects of prolonged head-down tilt on internal jugular vein cross-sectional area. Br J Anaesth 89:769–771
Schuier FJ, Hossmann KA (1980) Experimental brain infarct in cats. II: Ischemic brain oedema. Stroke 11:593–601
Schumann P, Touzani O, Young AR et al (1996) Effects of indomethacin on cerebral blood flow and oxygen metabolism: a positron emission tomographic investigation in the anaesthetized baboon. Neurosci Lett 220:137–141
Schürer L, Dautermann C, Härtl R et al (1992) Treatment of hemorrhagic hypotension with hypertonic/hyperoncotic solutions: effects on regional cerebral blood flow and brain surface oxygen tension. Eur Surg Res 24:1–12
Schwarz S, Bertram M, Aschoff A et al (1999) Indomethacin for brain edema following stroke. Cardiovasc Dis 9:248–250
Sedzimir CB (1959) Therapeutic hypothermia in cases of head injury. J Neurosurg 16:407–414
Seki H, Ogawa A, Yoshimoto T, Suzuki J (1981) Effect of mannitol on rCBF in canine thalamic ischemia. An experimental study. Brain Nerve (Tokyo) 33:1101–1105
Sgouros S, Goldin JH, Hockley AD et al (1999) Intracranial volume change in childhood. J Neurosurg 91:610–616
Shackford SR, Zhuang J, Schmoker J (1992) Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury. J Neurosurg 76:91–98
Shapira Y, Davidson E, Weidenfeld Y et al (1988) Dexamethasone and indomethacin do not affect brain edema following head injury in rats. J Cereb Blood Flow Metab 8:395–402
Shapiro K, Marmarou A (1989) Mechanisms of intracranial hypertension in children. In: McLaurin R, Venes J, Schut L et al (eds) Pediatric neurosurgery. Saunders, Philadelphia, p 338
Shapiro HM, Galindo A, Wyte SR et al (1973) Rapid intraoperative reduction of intracranial pressure with thiopental. Br J Anaesth 45:1057–1061
Shapiro HM, Wyte SR, Loeser J (1974) Barbiturate augmented hypothermia for reduction of persistent intracranial hypertension. J Neurosurg 40:90–100
Shenkin HA, Goluboff B, Haft H (1962) The use of mannitol for the reduction of intracranial pressure in intracranial surgery. J Neurosurg 19:897–901
Shigeno S, Fritschka E, Shigeno T et al (1985) Effects of indomethacin on rCBF during and after focal cerebral ischemia in the cat. Stroke 16:235–242
Shima K, Marmarou A (1993) Effect of posttraumatic hypoventilation. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 476–478
Shiozaki T, Sugimoto H, Taneda M et al (1993) Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 79:363–368
Shirane R, Weinstein PR (1992) Effect of mannitol on local cerebral blood flow after temporary complete cerebral ischemia in rats. J Neurosurg 76:486–492
Shohami E, Shapira Y, Sidi A et al (1987) Head injury induces increased prostaglandin synthesis in rat brain. J Cereb Blood Flow Metab 7:58–63
Sidi A, Cotev S, Hadani M et al (1983) Long-term barbiturate infusion to reduce intracranial pressure. Crit Care Med 11:478–481
Skippen P, Sear M, Poskitt K et al (1997) Effect of hyperventilation on regional cerebral blood flow in head-injured children. Crit Care Med 25:1402–1409
Sklar FH, Beyer CW, Ramanathan M et al (1980) The effects of furosemide on CSF dynamics in patients with pseudo tumor cerebri. In: Shulman K, Marmarou A, Miller JD, Becker DP, Hochwald GM, Brock M (eds) Intracranial pressure IV. Springer, Berlin, pp 660–663
Slocum HC, Hayes GW, Laezman BL (1961) Ventilator technique of anesthesia for neuroanaesthesia. Anesthesiology 22:143–145
Smedena RJ, Gaab MR, Hesiler HE (1993) A comparison study between mannitol and glycerol therapy in reducing intracranial pressure. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 605–608
Soloway M, Nadel W, Albin MS et al (1968) The effect of hyperventilation on subsequent cerebral infarction. Anesthesiology 29:975–980
Soloway M, Moriarty G, Fraser JG et al (1971) Effect of delayed hyperventilation on experimental cerebral infarction. Neurology 21:479–485
Steen PA, Milde JH, Michenfelder JD (1979) No barbiturate protection in a dog model of complete cerebral ischaemia Ann Neurol 5:343–349
Stephan H, Sonntag H, Schenk HD et al (1987) Einfluss von disoprivan (Propofol) auf die Durchblutung und Sauerstoffverbrauch des Gehirns and die CO2 Reaktivität der Hirngefässe beim Menschen. Anesthetist 36:60–65
Stewart L, Bullock R, Rafferty C et al (1994) Propofol sedation in severe head injury fails to control high ICP but reduces brain metabolism. Acta Neurochir Suppl 60:544–546
St Lawrence KS, Ye FQ, Lewis BK et al (2003) Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation. Magn Reson Med 50:99–106
Stocchetti N, Mattioli C, Paparella A et al (1993) Bedside assessment of CO2 reactivity in head injury: changes in CBF estimated by changes in ICP and cerebral extraction of oxygen (abstract). J Neurotrauma 10(suppl):187
Stocchetti N, Paparella A, Bridelli F et al (1994) Cerebral venous oxygen saturation studied with bilateral samples in the internal jugular veins. Neurosurgery 34:38–43
Stocchetti N, Parma A, Songa V et al (2000) Early translaryngeal tracheostomy in patients with severe brain damage. Intensive Care Med 26:1101–1107
Stocchetti N, Maas AIR, Chieregato A et al (2005) Hyperventilation in head injury. Chest 127:1812–1827
Stringer WA, Hasso AN, Thompson JR et al (1993) Hyperventilation-induced cerebral ischemia in patients with acute brain lesions: demonstrated by xenon-enhanced CT. AJNR Am J Neuroradiol 14:475–484
Stullken AH, Milde JH, Michenfelder JD et al (1977) The nonlinear responses of cerebral metabolism to low concentrations of halothane, enflurane, isoflurane and thiopental. Anesthesiology 46:28–34
Sutherland G, Lesiuk H, Bose R et al (1988) Effect of mannitol, nimodipine, and indomethacin singly or in combination on cerebral ischaemia in rats. Stroke 19:571–578
Suzuka T, Mabe H, Nagai H (1989) Role of arachidonic acid metabolites on development of ischemic cerebral edema in rat middle cerebral artery occlusion. J Cereb Blood Flow Metab 9(suppl 1):S89
Symon L (1970) Regional cerebrovascular responses to acute ischaemia in normocapnia and hypercapnia. J Neurol Neurosurg Psychiatry 33:756–762
Symon L, Pasztor E, Branston NM et al (1974) Effect of supratentorial space-occupying lesions on regional intracranial pressure and local cerebral blood flow: an experimental study in baboons. J Neurol Neurosurg Psychiatry 37:617–626
Symon L, Branston NM, Chikovani O (1979) Ischemic brain oedema following middle cerebral artery occlusion in baboons: relationship between regional cerebral water content and blood flow at 1 and 2 hours. Stroke 10:184–191
Takagi H, Tanaka M, Ohwada T et al (1993) Pharmacokinetic analysis of mannitol in relation to the decrease of ICP. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 596–600
Takahashi H, Koehler RC, Brusilow SW et al (1990) Glutamine synthetase inhibition prevents cerebral edema during hyperammonemia. Acta Neurochir Suppl 51:346–347
Tanaka A, Tomonaga M (1987) Effect of mannitol on cerebral blood flow and microcirculation during experimental middle cerebral artery occlusion. Surg Neurol 28: 189–195
Tankisi A, Cold GE (2007) Optimal reverse Trendelenburg position in patients undergoing craniotomy for cerebral tumors. J Neurosurg 106:239–244
Tankisi A, Rasmussen M, Juul N et al (2002) The effects of 10° reverse Trendelenburg position on ICP and CPP in prone positioned patients subjected to craniotomy for occipital or cerebellar tumours. Acta Neurochir 144:665–670
Tankisi A, Rasmussen M, Juul N et al (2006) The effects of 10° reverse Trendelenburg position on subdural intracranial pressure and cerebral perfusion pressure in patients subjected to craniotomy for cerebral aneurysm. J Neurosurg Anesthesiol 18:11–17
The Brain Trauma Foundation (2000) The American Association of Neurological Surgeons. The Joint Section of Neurotrauma and Critical Care. J Neurotrauma 17
The Brain Trauma Foundation (2007) The American Association of Neurological Surgeons, AANS and CNS the Joint Section of Neurotrauma and Critical Care Guidelines for the management of severe traumatic brain injury. J Neurotrauma 24(suppl 1)
Thelandersson A, Cider Å, Nellgård B (2006) Prone position in mechanically ventilated patients with reduced intracranial compliance. Acta Anaesthesiol Scand 50:937–941
Thenuwara K, Todd MM, Brian JE (2002) Effect of mannitol and furosemide on plasma and brain water. Anesthesiology 96:416–421
Thilmann J, Zeumer H (1974) Untersuchungen zur Behandlung des Hirnödems mit hohen Dosen Furosemid. Dtsch Med Wochenschr 99:932–935
Thomale UW, Griebenow M, Kroppenstedt M et al (2004) Small volume resuscitation with HyperHaes improves pericontusional perfusion and reduces lesion volume following controlled cortical impact injury in rats. J Neurotrauma 21:1737–1746
Tindall GT, Craddock A, Greenfield JC (1967) Effects of the sitting position on blood flow in the internal carotid artery of man during general anaesthesia. J Neurosurg 26: 383–389
Todd MM, Tommasino C, Moore S (1985) Cerebral effects of isovolemic hemodilution with a hypertonic solution. J Neurosurg 63:944–948
Todd NV, Picozzi P, Crockard A et al (1986) Reperfusion after cerebral ischemia: influence of duration of ischemia. Stroke 17:460–466
Tofteng F, Larsen FS (2004) The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 24:798–804
Troup H (1967) Intraventricular pressure in patients with severe brain injuries. J Trauma 7:875–883
Tsuda Y, Kitadai M, Hatanaka Y et al (1998) Effects of mannitol and glycerol on cerebral energy metabolism in gerbils. Acta Neurol Scand 98:36–40
Tsuji T, Chiba S (1986) Responses of isolated canine and simian basilar arteries to thiopentone by a newly designed pharmacological method for measuring vascular responsiveness. Acta Neurochir 80:57–61
Tsuji T, Chiba S (1987) Mechanism of vascular responsiveness to barbiturates in isolated and perfused canine basilar arteries. Neurosurgery 21:161–166
Tulleken CA, von Dieven A, Mollevanger WJ et al (1978) Differential intracranial pressure gradients created by expanding extradural temporal mass lesion. J Neurosurg 86:505–510
Uihlein A, MacCarty CS, Michenfelder JD et al (1966) Deep hypothermia and surgical treatment of intracranial aneurysms. JAMA 195:639–641
Ulatowski JA, Oja JM, Suarez JI et al (1999) In vivo determination of absolute cerebral blood volume using haemoglobin as a natural contrast agent: an MRI study using altered arterial carbon dioxide tension. J Cereb Blood Flow Metab 19:809–817
Unterberg AW, Kiening KL, Hartl R et al (1997) Multimodal monitoring in patients with head injury: evaluation of the effects of treatment on cerebral oxygenation. J Trauma 42:S32–S37
Urlesberger B, Muller W, Ritschi E et al (1991) The influence of head position on the intracranial pressure in preterm infants with post hemorrhagic hydrocephalus. Childs Nerv Syst 7:85–87
