Skip to main content

MARCO: A Reachability Algorithm for Multi-affine Systems with Applications to Biological Systems

  • Conference paper
Hybrid Systems: Computation and Control (HSCC 2007)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 4416))

Included in the following conference series:

Abstract

We present a new algorithm for the reachability analysis of multi-affine hybrid systems. In our previous work on reachability analysis and that of our collaborators [1,2,3], we exploited the convexity of multi-affine functions and the fact that the vector field in modes with rectangular invariants is uniquely determined by its values at the rectangle vertices. In this paper, we explicitly calculate conical overapproximations of the reachable set in the invariant of each mode. We describe our Multi-Affine Reachability analysis using Conical Overapproximations, Marco, and show that it yields results that are superior to those obtained by existing methods for multi-affine hybrid systems. Finally, we demonstrate the application of Marco to the analysis of an ant house hunting model that incorporates quorum sensing [4] and the analysis of bi-stability of the lactose induction system regulated by glucose and lactose [5].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Belta, C., Habets, L., Kumar, V.: Control of multi-affine systems on rectangles with applications to hybrid biomolecular networks. In: 41st IEEE Conference on Decision and Control, Las Vegas, NV, IEEE Computer Society Press, Los Alamitos (2002)

    Google Scholar 

  2. Kloetzer, M., Belta, C.: Reachability analysis of multi-affine systems. In: Hespanha, J.P., Tiwari, A. (eds.) HSCC 2006. LNCS, vol. 3927, pp. 348–362. Springer, Heidelberg (2006)

    Chapter  Google Scholar 

  3. Halász, A.M., et al.: Analysis of lactose metabolism in E.coli using reachability analysis of hybrid systems. Accepted to IET Systems Biology (2006), available at http://www.seas.upenn.edu/~spring

  4. Franks, N., et al.: Information flow, opinion polling and collective intelligence in house-hunting social insects. Phil. Trans. Roy. Soc. London B357, 1567–1584 (2002)

    Google Scholar 

  5. Santillan, M., Mackey, M.C.: Influence of catabolite repression and inducer exclusion on the bistable behavior of the lac operon. Biophys. J. 86, 1282–1292 (2004)

    Article  Google Scholar 

  6. Sastry, S.: Nonlinear systems: analysis, stability, and control. Springer, New York (1999)

    MATH  Google Scholar 

  7. Ptashne, M., Gann, A.: Genes and Signals. Cold Spring Harbor Laboratory Press, New York (2002)

    Google Scholar 

  8. Berman, S., et al.: Algorithms for the analysis and synthesis of a bio-inspired swarm robotic system. In: Şahin, E., Spears, W.M., Winfield, A.F.T. (eds.) SAB 2006 Ws 2007. LNCS, vol. 4433, Springer, Heidelberg (2007)

    Chapter  Google Scholar 

  9. Dang, T., Maler, O.: Reachability analysis via face lifting. In: Henzinger, T.A., Sastry, S.S. (eds.) HSCC 1998. LNCS, vol. 1386, pp. 96–109. Springer, Heidelberg (1998)

    Google Scholar 

  10. Henzinger, T., Ho, P., Wong-Toi, H.: HyTech: A model checker for hybrid systems. Software Tools for Technology Transfer 1(1), 110–122 (1998)

    Article  Google Scholar 

  11. Silva, B., et al.: Modeling and verifying hybrid dynamic systems using CheckMate. In: Proc. 4th Conference on Automation of Mixed Processes, pp. 323–328 (2000)

    Google Scholar 

  12. Lafferriere, G., Pappas, G., Yovine, S.: A new class of decidable hybrid systems. In: Vaandrager, F.W., van Schuppen, J.H. (eds.) HSCC 1999. LNCS, vol. 1569, pp. 137–151. Springer, Heidelberg (1999)

    Chapter  Google Scholar 

  13. Habets, L., van Schuppen, J.: A control problem for affine dynamical systems on a full-dimensional polytope. Automatica 40, 21–35 (2004)

    Article  MATH  Google Scholar 

  14. Frehse, G.: PHAVer: Algorithmic verification of hybrid systems past HyTech. In: Morari, M., Thiele, L. (eds.) HSCC 2005. LNCS, vol. 3414, pp. 258–273. Springer, Heidelberg (2005)

    Google Scholar 

  15. Girard, A., Pappas, G.: Approximate bisimulations for nonlinear dynamical systems. In: Proc. 44th IEEE Conf. on Decision and Control, Seville, Spain, IEEE Computer Society Press, Los Alamitos (2005)

    Google Scholar 

  16. van der Schaft, A.J., Schumacher, J.M.: An introduction to hybrid dynamical systems. Springer, Berlin (2000)

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Alberto Bemporad Antonio Bicchi Giorgio Buttazzo

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Berlin Heidelberg

About this paper

Cite this paper

Berman, S., Halász, Á., Kumar, V. (2007). MARCO: A Reachability Algorithm for Multi-affine Systems with Applications to Biological Systems. In: Bemporad, A., Bicchi, A., Buttazzo, G. (eds) Hybrid Systems: Computation and Control. HSCC 2007. Lecture Notes in Computer Science, vol 4416. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71493-4_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-71493-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-71492-7

  • Online ISBN: 978-3-540-71493-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics