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Proopiomelanocortin and Related Hormones

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Vitiligo

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Reference

  1. Abdel-Malek Z, Swope VB, Suzuki I et al (1995) Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 92:1789–1793

    Article  PubMed  CAS  Google Scholar 

  2. Al-Omari H, al-Sugair S, Ab Hussain A (1989) Intralesional injection of tetracosactid in the treatment of localized viti-ligo. Int J Dermatol 28:682

    Article  PubMed  CAS  Google Scholar 

  3. Böhm M, Raghunath M, Sunderkotter C et al (2004) Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone. J Biol Chem 279:6959–6966

    Article  PubMed  Google Scholar 

  4. Böhm M, Eickelmann M, Li Z et al (2005) Detection of functionally active melanocortin receptors and evidence for an immunoregulatory activity of alpha-melanocyte-stimulat-ing hormone in human dermal papilla cells. Endocrinology 146:4635–4646

    Article  PubMed  Google Scholar 

  5. Böhm M, Wolff I, Scholzen TE et al (2005) Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J Biol Chem 280:5795–5802

    Article  PubMed  Google Scholar 

  6. Böhm M, Luger TA, Tobin DJ, Garcia-Borron JC (2006) Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology. J Invest Dermatol 126:1966–1975

    Article  PubMed  Google Scholar 

  7. Brzoska T, Luger TA, Maaser C et al (2008) Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immunemediated inflammatory diseases. Endocr Rev 29:581–602

    Article  PubMed  CAS  Google Scholar 

  8. Caixia T, Daming Z, Xiran L (2001) Levels of beta-endor-phin in the plasma and skin tissue fluids of patients with viti-ligo. J Dermatol Sci 26:62–66

    Article  PubMed  CAS  Google Scholar 

  9. Cone RD, Lu D, Koppula S et al (1996) The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 51:287–318

    PubMed  CAS  Google Scholar 

  10. Eipper BA, Mains RE (1980) Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endocr Rev 1:1–27

    Article  PubMed  CAS  Google Scholar 

  11. Gokhale BB, Gokhale TB (1976) Corticotropin and vitiligo (preliminary observations). Br J Derrmatol 95:329

    Article  CAS  Google Scholar 

  12. Graham A, Westerhof W, Thody AJ (1999) The expression of alpha-MSH by melanocytes is reduced in vitiligo. Ann NY Acad Sci 885:470–473

    Article  PubMed  CAS  Google Scholar 

  13. Harrison C, Smart D, Lambert DG (1998) Stimulatory effects of opioids. Br J Anaesth 81:20–28

    Article  PubMed  CAS  Google Scholar 

  14. Hernández-Pérez E (1979) Vitiligo treated with ACTH. Int J Dermatol 18:578–579

    Article  PubMed  Google Scholar 

  15. Hruby VJ, Wilkes BC, Hadley ME et al (1987) Alpha-melanotropin: the minimal active sequence in the frog skin bioassay. J Med Chem 30:2126–2130

    Article  PubMed  CAS  Google Scholar 

  16. Ichimiya M (1999) Immunohistochemical study of ACTH and alpha-MSH in vitiligo patients successfully treated with a sex steroid-thyroid hormone mixture. J Dermatol 26:502–506

    PubMed  CAS  Google Scholar 

  17. Kauser S, Schallreuter KU, Thody AJ et al (2003) Regulation of human epidermal melanocyte biology by beta-endorphin. J Invest Dermatol 120:1073–1080

    Article  PubMed  CAS  Google Scholar 

  18. Kauser S, Thody AJ, Schallreuter KU et al (2004) Beta-endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatol 123:184–195

    Article  PubMed  CAS  Google Scholar 

  19. Kieffer BL, Evans CJ (2009) Opioid receptors: From binding sites to visible molecules in vivo. Neuropharmacology, 56(Suppl 1):205–212

    Article  PubMed  CAS  Google Scholar 

  20. Kingo K, Aunin E, Karelson M et al (2007) Gene expression analysis of melanocortin system in vitiligo. J Dermatol Sci 48:113–122

    Article  PubMed  CAS  Google Scholar 

  21. Kokot A, Sindrilaru A, Schiller M et al (2009) α-Melano-cyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma. Arthritis Rheum 60:592–603

    Article  PubMed  CAS  Google Scholar 

  22. Lerner AB, McGuire JS (1961) The effect of alpha- and beta melanocyte stimulating hormone on the skin colour of man. Nature 189:176–79

