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Cryptosporidium

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Genome Mapping and Genomics in Animal-Associated Microbes

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Cryptosporidium represents a group of early-branched apicomplexans. Various Cryptosporidium species may infect humans and/or animals, causing cryptosporidiosis for which no completely effective treatments are yet available. The chapter provides updated information on Cryptosporidium in the basic parasitology (e.g., taxonomy, life cycle, genotypes, and treatments), genomics (e.g., general features of the genomes, comparison between C. parvum and C. hominis genomes, genome maps, genome databases, and resources), and the insights into the Cryptosporidium biology delineated from the genomes, including streamlined metabolism, expanded families of transporters, lineage-specific expansion of proteases, Cryptosporidium-specific amplified gene families, surface protein repertoire, mucin-like proteins, TRAP family of motility and invasion proteins, oocyst wall proteins, and potential drug targets.

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Authors and Affiliations

  1. Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, and Faculty of Genetics Program, Texas A…M University, College Station, TX, 77843-4467, USA

    Guan Zhu & Jason M. Fritzler

  2. Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, 55108, USA

    Shinichiro Enomoto & Mitchell S. Abrahamsen

  3. Department of Microbiology and Immunology, Weill Cornell Medical College, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, 10021, USA

    Thomas J. Templeton

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  1. Guan Zhu
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  2. Shinichiro Enomoto
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  3. Jason M. Fritzler
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  4. Mitchell S. Abrahamsen
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  5. Thomas J. Templeton
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  1. Institute for Genome Sciences and Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, 21021, USA

    Vishvanath Nene

  2. Department of Genetics & Biochemistry, Clemson University, 111 Jordan Hall, Clemson, SC, 29634, USA

    Chittaranjan Kole

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Zhu, G., Enomoto, S., Fritzler, J.M., Abrahamsen, M.S., Templeton, T.J. (2009). Cryptosporidium . In: Nene, V., Kole, C. (eds) Genome Mapping and Genomics in Animal-Associated Microbes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74042-1_5

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