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Optical Agents

  • Chapter
Molecular Imaging I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 185/1))

Abstract

Optical imaging is an emerging modality in the growing field of biomedical diagnostics. The past decade has witnessed the development of a variety of promising strategies for optical imaging techniques. Fundamental to these techniques is the design and application of novel fluorescent markers to allow molecular level in-vivo studies of disease in animal models in the laboratory and eventually in human clinical studies.

This review surveys the range of fluorophores employed in these probes and the alternative probe systems in which they are used: non-specific, targeted and activatable; recent developments in the area of fluorescent nanoprobes and multimodality constructs are also reviewed.

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References

  • Achilefu S, Jimenez HN, Dorshow RB, Bugaj JE, Webb EG, Wilhelm RR, Rajagopalan R, Johler J, Erion JL (2002) Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. J Med Chem 45:2003-2015

    Article  PubMed  CAS  Google Scholar 

  • Achilefu S, Bloch S, Markiewicz MA, Zhong T, Ye Y, Dorshow R, Chance B, Liang K (2005) Synergistic effects of light-emitting probesand peptides for targeting and monitoring integrin expression. Proc Natl Acad Sci USA 102:7976-7981

    Article  PubMed  CAS  Google Scholar 

  • Aina OH, Marik J, Gandour-Edwards R, Lam KT (2005) Near-infrared optical imaging of ovarian cancer xenografts with novel A3-integrin binding peptide ‘OA02’. Mol Imaging 4:439-447

    PubMed  Google Scholar 

  • Akerman ME, Chan WC, Laakkonen P, Bhatia SN, Ruoslahti E (2002) Nanocrystal targeting in vivo. Proc Natl Acad Sci USA 99:12617-12621

    Article  PubMed  CAS  Google Scholar 

  • Ballou B, Fisher GW, Waggoner AS, Farkas DL, Reiland JM, Jaffe R, Mujumdar RB, Mujumdar SR, Hakala TR (1995) Tumor labeling in vivo using cyanine-conjugated monoclonal antibod-ies. Cancer Immunol Immunother 41:257-263

    Article  PubMed  CAS  Google Scholar 

  • Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS (2004) Noninvasive imaging of quantum dots in mice. Bioconjugate Chem 15:79-86

    Article  CAS  Google Scholar 

  • Ballou B, Ernst LA, Waggoner AS (2005) Fluorescence imaging of tumors in vivo. Curr Med Chem 12:795-805

    Article  PubMed  CAS  Google Scholar 

  • Becker A, Ebert B, Sukowski U, Rinneberg H, Semmler W, Licha K (2000) Macromolecular con-trast agents for optical imaging of tumors: indotricarbocyanine-labeled humans serum albumin and transferrin. Photochem Photobiol 72:234-241

    Article  PubMed  CAS  Google Scholar 

  • Becker A, Hessenius C, Licha K, Ebert B, Sukowski U, Semmler W, Wiedenmann B, Gr ötzinger C (2001) Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nat Biotechnol 19:327-331

    Article  PubMed  CAS  Google Scholar 

  • Berger Y, Greppi A, Siri O, Neier R, Juillerat-Jeanneret L. (2000) Ethylene glycol and amino acid derivatives of 5-aminolevulinic acid as new photosensitizing precursors of protoporphyrin IX in cells. J Med Chem 43:4738-4746

    Article  PubMed  CAS  Google Scholar 

  • Bhargava S, Licha K, Knaute T, Ebert B, Becker A, Gr ötzinger C, Hessenius C, Wiedenmann B, Schneider-Mergener J, Volkmer-Engert R (2002) A complete substitutional analysis of VIP for better tumor imaging properties. J Mol Recognit 15:145-153

    Article  PubMed  CAS  Google Scholar 

  • Birchler M, Neri G, Tarli L, Halin C, Viti F, Neri D (1999a) Infrared photodetection for the in vivo localisation of phage-derived antibodies directed against angiogenic markers. J Immunol Methods 231:239-248

    Article  CAS  Google Scholar 

  • Birchler M, Viti F, Zardi L, Spiess B, Neri D (1999b) Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment. Nat Biotechnol 17:984-988

    Article  CAS  Google Scholar 

  • Bornhop DJ, Griffin JM, Goebel TS, Sudduth MR, Bell B, Motamedi M (2003) Luminescent lan-thanide chelate contrast agents and detection of lesions in the hamster oral cancer model. Appl Spectr 57:1216-1222

    Article  CAS  Google Scholar 

  • Bremer C, Tung CH, Weissleder R (2001) In vivo molecular target assessment of matrix metallo-proteinase inhibition. Nat Med 7:743-748

    Article  PubMed  CAS  Google Scholar 

  • Bremer C, Tung CH, Bogdanov Jr A, Weissleder R (2002) Imaging of differential protease expres-sion in breast cancers for detection of aggressive tumor phenotypes. Radiology 222:814-818

    Article  PubMed  Google Scholar 

  • Bugaj JE, Achilefu S, Dorshow RB, Rajagopalan R. (2001) Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. J Biomed Opt 6:122-133

    Article  PubMed  CAS  Google Scholar 

  • Chan WC, Maxwell DJ, Gao X, Bailey RE, Han M, Nie S (2002) Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 13:40-46

    Article  PubMed  CAS  Google Scholar 

  • Chen WT, Mahmood U, Weissleder R, Tung CH (2005) Arthritis imaging using a near-infrared fluorescence folate-targeted probe. Arthritis Res Ther 7:R310-R317

    Article  PubMed  CAS  Google Scholar 

  • Chen X, Conti PS, Moats RA (2004) In vivo near-infrared fluorescence imaging of integrin αvß3 in brain tumor xenografts. Cancer Res 64:8009-8014

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Zheng G, Zhang ZH, Blessington D, Zhang M, Li H, Liu Q, Zhou L, Intes X (2003) Metabolism-enhanced tumor localization by fluorescence imaging: in vivo animal studies. Opt Lett 28:2070-2072

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Gryshuk A, Achilefu S, Ohulchansky T, Potter W, Zhong T, Morgan J, Chance B, Prasad PN, Henderson BW, Oseroff A, Pandey RK (2005) A novel approach to a bifunctional photo-sensitizer for tumor imaging and phototherapy. Bioconjugate Chem 16:1264-1274

    Article  CAS  Google Scholar 

  • Citrin D, Scott T, Sproull M, Menard C, Tofilo PJ, Camphausen K (2004) In vivo tumor imag-ing using a near-infrared-labeled endostatin molecule. Int J Radiation Oncology Biol Phys 58: 536-541  Optical Agents219

    Google Scholar 

  • Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A (2002) In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298:1759-1762

    Article  PubMed  CAS  Google Scholar 

  • Ebert B, Sukowski U, Grosenick D, Wabnitz H, Moesta KT, Licha K, Becker A, Semmler W, Schlag PM, Rinneberg H (2001) Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments. J Biomed Opt 6:134-140

    Article  PubMed  CAS  Google Scholar 

  • Folli S, Westermann P, Braichotte D, Pelegrin A, Wagnieres G, van den Bergh H, Mach JP, (1994) Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carci-noma in nude mice. Cancer Res 54:2643-2649

    PubMed  CAS  Google Scholar 

  • Fukuda H, Casas A, Batlle A (2005) Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy. Int J Biochem Cell Biol 37:272-276

    Article  PubMed  CAS  Google Scholar 

  • Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L (2005) Nanoparticles for the optical imaging of tumor E-selectin. Neoplasia 7:904-911

    Article  PubMed  CAS  Google Scholar 

  • Gao X, Cui Y, Levenson RM, Chung LW, Nie S (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 22:969-976

