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Neuroendocrine Complications of Radiation and Cancer Therapy

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ALERT • Adverse Late Effects of Cancer Treatment

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Abbreviations

ACTH:

Adrenocorticotropin

BMD:

Bone mineral density

FSH:

Follicle-stimulating hormone

GnRH:

Gonadotropin-releasing hormone

GH:

Growth hormone

GHRH:

Growth-hormone-releasing hormone

HPA:

Hypothalamic-pituitary axis

IGF-I:

Insulin-like growth factor I

LH:

Luteinizing hormone

OGTT:

Oral glucose tolerance testing

PRL:

Prolactin

QOL:

Quality of life

RT:

Radiation therapy

SD:

Standard deviation

TRT:

Testosterone replacement therapy

TSH:

Thyroid-stimulating hormone

TRH:

Thyrotropin (or Thyroid-stimulating hormone)-releasing hormone

References

  • Agha A, Sherlock M, Brennan S, O’Connor SA, O’Sullivan E, Rogers B, Faul C, Gurney JG, Ness KK, Sibley SD, O’Leary M, Dengel DR, Lee JM, Youngren NM, Glasser SP, Baker KS (2006) Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer 107(6):1303–1312

    Google Scholar 

  • Aragon-Ching JB, Ning YM, Chen CC, Latham L, Guadagnini JP, Gulley JL, Arlen PM, Wright JJ, Parnes H, Figg WD, Dahut WL (2009) Higher incidence of Osteonecrosis of the Jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents. Cancer Invest 27(2):221–226

    PubMed  CAS  PubMed Central  Google Scholar 

  • Argente J (1999) Diagnosis of late puberty. Horm Res 51(Suppl 3):95–100

    PubMed  CAS  Google Scholar 

  • Bakker B, Oostdijk W, Geskus RB, Stokvis-Brantsma WH, Vossen JM, Wit JM (2007) Growth hormone (GH) secretion and response to GH therapy after total body irradiation and haematopoietic stem cell transplantation during childhood. Clin Endocrinol (Oxf) 67(4):589–597

    CAS  Google Scholar 

  • Beckers D, Thomas M, Jamart J, Francois I, Maes M, Lebrethon MC, De Waele K, Tenoutasse S, De Schepper J (2010) Adult final height after GH therapy for irradiation-induced GH deficiency in childhood survivors of brain tumors: the Belgian experience. 1. Eur J Endocrinol 162(3):483–490

    PubMed  CAS  Google Scholar 

  • Bentel GC, Marks LB, Anscher MS (1999) The effect of beam divergence on target coverage. Med Dosim 24(2):99–113

    Google Scholar 

  • Berges O, Belkacemi Y, Giraud P (2010) Normal tissue tolerance to external beam radiation therapy: thyroid. Cancer Radiother 14(4–5):307–311

    Google Scholar 

  • Bese NS, Iribas A, Dirican A, Oksuz D, Atkovar G, Ober A (2009) Ovarian ablation by radiation therapy: is it still an option for the ablation of ovarian function in endocrine responsive premenopausal breast cancer patients? Breast 18(5):304–308 (Epub 2009 Oct 1. PubMed PMID: 19800233)

    Google Scholar 

  • Biller BM, Samuels MH, Zagar A, Cook DM, Arafah BM, Bonert V, Stavrou S, Kleinberg DL, Chipman JJ, Hartman ML (2002) Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency. J Clin Endocrinol Metab 87(5):2067–2079

    PubMed  CAS  Google Scholar 

  • Blatt J, Bercu BB, Gillin JC, Mendelson WB, Poplack DG (1984) Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia. J Pediatr 104:182–186

    PubMed  CAS  Google Scholar 

  • Blethen SL, Allen DB, Graves D, August G, Moshang T, Rosenfeld R (1996) Safety of recombinant deoxyribonucleic acid-derived growth hormone: The National Cooperative Growth Study Experience. J Clin Endocrinol Metab 81:1704–1710

    PubMed  CAS  Google Scholar 

  • Bloemers MC, Portelance L, Legler C, Renaud MC, Tan SL (2010) Preservation of ovarian function by ovarian transposition prior to concurrent chemotherapy and pelvic radiation for cervical cancer. A case report and review of the literature. Eur J Gynaecol Oncol 31(2):194–197

    PubMed  CAS  Google Scholar 

  • Boepple PA, Crowley WF Jr (1996) Precocious puberty. In: Adashi EY, Rock JA, Rosenwaks Z (eds) Reproductive endocrinology, surgery, and technology, vol 1. Lippincott-Raven, Philadelphia, p 989

    Google Scholar 

  • Bonato C, Severino RF, Elnecave RH (2008) Reduced thyroid volume and hypothyroidism in survivors of childhood cancer treated with radiotherapy. J Pediatr Endocrinol Metab 21(10):943–949

    PubMed  Google Scholar 

  • Bourguignon JP, Pierard GE, Ernould C, Heinrichs C, Craen M, Rochioccioli P, Arrese JE, Franchimont C (1993) Effects of human growth hormone therapy on melanocytic naevi. Lancet 341:1505–1506

    PubMed  CAS  Google Scholar 

  • Brauner R, Malandry F, Rappaport R, Zucker JM, Kalifa C, Pierre-Kahn A, Bataini P, Dufier JL (1990) Growth and endocrine disorders in optic glioma. Eur J Pediatr 149:825–828

    PubMed  CAS  Google Scholar 

  • Brownstein CM, Mertens AC, Mitby PA, Stovall M, Qin J, Heller C, Robison LL, Sklar CA (2004) Factory that affect final height and change in height standard deviation scores in survivors of childhood career treated with growth hormone: a report from the childhood career survivor study. J Clin Endocrinol Metab 89(9):4422–4427

    Google Scholar 

  • Brydøy M, Fosså SD, Dahl O, Bjøro T (2007) Gonadal dysfunction and fertility problems in cancer survivors. Acta Oncol 46(4):480–489

    PubMed  Google Scholar 

  • Burstein S (1994) Growth disorders after cranial radiation in childhood. J Clin Endocrinol Metab 78:1280–1281

    PubMed  CAS  Google Scholar 

  • Camats N, García F, Parrilla JJ, Calaf J, Martín-Mateo M, Caldés MG (2009) The GnRH analogue triptorelin confers ovarian radio-protection to adult female rats. Mutat Res 669(1–2):67–79 (Epub 2009 May 13)

    Google Scholar 

  • Cassorla F, Mericq V, Eggers M, Avila A, Garcia C, Fuentes A, Rose SR, Cutler GB Jr (1997) Effects of luteinizing hormone-releasing hormone analog-induced pubertal delay in growth hormone (GH)-deficient children treated with GH: preliminary results. J Clin Endocrinol Metab 82(12):3989–3992

    PubMed  CAS  Google Scholar 

  • Chemaitilly W, Mertens AC, Mitby P, Whitton J, Stovall M, Yasui Y, Robison LL, Sklar CA (2006) Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab 91(5):1723–1728 (Epub 2006 Feb 21)

    Google Scholar 

  • Chera BS, Rodriguez C, Morris CG, Louis D, Yeung D, Li Z, Mendenhall NP (2009) Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin’s lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy. Int J Radiat Oncol Biol Phys 75(4):1173–1180 (Epub 2009 Apr 20)

    Google Scholar 

  • Chin D, Sklar C, Donahue B, Uli N, Geneiser N, Allen J, Nirenberg A, David R, Kohn B, Oberfield SE (1997) Thyroid dysfunction as a late effect in survivors of pediatric medulloblastoma/primitive neuroectodermal tumors: a comparison of hyperfractionated versus conventional radiotherapy. Cancer 80(4):798–804

    PubMed  CAS  Google Scholar 

  • Chow EJ, Friedman DL, Yasui Y et al (2007) Decreased adult height in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivors Study. J Pediatr 150:370–375

    Google Scholar 

  • Chrousos GP (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351–1362

    PubMed  CAS  Google Scholar 

  • Chung TT, Drake WM, Evanson J, Walker D, Plowman PN, Chew SL, Grossman AB, Besser GM, Monson JP (2005) Tumour surveillance imaging in patients with extrapituitary tumours receiving growth hormone replacement. Clin Endocrinol (Oxf) 63(3):274–279

    CAS  Google Scholar 

  • Clayton RN (1996) Short Synacthen test versus insulin stress test for assessment of the hypothalamo-pituitary-adrenal axis: controversy revisited. Clin Endocrinol (Oxf) 44:147–149

    CAS  Google Scholar 

  • Constine LS (1995) What else don’t we know about the late effects of radiation in patients treated for head and neck cancer? Int J Radiat Oncol Biol Phys 31(2):427–429

    PubMed  CAS  Google Scholar 

  • Constine LS, Woolf PD, Cann D, Mick G, McCormick K, Raubertas RF, Rubin P (1993) Hypothalamic-pituitary dysfunction after radiation for brain tumors. N Engl J Med 328(2):87–94

    PubMed  CAS  Google Scholar 

  • Corrias A, Einaudi S, Ricardi U, Sandri A, Besenzon L, Altare F, Artesani L, Genitori L, Andreo M, De Sanctis C (2001) Thyroid diseases in patients treated during pre-puberty for medulloblastoma with different radiotherapic protocols. J Endocrinol Invest 24(6):387–392

    PubMed  CAS  Google Scholar 

  • Cummings DE, Merriam GR (2003) Growth hormone therapy in adults. Annu Rev Med 54:513–533

    PubMed  CAS  Google Scholar 

  • Darendeliler F, Karagiannis G, Wilton P, Ranke MB, Albertsson-Wikland K, Anthony Price D, On behalf of the Kigs International Board (2006) Recurrence of brain tumours in patients treated with growth hormone: analysis of KIGS (Pfizer International Growth Database). Acta Paediatr 95(10):1284–1290

    PubMed  Google Scholar 

  • Darzy KH (2009) Radiation-induced hypopituitarism after cancer therapy: who, how and when to test. Nat Clin Pract Endocrinol Metab 5(2):88–99

    PubMed  CAS  Google Scholar 

  • Darzy KH, Shalet SM (2006) Pathophysiology of radiation-induced growth hormone deficiency: efficacy and safety of GH replacement. Growth Horm IGF Res 16(Suppl A):S30–S40

    Google Scholar 

  • Darzy KH, Shalet SM (2009) Hypopituitarism following radiotherapy revisited. Endocr Dev 15:1–24

    PubMed  Google Scholar 

  • De Bruin ML, Sparidans J, van’t Veer MB, Noordijk EM, Louwman MW, Zijlstra JM, van den Berg H, Russell NS, Broeks A, Baaijens MH, Aleman BM, van Leeuwen FE (2009) Breast cancer risk in female survivors of Hodgkin’s lymphoma: lower risk after smaller radiation volumes. J Clin Oncol 27(26):4239–4246

    Google Scholar 

  • Di Battista E, Naselli A, Queirolo S, Gallarotti F, Garré ML, Milanaccio C, Cama A (2006) Endocrine and growth features in childhood craniopharyngioma: a mono-institutional study. J Pediatr Endocrinol Metab 19(Suppl 1):431–437

    PubMed  Google Scholar 

  • Diaz R, Jaboin JJ, Morales-Paliza M, Koehler E, Phillips JG, Stinson S, Gilbert J, Chung CH, Murphy BA, Yarbrough WG, Murphy PB, Shyr Y, Cmelak AJ (2009) Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 77(2):468–476 (Epub 2009 Jul 4. PubMed PMID: 19577867)

    Google Scholar 

  • Elias AN, Gwinup G (1980) Effects of some clinically encountered drugs on steroid synthesis and degradation. Metabolism 29:582–592

    PubMed  CAS  Google Scholar 

  • Ergun-Longmire B, Mertens AC, Mitby P, Qin J, Heller G, Shi W, Yasui Y, Robison LL, Sklar CA (2006) Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor. J Clin Endocrinol Metab 91(9):3494–3498

    PubMed  CAS  Google Scholar 

  • Fajardo LF, Berthrong M, Anderson RE (2001) Radiation pathology. Oxford University Press, USA

    Google Scholar 

  • Faraci M, Barra S, Cohen A, Lanino E, Grisolia F, Miano M, Foppiano F, Sacco O, Cabria M, De Marco R, Stella G, Dallorso S, Bagnasco F, Vitale V, Dini G, Haupt R (2005) Very late nonfatal consequences of fractionated TBI in children undergoing bone marrow transplant. Int J Radiat Oncol Biol Phys 63(5):1568–1575 (Epub 2005 Jun 28. PubMed PMID: 15990246)

    Google Scholar 

  • Feng W, Cui Y, Zhan H, Shi M, Cui W, Guo K, Li Q, Song C, Zhang Y, Mori T, Gershwin ME, Abraham NG, Ikehara S (2010) Prevention of premature ovarian failure and osteoporosis induced by irradiation using allogeneic ovarian/bone marrow transplantation. Transplantation 89(4):395–401