Valentin A, Lang T, Karnik R et al (2003) Intracranial pressure monitoring and case mix-adjusted mortality in intracranial haemorrhage. Crit Care Med 31:1539–1542
van Hulst RA, Hassan D, Lachmann B (2002) Intracranial pressure, brain PaCO2, P O2, and pH during hypo- and hyperventilation at constant mean airway pressure in pigs. Intensive Care Med 28:68–73
van Hulst RA, Lameris TW, Haitsma JJ et al (2004) Brain glucose and lactate levels during ventilator-induced hypo- and hypercapnia. Clin Physiol Funct Imaging 24:243–248
Vannucci C, Brucklacher RM, Vannucci SJ (1997) Effect of carbon dioxide on cerebral metabolism during hypoxia-ischemia in the immature rat. Pediatr Res 42:24–29
Van Roost D, Hartmann A, Quade G (2001) Changes of cerebral blood flow following dexamethasone treatment in brain tumour patients. A Xe/CT study. Acta Neurochir 143:37–44
van Santbrink H, Maas AI, Avezaat CJ (1996) Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 38:21–31
Vapalahti M, Troupp H, Heiskanen O (1969) Extremely severe brain injuries treated with hyperventilation and ventricular drainage. In: Brock M, Fieschi C, Ingvar DH, Lassen NA, Schurmann K (eds) Cerebral blood flow. Springer, Berlin, pp 266–267
Vassar MJ, Fischer RP, O’Brien PE (1993) A multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. Arch Surg 128:1003–1013
Videtta W, Villarejo F, Cohen M et al (2002) Effects of positive end-expiratory pressure on intracranial pressure and cerebral perfusion pressure. Acta Neurochir Suppl 81:93–97
Voldby B, Enevoldsen EM, Jensen FT (1985) Regional cerebral blood flow, intraventricular pressure, and cerebral metabolism in patients with ruptured intracranial aneurysms. J Neurosurg 62:48–58
Vollmar B, Lang G, Menger MD et al (1994) Hypertonic hydroxyethyl starch restores hepatic microvascular perfusion in hemorrhagic shock. Am J Physiol 266:H1927–H1934
von Berenberg P, Unterberg A, Schneider GH et al (1994) Treatment of traumatic brain edema by multiple doses of mannitol. Acta Neurochir 60:531–533
von Helden A, Schneider GH, Unterberg A et al (1993) Monitoring of jugular venous saturation in comatose patients with subarachnoid haemorrhage and intracerebral haematomas. Acta Neurochir Suppl 59:102–106
Ward JD, Becker DP, Miller JD et al (1985) Failure of prophylactic barbiturate coma in the treatment of severe head injury. J Neurosurg 62:383–388
Waschke KF, Albrecht DM, van Ackern K et al (1996) Coupling between local cerebral blood flow and metabolism after hypertonic/hyperoncotic fluid resuscitation from hemorrhage in conscious rats. Analg Anesth 82:52–60
Wass CT, Lanier WL (1996) Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin Proc 71:801–812
Wasserman K (1994) Coupling of external to cellular respiration during exercise: the wisdom of the body revisited. Am J Physiol 266:E519–E539
Watanabe T, Yoshimoto T, Ogawa A et al (1979) The effect of mannitol in preserving the development of cerebral infarction. An electron microscopic investigation. Neurol Surg (Tokyo) 7:859–866
Weaver DD, Winn HR, Jane JA (1982) Differential intracranial pressure in patients with unilateral mass lesions. J Neurosurg 56:660–665
Weiss MH, Nulsen FE (1970) The effect of glucocorticoids on CSF flow in dogs. J Neurosurg 32:452–458
Weiss KL, Wax MK, Haydon RC et al (1993) Intracranial pressure changes during bilateral radical neck dissections. Head Neck 15:546–552
Welch K (1980) Intracranial pressure in infants. J Neurosurg 52:693–699
Wennmalm Å, Eriksson S, Wahren J (1981) Effect of indomethacin on basal and carbon dioxide stimulated cerebral blood flow in man. Clin Phys 1:227–234
White RJ (1972) Preservation of cerebral function during circulatory arrest and resuscitation: hypothermic protective considerations. Resuscitation 1:107–115
White RJ, Likavec MJ (1992) The diagnosis and initial management of head injury. N Engl J Med 327:1507–1511
White RJ, Albin MS, Verdura J et al (1967) Differential extracorporeal hypothermic perfusion of and circulatory arrest to the human brain. Med Res Engineering 6:18–24
Whitley JM, Prough DS, Lamb AK et al (1988) Regional cerebral blood flow following resuscitation from hemorrhagic shock in dogs with a subdural mass. Anesthesiology 69(suppl A):539
Whitley JM. Prough DS, Taylor CL et al (1991) Cerebrovascular effects of small volume resuscitation from hemorrhagic shock: comparison of hypertonic saline and concentrated hydroxyethyl starch in dogs. J Neurosurg Anesthesiol 3:47–55
Williams A, Coyne SM (1993) Effects of neck position on intracranial pressure. Am J Crit Care 2:68–71
Wise BL, Chater N (1962) The value of hypertonic mannitol solution in decreasing brain mass and lowering cerebrospinal-fluid pressure. J Neurosurg 19:1038–1043
Wisner DH, Schuster L, Quinn C (1990) Hypertonic saline resuscitation of head injury: effects on cerebral water content. J Trauma 30:75–78
Wolfla C, Luerssen TG, Bowman RM et al (1996) Brain tissue pressure gradients created by expanding frontal epidural mass lesion. J Neurosurg 84:642–647
Worthley IGL, Cooper DJ, Jones N (1988) Treatment of resistant intracranial hypertension with hypertonic saline. J Neurosurg 68:478–481
Yano M, Nishiyama H, Yokota H et al (1986) Effect of lidocaine on ICP response to endotracheal suctioning. Anesthesiology 64:651–653
Yano M, Ikeda Y, Kobayashi S et al (1987) Intracranial pressure in head-injured patients with various intracranial lesions is identical throughout the supratentorial intracranial compartment. Neurosurgery 21:688–692
Yau YH, Piper IR, Clutton RE et al (2000) Experimental evaluation of the Spiegelberg intracranial pressure and intracranial compliance monitor. Technical note. J Neurosurg 93:1072–1077
Yen MH, Lee SH (1987) Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats. Eur J Pharmacol 144:369–373
Yoon BH, Romero R, Kim CJ et al (1997) High expression of tumor necrosis factor-alpha and interleukin-6 in periventricular leukomalacia. Am J Obstet Gynecol 177:406–411
Yoshida A, Shima T, Okada Y et al (1991) Effects of postural changes on epidural pressure in patients with serious intracranial lesions. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 433–436
Yoshida A, Shima T, Okada Y et al (1993) Effects of postural changes on epidural pressure and cerebral perfusion pressure in patients with serious intracranial lesions. In: Avezaat CJJ, van Eijndhoven JHM, Maas AIR, Tans JTJ (eds) Intracranial pressure VIII. Springer, Berlin, pp 433–436
Yoshihara M, Bandoh K, Marmarou A (1995) Cerebrovascular carbon dioxide reactivity assessed by intracranial pressure dynamics in severely head injured patients. J Neurosurg 82:386–393
Zornow MH (1996) Hypertonic saline as a safe and efficacious treatment of intracranial hypertension. J Neurosurg Anesthesiology 8:175–177
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Kolsen-Petersen, J., Dahl, B., Cold, G. (2008). Monitoring of Intracranial Pressure (ICP): A Review. In: Cold, G., Juul, N. (eds) Monitoring of Cerebral and Spinal Haemodynamics During Neurosurgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77873-8_1
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