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Thymoma

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Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Thymoma is a tumor originating from the epithelial cells of the thymus. Thymic tumors are the most commonly diagnosed tumors in the anterior mediastinum in adults, accounting for approximately 50% of anterior mediastinal tumors. Thymoma is usually an indolent disease with a potential of local invasion.

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References

  • Akaogi E, Ohara K, Mitsui K et al. (1996) Preoperative radiotherapy and surgery for advanced thymoma with invasion to the great vessels. J Surg Oncol 63:17–22

    Article  PubMed  CAS  Google Scholar 

  • Blumberg D, Port JL, Weksler B et al. (1995) Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg 60:908–913

    Article  PubMed  CAS  Google Scholar 

  • Bretti S, Berruti A, Loddo C et al. (2004) Piemonte Oncology Network. Multimodal management of stages III-IVa malignant thymoma. Lung Cancer 44:69–77

    Article  PubMed  CAS  Google Scholar 

  • Chen G, Marx A, Wen-Hu C et al. (2002) New WHO histologic classification predicts prognosis of thymic epithelial tumors: a clinicopathologic study of 200 thymoma cases from China. Cancer 95:420–429

    Article  PubMed  Google Scholar 

  • Curran WJ Jr, Kornstein MJ, Brooks JJ et al. (1988) Invasive thymoma: the role of mediastinal irradiation following complete or incomplete surgical resection. J Clin Oncol 6:1722–1727

    PubMed  Google Scholar 

  • Emami B, Lyman J, Brown A et al. (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21:109–122

    PubMed  CAS  Google Scholar 

  • Eng TY, Fuller CD, Jagirdar J et al. (2004) Thymic carcinoma: state of the art review. Int J Radiat Oncol Biol Phys 59:654–664

    PubMed  Google Scholar 

  • Gamondès JP, Balawi A, Greenland T et al. (1991) Seventeen years of surgical treatment of thymoma: factors influencing survival. Eur J Cardiothorac Surg 5:124–131

    Article  PubMed  Google Scholar 

  • Gripp S, Hilgers K, Wurm R et al. (1998) Thymoma: prognostic factors and treatment outcomes. Cancer 83:1495–1503

    Article  PubMed  CAS  Google Scholar 

  • Haniuda M, Miyazawa M, Yoshida K et al. (1996) Is postoperative radiotherapy for thymoma effective? Ann Surg 224:219–224

    Article  PubMed  CAS  Google Scholar 

  • Kim ES, Putnam JB, Komaki R et al. (2004) Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report. Lung Cancer 44:369–379

    Article  PubMed  Google Scholar 

  • Kondo K, Monden Y (2005) Thymoma and myasthenia gravis: a clinical study of 1,089 patients from Japan. Ann Thorac Surg 79:219–224

    Article  PubMed  Google Scholar 

  • Kondo K, Monden Y (2003) Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg 76:878–884

    Article  PubMed  Google Scholar 

  • Kondo K, Yoshizawa K, Tsuyuguchi M et al. (2004) WHO histologic classification is a prognostic indicator in thymoma. Ann Thorac Surg 77:1183–1188

    Article  PubMed  Google Scholar 

  • Kong FM, Hayman JA, Griffith KA et al. (2006) Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 65:1075–1086

    PubMed  Google Scholar 

  • Lastoria S, Vergara E, Palmieri G et al. (1998) In vivo detection of malignant thymic masses by indium-111-DTPA-D-Phe1-octreotide scintigraphy. J Nucl Med 39:634–639

    PubMed  CAS  Google Scholar 

  • Loehrer PJ Sr, Chen M, Kim K et al. (1997) Cisplatin, doxorubicin, and cyclophosphamide plus thoracic radiation therapy for limited-stage unresectable thymoma: an intergroup trial. J Clin Oncol 15:3093–3099

    PubMed  CAS  Google Scholar 

  • López-Cano M, Ponseti-Bosch JM, Espin-Basany E et al. (2003) Clinical and pathologic predictors of outcome in thymoma-associated myasthenia gravis. Ann Thorac Surg 76:1643–1649

    Article  PubMed  Google Scholar 

  • Lucchi M, Ambrogi MC, Duranti L et al. (2005) Advanced stage thymomas and thymic carcinomas: results of multimodality treatments. Ann Thorac Surg 79:1840–1844

    Article  PubMed  Google Scholar 

  • Maggi G, Giaccone G, Donadio M et al. (1986) Thymomas. A review of 169 cases, with particular reference to results of surgical treatment. Cancer 58:765–776

    Article  PubMed  CAS  Google Scholar 

  • Maggi G, Casadio C, Cavallo A et al. (1991) Thymoma: results of 241 operated cases. Ann Thorac Surg 51:152–156

    Article  PubMed  CAS  Google Scholar 

  • Mangi AA, Wright CD, Allan JS et al. (2002) Adjuvant radiation therapy for stage II thymoma. Ann Thorac Surg 74:1033–1037