    Article  PubMed  CAS  Google Scholar 

  23. Lerner AB, Snell RS, Chanco-Turner ML, McGuire JS (1966)Vitiligo and sympathectomy. The effect of sympath-ectomy and alpha-melanocyte stimulating hormone. Arch Dermatol 94:269–278

    Article  PubMed  CAS  Google Scholar 

  24. Miller MW, Duhl DM, Vrieling H et al (1993) Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7:454–467

    Article  PubMed  CAS  Google Scholar 

  25. Mozzanica N, Villa ML, Foppa S et al (1992) Plasma alpha-melanocyte-stimulating hormone, beta-endorphin, met-enkephalin, and natural killer cell activity in vitiligo. J Am Acad Dermatol 26:693–700

    Article  PubMed  CAS  Google Scholar 

  26. Na GY, Lee KH, Kim MK et al (2003) Polymorphisms in the melanocortin-1 receptor (MC1R) and agouti signaling protein (ASIP) genes in Korean vitiligo patients. Pigment Cell Res 16:383–387

    Article  PubMed  CAS  Google Scholar 

  27. Pichler R, Sfetsos K, Badics B et al (2006) Vitiligo patients present lower plasma levels of alpha-melanotropin immuno-reactivities. Neuropeptides 40:177–183

    Article  PubMed  CAS  Google Scholar 

  28. Robbins LS, Nadeau JH, Johnson KR et al (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72:827–834

    Article  PubMed  CAS  Google Scholar 

  29. Seidah NG, Benjannet S, Hamelin J et al (1999) The subtili-sin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1. Ann N Y Acad Sci 885:57–74

    Article  PubMed  CAS  Google Scholar 

  30. Schallreuter KU, Moore J, Wood JM et al (1999) In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Investig Dermatol Symp Proc 4:91–96

    Article  PubMed  CAS  Google Scholar 

  31. Slominski A, Paus R, Wortsman J (1991) Can some melan-otropins modulate keratinocyte proliferation? J Invest Dermatol 97:747

    Article  PubMed  CAS  Google Scholar 

  32. Slominski A, Wortsman J, Luger T et al (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80:979–1020

    PubMed  CAS  Google Scholar 

  33. Spencer JD, Gibbons NC, Rokos H et al (2006) Oxidative stress via hydrogen peroxide affects proopiomelanocortin peptides directly in the epidermis of patients with vitiligo. J Invest Dermatol 127:411–420

    Article  PubMed  Google Scholar 

  34. Spencer JD, Gibbons NC, Böhm M, Schallreuter KU (2008) The Ca2+-binding capacity of epidermal furin is disrupted by H2O2-mediated oxidation in vitiligo. Endocrinology 149:1638–1645

    Article  PubMed  CAS  Google Scholar 

  35. Spencer JD, Schallreuter KU (2009) Regulation of pigmentation in human epidermal melanocytes by functional high affinity α-MSH/MC4-R signalling. Endocrinology 150:1250–1258

    Article  PubMed  CAS  Google Scholar 

  36. Széll M, Baltás E, Bodai L et al (2008) The Arg160Trp allele of melanocortin-1 receptor gene might protect against viti-ligo. Photochem Photobiol 84:565–571

    Article  PubMed  Google Scholar 

  37. Thody AJ, Ridley K, Penny RJ et al (1983) MSH peptides are present in mammalian skin. Peptides 4:813–816

    Article  PubMed  CAS  Google Scholar 

  38. Valverde P, Healy E, Jackson I et al (1995) Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet 11:328–330

    Article  PubMed  CAS  Google Scholar 

  39. Voisey J, van Daal A (2002) Agouti: from mouse to man, from skin to fat. Pigment Cell Res 15:10–18

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, University of Münster, Münster, Germany

    Markus Böhm

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  1. Markus Böhm
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Correspondence to Markus Böhm .

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Editors and Affiliations

  1. Istituto Dermatologico San Gallicano, via Elio Chianesi 53, Roma, 00144, Italy

    Mauro Picardo

  2. Service de Dermatologie De Dermatologie Pédiatrique, Centre de référence des maladies rares de la Peau Hôpital Saint-André, 1 rue Jean Burguet, Bordeaux, 33000, France

    Alain Taïeb

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Böhm, M. (2010). Proopiomelanocortin and Related Hormones. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69361-1_30

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  • DOI: https://doi.org/10.1007/978-3-540-69361-1_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69360-4

  • Online ISBN: 978-3-540-69361-1

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