    Article  PubMed  CAS  Google Scholar 

  • Gurfinkel M, Thompson AB, Ralston W, Troy TL, Moore AL, Moore TA, Gust JD, Tatman D, Reynolds JS, Muggenburg B, Nikula K, Pandey R, Mayer RH, Hawrysz DJ, Sevick-Muraca EM (2000) Pharmacokinetics of ICG and HPPH-car for the detection of normal and tumor tissue using fluorescence, near-infrared reflectance imaging: a case study. Photochem Photobiol 72:94-102

    Article  PubMed  CAS  Google Scholar 

  • Hintersteiner M, Enz A, Frey P, Jaton AL, Kinzy W, Kneuer R, Neumann U, Rudin M, Staufenbriel M, Stoeckli M, Wiederholt KH, Gremlich HU (2005) In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe. Nat Biotechnol 23:577-583

    Article  PubMed  CAS  Google Scholar 

  • H ödl C, Strauss WSL, Sailer R, Heger C, Steiner R, Haslinger E, Schramm HW (2004) A novel, high-affinity, fluorescent progesterone receptor antagonist: synthesis and in vitro studies. Bio-conjug Chem 15:359-365

    Google Scholar 

  • Hogan RN, Zimmerman CF (1997) Sodium fluorescein and other tissue dyes. In: Zimmerman TJ (ed) Textbook of ocular pharmacology. Lippincott-Raven, Philadelphia, p 849

    Google Scholar 

  • Huh YM, Jun YW, Song HT, Kim S, Choi JS, Lee JH, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J (2005) In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J Am Chem Soc 127:12387-12391

    Article  PubMed  CAS  Google Scholar 

  • Humblet V, Lapidus R, Williams LR, Tsukamoto T, Rojas C, Majer P, Hin B, Ohnishi S, De Grand AM, Zaheer A, Renze JT, Nakayama A, Slusher BS, Frangioni JV (2005) High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen. Mol Imaging 4:448-462

    PubMed  Google Scholar 

  • Hyman ES, Hynninen PH (2004) Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy. J Photochem Photobiol B: Biol 73:1-28

    Article  CAS  Google Scholar 

  • Jaffer FH, Tung CH, Gerszten RE, Weissleder R (2002) In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol 22:1929-1935

    Article  PubMed  CAS  Google Scholar 

  • Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R (2002) Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjugate Chem. 13:554-560

    Article  CAS  Google Scholar 

  • Ke S, Wen X, Gurfinkel M, Charnsangarvej C, Wallace S, Sevick-Muraca EM, Li C (2003) Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenographs. Can-cer Res 63:7870-7875

    CAS  Google Scholar 

  • Kim SW, Bawendi MG (2003) Oligomeric ligands for luminescent and stable nanocrystal quantum dots. J Am Chem Soc 125:14652-14653

    Article  PubMed  CAS  Google Scholar 

  • Kim SW, Lim YT, Soltesz EG, DeGrand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi RG, Frangioni JV (2004) Near-infrared fluores-cent type II qunatum dots for sentinel lymph node mapping. Nat Biotechnol 22:93-97

    Article  PubMed  Google Scholar 

  • Kim SW, Zimmer JP, Ohnishi S, Tracy JB, Frangioni JV, Bawendi MG (2005) Engineering InAs(x)P(1-x)/InP/ZnSe III-V alloyed core/shell quantum dots for the near-infrared. J Am Chem Soc 127:10526-10532 220K. Licha et al.

