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A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases

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cGMP: Generators, Effectors and Therapeutic Implications

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 191))

Abstract

Here, we review the early studies on cGMP, guanylyl cyclases, and cGMP-dependent protein kinases to facilitate understanding of development of this exciting but complex field of research encompassing pharmacology, biochemistry, physiology, and molecular biology of these important regulatory molecules.

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Authors and Affiliations

  1. The University of Texas Health Science Center at Houston, Institute of Molecular Medicine, 1825 Pressler St., Houston, TX, 77030, USA

    Alexander Y. Kots, Iraida G. Sharina & Ferid Murad

  2. Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Versbacher Strasse 9, Würzburg, 97078, Germany

    Emil Martin

Authors
  1. Alexander Y. Kots
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  2. Emil Martin
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  3. Iraida G. Sharina
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  4. Ferid Murad
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Corresponding author

Correspondence to Ferid Murad .

Editor information

Editors and Affiliations

  1. Dept. Pharmacology, Monash University, Wellington Road, Clayton, VIC, 3800, Australia

    Harald H. H. W. Schmidt

  2. Inst. Pharmakologie und Toxikologie, TU München, Biedersteiner Str. 29, München, 80802, Germany

    Franz Hofmann

  3. Bayer Schering Pharma AG Cardiology Research, Pharma Research Center, Wuppertal, 42096, Germany

    Johannes-Peter Stasch

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Kots, A.Y., Martin, E., Sharina, I.G., Murad, F. (2009). A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases. In: Schmidt, H.H.H.W., Hofmann, F., Stasch, JP. (eds) cGMP: Generators, Effectors and Therapeutic Implications. Handbook of Experimental Pharmacology, vol 191. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68964-5_1

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