    PubMed  Google Scholar 

  • Ferretti E, Persani L, Jaffrain-Rea ML, Giambona S, Tamburrano G, Beck-Peccoz P (1999) Evaluation of the adequacy of levothyroxine replacement in patients with central hypothyroidism. J Clin Endocrinol Metab 84:924–929

    PubMed  CAS  Google Scholar 

  • Follin C, Thilén U, Ahrén B, Erfurth EM (2006) Improvement in cardiac systolic function and reduced prevalence of metabolic syndrome after two years of growth hormone (GH) treatment in GH-deficient adult survivors of childhood-onset acute lymphoblastic leukemia. J Clin Endocrinol Metab 91(5):1872–1875

    PubMed  CAS  Google Scholar 

  • Forstner D, Borg M, Saxon B (2006) Orbital rhabdomyosarcoma: multidisciplinary treatment experience. 36. Australas Radiol 50(1):41–45

    PubMed  CAS  Google Scholar 

  • Fouladi M, Wallace D, Langston JW, Mulhern R, Rose SR, Gajjar A, Sanford RA, Merchant TE, Jenkins JJ, Kun LE, Heideman RL (2003) Survival and functional outcome of children with hypothalamic/chiasmatic tumors. Cancer 97(4):1084–1092

    PubMed  Google Scholar 

  • Gershwin ME, Abraham NG, Ikehara S (2010) Prevention of premature ovarian failure and osteoporosis induced by irradiation using allogeneic ovarian/bone marrow transplantation. Transplantation 89(4):395–401

    PubMed  Google Scholar 

  • Gilchrist FJ, Murray RD, Shalet SM (2002) The effect of long-term untreated growth hormone deficiency (GHD) and 9 years of GH replacement on the quality of life (QoL) of GH-deficient adults. Clin Endocrinol (Oxf) 57(3):363–370

    CAS  Google Scholar 

  • Giuseppe L, Attilio G, Edoardo DN, Loredana G, Cristina L, Vincenzo L (2007) Ovarian function after cancer treatment in young women affected by Hodgkin disease (HD). Hematology 12(2):141–147

    PubMed  Google Scholar 

  • Green DM, Brecher ML, Yakar D, Blumenson LE, Lindsay AN, Voorhess ML, MacGillivray M, Freeman AI (1980) Thyroid function in pediatric patients after neck irradiation for Hodgkin disease. Med Pediatr Oncol 8(2):127–136

    PubMed  CAS  Google Scholar 

  • Green DM, Kawashima T, Stovall M, Leisenring W, Sklar CA, Mertens AC, Donaldson SS, Byrne J, Robison LL (2009) Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 27(16):2677–2685 (Epub 2009 Apr 13. PubMed PMID: 19364965; PubMed Central)

    Google Scholar 

  • Growth Hormone Research Society (2000) Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 85:3990–3993

    Google Scholar 

  • Gurgan T, Salman C, Demirol A (2008) Pregnancy and assisted reproduction techniques in men and women after cancer treatment. Placenta 29 (Suppl B):152–159

    Google Scholar 

  • Gurney JG, Ness KK, Sibley SD et al (2006) Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. Cancer 107:1303–1312

    PubMed  CAS  Google Scholar 

  • Haddy TB, Mosher RB, Nunez SB, Reaman GH (2006) Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. Pediatr Blood Cancer 46(2):258–261

    PubMed  Google Scholar 

  • Halperin EC, Constine LS, Tarbell NJ, Kun LE (2010) Pediatric Radiation Oncology, 5th edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  • Hamre MR, Robison LL, Nesbit ME, Sather HN, Meadows AT, Ortega JA, D’Angio GJ, Hammond GD (1987) Effects of radiation on ovarian function in long-term survivors of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group. J Clin Oncol 5(11):1759–1765

    PubMed  CAS  Google Scholar 

  • Hancock SL, Cox RS, McDougall IR (1991) Thyroid diseases after treatment of Hodgkin’s disease. N Engl J Med 325(9):599–605 (PubMed PMID)

    Google Scholar 

  • Harris E, Mahendra P, McGarrigle HH, Linch DC, Chatterjee R (2001a) Gynaecomastia with hypergonadotrophic hypogonadism and Leydig cell insufficiency in recipients of high-dose chemotherapy or chemo-radiotherapy. Bone Marrow Transplant 28(12):1141–1144

    PubMed  CAS  Google Scholar 

  • Harris E, Mahendra P, McGarrigle HH, Linch DC, Chatterjee R (2001b) Gynaecomastia with hypergonadotrophic hypogonadism and Leydig cell insufficiency in recipients of high-dose chemotherapy or chemo-radiotherapy. Bone Marrow Transplant 28(12):1141–1144

    PubMed  CAS  Google Scholar 

  • Heikens J, Michiels EM, Behrendt H, Endert E, Bakker PJ, Fliers E (1998) Long-term neuro-endocrine sequelae after treatment for childhood medulloblastoma. Eur J Cancer 34(10):1592–1597

    PubMed  CAS  Google Scholar 

  • Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM (1997) Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 99(4):505–512

    PubMed  CAS  Google Scholar 

  • Hermann RM, Henkel K, Christiansen H, Vorwerk H, Hille A, Hess CF, Schmidberger H (2006) Testicular dose and hormonal changes after radiotherapy of rectal cancer. Radiother Oncol. 2005 Apr, 75(1), pp. 83–8 (Epub 2005 Apr 1. Comment in Radiother Oncol 78(1):107–108)

    Google Scholar 

  • Hovi L, Saarinen-Pihkala UM, Vettenranta K, Lipsanen M, Tapanainen P (1999) Growth in children with poor-risk neuroblastoma after regimens with or without total body irradiation in preparation for autologous bone marrow transplantation. Bone Marrow Transplant 24(10):1131–1136

    PubMed  CAS  Google Scholar 

  • Howell S, Shalet S (1998) Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin N Am 27(4):927–943 (Review. PubMed PMID: 9922915)

    Google Scholar 

  • Howell SJ, Shalet SM (2002) Fertility preservation and management of gonadal failure associated with lymphoma therapy. Curr Oncol Rep 4(5):443–452 (Review. PubMed PMID: 12162920)

    Google Scholar 

  • Hulvat MC, Jeruss JS (2009) Maintaining fertility in young women with breast cancer. Curr Treat Options Oncol 10(5–6):308–317 (Review. PubMed PMID: 20238254)

