Skip to main content

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 1488 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ADL:

Activities of daily living

AND:

Axillary node dissection

BCT:

Breast conserving surgery and radiotherapy

BMI:

Body mass index

CDT:

Complete decongestive therapy

DBCG:

Danish Breast Cancer Cooperative Group

HC:

Hydrocolloid

NCCTG:

North Central Cancer Treatment Group

QOL:

Quality of life

ROM:

Range of motion

RA:

Rheumatoid arthritis

SCD:

Scleroderma

SPADI:

Shoulder pain and disability index

S or DL:

Systemic or discoid lupus

START:

Standardization of breast radiotherapy

VAS:

Visual analog scale

References

  • Bajrovic A, Rades D, Fehlauer F et al (2004) Is there a life-long risk of brachial plexopathy after radiotherapy of supraclavicular lymph nodes in breast cancer patients? Radiother Oncol 71:297–301

    PubMed  Google Scholar 

  • Bellon J, Lindsley K, Ellis G et al (2000) Concurrent radiation therapy and paclitaxel or docetaxel chemotherapy in high-risk breast cancer. Int J Radiat Oncol Biol Phy 48(2):393–397

    CAS  Google Scholar 

  • Bentzen SM, Overgaard M, Thames HD (1989a) Fractionation sensitivity of a functional endpoint: impaired shoulder movement after post-mastectomy radiotherapy. Int J Radiat Oncol Biol Phys 17:531–537

    PubMed  CAS  Google Scholar 

  • Bentzen S, Thames H, Overgaard M (1989b) Latent-time estimation for late cutaneous and subcutaneous radiation reactions in a single follow-up clinical study. Radiother Oncol 15:267–274

    PubMed  CAS  Google Scholar 

  • Bijker N, Rutgers E, Peterse J et al (1999) Low risk of locoregional recurrence of a primary breast carcinoma after treatment with a modification of the Halsted radical mastectomy and selective use of radiotherapy. Cancer 85(8):1773–1781

    PubMed  CAS  Google Scholar 

  • Bostrom A, Lindman H, Swartling C et al (2001) Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother Oncol 59:257–265

    PubMed  CAS  Google Scholar 

  • Box RC, Reul-Hirche HM, Bullock-Saxton JE et al (2002) Shoulder movement after breast cancer surgery: results of a randomised controlled study of postoperative physiotherapy. Breast Cancer Res Treat 75:35–50

    PubMed  Google Scholar 

  • Brennan MJ, Miller LT (1998) Overview of treatment options and review of the current role of compression garments, intermittent pumps, and exercise programs in the management of lymphedema. Cancer 83(Suppl 12):2821–2827

    PubMed  CAS  Google Scholar 

  • Burak WE, Hollenbeck ST, Zervos EE et al (2002) Sentinel lymph node biopsy results in less postoperative morbidity compared with axillary lymph node dissection for breast cancer. Am J Surg 183:23–27

    PubMed  Google Scholar 

  • Caiozzo VJ, Giedzinski E, Baker M et al (2010) The radiosensitivity of satellite cells: cell cycle regulation, apoptosis and oxidative stress. Radiat Res 174:582–589

    PubMed  CAS  Google Scholar 

  • Carpenter J, Andrykowski M, Sloan P et al (1998) Postmastectomy/postlumpectomy pain in breast cancer survivors. J Clin Epidermiol 51(12):1285–1292

    CAS  Google Scholar 

  • Catterall M, Errington RD, Bewley DK (1987) Fast neutrons in the treatment of locally advanced breast cancer. Eur J Surg Oncol 13(4):315–319

    PubMed  CAS  Google Scholar 

  • Charge S, Rudnicki M (2004) Cellular and molecular regulation of muscle regeneration. Physil Rev 84:209–238

    CAS  Google Scholar 

  • Chen A, Obedian E, Haffty B (2001) Breast-conserving therapy in the setting of collagen vascular disease. Cancer J 7(6):480–491

    PubMed  CAS  Google Scholar 

  • Clarke D, Martinez A, Cox RS (1983) Analysis of cosmetic results and complications in patients with stage I and II breast cancer treated by biopsy and irradiation. Int J Radiat Oncol Biol Phys 9:1807–1813