    Article  PubMed  Google Scholar 

  • Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48:2485–2492

    Article  PubMed  CAS  Google Scholar 

  • Moran CA, Travis WD, Rosado-de-Christenson M et al. (1992) Thymomas presenting as pleural tumors. Report of eight cases. Am J Surg Pathol 16:138–144

    Article  PubMed  CAS  Google Scholar 

  • Mornex F, Resbeut M, Richaud P et al. (1995) Radiotherapy and chemotherapy for invasive thymomas: a multicentric retrospective review of 90 cases. The FNCLCC trialists. Fédération Nationale des Centres de Lutte Contre le Cancer. Int J Radiat Oncol Biol Phys 32:651–659

    PubMed  CAS  Google Scholar 

  • Myojin M, Choi NC, Wright CD et al. (2000) Stage III thymoma: pattern of failure after surgery and postoperative radiotherapy and its implication for future study. Int J Radiat Oncol Biol Phys 46:927–933

    PubMed  CAS  Google Scholar 

  • National Comprehensive Cancer Network (2008) Clinical practice guidelines in oncology: non-small-cell lung cancer. Available at http://www.nccn.org/professionals/physician_gls/PDF/nscl.pdf. Accessed on March 8, 2007

    Google Scholar 

  • Ogawa K, Uno T, Toita T, Onishi H et al. (2002) Postoperative radiotherapy for patients with completely resected thymoma: a multi-institutional, retrospective review of 103 patients. Cancer 94:1405–1413

    Article  PubMed  Google Scholar 

  • Ohara K, Okumura T, Sugahara S et al. (1990) The role of preoperative radiotherapy for invasive thymoma. Acta Oncol 29:425–429

    Article  PubMed  CAS  Google Scholar 

  • Okumura M, Ohta M, Tateyama H et al. (2002) The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer 94:624–632

    Article  PubMed  Google Scholar 

  • Pescarmona E, Rendina EA, Venuta F et al. (1990) Analysis of prognostic factors and clinicopathological staging of thymoma. Ann Thorac Surg 50:534–538

    PubMed  CAS  Google Scholar 

  • Quintanilla-Martinez L, Wilkins EW Jr, Choi N et al. (1994) Thymoma. Histologic subclassification is an independent prognostic factor. Cancer 74:606–617

    Article  PubMed  CAS  Google Scholar 

  • Rena O, Papalia E, Maggi G et al. (2005) World Health Organization histologic classification: an independent prognostic factor in resected thymomas. Lung Cancer 50:59–66

    Article  PubMed  Google Scholar 

  • Rosai J (1999) Histological typing of tumors of the thymus, 2nd edn. Springer-Verlag, Berlin Heidelberg New York

    Google Scholar 

  • Ruffini E, Mancuso M, Oliaro A et al. (1997) Recurrence of thymoma: analysis of clinicopathologic features, treatment, and outcome. J Thorac Cardiovasc Surg 113:55–63

    Article  PubMed  CAS  Google Scholar 

  • Ströbel P, Bauer A, Puppe B et al. (2004) Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J Clin Oncol 22:1501–1509

    Article  PubMed  Google Scholar 

  • Tomiyama N, Honda O, Tsubamoto M et al. (2007) Anterior mediastinal tumors: diagnostic accuracy of CT and MRI. Eur J Radiol 2007 Nov 17; [Epub ahead of print]

    Google Scholar 

  • Urgesi A, Monetti U, Rossi G et al. (1990) Role of radiation therapy in locally advanced thymoma. Radiother Oncol 19:273–280

    Article  PubMed  CAS  Google Scholar 

  • Venuta F, Rendina EA, Longo F et al. (2003) Long-term outcome after multimodality treatment for stage III thymic tumors. Ann Thorac Surg 76:1866–1872

    Article  PubMed  Google Scholar 

  • Wang SL, Liao Z, Vaporciyan AA et al. (2006) Investigation of clinical and dosimetric factors associated with postoperative pulmonary complications in esophageal cancer patients treated with concurrent chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys 64:692–699

    PubMed  Google Scholar 

  • Wilkins KB, Sheikh E, Green R et al. (1999) Clinical and pathologic predictors of survival in patients with thymoma. Ann Surg 230:562–572

    Article  PubMed  CAS  Google Scholar 

  • Wright CD, Choi NC, John C., Wain JC et al. (2008) Induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors. Ann Thorac Surg 85:385–389

    Article  PubMed  Google Scholar 

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© 2008 Springer-Verlag Berlin Heidelberg

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Kong, FM., Lu, J.J. (2008). Thymoma. In: Lu, J.J., Brady, L.W. (eds) Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77385-6_11

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  • DOI: https://doi.org/10.1007/978-3-540-77385-6_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-77384-9

  • Online ISBN: 978-3-540-77385-6

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