    Google Scholar 

  • Inge TH, Pfluger P, Zeller M, Rose SR, Burget L, Sundararajan S, Daniels SR, Tschöp MH (2007) Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy. Nat Clin Pract Endocrinol Metab 3(8):606–609

    PubMed  Google Scholar 

  • Inskip PD, Robison LL, Stovall M, Smith SA, Hammond S, Mertens AC, Whitton JA, Diller L, Kenney L, Donaldson SS, Meadows AT, Neglia JP (2009) Radiation dose and breast cancer risk in the childhood cancer survivor study. J Clin Oncol 27(24):3901–3907 (Epub 2009 Jul 20. PubMed PMID: 19620485)

    Google Scholar 

  • Ishiguro H, Yasuda Y, Tomita Y, Shinagawa T, Shimizu T, Morimoto T, Hattori K, Matsumoto M, Inoue H, Yabe H, Yabe M, Shinohara O, Kato S (2007) Gonadal shielding to irradiation is effective in protecting testicular growth and function in long-term survivors of bone marrow transplantation during childhood or adolescence. Bone Marrow Transplant 39(8):483–490 (Epub 2007 Mar 5)

    Google Scholar 

  • Jakob A, Kollmannsberger C, Kanz L, Bokemeyer C (1998) Late toxicity after chemotherapy of malignant testicular tumors. Urologe A 37(6):635–647

    PubMed  CAS  Google Scholar 

  • Jereczek-Fossa BA, Alterio D, Jassem J, Gibelli B, Tradati N, Orecchia R (2004) Radiotherapy-induced thyroid disorders. Cancer Treat Rev 30(4):369–384 (Review. PubMed PMID: 15145511)

    Google Scholar 

  • Kadan-Lottick NS, Dinu I, Wasilewski-Masker K, Kaste S, Meacham LR, Mahajan A, Stovall M, Yasui Y, Robison LL, Sklar CA (2008) Osteonecrosis in adult survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 26(18):3038–3045

    PubMed  Google Scholar 

  • Kamischke A, Kuhlmann M, Weinbauer GF, Luetjens M, Yeung CH, Kronholz HL, Nieschlag E (2003) Gonadal protection from radiation by GnRH antagonist or recombinant human FSH: a controlled trial in a male nonhuman primate (Macaca fascicularis). J Endocrinol 179(2):183–194

    PubMed  CAS  Google Scholar 

  • Kaste SC, Jones-Wallace D, Rose SR, Boyett JM, Lustig RH, Rivera GK, Pui CH, Hudson MM (2001) Bone mineral decrements in survivors of childhood acute lymphoblastic leukemia: frequency of occurrence and risk factors for their development. Leukemia 15:728–734

    PubMed  CAS  Google Scholar 

  • Kaste SC, Metzger ML, Minhas A, Xiong Z, Rai SN, Ness KK, Hudson MM (2009) Pediatric Hodgkin lymphoma survivors at negligible risk for significant bone mineral density deficits. Pediatr Blood Cancer 52(4):516–521

    PubMed  PubMed Central  Google Scholar 

  • Kazlauskaite R, Evans AT, Villabona CV, Abdu TAM, Ambrosi B, Atkinson AB, Choi CH, Courtney CH, Gonc EN, Maghnie M, Oelkers W, Rose SR, Soule SG, Tordjman K (2008) Consortium for evaluation of corticotropin test in hypothalamic-pituitary insufficiency. Corticotropin tests for hypothalamic-pituitary adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab 93:4245–4253

    PubMed  CAS  Google Scholar 

  • Klose M, Jonsson B, Abs R, Popovic V, Koltowska-Häggström M, Saller B, Feldt-Rasmussen U, Kourides I (2009) From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum—a KIMS analysis. Eur J Endocrinol 161(Suppl 1):S75–S83

    PubMed  CAS  Google Scholar 

  • Koc M, Capoglu I (2009) Thyroid dysfunction in patients treated with radiotherapy for neck. Am J Clin Oncol 32(2):150–153

    PubMed  Google Scholar 

  • Kokcu A (2010) Premature ovarian failure from current perspective. Gynecol Endocrinol 26(8):555–562

    PubMed  Google Scholar 

  • Kokona G, Mazonakis M, Varveris H, Liraraki E, Damilakis J (2006) Treatment of benign diseases with megavoltage X-ray beams: is there a risk for gonadal damage? Clin Oncol (R Coll Radiol) 18(9):658–662

    Google Scholar 

  • Kuten A, Lubochitski R, Fishman G, Dale J, Stein ME (1996) Postradiotherapy hypothyroidism: radiation dose response and chemotherapeutic radiosensitization at less than 40 Gy. J Surg Oncol 61(4):281–283

    PubMed  CAS  Google Scholar 

  • Lam KS, Tse VK, Wang C, Yeung RT, Ho JH (1991) Effects of cranial irradiation on hypothalamic-pituitary function—a 5-year longitudinal study in patients with nasopharyngeal carcinoma. Q J Med 78:165–176

    PubMed  CAS  Google Scholar 

  • Laufer MR, Upton J, Schuster SR, Grier H, Emans SJ, Diller L (2010) Ovarian tissue autologous transplantation to the upper extremity for girls receiving abdominal/pelvic radiation: 20-year follow-up of reproductive endocrine function. J Pediatr Adolesc Gynecol 23(2):107–110 (Epub 2009 Nov 5. PubMed PMID: 19896400)

    Google Scholar 

  • Laughton SJ, Merchant TE, Sklar CA, Kun LE, Fouladi M, Broniscer A, Morris EB, Sanders RP, Krasin MJ, Shelso J, Xiong Z, Wallace D, Gajjar A (2008) Endocrine outcomes for children with embryonal brain tumors after risk-adapted craniospinal and conformal primary-site irradiation and high-dose chemotherapy with stem-cell rescue on the SJMB-96 trial. J Clin Oncol 26(7):1112–1118

    PubMed  CAS  Google Scholar 

  • Lee KO, Persani L, Tan M, Sundram FX, Beck-Peccoz P (1995) Thyrotropin with decreased biological activity, a delayed consequence of cranial irradiation for nasopharyngeal carcinoma. J Endocrinol Invest 18:800–805

    Google Scholar 

  • Lee HM, Zhu J, Wheeler GC, Helton KJ, Merchant TE (2002) The influence of hydrocephalus on pre-irradiation IQ and endocrine function in children with infratentorial ependymoma. 44th annual meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), New Orleans, LA, 6–10 Oct 2002. Int J Radiat Oncology Biol Phys 54(2S):150

    Google Scholar 

  • LeRoith D, Helman L (2004) The new kid on the block(ade) of the IGF-I receptor. Cancer Cell 5(3):201–202