    PubMed  CAS  Google Scholar 

  • Collins EE, Collins C (1935) Roentgen dermatitis treated with fresh whole leaf of aloe vera. AJR 33:396–397

    Google Scholar 

  • Delanian S, Porcher R, Balla-Mekias S et al (2003) Randomized, placebo-controlled trial of combined pentoxifylline and tocopherol for regression of superficial radiation-induced fibrosis. J Clin Oncol 21:2545–2550

    PubMed  CAS  Google Scholar 

  • De la Rochefordiere A, Abner AL, Silver B et al (1992) Are cosmetic results following conservative surgery and radiation therapy for early breast cancer dependent on technique? Int J Radiat Oncol Biol Phys 23:925–931

    PubMed  Google Scholar 

  • Dobrzanski S, Kelly CM, Gray JI et al (1990) Granuflex dressings in treatment of full thickness pressure sores. Prof Nurse 5(11):594–599

    PubMed  CAS  Google Scholar 

  • Donovan E, Bleakley N, Denholm E et al (2007) Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy. Radiother Oncol 82:254–264

    PubMed  Google Scholar 

  • Ellerbroek N, Martino S, Mautner B et al (2003) Breast-conserving therapy with adjuvant paclitaxel and radiation therapy: feasibility of concurrent treatment. Breast J 9(2):74–78

    PubMed  Google Scholar 

  • Erickson V, Pearson M, Ganz P et al (2001) Arm edema in breast cancer patients. J Natl Cancer Instit 93(2):96–111

    CAS  Google Scholar 

  • Engel J, Kerr J, Schlesinger-Raab A et al (2003) Axilla surgery severely affects quality of life: results of a 5-year prospective study in breast cancer patients. Breast Cancer Res Treat 79:47

    PubMed  Google Scholar 

  • Ernst MF, Voogd AC, Balder W et al (2002) Early and late morbidity associated with axillary levels I-III dissection in breast cancer. J Surg Oncol 79:151–155

    PubMed  Google Scholar 

  • Fathers E, Thrush D, Huson S et al (2002) Radiation-induced brachial plexopathy in women treated for carcinoma of the breast. Clin Rehabil 16:160–165

    PubMed  Google Scholar 

  • Fajardo L, Berthrong M, Anderson R (2001) Radiation pathology. Oxford University Press, New York, pp 303

    Google Scholar 

  • Fehlauer F, Tribius S, Holler U et al (2003) Long-term radiation sequelae after breast-conserving therapy in women with early-stage breast cancer: an observational study using the LENT-SOMA scoring system. Int J Radiat Oncol Biol Phys 55(3):651–658

    PubMed  Google Scholar 

  • Fiets WE, van Helvoirt JWR, Nortier I et al (2003) Acute toxicity of concurrent adjuvant radiotherapy and chemotherapy (CMF or AC) in breast cancer patients: a prospective, comparative, non-randomised study. Eur J Cancer 39:1081–1088

    PubMed  CAS  Google Scholar 

  • Formenti S, Volm M, Skinner K et al (2003) Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: a phase I/II trial. J Clin Oncol 21(5):864–870

    PubMed  CAS  Google Scholar 

  • Fowble BL, Solin LJ, Schultz DJ et al (1991) Ten year results of conservative surgery and irradiation for stage I and II breast cancer. Int J Radiat Oncol Biol Phys 21:269–277

    PubMed  CAS  Google Scholar 

  • Fenig E, Brenner B, Katz A et al (2001) Topical Biafine and Lipiderm for the preventions of radiation dermatitis: a randomized prospective trial. Oncol Rep 8:305–309

    PubMed  CAS  Google Scholar 

  • Findlay PA, Gorrell CR, d’Angelo T et al (1988) Lactation after breast radiation. Int J Radiat Oncol Biol Phys 15:511–512

    PubMed  CAS  Google Scholar 

  • Fisher J, Scott C, Stevens R et al (2000) Randomized phase III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast radiation: Radiation Therapy Oncology Group (RTOG) 97–13. Int J Radiat Oncol Biol Phys 48(5):1307–1310

    PubMed  CAS  Google Scholar 

  • Gothard L, Cornes P, Earl J et al (2004) Double-blind placebo-controlled randomised trial of vitamin E and pentoxifylline in patients with chronic arm lymphoedema and fibrosis after surgery and radiotherapy for breast cancer. Radiother Oncol 73:133–139

    PubMed  CAS  Google Scholar 

  • Gosselink R, Rouffaier L, Vanhelden P et al (2003) Recovery of Upper Limb Function after Axillary Dissection. J of Surg Onc 83:204–211

    Google Scholar 

  • Green JP (1989) Post-irradiation lactation. Int J Radiat Oncol Biol Phys 17:244

    PubMed  CAS  Google Scholar 

  • Gutman H, Kersz T, Barzilai T et al (1990) Achievements of physical therapy in patients after modified radical mastectomy compared with quadrantectomy, axillary dissection, and radiation for carcinoma of the breast. Arch Surg 125:389–391

    PubMed  CAS  Google Scholar 

  • Guiliano AE, Haigh PI, Brennan MB et al (2000) Perspective observational study of sentinel lymphadenectomy without further axillary dissection in patients with sentinel node negative breast cancer. J Clin Oncol 18:2553–2559

    Google Scholar 

  • Hanna Y, Baglan K, Stromberg J et al (2002) Acute and subacute toxicity associated with concurrent adjuvant radiation therapy and paclitaxel in primary breast cancer therapy. Breast J 8(3):149–153

    PubMed  CAS  Google Scholar 

  • Harris JR, Levene MB, Svensson G et al (1979) Analysis of cosmetic results following primary radiation therapy for stage I and II carcinoma of the breast. Int J Radiat Oncol Biol Phys 5:257–261

    PubMed  CAS  Google Scholar 

  • Herd-Smith A, Russo A, Grazia Muraca M et al (2001) Prognostic factors for lymphedema after primary treatment of breast carcinoma. Cancer 92(7):1783–1787

    PubMed  CAS  Google Scholar 

  • Haid A, Koberle-Wuhrer R, Knauer M et al (2002) Morbidity of breast cancer patients following complete axillary dissection or sentinel node biopsy only: a comparative evaluation. Breast Cancer Res Treat 73:31–36

    PubMed  Google Scholar 

  • Haddad P, Kalaghchi B, Amouzegar-Hashemi F (2005) Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial. Radiother Oncol 77:324–326

    PubMed  CAS  Google Scholar 

  • Heggie S, Bryant G, Tripcony L et al (2002) A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs 25(6):442–451

    PubMed  Google Scholar 

  • Higgins S, Haffty BG (1994) Pregnancy and lactation after breast-conserving therapy for early stage breast cancer. Cancer 73:2175–2180

    PubMed  CAS  Google Scholar 

  • Hojris I, Andersen J, Overgaard M et al (2000) Late treatment-related morbidity in breast cancer patients randomized to postmastectomy radiotherapy and systemic treatment versus systemic treatment alone. Acta Oncol 39:355–372

    PubMed  CAS  Google Scholar 

  • Hopwood P, Haviland J, Sumo G et al (2010) Comparison of patient reported breast, arm and shoulder symptoms and body image after radiotherapy for early breast cancer: 5 years follow-up in the randomized standardization of breast radiotherapy (START) trials. Lancet Oncol 11:231–240

    PubMed  Google Scholar 

  • International Society of Lymphology Executive Committee (1998) The diagnosis and treatment of peripheral edema: consensus development of the international society of lymphology executive committee. Lymphology 28:113

    Google Scholar 

  • Issac N, Panzarella T, Lau A et al (2002) Concurrent cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy and radiotherapy for breast carcinoma. Cancer 95(4):696–703

    Google Scholar 

  • Ivens D, Hoe AL, Podd TJ et al (1992) Assessment of morbidity from complete axillary dissection. Br J Cancer 66(1):136–138

    PubMed  CAS  PubMed Central  Google Scholar 

  • Jannuzzi C, Atencio D, Green S et al (2002) ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. Int J Radiat Oncol Biol Phys 52(3):606–613

    Google Scholar 

  • Johansson S, Svensson H, Denekamp J (2002) Dose response and latency for radiation-induced fibrosis, edema, and neuropathy in breast cancer patients. Int J Radiat Oncol Biol Phys 52(5):1207–1219