    Google Scholar 

  • Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L (2003) Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjugate Chem 14:1115-1121

    Article  CAS  Google Scholar 

  • Kremer P, Wunder A, Sinn H, Haase T, Rheinwald M, Zillmann U, Albert FK, Kunze S (2000) Laser-induced fluorescence detection of malignant gliomas using fluorescein-labeled serum albumin: experimental and preliminary clinical results. Neurol Res 22:481-489

    PubMed  CAS  Google Scholar 

  • Lange N, Jichlinski P, Zellweger M, Forrer M, Marti A, Guillou L, Kucera P, Wagni ères G, van den Bergh H (1997) Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study. Br J Cancer 80:185-193

    Article  CAS  Google Scholar 

  • Law B, Curino A, Bugge TH, Weissleder R, Tung CH (2004) Design, synthesis, and Characteriza-tion of urokinase plasminogen-activator-sensitive near-infrared reporter. Chem Biol 11:99-106

    PubMed  CAS  Google Scholar 

  • Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN (2003) Near-infrared fluorescence imaging of microcalcification in an animal model of breast cancer. Acad Radiol 10:1159-1164

    Article  PubMed  Google Scholar 

  • Li G, Slansky A, Dobhal MP, Goswami LN, Graham A, Chen Y, Kanter P, Alberico RA, Spernyak J, Morgan J, Mazurchuk R, Oseroff A, Grossman Z, Pandey RK (2005) Chlorophyll-a ana-logues conjugated with aminobenzyl-DTPA as potential bifunctional agents for magnetic reso-nance imaging and photodynamic therapy. Bioconjugate Chem 16:32-42

    Article  CAS  Google Scholar 

  • Li H, Chen J, Zhang M, Zhang Z, Benaron D, Chance B, Glickson J, Zheng G (2004) NIR optical probes targeting glucose transporters. Proc SPIE 5329:254-261

    Article  CAS  Google Scholar 

  • Li H, Gray BD, Corbin I, Lebherz C, Choi H, Lund-Katz S, Wilson JM, Glickson JD, Zhou R (2004) MR and fluorescent imaging of low-density lipoprotein receptors. Acad Radiol 11:1251-1259

    Article  PubMed  Google Scholar 

  • Licha K (2002) Contrast agents for optical imaging. In: Krause W (ed) Topics in current chemistry, vol 222. Springer, Heidelberg, pp 1-29

    Google Scholar 

  • Licha K, Riefke B, Ntziachristos V, Becker A, Chance B. Semmler W (2000) Hydrophilic cyanine dyes as contrast agents for near-infrared tumor imaging: synthesis, photophysical properties and spectroscopic in vivo characterization. Photochem Photobiol 72:392-398

    Article  PubMed  CAS  Google Scholar 

  • Licha K, Debus N, Ebert B, Vollmer-Emig S, Hasbach M, Sydow S, Stibenz D, Semmler W, B ührer C, Schirner M, Tauber R (2005) Optical molecular imaging of lymph nodes using a targeted vascular contrast agent. J Biomed Optics 10(4), 041205

    Article  Google Scholar 

  • Lim YT, Kim S, Nakayama A, Stott NE, Bawendi MG, Frangioni JV (2003) Selection of quantum dot wavelengths for biomedical assays and imaging. Mol Imaging 2:50-64

    Article  PubMed  CAS  Google Scholar 

  • Manning HC, Goebel T, Thompson RC, Price RR, Lee H, Bornhop DJ (2004) Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug Chem 15:1488-1495

    Article  PubMed  CAS  Google Scholar 

  • Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R (2002) Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterol 122:406-414

    Article  Google Scholar 

  • Matter CM, Schuler PK, Alessi P, Meier P, Ricci R, Zhang D, Halin C, Castellani P, Zardi L, Hofer CK, Montani M, Neri D, Luscher TF (2004) Molecular imaging of atherosclerotic plaques using a human antibody against the extra-domain B of fibronectin. Circ Res 95:1225-1233

    Article  PubMed  CAS  Google Scholar 

  • McGreevy JM, Cannon MJ, Grissom CB (2003) Minimally invasive lymphatic mapping using fluorescently labeled vitamin B12. J Surg Res 111:38-44

    Article  PubMed  CAS  Google Scholar 

  • Messerli SH, Prabhakar S, Tang Y, Shah K, Cortes M, Murthy V, Weissleder R, Breakefield SO, Tung CH (2004) A novel method for imaging of apopthosis using a caspase-1 near-infrared fluorescent probe. Neoplasia 6:95-105

    Article  PubMed  CAS  Google Scholar 

  • Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538-544

    Article  PubMed  CAS  Google Scholar 

  • Mier W, Beijer B, Graham K, Hull WE (2002) Fluorescent somatostatin receptor probes for the intraoperative detection of tumor tissue with long-wavelength visible light. Bioorg Med Chem 10:2543-2552

    Article  PubMed  CAS  Google Scholar 

  • Moon WK, Lin Y, O’Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH (2003) Enhanced tu-mor detection using a folate receptor-targeted near-infrared fluorochrome conjugate, Bioconjug Chem 14:539-545 Optical Agents221

    Google Scholar 

  • Nakayama A, del Monte F, Hajjar RJ, Frangioni JV (2002) Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapy. Mol Imaging 1:365-377

    Article  PubMed  Google Scholar 

  • Nakajima M, Takeda M, Kobayashi M, Suzuki S, Ohuchi N (2005) Nano-sized fluorescent particles as new tracers for sentinel node detection: experimental model for decision of appropriate size and wavelength. Cancer Sci 96:353-356

    Article  PubMed  CAS  Google Scholar 

  • Ntziachristos V, Yodh AG, Schnall M, Chance B (2000) Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. Proc Natl Acad Sci USA 97: 2767-2772

    Article  PubMed  CAS  Google Scholar 

  • Nyman ES, Hynninen PH (2004) Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy. J Photochem Photobiol B 73:1-28

    Article  PubMed  CAS  Google Scholar 

  • Pandey SK, Gryshuk AL, Sajjad M, Zheng X, Chen Y, Abouzeid MM, Morgan J, Charamisinau I, Nabi HA, Oseroff A, Pandey RK (2005) Multimodality agents for tumor imaging (PET, fluorescence) and photodynamic therapy. A possible “see and treat” approach. J Med Chem 48:6286-6295

    Article  PubMed  CAS  Google Scholar 

  • Parungo CP, Ohnishi S, Kim SW, Kim S, Laurence RG, Soltesz EG, Chen FY, Colson YL, Cohn LH, Bawendi MG, Frangioni JV (2005) Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J Thorac Cardiovasc Surg 129:844-850

    Article  PubMed  Google Scholar 

  • Perlitz C, Licha K, Scholle FD, Ebert B, Bahner M, Hauff P, Moesta KT, Schirner M (2005) Comparison of two carbocyanine-based dyes for fluorescence optical imaging. J Fluoresc 15: 443-454

    Article  PubMed  CAS  Google Scholar 

  • Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr (2003) Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res 63:1936-1942

    PubMed  CAS  Google Scholar 

  • Pham W, Weissleder R, Tung CH (2002) An azulene dimer as a near-infrared quencher. Angew Chem Int Ed 41:3659-3662

    Article  CAS  Google Scholar 

  • Pham W, Choi Y, Weissleder R, Tung CH (2004) Developing a peptide-based near-infrared mole-cular probe for protease sensing. Bioconjug Chem 15:1403-1407

    Article  PubMed  CAS  Google Scholar 

  • Pitsillides CM, Joe EK, Wei X, Anderson RR, Lin CP (2003) Selective cell targeting with light-absorbing microparticles and nanoparticles. Biophys J 84:4023-4032

    Article  PubMed  CAS  Google Scholar 

  • Pu Y, Wang WB, Tang GC, Zeng F, Achilefu S, Vitenson JH, Sawczuk I, Peters S, Lombardo JM, Alfano RR (2005) Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent. Technol Cancer Res Treat 4:429-436

    PubMed  CAS  Google Scholar 

  • Quinti L, Weissleder R, Tung CH (2006) A fluorescent nanosensor for apoptotic cells. Nano Lett 6:488-490

    Article  PubMed  CAS  Google Scholar 

  • Richard G, Soubrane G, Yanuzzi L (eds) (1998) Fluorescein and ICG angiography. Thieme, Stuttgart

    Google Scholar 

  • Riefke B, Licha K, Nolte D, Ebert B, Rinneberg H, Semmler W (1998) Tumor detection with cya-nine dye-poly(ethylene glycol) conjugates as contrast agents for near-infrared imaging. Pro-ceedings of SPIE 3196:103-110

    Article  CAS  Google Scholar 

  • Santra S, Zhang P, Wang K, Tapec R, Tan W (2001) Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem 73:4988-4993

    Article  PubMed  CAS  Google Scholar 

  • Santra S, Xu J, Wang K, Tan W (2004) Luminescent nanoparticle probes for bioimaging. J Nanosci Nanotechnol 4:590-599

    Article  PubMed  CAS  Google Scholar 

  • Schellenberger EA, Bogdanov Jr A, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L (2003) Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neo-plasia 5:187-192

    CAS  Google Scholar 

  • Schellenberger EA, Weissleder R, Josephson L (2004) Optimal modification of annexin V with fluorescent dyes. Chembiochem 4:271-274

    Article  CAS  Google Scholar 

  • Soltesz EG, Kim S, Laurence RG, DeGrand AM, Parungo CP, Dor DM, Cohn LH, Bawendi MG, Frangioni JV, Mihaljevic T (2005) Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg 79:269-277

    Article  PubMed  Google Scholar 

  • Tadatsu M, Ito S, Muguruma N, Kusaka Y, Inayama K, Bandu T, Tadatsu Y, Okamoto K, Ii K, Nagao Y, Sano S, Taue H (2003) A new infrared fluorescent-labeling agent and labeled antibody for diagnosing microcancers. Bioorg Med Chem 11:3289-3294

    Article  PubMed  CAS  Google Scholar 

  • Tung CH, Lin Y, Moon WK, Weissleder R (2002) A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging. Chembiochem 3:784-786

    Article  PubMed  CAS  Google Scholar 

  • Uehlinger P, Zellweger M, Wagni ères G, Juillerat-Jeanneret L, van den Bergh H, Lange N (2000) Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells. J Photochem Photobiol 54:72-80

    Article  CAS  Google Scholar 

  • Veiseh O, Sun C, Gunn J, Kohler N, Gabikian P, Lee D, Bhattarai N, Ellenbogen R, Sze R, Hallahan A, Olson J, Zhang M (2005) Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Lett. 5:1003-1008

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Miller S, Sima M, Kopeckov á P, Kopecek J (2003) Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. Bioconjug Chem 14:853-859

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Huff TB, Zweifel DA, He W, Low PS, Wei A, Cheng JX (2005) In vitro and in vivo two-photon luminescence imaging of single gold nanorods. Proc Natl Acad Sci USA 102: 15752-15756

    Article  PubMed  CAS  Google Scholar 

  • Wang W, Ke K, Wu Q, Charnsangavej C, Gurfinkel M, Gelovani JG, JameAbbruzzese JL, Sevick-Muraca EM, Li C (2004) Near-infrared optical imaging of integrin αvß3 in human tumor xenografts. Mol Imaging 3:343-351

    Article  PubMed  CAS  Google Scholar 

  • Weissleder R, Tung CH, Mahmood U, Bognanov A (1999) In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotech 17:375-378

    Article  CAS  Google Scholar 

  • Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L (2005) Cell-specific targeting of nanopar-ticles by multivalent attachment of small molecules. Nat Biotechnol 23:1418-1423

    Article  PubMed  CAS  Google Scholar 

  • Witjes JA, Moonen PM, van der Heijden AG (2005) Comparison of hexaminolevulinate based flexible and rigid fluorescence cystoscopy with rigid white light cystoscopy in bladder cancer: results of a prospective Phase II study. Eur Urol 47:319-322

    Article  PubMed  Google Scholar 

  • Wu X, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP (2003) Im-munofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 21:41-46

    Article  PubMed  CAS  Google Scholar 

  • Ye Y, Bloch S, Kao J, Achilefu S (2005) Multivalent carbocyanine molecular probes: synthesis and applications. Bioconjug Chem 16:51-61

    Article  PubMed  CAS  Google Scholar 

  • Yu SJ, Kang MW, Chang HC, Chen KM, Yu YC (2005) Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity. J Am Chem Soc 127:17604-17605

    Article  PubMed  CAS  Google Scholar 

  • Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV (2001) In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol 19:1148-1154

    Article  PubMed  CAS  Google Scholar 

  • Zhang M, Zhang Z, Blessington B, Li H, Busch TM, Madrak V, Miles J, Chance B, Glickson JD, Zheng G (2003) Pyropheophorbide 2-deoxyglucosamide: A new photosensitizer targeting glucose transporters. Bioconjug Chem 14:709-714

    Article  PubMed  CAS  Google Scholar 

  • Zhang Z, Achilefu S (2004) Synthesis and evaluation of polyhydroxylated near-infrared carbocya-nine molecular probes. Org Lett 6:2067-2070

    Article  PubMed  CAS  Google Scholar 

  • Zhang Z, Li H, Lui Q, Zhou L, Zhang M, Luo Q, Glickson J, Chance B, Zheng G (2004) Metabolic imaging of tumors using intrinsic and extrinsic fluorescent markers. Biosens Bio-electron 20:643-650

    Google Scholar 

  • Zhang Z, Liang K, Bloch S, Berezin M, Achilefu S (2005) Monomolecular multimodal fluorescence-radioisotope imaging agents. Bioconjugate Chem. 16:1232-1239

    Article  CAS  Google Scholar 

  • Zheng G, Li H, Yang K, Blessington D, Licha K, Lund-Katz S, Chance B, Glickson JD (2002a) Tri-carbocyanine cholesteryl laurates labeled LDL: new near infrared fluorescent probes (NIRFs) for monitoring tumors and gene therapy of familial hypercholesterolemia. Bioorg Med Chem Lett 12:1485-1488

    Article  CAS  Google Scholar 

  • Zheng G, Li H, Zhang M, Lund-Katz S, Chance B, Glickson JD (2002b) Low-density lipoprotein reconstituted by pyropheophorbide cholesteryl oleate as target-specific photosensitizer. Bio-conjug Chem 13:392-396

    CAS  Google Scholar 

  • Zimmer JP, Kim SW, Ohnishi S, Tanaka E, Frangioni JV, Bawendi MG (2006) Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging. J Am Chem Soc 128:2526-2527

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. migenion GmbH, Robert-Koch-Platz 4-8, 10115, Berlin, Germany

    Kai Licha & Michael Schirner

  2. Global Drug Discovery, Bayer Schering Pharma, 13342, Berlin, Germany

    Gavin Henry

Authors
  1. Kai Licha
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  2. Michael Schirner
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  3. Gavin Henry
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Correspondence to Kai Licha .

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Editors and Affiliations

  1. Forschungsschwerpunkt Innovative Krebsdiagnostik und -therapie (E), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Wolfhard Semmler (Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020) (Leiter der Abteilung für Medizinische Physik in der Radiologie (E 020)

  2. Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts des Isar des Technischen Universität München, Ismaninger Str. 22, 81675, München, Germany

    Markus Schwaiger

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© 2008 Springer-Verlag Berlin Heidelberg

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Licha, K., Schirner, M., Henry, G. (2008). Optical Agents. In: Semmler, W., Schwaiger, M. (eds) Molecular Imaging I. Handbook of Experimental Pharmacology, vol 185/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72718-7_10

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