    PubMed  CAS  Google Scholar 

  • Leung W, Hudson M, Zhu Y, Rivera GK, Ribeiro RC, Sandlund JT, Bowman LC, Evans WE, Kun L, Pui CH (2000a) Late effects in survivors of infant leukemia. Leukemia 14:1185–1190

    PubMed  CAS  Google Scholar 

  • Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH (2000b) Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol 18(18):3273–3279

    PubMed  CAS  Google Scholar 

  • Leung W, Rose SR, Zhou Y, Hancock ML, Burstein S, Schriock EA, Lustig R, Danish RK, Evans WE, Hudson MM, Pui CH (2002) Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 20(13):2959–2964

    PubMed  CAS  Google Scholar 

  • Leung W, Ahn H, Rose SR, Phipps S, Smith T, Gan K, O’Connor M, Hale GA, Kasow KA, Barfield RC, Madden RM, Pui CH (2007) A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Medicine (Baltimore) 86(4):215–224

    Google Scholar 

  • Loeffler JS, Leibsch NJ, Klibanski A, Munzenrider JE (2001) Hypothalamic/pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. Int J Radiat Oncol Biol Phys 49(4):1079–1092

    PubMed  Google Scholar 

  • Lustig RH (2001) The neuroendocrinology of childhood obesity. Pediatr Clin N Am 48(4):909–930

    CAS  Google Scholar 

  • Lustig RH, Rose SR, Burghen GA, Velasquez-Mieyer P, Broome DC, Smith K, Li H, Hudson MM, Heideman RL, Kun LE (1999) Hypothalamic obesity caused by cranial insult in children: altered glucose and insulin dynamics and reversal by a somatostatin agonist. J Pediatr 135(2 Pt 1):162–168

    PubMed  CAS  Google Scholar 

  • Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X (2003a) Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 88(6):2586–2592

    PubMed  CAS  Google Scholar 

  • Lustig RH, Post SR, Srivannaboon K, Rose SR, Danish RK, Burghen GA, Xiong X, Wu S, Merchant TE (2003b) Risk factors for the development of obesity in children surviving brain tumors. J Clin Endocrinol Metab 88(2):611–616

    PubMed  CAS  Google Scholar 

  • Maiter D, Abs R, Johannsson G, Scanlon M, Jönsson PJ, Wilton P, Koltowska-Häggström M (2006) Baseline characteristics and response to GH replacement of hypopituitary patients previously irradiated for pituitary adenoma or craniopharyngioma: data from the Pfizer International Metabolic Database. Eur J Endocrinol 155(2):253–260

    PubMed  CAS  Google Scholar 

  • Massimino M, Gandola L, Mattavelli F, Pizzi N, Seregni E, Pallotti F, Spreafico F, Marchianò A, Terenziani M, Cefalo G, Biassoni V, Meazza C, Trecate G, Collini P (2009) Radiation-induced thyroid changes: a retrospective and a prospective view. Eur J Cancer 45(14):2546–2551 (Epub 2009 Jul 14)

    Google Scholar 

  • Meikle AW (2004) The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 14(Suppl 1):S17–S25

    PubMed  CAS  Google Scholar 

  • Merchant TE (2006) Craniopharyngioma radiotherapy: endocrine and cognitive effects. J Pediatr Endocrinol Metab 19(Suppl 1):439–446

    PubMed  Google Scholar 

  • Merchant TE, Pritchard DL, Vargo JA, Sontag MR (2001) Radiation therapy for the treatment of childhood medulloblastoma: the rationale for current techniques, strategies, and dose-volume considerations. Electro Medica 69:69–71

    Google Scholar 

  • Merchant TE, Goloubeva O, Pritchard DL, Gaber MW, Xiong X, Danish RK, Lustig RH (2002a) Radiation dose-volume effects on growth hormone secretion. Int J Radiat Oncol Biol Phys 52(5):1264–1270

    PubMed  CAS  Google Scholar 

  • Merchant TE, Kiehna EN, Sanford RA, Mulhern RK, Thompson SJ, Wilson MW, Lustig RH, Kun LE (2002b) Craniopharyngioma: the St. Jude Children’s Research Hospital experience 1984–2001. Int J Radiat Oncol Biol Phys 53(3):533–542

    PubMed  Google Scholar 

  • Merchant TE, Williams T, Smith JM, Rose SR, Danish RK, Burghen GA, Kun LE, Lustig RH (2002c) Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function. Int J Radiat Oncol Biol Phys 54(1):45–50

    PubMed  Google Scholar 

  • Merchant TE, Zhu Y, Thompson SJ, Sontag MR, Heideman RL, Kun LE (2002d) Preliminary results from a phase II trial of conformal radiation therapy for pediatric patients with localized low-grade astrocytoma and ependymoma. Int J Radiat Oncol Biol Phys 52:325–332

    PubMed  Google Scholar 

  • Merchant TE, Mulhern RK, Krasin MJ, Kun LE, Williams T, Li C, Xiong X, Khan RB, Lustig RH, Boop FA, Sanford RA (2004) Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol 22(15):3156–3162

    PubMed  Google Scholar 

  • Merchant TE, Conklin HM, Wu S, Lustig RH, Xiong X (2009) Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits. J Clin Oncol 27(22):3691–3697

    PubMed  PubMed Central  Google Scholar 

  • Merchant TE, Rose SR, Bosley C, Wu S, Xiong X, Lustig RH (2011) Growth hormone secretion after conformal radiation therapy in pediatric patients with localised brain tumors. J Clin Oncol 29(36):5776–5780

    Google Scholar 

  • Midyett LK, Moore WV, Jacobson JD (2003) Are pubertal changes in girls before age 8 benign? Pediatrics 111(1):47–51

    PubMed  Google Scholar 

  • Morris EB, Shelso J, Smeltzer MP, Thomas NA, Karimova EJ, Li CS, Merchant T, Gajjar A, Kaste SC (2008) The use of bone age for bone mineral density interpretation in a cohort of pediatric brain tumor patients. Pediatr Radiol 38(12):1285–1292

    PubMed  Google Scholar 

  • Mulder RL, Kremer LC, van Santen HM, Ket JL, van Trotsenburg AS, Koning CC, Schouten-van Meeteren AY, Caron HN, Neggers SJ, van Dalen EC (2009) Prevalence and risk factors of radiation-induced growth hormone deficiency in childhood cancer survivors: a systematic review. Cancer Treat Rev 35(7):616–632

    PubMed  CAS  Google Scholar 

  • Murray RD, Skillicorn CJ, Howell SJ, Lissett CA, Rahim A, Smethurst LE, Shalet SM (1999) Influences on quality of life in GH deficient adults and their effect on response to treatment. Clin Endocrinol (Oxf) 51(5):565–573

    CAS  Google Scholar 

  • Norris AA, Amdur RJ, Morris CG, Mendenhall WM (2006) Hypothyroidism when the thyroid is included only in the low neck field during head and neck radiotherapy. Am J Clin Oncol 29(5):442–445

    PubMed  Google Scholar 

  • Oberfield SE, Soranno D, Nirenberg A, Heller G, Allen JC, David R, Levine LS, Sklar CA (1996) Age at onset of puberty following high-dose central nervous system radiation therapy. Arch Pediatr Adolesc Med 150(6):589–592

    PubMed  CAS  Google Scholar 

  • Oberfield SE, Chin D, Uli N, David R, Sklar C (1997) Endocrine late effects of childhood cancers. J Pediatr 131(1 Pt 2):S37–S41

    PubMed  CAS  Google Scholar 

  • Ogilvy-Stuart AL, Shalet SM (1993) Effect of radiation on the human reproductive system. Environ Health Perspect 101(Suppl 2):109–116 (PubMed PMID: 8243379; PubMed Central PMCID: PMC1519954)

    Google Scholar 

  • Ogilvy-Stuart AL, Clark DJ, Wallace WH, Gibson BE, Stevens RF, Shalet SM, Donaldson MD (1992) Endocrine deficit after fractionated total body irradiation. Arch Dis Child 67(9):1107–1110

    PubMed  CAS  PubMed Central  Google Scholar 

  • Ogilvy-Stuart AL, Clayton PE, Shalet SM (1994) Cranial irradiation and early puberty. J Clin Endocrinol Metab 78(6):1282–1286

    PubMed  CAS  Google Scholar 

  • Ogilvy-Stuart AL, Stirling HF, Kelnar CJ, Savage MO, Dunger DB, Buckler JM, Shalet SM (1997) Treatment of radiation-induced growth hormone deficiency with growth hormone-releasing hormone. Clin Endocrinol (Oxf) 46:571–578

    CAS  Google Scholar 

  • Olshan JS, Willi SM, Gruccio D, Moshang T Jr (1993) Growth hormone function and treatment following bone marrow transplant for neuroblastoma. Bone Marrow Transplant 12(4):381–385

    PubMed  CAS  Google Scholar 

  • Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M, Greenberg M, Goldman S, Hyder D, Heideman R, Jones-Wallace D, August GP, Smith SH, Moshang T (2001) Growth hormone replacement therapy in children with medulloblastoma: use and effect on tumor control. J Clin Oncol 19(2):480–487

    PubMed  CAS  Google Scholar 

  • Pai HH, Thornton A, Katznelson L, Finkelstein DM, Adams JA, Fullerton BC, Pesty A, Doussau M, Lahaye JB, Lefèvre B (2010) Whole-body or isolated ovary (60)Co irradiation: effects on in vivo and in vitro folliculogenesis and oocyte maturation. Reprod Toxicol 29(1):93–98 (Epub 2009 Oct 27)

    Google Scholar 

  • Pesty A, Doussau M, Lahaye JB, Lefèvre B (2010) Whole-body or isolated ovary (60)Co irradiation: effects on in vivo and in vitro folliculogenesis and oocyte maturation. Reprod Toxicol 29(1):93–98 (Epub 2009 Oct 27)

    Google Scholar 

  • Pietilä S, Mäkipernaa A, Sievänen H, Koivisto AM, Wigren T, Lenko HL (2009) Obesity and metabolic changes are common in young childhood brain tumor survivors. Pediatr Blood Cancer 52(7):853–859

    PubMed  Google Scholar 

  • Pitukcheewanont P, Rose SR (1997) Nocturnal TSH surge: a sensitive diagnostic test for central hypothyroidism in children. The Endocrinologist 7:226–232

    Google Scholar 

  • Rawluk D, Tormey W, Thompson CJ (2005) Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults. J Clin Endocrinol Metab 90(12):6355–6360 (Epub 2005 Sep 6)

    Google Scholar 

  • Ricardi U, Corrias A, Einaudi S, Genitori L, Sandri A, di Montezemolo LC, Besenzon L, Madon E, Urgesi A (2001) Thyroid dysfunction as a late effect in childhood medulloblastoma: a comparison of hyperfractionated versus conventionally fractionated craniospinal radiotherapy. Int J Radiat Oncol Biol Phys 50(5):1287–1294

    PubMed  CAS  Google Scholar 

  • Rohrer TR, Beck JD, Grabenbauer GG, Fahlbusch R, Buchfelder M, Dörr HG (2009) Late endocrine sequelae after radiotherapy of pediatric brain tumors are independent of tumor location. J Endocrinol Invest 32(4):294–297

    PubMed  CAS  Google Scholar 

  • Rose SR (1994) Neuroendocrine basis for insufficient growth hormone and its assessment. In: Savage MO, Bourguignon JP, Grossman AB (eds) Frontiers paediatric neuroendocrinology. Blackwell Scientific Publications, Oxford, pp 149–155

    Google Scholar 

  • Rose SR (1995) Isolated central hypothyroidism in short stature. Pediatr Res 38:967–973

    PubMed  CAS  Google Scholar 

  • Rose SR (1996) Induction of puberty in female hypogonadism. The Endocrinologist 6:439–442

    Google Scholar 

  • Rose SR (2000) Disorders of thyrotropin synthesis, secretion, and function. Curr Opin Pediatr 12(4):375–381

    PubMed  CAS  Google Scholar 

  • Rose SR (2001) Cranial irradiation and central hypothyroidism. Trends Endocrinol Metab 12(3):97–104

    PubMed  CAS  Google Scholar 

  • Rose SR (2008) Mechanisms of hypothalamic-pituitary injury after oncologic disease. Endocrinologist 18:85–89

    CAS  Google Scholar 

  • Rose SR (2010) Improved Diagnosis of mild Hypothyroidism using time-of–day normal ranges for thyrotropin. J Pediatr 157:662–667

    Google Scholar 

  • Rose SR, Municchi G (1999) Six-hour and four-hour nocturnal sampling for growth hormone. J Pediatr Endocrinol Metab 12:167–173

    PubMed  CAS  Google Scholar 

  • Rose SR, Nisula BC (1989) Circadian variation of thyrotropin in childhood. J Clin Endocrinol Metab 68:1086–1090

    PubMed  CAS  Google Scholar 

  • Rose SR, Ross JL, Uriarte M, Barnes KM, Cassorla FG, Cutler GB Jr (1988) The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med 319(4):201–207

    PubMed  CAS  Google Scholar 

  • Rose SR, Manasco PK, Pearce S, Nisula BC (1990) Hypothyroidism and deficiency of the nocturnal thyrotropin surge in children with hypothalamic-pituitary disorders. J Clin Endocrinol Metab 70:1750–1755

    PubMed  CAS  Google Scholar 

  • Rose SR, Lustig RH, Burstein S, Pitukcheewanont P, Broome DC, Burghen GA (1999a) Diagnosis of ACTH deficiency. Comparison of overnight metyrapone test to either low-dose or high-dose ACTH test. Horm Res 52:73–79

    PubMed  CAS  Google Scholar 

  • Rose SR, Lustig RH, Pitukcheewanont P, Broome DC, BurghenCA Li H, Hudson MM, Kun L, Heideman RLA (1999b) Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J Clin Endocrinol Metab 84:4472–4479

    PubMed  CAS  Google Scholar 

  • Rose SR, Schreiber RE, Kearney NS, Lustig RH, Danish RK, Burghen GA, Hudson MM (2004) Hypothalamic dysfunction after chemotherapy. J Pediatr Endocrinol Metab 17:55–66

    PubMed  Google Scholar 

  • Rose SR, Danish RK, Kearney NS, Schreiber RE, Hudson MM (2005) ACTH deficiency in childhood cancer survivors. Pediatr Blood Cancer 45:808–813

    PubMed  Google Scholar 

  • Roth C, Lakomek M, Schmidberger H, Jarry H (2001) Cranial irradiation induces premature activation of the gonadotropin-releasing-hormone. Klin Paediatr 213:239–243

    CAS  Google Scholar 

  • Rottembourg D, O’Gorman CS, Urbach S, Garneau PY, Langer JC, Van Vliet G, Hamilton J, Huot C (2009) Outcome after bariatric surgery in two adolescents with hypothalamic obesity following treatment of craniopharyngioma. J Pediatr Endocrinol Metab 22(9):867–872

    PubMed  Google Scholar 

  • Rubin P, Casarett GW (1968) Alimentary tract: esophagus and stomach. In: Rubin P, Casarett GW (eds) Clinical radiation pathology, vol 1, 1 edn. W. B. Saunders Company, Philadelphia p 517

    Google Scholar 

  • Schmidt KT, Larsen EC, Andersen CY, Andersen AN (2010) Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease. BJOG 117(2):163–174 (Epub. Review)

    Google Scholar 

  • Schwarzer JU, Fiedler K, Hertwig I, Krüsmann G, Würfel W, Mühlen B, Pickl U, Löchner-Ernst D, Schleyer M, Ovens-Räder A, Hennig M (2003) Male factors determining the outcome of intracytoplasmic sperm injection with epididymal and testicular spermatozoa. Andrologia 35(4):220–226

    PubMed  CAS  Google Scholar 

  • Shalet SM (1982) Growth and hormonal status of children treated for brain tumours. Childs Brain 9(3–4):284–293

    PubMed  CAS  Google Scholar 

  • Shalet SM (1993) Radiation and pituitary dysfunction. N Engl J Med 328:131–133

    PubMed  CAS  Google Scholar 

  • Shalet SM (1997) Cytotoxic endocrinopathy: a legacy of insults. J R Soc Med 90(4):192–199 (Review. PubMed PMID: 9155752; PubMed Central PMCID: PMC1296214)

    Google Scholar 

  • Shalet SM, Beardwell CG, Jones PH, Pearson D, Orrell DH (1976a) Ovarian failure following abdominal irradiation in childhood. Br J Cancer 33(6):655–658 (PubMed PMID: 938613; PubMed Central PMCID: PMC2025110)

    Google Scholar 

  • Shalet SM, Beardwell CG, Pearson D, Jones PH (1976b) The effect of varying doses of cerebral irradiation on growth hormone production in childhood. Clin Endocrinol (Oxf) 5:287–290

    CAS  Google Scholar 

  • Shalet SM, Beardwell CG, Twomey JA, Jones PH, Pearson D (1977) Endocrine function following the treatment of acute leukemia in childhood. J Pediatr 90(6):920–923

    PubMed  CAS  Google Scholar 

  • Shankar RR, Jakacki RI, Haider A, Lee MW, Pescovitz OH (1997) Testing the hypothalamic-pituitary-adrenal axis in survivors of childhood brain and skull-based tumors. J Clin Endocrinol Metab 82:1995–1998

    PubMed  CAS  Google Scholar 

  • Sherlock M, Ayuk J, Tomlinson JW, Toogood AA, Aragon-Alonso A, Sheppard MC, Bates AS, Stewart PM (2010) Mortality in patients with pituitary disease. Endocr Rev (Epub ahead of print)

    Google Scholar 

  • Shinohara T, Inoue K, Ogonuki N, Kanatsu-Shinohara M, Miki H, Nakata K, Kurome M, Nagashima H, Toyokuni S, Kogishi K, Honjo T, Ogura A (2002) Birth of offspring following transplantation of cryopreserved immature testicular pieces and in vitro microinsemination. Hum Reprod 17(12):3039–3045

    PubMed  CAS  Google Scholar 

  • Sklar CA (1997) Growth and neuroendocrine dysfunction following therapy for childhood cancer. Pediatr Clin N Am 44:489–503

    CAS  Google Scholar 

  • Sklar CA, Kim TH, Ramsay NK (1982) Thyroid dysfunction among long-term survivors of bone marrow transplantation. Am J Med 73(5):688–694

    PubMed  CAS  Google Scholar 

  • Sklar CA, Mertens AC, Mitby P, Occhiogrosso G, Qin J, Heller G, Yasui Y, Robison LL (2002) Risk of disease recurrence and second neoplasms in survivors of childhood cancer treated with growth hormone: a report from the Childhood Cancer Survivor Study. J Clin Endocrinol Metab 87(7):3136–3141

    PubMed  CAS  Google Scholar 

  • Sklar CA, Mertens AC, Mitby P, Whitton J, Stovall M, Kasper C, Mulder J, Green D, Nicholson HS, Yasui Y, Robison LL (2006) Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. J Natl Cancer Inst 98(13):890–896

    PubMed  Google Scholar 

  • Smith GL, Smith BD, Giordano SH, Shih YC, Woodward WA, Strom EA, Perkins GH, Tereffe W, Yu TK, Buchholz TA (2008) Risk of hypothyroidism in older breast cancer patients treated with radiation. Cancer 112(6):1371–1379