    PubMed  Google Scholar 

  • Johansson S, Svensson H, Denekamp J (2000) Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients. Int J Radiat Oncol Biol Phys 48(3):745–750

    PubMed  CAS  Google Scholar 

  • Johansson K, Ingvar C, Albertsson M et al (2001) Arm lymphoedema, shoulder mobility and muscle strength after breast cancer treatment—a prospective 2-year study. Adv in Physiother 3:55–66

    Google Scholar 

  • Kärki A, Simonen R, Mälkiä E et al (2005) Impairments, activity limitations and participation restrictions 6 and 12 months after breast cancer operation. J Rehabil Med 37:180–188

    PubMed  Google Scholar 

  • Khan M (1974) Radiation-induced changes in skeletal muscle: an electron microscopic study. J Neuropathol Exp Neurol 33:42–57

    PubMed  CAS  Google Scholar 

  • Kilbreath SL, Refshauge KM, Beith JM et al (2006) Progressive resistance training and stretching following surgery for breast cancer: study protocol for a randomised controlled trial. BMC Cancer 6:273

    PubMed  PubMed Central  Google Scholar 

  • Kiel K, Rademacker A (1996) Early-stage breast cancer: arm edema after wide excision and breast irradiation. Radiology 198(1):279–283

    PubMed  CAS  Google Scholar 

  • Kini V, White J, Horwitz E et al (1998) Long term results with breast-conserving therapy for patients with early stage breast carcinoma in a community hospital setting. Cancer 82(1):127–133

    PubMed  CAS  Google Scholar 

  • Kissin MW, Querci della Rovere G, Easton D et al (1986) Risk of lymphoedema following the treatment of breast cancer. Br J Surg 73(7):580–584

    PubMed  CAS  Google Scholar 

  • Larson D, Weinstein M, Goldberg I et al (1986) Edema of the arm as a function of the extent of axillary surgery in patients with stage I-II carcinoma of the breast treated with primary radiotherapy. Int J Radiat Oncol Biol Phys 12(9):1575–1582

    PubMed  CAS  Google Scholar 

  • LENT-SOMA (1995) LENT-SOMA scales for all anatomical sites. Int J Radiat Oncol Biol Phys 31:1049–1091

    Google Scholar 

  • Lin PP, Allison DC, Wainstock J et al (1993) Impact of axillary lymph node dissection on the therapy of breast cancer patients. J Clin Oncol 11(8):1536–1544

    PubMed  CAS  Google Scholar 

  • Lauridsen MC, Christiansen P, Hessov I (2005) The effect of physiotherapy on shoulder function in patients surgically treated for breast cancer: a randomized study. Acta Oncol 44:449–457

    PubMed  Google Scholar 

  • Lee T, Kilbreath S, Refshauge K et al (2008) Prognosis of the upper limb following surgery and radiation for breast cancer. Breast Cancer Res Treat 110:19–37

    PubMed  Google Scholar 

  • Lee TS, Kilbreasth S, Refshauge S (2007) Pectoral stretching program for women undergoing RT from breast cancer. Breast Cancer Res Treat 102:313–321

    PubMed  CAS  Google Scholar 

  • Liguori V, Guillemin C, Pesce G et al (1997) Double-blind randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother Oncol 42:155–161

    PubMed  CAS  Google Scholar 

  • Liljegren G, Holmberg L et al (1997) Arm morbidity after sector resection and axillary dissection with or without postoperative radiotherapy in breast cancer stage I. results from a randomised trial. Eur J Cancer 33:193–199

    PubMed  CAS  Google Scholar 

  • Leidenius M, Leppanen E, Krogerus L et al (2003) Motion restriction and axillary web syndrome after sentinel node biopsy and axillary clearance in breast cancer. Am J Surg 185:127–130

    PubMed  Google Scholar 

  • Lokkevik E, Slovlund E, Reitan J et al (1996) Skin treatment with bepanthen cream versus no cream during radiotherapy. Acta Oncol 35(8):1021–1026

    PubMed  CAS  Google Scholar 

  • Mak S, Molassiotis A, Wan W et al (2000) The effects of hydrocolloid dressing and gentian violet on radiation-induced moist desquamation wound healing. Cancer Nurs 23(3):220–228

