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Target-Based Interventions to Treat Radiation-Induced Lung Injury

  • Chapter
The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The ability to achieve local tumor control and improved overall survival with radiation therapy is limited by the risk of unacceptable normal tissue toxicity. A number of therapeutic interventions targeting the molecular pathways responsible for the development of acute and long-term injury have been investigated in pre-clinical and clinical studies. These interventions have primarily targeted apoptosis, growth factors, and pro-inflammatory and pro-fibrogenic pathways in an attempt to prevent, mitigate, or treat radiation-induced injury. As the mechanisms underlying radiation-induced normal tissue injury are better elucidated, the identification of new potential targets and improved therapeutic interventions will allow patient-stratified dose escalation and improve long-term response rates. The following chapter outlines current target-based interventions being investigated and discusses the recent discovery of novel pathways that may be targeted in the future.

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Authors and Affiliations

  1. Department of Radiation Oncology, Box 3455 MSRB, Duke University Medical Center, 27705, Durham, NC, USA

    Isabel L. Jackson B. S. & Zeljko Vujaskovic MD, PhD

  2. Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401 College Street, 980058, 23298-0058, Richmond, VA, USA

    Mitchell S. Anscher MD, FACR, FACRO

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  1. Isabel L. Jackson B. S.
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  2. Mitchell S. Anscher MD, FACR, FACRO
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  3. Zeljko Vujaskovic MD, PhD
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  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Michael Molls MD

  2. Institute of Physiology and Pathophysiology, University Medical Center, Duesbergweg 6, 55099, Mainz, Germany

    Peter Vaupel MD, MA

  3. Department of Internal Medicine – Oncology, Nordlandssykehuset HF Hospital, 8092, Bodø, Norway

    Carsten Nieder MD

  4. Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401 College Street, 980058, 23298-0058, Richmond, VA, USA

    Mitchell S. Anscher MD, FACR, FACRO

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Jackson, I., Anscher, M., Vujaskovic, Z. (2009). Target-Based Interventions to Treat Radiation-Induced Lung Injury. In: Molls, M., Vaupel, P., Nieder, C., Anscher, M. (eds) The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74386-6_12

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