    PubMed  Google Scholar 

  • Smith GL, Smith BD, Garden AS, Rosenthal DI, Sherman SI, Morrison WH, Schwartz DL, Weber RS, Buchholz TA (2009) Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study. Head Neck 31(8):1031–1038

    PubMed  Google Scholar 

  • Sonmezer M, Oktay K (2010) Orthotopic and heterotopic ovarian tissue transplantation. Best Pract Res Clin Obstet Gynaecol 24(1):113–126 (Epub 2009 Oct 23. Review. PubMed PMID: 19853515)

    Google Scholar 

  • Soule SG, Fahie-Wilson M, Tomlinson S (1996) Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. Clin Endocrinol (Oxf) 44:137–140

    CAS  Google Scholar 

  • Spoudeas HA (1996) Hypothalamic dysregulation after cranio-spinal irradiation for childhood cerebellar tumors. Tenth international congress of endocrinology, San Francisco, CA,165, P1–P123 (abstract)

    Google Scholar 

  • Spoudeas HA (2002) Growth and endocrine function after chemotherapy and radiotherapy in childhood. Eur J Cancer 38(13):1748–1759

    PubMed  CAS  Google Scholar 

  • Spoudeas HA, Charmandari E, Brook CG (2003a) Hypothalamo-pituitary-adrenal axis integrity after cranial irradiation for childhood posterior fossa tumors. Med Pediatr Oncol 40:224–229

    PubMed  CAS  Google Scholar 

  • Spoudeas HA, Charmandari E, Brook CG (2003b) Hypothalamo-pituitary-adrenal axis integrity after cranial irradiation for childhood posterior fossa tumours. Med Pediatr Oncol 40(4):224–229

    PubMed  CAS  Google Scholar 

  • Stava CJ, Jimenez C, Vassilopoulou-Sellin R (2007) Endocrine sequelae of cancer and cancer treatments. J Cancer Surviv 1(4):261–274

    PubMed  Google Scholar 

  • Stovall M, Donaldson SS, Weathers RE, Robison LL, Mertens AC, Winther JF, Olsen JH, Boice JD Jr (2004) Genetic effects of radiotherapy for childhood cancer: gonadal dose reconstruction. Int J Radiat Oncol Biol Phys 60(2):542–552

    PubMed  Google Scholar 

  • Swerdlow AJ, Reddingius RE, Higgins CD, Spoudeas HA, Phipps K, Qiao Z, Ryder WD, Brada M, Hayward RD, Brook CG, Hindmarsh PC, Shalet SM (2000) Growth hormone treatment of children with brain tumors and risk of tumor recurrence. J Clin Endocrinol Metab 85:4444–4449

    PubMed  CAS  Google Scholar 

  • Tanner JM, Davies PS (1985) Clinical longitudinal standards for height and height velocity in North American children. J Pediatr 107:317–329

    PubMed  CAS  Google Scholar 

  • Thomas O, Mahé M, Campion L, Bourdin S, Milpied N, Brunet G, Lisbona A, Le Mevel A, Moreau P, Harousseau J, Cuillière J (2001) Long-term complications of total body irradiation in adults. Int J Radiat Oncol Biol Phys 49(1):125–131

    PubMed  Google Scholar 

  • Toogood AA, Taylor NF, Shalet SM, Monson JP (2000) Modulation of cortisol metabolism by low-dose growth hormone replacement in elderly hypopituitary patients. J Clin Endocrinol Metab 85:1727–1730

    PubMed  CAS  Google Scholar 

  • van Beek RD, van den Heuvel-Eibrink MM, Hakvoort-Cammel FG, van den Bos C, van der Pal HJ, Krenning EP, de Rijke YB, Pieters R, de Muinck Keizer-Schrama SM (2009) Bone mineral density, growth, and thyroid function in long-term survivors of pediatric Hodgkin’s lymphoma treated with chemotherapy only. J Clin Endocrinol Metab 94(6):1904–1909 (Epub 2009 Mar 17)

    Google Scholar 

  • Vance ML, Mauras N (1999) Growth hormone therapy in adults and children. N Engl J Med 341(16):1206–1216

    PubMed  CAS  Google Scholar 

  • Wagner C, Caplan SR, Tannenbaum GS (2009) Interactions of ghrelin signaling pathways with the GH neuroendocrine axis: a new and experimentally tested model. J Mol Endocrinol 43(3):105–119

    PubMed  CAS  Google Scholar 

  • Wallace WH, Shalet SM, Crowne EC, Morris-Jones PH, Gattamaneni HR (1989a) Ovarian failure following abdominal irradiation in childhood: natural history and prognosis. Clin Oncol (R Coll Radiol) 1(2):75–79

    CAS  Google Scholar 

  • Wallace WH, Shalet SM, Hendry JH, Morris-Jones PH, Gattamaneni HR (1989b) Ovarian failure following abdominal irradiation in childhood: the radiosensitivity of the human oocyte. Br J Radiol 62(743):995–998

    PubMed  CAS  Google Scholar 

  • Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal SM, Silverman L, Speiser P (2003) Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr 143:415–421

    PubMed  Google Scholar 

  • Wu YH, Wang HM, Chen HH, Lin CY, Chen EY, Fan KH, Huang SF, Chen IH, Liao CT, Cheng AJ, Chang JT (2010) Hypothyroidism after radiotherapy for nasopharyngeal cancer patients. Int J Radiat Oncol Biol Phys 76(4):1133–1139

    PubMed  Google Scholar 

  • Yanovski JA, Rose SR, Municchi G, Pescovitz OH, Hill SC, Cassorla FG, Cutler GB Jr (2003) Treatment with a luteinizing hormone-releasing hormone agonist in adolescents with short stature. N Engl J Med 348(10):908–917

    PubMed  CAS  Google Scholar 

  • Yau I, Vuong T, Garant A, Ducruet T, Doran P, Faria S, Liberman S, Richard C, Letellier F, Charlebois P, Loungnarath R, Stein B, Devic S (2009) Risk of hypogonadism from scatter radiation during pelvic radiation in male patients with rectal cancer. Int J Radiat Oncol Biol Phys 74(5):1481–1486

    PubMed  Google Scholar 

  • Zhang S-x (1999) An atlas of histology. Springer, New York

    Google Scholar 

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Merchant, T.E., Rose, S.R. (2014). Neuroendocrine Complications of Radiation and Cancer Therapy. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT • Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75863-1_3

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