    PubMed  CAS  Google Scholar 

  • Mallet J, Mulholland J, Laverty D et al (1999) An integrated approach to wound management. Palliat Nurs 5(3):124–132

    Google Scholar 

  • Margolin SG, Breneman JC, Denman DL et al (1990) Management of radiation induced moist skin desquamation using hydrocolloid dressing. Cancer Nurs 13(2):71–80

    PubMed  CAS  Google Scholar 

  • Maunsell E, Brisson J, Deshenes L (1993) Arm problems and psychological distress after surgery for breast cancer. Can J Surg 363:315–320

    Google Scholar 

  • Meric F, Buchholz T, Mirza N et al (2002) Long-term complications associated with breast-conservation surgery and radiotherapy. Ann Surg Oncol 9(6):543–549

    PubMed  Google Scholar 

  • Mondry T, Riffenburgh R, Johnstone P et al (2004) Prospective trial of complete decongestive therapy for upper extremity lymphedema after breast cancer therapy. Cancer J 19(1):42–48

    Google Scholar 

  • Morris M, Powell S (1997) Irradiation in the setting of collagen vascular disease: acute and late complications. J Clin Oncol 15(7):2728–2735

    PubMed  CAS  Google Scholar 

  • Maiche AG, Grohn P, Maki-Hokkonen H (1991) Effect of chamomile cream and almond ointment on acute radiation skin reaction. Acta Oncol 30(3):395–396

    PubMed  CAS  Google Scholar 

  • Martin M (1993) leFaix JL, Pinton P, et al. Temporal Modulation of TGF β and β-actin gene expression in pigskin and muscular fibrosis after ionizing radiation. Radiat Res 134:63–70

    PubMed  CAS  Google Scholar 

  • Magnusson M, Hoglund P, Johansson K et al (2009) Pentoxifylline and vitamin E treatment for prevention of radiation-induced side-effects in women with breast cancer: a phase two, double-blind, placebo-controlled randomised clinical trial (Ptx-5). Eur J Cancer 45:2488–2495

    PubMed  CAS  Google Scholar 

  • McCullough L, Ng A, Najita J et al (2010) Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy. Cancer 116:4866–4871

    PubMed  Google Scholar 

  • Nesvold I, Dahl A, Lokkevik E et al (2008) Arm and shoulder morbidity in breast cancer patients after breast-conserving therapy versus mastectomy. Acta Oncol 47:835–842

    PubMed  Google Scholar 

  • Olivotto IA, Rose MA, Osteen RT et al (1989) Late cosmetic outcome after conservative surgery and radiotherapy: analysis of causes of cosmetic failure. Int J Radiat Oncol Biol Phys 17(4):747–753

    PubMed  CAS  Google Scholar 

  • Olsen N, Pfeiffer P, Johannsen L et al (1993) Radiation-induced brachial plexopathy: neurological follow-up in 161 recurrence-free breast cancer patients. Int J Radiat Oncol Biol Phys 26(1):43–49

    PubMed  CAS  Google Scholar 

  • Okunieff P, Augustine E, Hicks JE et al (2004) Pentoxifylline in the treatment of radiation-induced fibrosis. J Clin Oncol 22:2207–2213

    PubMed  CAS  Google Scholar 

  • Olsen D, Raub W, Bradley C et al (2001) The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol Nurs Forum 28(3):543–547

    PubMed  CAS  Google Scholar 

  • Petrek J, Senie R, Peters M et al (2001) Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer 92(6):1368–1377

    PubMed  CAS  Google Scholar 

  • Phan C, Mindrum M, Silverman C et al (2003) Matched-control retrospective study of the acute and late complications in patients with collagen vascular diseases treated with radiation therapy. Cancer J 9(6):461–466

    PubMed  Google Scholar 

  • Pierce L, Oberman H, Strawderman M et al (1995) Microscopic extracapsular extension of the axilla: is this an indication for axillary radiotherapy? Int J Radiat Oncol Biol Phys 33(2):252–259

    Google Scholar 

  • Pierce S, Recht A, Lingos T et al (1992) Long-term radiation complications following conservative surgery (CS) and radiation therapy (RT) in patients with early stage breast cancer. Int J Radiat Oncol Biol Phys 23(5):915–923

    PubMed  CAS  Google Scholar 

  • Pommier P, Gomez F, Sunyach A et al (2004) Phase III randomized trial of calendula officinalis compared with Trolamine for the prevention of acute dermatitis during irradiation of breast cancer. J Clin Oncol 22(8):1447–1453

    PubMed  CAS  Google Scholar 

  • Pignol JP, Olivotto I, Rakovitch E et al (2008) A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J Clin Oncol 26(13):2085–2092

    PubMed  Google Scholar 

  • Powell S, Taghian A, Kachnic L et al (2003) Risk of lymphedema after regional nodal irradiation with breast conservation therapy. Int J Radiat Oncol Biol Phys 55(5):1209–1215

    PubMed  Google Scholar 

  • Peintinger F, Reitsamer R, Stranzl H et al (2003) Comparison of quality of life and arm complaints after axillary lymph node dissection vs sentinel lymph node biopsy in breast cancer patients. Br J Cancer 89:648–652

    PubMed  CAS  PubMed Central  Google Scholar 

  • Pezner RD, Patterson MP, Lipsett JA et al (1992) Factors affecting cosmetic outcome in breast-conserving cancer treatment—objective quantitative assessment. Breast Cancer Res Treat 20:85–92

    PubMed  CAS  Google Scholar 

  • Pezner RD, Patterson MP, Hill LR et al (1986) Arm lymphedema in patients treated conservatively for breast cancer: relationship to patient age and axillary node dissection technique. Int J Radiat Oncol Biol Phys 12:2079–2083

    PubMed  CAS  Google Scholar 

  • Porock D, Kristjanson L (1999) Skin reactions during radiotherapy for breast cancer: the use and impact of topical agents and dressings. Eur J Cancer Care (Engl) 8:143–153

    CAS  Google Scholar 

  • Potera M, Lookingbill D, Stryker J (1982) Prophylaxis of radiation dermatitis with topical cortisone cream. Radiology 143:775–777

    PubMed  CAS  Google Scholar 

  • Purushotham AD, Upponi S, Klevesath MB et al (2005) Morbidity after sentinel lymph node biopsy in primary breast cancer: results from a randomized controlled trial. J Clin Oncol 23:4312–4321

    PubMed  Google Scholar 

  • Ragaz J, Jackson SM, Le N et al (1997) Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 337:956–962

    PubMed  CAS  Google Scholar 

  • Robertson J, Clarke D, Pevzner M et al (1991) Breast conservation therapy. Severe breast fibrosis after radiation therapy in patients with collagen vascular disease. Cancer 68:502–508

    PubMed  CAS  Google Scholar 

  • Ross J, Hussey D, Mayr N et al (1993) Acute and late reactions to radiation therapy in patients with collagen vascular diseases. Cancer 71:744–752

    Google Scholar 

  • Rubin P, Casarett GW (1968) Clinical Radiation Pathology. WB Saunders, Philadelphia

    Google Scholar 

  • Ryan G, Dawson L, Bezjak A et al (2003) Prospective comparison of breast pain in patients participating in a randomized trial of breast-conserving surgery and tamoxifen with or without radiotherapy. Int J Radiat Oncol Biol Phys 55(1):154–161

    Google Scholar 

  • Ryoo M, Kagan AR, Wollin M et al (1989a) Prognostic factors for recurrence and cosmesis in 393 patients after radiation therapy for early mammary carcinoma. Radiology 172:555–559

    PubMed  CAS  Google Scholar 

  • Ryttov N, Holm NV, Qvist N et al (1998) Influence of adjuvant irradiation on the development of late arm lymphedema and impaired shoulder mobility after mastectomy for carcinoma of the breast. Acta Oncol 27:667–670

    Google Scholar 

  • Remy J, Martin M, Lefaix J et al (1989) Radiation induced fibrosis in pig muscle: pathological and cellular observation. Brit J Cancer 53:559–567

    Google Scholar 

  • Rietman J, Dijkstra P, Hoekstra H et al (2003) Late morbidity after treatment of breast cancer in relation to daily activities and quality of life: a systematic review. EJSO 29:229–238

    PubMed  CAS  Google Scholar 

  • Rodger A, Corbett PJ, Chetty U (1989) Lactation after breast conserving therapy, including radiation therapy, for early breast cancer. Radiother Oncol 15:243–244

    PubMed  CAS  Google Scholar 

  • Romestaing P, Lehingue Y, Carrie C et al (1997) Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon. France J Clin Oncol 15:963–968

    CAS  Google Scholar 

  • Roy I, Fortin A, Larochelle M (2001) The impact of skin washing with water and soap during breast irradiation: a randomized study. Radiother Oncol 58:333–339

    PubMed  CAS  Google Scholar 

  • Ryoo MC, Kagan AR, Wollin M et al (1989b) Prognostic factors for recurrence and cosmesis in 393 patients after radiation therapy for early mammary carcinoma. Radiology 172:555–559

    PubMed  CAS  Google Scholar 

  • Sacchini V, Luini A, Agresti R et al (1995) The influence of radiotherapy on cosmetic outcome after breast conservative surgery. Int J Radiat Oncol Biol Phys 33(1):59–64

    PubMed  CAS  Google Scholar 

  • Segerstrom K, Bjerle P, Graffman S et al (1992) Factors that influence the incidence of brachial oedema after treatment of breast cancer. Scand J Plast Reconstr Hand Surg 26:223–227

    CAS  Google Scholar 

  • Shell JA, Stanutz F, Grimm J (1986) Comparison of moisture vapor permeable dressings to conventional dressings for management of radiation skin reactions. Oncol Nurs Forum 13:11–16

    PubMed  CAS  Google Scholar 

  • Sneeuw KCA, Aaronson NK, Yarnold JR et al (1992) Cosmetic and functional outcomes of breast conserving treatment for early stage breast cancer. 1. Comparisons of patients’ ratings, observers’ ratings and objective assessments. Radiother Oncol 25:153–159

    PubMed  CAS  Google Scholar 

  • Schwenen M, Altman K, Schroder W (1989) Radiation-induced Increase in the Release of Amino Acids by Isolated, Perfused Skeletal Muscle. Int J Radiat Biol 55:257–269

    PubMed  CAS  Google Scholar 

  • Schmuth M, Wimmer MA, Hofer S et al (2002) Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized double-blind study. Br J Dermatol 146:983–991

    PubMed  CAS  Google Scholar 

  • Shamley DR, Srinanaganathan R, Weatherall R et al (2007) Changes in shoulder muscle size and activity following treatment for breast cancer. Breast Cancer Res Treat 106:19–27

    PubMed  Google Scholar 

  • Shoma A, Eldars W, Noman N et al (2010) Pentoxifylline and local honey for radiation-induced burn following breast conservative surgery. Curr Clin Pharmacol 5:251–256

    PubMed  CAS  Google Scholar 

  • Sugden EM, Rezvani M, Harrison JM et al (1998) Shoulder movement after the treatment of early stage breast cancer. Clin Oncol (R Coll Radiol) 10:173–181

    CAS  Google Scholar 

  • Szumacher E, Wighton A, Franssen E et al (2001) Phase II study assessing the effectiveness of Biafine cream as a prophylactic agent for radiation-induced acute skin toxicity to the breast in women undergoing radiotherapy with concomitant CMF chemotherapy. Int J Radiat Oncol Biol Phys 51(1):81–86

    PubMed  CAS  Google Scholar 

  • Taylor M, Perez C, Halverson K et al (1995) Factors influencing cosmetic results after conservation therapy for breast cancer. Int J Radiat Oncol Biol Phys 31(4):753–764

    PubMed  CAS  Google Scholar 

  • Tillman B (2007) Atlas of Human Anatomy, Mud Puddle Books Inc, New York, pp 224

    Google Scholar 

  • Tobin MB, Lacey HJ, Meyer L, Mortimer PS (1993) The psychological morbidity of breast cancer-related arm swelling. Cancer 72:3248–3252

    PubMed  CAS  Google Scholar 

  • Tuamokumo N, Haffty B (2003) Clinical outcome and cosmesis in African-American patients treated with conservative surgery and radiation therapy. Cancer J 9(4):313–320

    PubMed  Google Scholar 

  • Tralins AH (1995) Lactation after conservative breast surgery combined with radiation therapy. Am J Clin Oncol 18:40–43

