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A Library of Protein Cage Architectures as Nanomaterials

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Viruses and Nanotechnology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 327))

Virus capsids and other structurally related cage-like proteins such as ferritins, dps, and heat shock proteins have three distinct surfaces (inside, outside, interface) that can be exploited to generate nanomaterials with multiple functionality by design. Protein cages are biological in origin and each cage exhibits extremely homogeneous size distribution. This homogeneity can be used to attain a high degree of homogeneity of the templated material and its associated property. A series of protein cages exhibiting diversity in size, functionality, and chemical and thermal stabilities can be utilized for materials synthesis under a variety of conditions. Since synthetic approaches to materials science often use harsh temperature and pH, it is an advantage to utilize protein cages from extreme environments. In this chapter, we review recent studies on discovering novel protein cages from harsh natural environments such as the acidic thermal hot springs at Yellowstone National Park (YNP) and on utilizing protein cages as nano-scale platforms for developing nanomaterials with wide range of applications from electronics to biomedicine.

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Abbreviations

CCMV:

Cowpea chlorotic mottle virus

Dps:

DNA-binding proteins from starved cells

Dps-L:

Dps-like protein

Hsp:

Heat shock protein

MRI:

Magnetic resonance imaging

STIV:

Sulfulobus turreted icosahedral virus

TMV:

Tobacco Mosaic Virus

YNP:

Yellowstone National Park

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Authors and Affiliations

  1. Microbiology and Immunology Department, University of California, San Francisco, 600 16th Street, Genentech Hall S576, Box 2280, San Francisco, CA, 94158-2517, USA

    M. L. Flenniken

  2. Microbiology and Immunology Department, Dept. of Chemistry and Biochemistry, 108 Gaines Hall, PO Box 173400, Bozeman, MT, 59717, USA

    M. Uchida, L. O. Liepold, S. Kang, M. J. Young & T. Douglas

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  1. M. L. Flenniken
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  2. M. Uchida
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  3. L. O. Liepold
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  4. S. Kang
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  5. M. J. Young
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  6. T. Douglas
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Correspondence to M. L. Flenniken .

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  1. Department of Cell Biology Center for Integrative Molecular Biosciences, Scripps Research Institute, 10550 N. Torrey Pines Road, CB262, La Jolla, CA, 92037, USA

    Marianne Manchester  & Nicole F. Steinmetz  & 

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© 2009 Springer-Verlag Berlin Heidelberg

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Flenniken, M.L., Uchida, M., Liepold, L.O., Kang, S., Young, M.J., Douglas, T. (2009). A Library of Protein Cage Architectures as Nanomaterials. In: Manchester, M., Steinmetz, N.F. (eds) Viruses and Nanotechnology. Current Topics in Microbiology and Immunology, vol 327. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69379-6_4

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