Abstract
Currently, topical glucocorticosteroids (TCS) or topical calcineurin inhibitors (TCI) are the usual first-line treatments of vitiligo. The TCS have been used widely as topical and sometimes intralesional therapy in viti-ligo since their introduction in dermatology in the 1950s. However, based on current criteria for clinical trials, the studies are of poor quality and since 1977, no randomized controlled trial (RCT) has been published.
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References
Barman KD, Khaitan BK, Verma KK (2004) A comparative study of punch grafting followed by topical corticosteroid versus punch grafting followed by PUVA therapy in stable vitiligo. Dermatol Surg 30:49–53
Bleehen SS (1976) The treatment of vitiligo with topical steroids. Light and electronmicroscopic studies. Br J Dermatol 94(S12):43–50
Clayton R (1977) A double-blind trial of 0.05% clobetasol propionate in the treatment of vitiligo. Br J Dermatol 96:71–73
Coskun B, Saral Y, Turgut D (2005) Topical 0.05% clobeta-sol propionate versus 1% pimecrolimus ointment in vitiligo. Eur J Dermatol 15:88–91
Forschner T, Buchholtz S, Stockfleth E (2007) Current state of vitiligo therapy-evidence-based analysis of the literature. J Dtsch Dermatol Ges 5:467–476
Gawkrodger DJ, Ormerod AD, Shaw L et al (2008) Guideline for the diagnosis and management of vitiligo. Br J Dermatol 159:1051–1076
Geraldez CB, Gutierrez GT (1987) A clinical trial of clobetasol propionate in Filipino vitiligo patients. Clin Ther 9:474–482
Kandil E (1974) Treatment of vitiligo with 0.1% betametha-sone 17-valerate in isopropyl alcohol-a double-blind trial. Br J Dermatol 91:457–460
Khalid M, Mujtaba G, Haroon TS (1995) Comparison of 0.05% clobetasol propionate cream and topical PUVAsol in childhood vitiligo. Int J Dermatol 34:203–205
Koopmans-van Dorp B, Goedhart-van Dijk B, Neering H et al (1973) Treatment of vitiligo by local application of betamethasone 17-valerate in a dimethyl sulfoxide cream base. Dermatologica 146:310–314
Kumari J (1984) Vitiligo treated with topical clobetasol pro-pionate. Arch Dermatol 120:631–635
Kumaran MS, Kaur I, Kumar B (2006) Effect of topical cal-cipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo. J Eur Acad Dermatol Venereol 20:269–273
Kwinter J, Pelletier J, Khambalia A et al (2007) High-potency steroid use in children with vitiligo: a retrospective study. J Am Acad Dermatol 56:236–241
Lepe V, Moncada B, Castanedo-Cazares JP et al (2003) A double-blind randomized trial of 0.1% tacrolimus vs 0.05% clobetasol for the treatment of childhood vitiligo. Arch Dermatol 139:581–585
Njoo MD, Spuls PI, Bos JD et al (1998) Nonsurgical repigmentation therapies in vitiligo. meta-analysis of the literature. Arch Dermatol 134:1532–1540
Sassi F, Cazzaniga S, Tessari G et al (2008) Randomized controlled trial comparing the effectiveness of 308-nm exci-mer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. Br J Dermatol 159:1186–1191
Schake H, Rehwinkel H, Asadullah K, Cato AC (2006) Insight into the molecular mechanisms of glucocorticoid receptor action promotes identification of novel ligands with an improved therapeutic index. Exp Dermatol 15:565–573
Schaffer JV, Bolognia JL (2003) The treatment of hypopig-mentation in children. Clin Dermatol 21:296–310
Westerhof W, Nieuweboer-Krobotova L, Mulder PGH et al (1999) Left-right comparison study of the combination of fluticasone propionate and UV-A vs either fluticasone propi-onate or UV-A alone for the long-term treatment of vitiligo. Arch Dermatol 135:1061–1066
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Van der Veen, J.P.W., Wind, B.S., Taïeb, A. (2010). Topical Corticosteroids. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69361-1_38
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DOI: https://doi.org/10.1007/978-3-540-69361-1_38
Publisher Name: Springer, Berlin, Heidelberg
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