    PubMed  CAS  Google Scholar 

  • Tengrup I, Tennvall-Nittby L, Christiansson I et al (2000) Arm morbidity after breast-conserving therapy for breast cancer. Acta Oncol 39:393–397

    PubMed  CAS  Google Scholar 

  • Varga J, Haustein UF, Creech R et al (1991) Exaggerated radiation-induced fibrosis in patients with systemic sclerosis. JAMA 265(24):3292–3295

    PubMed  CAS  Google Scholar 

  • Veronesi U, Marubini E, Galimberti V et al (2001) Radiotherapy after breast-conserving surgery in small breast carcinoma: long term results of randomized trial. Ann Oncol 12(7):997–1003

    PubMed  CAS  Google Scholar 

  • Veronesi U, Paganelli G, Viale G et al (2003) A randomized comparison of sentinel-node biopsy with routine axcillary dissection in breast cancer. NEJM 349(6):546–553

    PubMed  Google Scholar 

  • Ververs J, Roumen R, Vingerhoerts A et al (2001) Risk, severity and predictors of physical and psychological morbidity after axillary lumph node dissection for breast cancer. Eur J Cancer 37:991–999

    PubMed  CAS  Google Scholar 

  • Vreilng C, Collette L, Fourquet A et al (1999) The influence of the boost in breast-conserving therapy on cosmetic outcome in the EORTC “boost versus no boost” trial. Int J Radiat Oncol Biol Phys 45(3):677–685

    Google Scholar 

  • Voogd AC, Ververs J, Vingerhoets A et al (2003) Lymphoedema and reduced shoulder function as indicators of quality of life after axillary lymph node dissection for invasive breast cancer. Brit Jrnl of Surgery 90:76–81

    CAS  Google Scholar 

  • Wazer D, Dipetrillo T, Schmidt-Ullirch R et al (1992) Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast carcinoma. J Clin Oncol 10(3):356–363

    PubMed  CAS  Google Scholar 

  • Werner R, McCormick B, Petrek J et al (1991) Arm edema in conservatively managed breast cancer: obesity is a major predictive facor. Radiology 180(1):177–184

    PubMed  CAS  Google Scholar 

  • Whelan T, Levine M, Julian J et al (2000) The effects of radiation therapy on quality of life of women with breast carcinoma. Cancer 88(10):2260–2266

    PubMed  CAS  Google Scholar 

  • White J, Moughan J, Pierce LJ et al (2004) The status of post-mastectomy radiation therapy in the United States: a patterns of care study. Int J Radiat Oncol Biol Phys 60(1):77–85

    PubMed  Google Scholar 

  • White J, Joiner MC (2006) Toxicity from radiation in breast cancer. Radiation Toxicity: A Practical Guide. Springer US. 65–109

    Google Scholar 

  • Wegrowski J, Lafuma C, Lefaix J, Daburon F, Robert L (1988) Modification of collagen and noncollagenous proteins in radiation-induced muscular fibrosis. Exp Molecular Path 48:273–285

    CAS  Google Scholar 

  • Williams M, Burk M, Loprinzi C et al (1996) Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 36(2):345–349

    PubMed  CAS  Google Scholar 

  • Wingate L, Croghan I, Natarajan N et al (1989) Rehabilitation of the mastectomy patient: a randomized, blind, prospective study. Arch Phys Med Rehabil 70:21–24

    PubMed  CAS  Google Scholar 

  • Yap K, McCready D, Narod S et al (2003) Factors influencing arm and axillary symptoms after treatment for node negative breast carcinoma. Cancer 97:1369–1375

    PubMed  Google Scholar 

  • Zhang Shu-Xin (1999) An atlas of histology. Springer, New York, pp 337–339

    Google Scholar 

Download references

Acknowledgments

Portions of this chapter were adapted from Toxicity from Radiation in Breast Cancer, in Radiation Toxicity: A Practical Guide, by Small and Woloschak, Chap. 5; and from Zhang. Thanks to Dorothy Riguera for her assistance in preparing this document.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Julia White .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

White, J., Joiner, M.C., Xie, L. (2014). Breast Cancer. In: Rubin, P., Constine, L., Marks, L. (eds) ALERT • Adverse Late Effects of Cancer Treatment. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75863-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-75863-1_10

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-75862-4

  • Online ISBN: 978-3-540-75863-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics