Skip to main content

Topical Corticosteroids

  • Chapter
Vitiligo

Abstract

Currently, topical glucocorticosteroids (TCS) or topical calcineurin inhibitors (TCI) are the usual first-line treatments of vitiligo. The TCS have been used widely as topical and sometimes intralesional therapy in viti-ligo since their introduction in dermatology in the 1950s. However, based on current criteria for clinical trials, the studies are of poor quality and since 1977, no randomized controlled trial (RCT) has been published.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Barman KD, Khaitan BK, Verma KK (2004) A comparative study of punch grafting followed by topical corticosteroid versus punch grafting followed by PUVA therapy in stable vitiligo. Dermatol Surg 30:49–53

    Article  PubMed  Google Scholar 

  2. Bleehen SS (1976) The treatment of vitiligo with topical steroids. Light and electronmicroscopic studies. Br J Dermatol 94(S12):43–50

    Article  PubMed  Google Scholar 

  3. Clayton R (1977) A double-blind trial of 0.05% clobetasol propionate in the treatment of vitiligo. Br J Dermatol 96:71–73

    Article  PubMed  CAS  Google Scholar 

  4. Coskun B, Saral Y, Turgut D (2005) Topical 0.05% clobeta-sol propionate versus 1% pimecrolimus ointment in vitiligo. Eur J Dermatol 15:88–91

    PubMed  Google Scholar 

  5. Forschner T, Buchholtz S, Stockfleth E (2007) Current state of vitiligo therapy-evidence-based analysis of the literature. J Dtsch Dermatol Ges 5:467–476

    Article  PubMed  Google Scholar 

  6. Gawkrodger DJ, Ormerod AD, Shaw L et al (2008) Guideline for the diagnosis and management of vitiligo. Br J Dermatol 159:1051–1076

    Article  PubMed  CAS  Google Scholar 

  7. Geraldez CB, Gutierrez GT (1987) A clinical trial of clobetasol propionate in Filipino vitiligo patients. Clin Ther 9:474–482

    PubMed  CAS  Google Scholar 

  8. Kandil E (1974) Treatment of vitiligo with 0.1% betametha-sone 17-valerate in isopropyl alcohol-a double-blind trial. Br J Dermatol 91:457–460

    Article  PubMed  CAS  Google Scholar 

  9. Khalid M, Mujtaba G, Haroon TS (1995) Comparison of 0.05% clobetasol propionate cream and topical PUVAsol in childhood vitiligo. Int J Dermatol 34:203–205

    Article  PubMed  CAS  Google Scholar 

  10. Koopmans-van Dorp B, Goedhart-van Dijk B, Neering H et al (1973) Treatment of vitiligo by local application of betamethasone 17-valerate in a dimethyl sulfoxide cream base. Dermatologica 146:310–314

    Article  PubMed  CAS  Google Scholar 

  11. Kumari J (1984) Vitiligo treated with topical clobetasol pro-pionate. Arch Dermatol 120:631–635

    Article  PubMed  CAS  Google Scholar 

  12. Kumaran MS, Kaur I, Kumar B (2006) Effect of topical cal-cipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo. J Eur Acad Dermatol Venereol 20:269–273

    Article  PubMed  CAS  Google Scholar 

  13. Kwinter J, Pelletier J, Khambalia A et al (2007) High-potency steroid use in children with vitiligo: a retrospective study. J Am Acad Dermatol 56:236–241

    Article  PubMed  Google Scholar 

  14. Lepe V, Moncada B, Castanedo-Cazares JP et al (2003) A double-blind randomized trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. Arch Dermatol 139:581–585

    Article  PubMed  CAS  Google Scholar 

  15. Njoo MD, Spuls PI, Bos JD et al (1998) Nonsurgical repigmentation therapies in vitiligo. meta-analysis of the literature. Arch Dermatol 134:1532–1540

    Article  PubMed  CAS  Google Scholar 

  16. Sassi F, Cazzaniga S, Tessari G et al (2008) Randomized controlled trial comparing the effectiveness of 308-nm exci-mer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. Br J Dermatol 159:1186–1191

    PubMed  CAS  Google Scholar 

  17. Schake H, Rehwinkel H, Asadullah K, Cato AC (2006) Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index. Exp Dermatol 15:565–573

    Article  Google Scholar 

  18. Schaffer JV, Bolognia JL (2003) The treatment of hypopig-mentation in children. Clin Dermatol 21:296–310

    Article  PubMed  Google Scholar 

  19. Westerhof W, Nieuweboer-Krobotova L, Mulder PGH et al (1999) Left-right comparison study of the combination of fluticasone propionate and UV-A vs either fluticasone propi-onate or UV-A alone for the long-term treatment of vitiligo. Arch Dermatol 135:1061–1066

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Van der Veen, J.P.W., Wind, B.S., Taïeb, A. (2010). Topical Corticosteroids. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69361-1_38

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-69361-1_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69360-4

  • Online ISBN: 978-3-540-69361-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics