Skip to main content

Planung und Umsetzung experimenteller Paradigmen

  • Chapter
Funktionelle MRT in Psychiatrie und Neurologie

Zusammenfassung

Die Untersuchung mittels der fMRT konfrontiert den Versuchsleiter aufgrund externer aber auch interner methodischer Besonderheiten mit besonderen Untersuchungsbedingungen. Dies darf aber nicht dazu verleiten, experimentalpsychologisch wichtige Gütekriterien bei der Wahl und Umsetzung experimenteller Paradigmen außer Acht zu lassen. Hier — wie auch in anderem Kontext — beeinflusst die sorgfältige Wahl und Planung der Experimente sehr wesentlich die Ergebnisse. Die Möglichkeiten der Stimulusvorgabe und der Reaktionserfassung sollen im Folgenden vorgestellt und diskutiert werden. Im Anschluss daran werden die charakteristischen Formen des experimentellen Designs bei funktionell bildgebenden Untersuchungen erörtert. Allgemeine Planungshinweise können nur einen groben Anhalt liefern; eine intensive Beschäftigung mit inhaltlichen und methodischen Fragestellungen, den Charakteristika des interessierenden Konstruktes sowie der Messmethode ist bei der Realisierung experimentell valider funktioneller Magnetresonanzuntersuchungen unerlässlich.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

6.6 Literatur

  • Anders S, Lotze M, Erb M, Grodd W, Birbaumer N (2004) Brain activity underlying emotional valence and arousal: a response-related fMRI study. Hum Brain Mapp 23:200–209

    Article  PubMed  Google Scholar 

  • Bandettini PA, Kwong KK, Davis TL, Tootell RB, Wong EC, Fox PT, Belliveau JW, Weisskoff RM, Rosen BR (1997) Characterization of cerebral blood oxygenation and flow changes during prolonged brain activation. Hum Brain Mapp 5:93–109

    Article  PubMed  CAS  Google Scholar 

  • Birbaumer N, Grodd W, Diedrich O, Klose U, Erb M, Lotze M, Schneider F, Weiss U, Flor H (1998) fMRI reveals amygdala activation to human faces in social phobics. Neuroreport 9:1223–1226

    Article  PubMed  CAS  Google Scholar 

  • Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen BR (1996) Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17:875–887

    Article  PubMed  CAS  Google Scholar 

  • Büchel C, Morris J, Dolan RJ. Friston KJ (1998) Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron 20:947–957

    Article  PubMed  Google Scholar 

  • Büchel C, Dolan RJ, Armony JL, Friston K J (1999) Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci 19:10869–10876

    PubMed  Google Scholar 

  • Cahn W, Pol HE, Lems EB, van Haren NE, Schnack HG, van der Linden JA, Schothorst PF, van Engeland H, Kahn RS (2002) Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Arch Gen Psychiatry 59:1002–1010

    Article  PubMed  Google Scholar 

  • Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O’Brien CP (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 156:11–18

    PubMed  CAS  Google Scholar 

  • Condon B, McFadzean R, Hadley DM, Bradnam MS, Shahani U (1997) Habituation-like effects cause a significant decrease in response in MRI neuroactivation during visual stimulation. Vision Res 37:1243–1247

    Article  PubMed  CAS  Google Scholar 

  • Dolcos F, LaBar KS, Cabeza R (2004) Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study. NeuroImage 23:64–74

    Article  PubMed  Google Scholar 

  • Due DL, Hall WG, Rubin DC (2000) Smoking cues induce neural activation in deprived smokers. NeuroImage 11:37

    Article  Google Scholar 

  • Frommann N, Streit M, Wölwer W (2003) Remediation of facial affect recognition impairments in patients with schizophrenia: a new training program. Psychiatry Res 117:281–284

    Article  PubMed  Google Scholar 

  • Gray JR (2001) Emotional modulation of cognitive control: approach-withdrawal states double-dissociate spatial from verbal two-back task performance. J Exp Psychol Gen 130:436–452

    Article  PubMed  CAS  Google Scholar 

  • Habel U, Klein M, Shah NJ, Toni I, Zilles K, Falkai P, Schneider F (2004) Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients. Am J Psychiatry 16:1806–1813

    Article  Google Scholar 

  • Habel U, Klein M, Kellermann T, Shah NJ, Schneider F (2005) Same or different? Neural correlates of happy and sad mood in healthy males. NeuroImage 26:206–214

    Article  PubMed  Google Scholar 

  • Iriki A, Tanaka M, Iwamura Y (1996) Attention-induced neuronal activity in the monkey somatosensory cortex revealed by pupillometrics. Neurosc Res 25:173–181

    CAS  Google Scholar 

  • Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Lee CU, Ciszewski AA, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW (2003) Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry 160:156–164

    Article  PubMed  Google Scholar 

  • Kilzer M, Windischberger C, Moser E (2003) A quantitative comparison of algorithms for physiological artefacts correction. MAGMA 16:152

    Google Scholar 

  • Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RS (1992) Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 160:179–186

    Article  PubMed  CAS  Google Scholar 

  • Manoach DS, Halpern EF, Kramer TS, Chang Y, Goff DC, Rauch SL, Kennedy DN, Gollub RL (2001) Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am J Psychiatry 158:955–958

    PubMed  CAS  Google Scholar 

  • Mohr C, Binkofski F, Erdmann C, Büchel C, Helmchen C (2005) The anterior cingulate cortex contains distinct areas dissociating external from self-administered painful stimulation: a parametric fMRI study. Pain 114:347–357

    Article  PubMed  CAS  Google Scholar 

  • Munhall KG (2001) Functional imaging during speech production. Acta Psychol (Amst) 107:95–117

    Article  CAS  Google Scholar 

  • Pfleiderer B, Ostermann J, Michael N, Heindel W (2002) Visualization of auditory habituation by fMRI. NeuroImage 17:1705–1710

    Article  PubMed  CAS  Google Scholar 

  • Poellinger A, Thomas R, Lio P, Lee A, Makris N, Rosen BR, Kwong KK (2001) Activation and habituation in olfaction — an fMRI study. NeuroImage 13:547–560

    Article  PubMed  CAS  Google Scholar 

  • Price CJ, Friston KJ (1997) Cognitive conjunction: a new approach to brain activation experiments. NeuroImage 5:261–270

    Article  PubMed  CAS  Google Scholar 

  • Price CJ, Veltman DJ, Ashburner J, Josephs O, Friston KJ (1999) The critical relationship between the timing of stimulus presentation and data acquisition in blocked designs with fMRI. NeuroImage 10:36–44

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Gur RC, Gur RE, Muenz LR (1994) Standardized mood induction with happy and sad facial expressions. Psychiatry Res 51:19–31

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Gur RC, Gur RE, Shtasel DL (1995) Emotional processing in schizophrenia: neurobehavioral probes in relation to psychopathology. Schizophr Res 17:67–75

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Grodd W, Weiss U, Klose U, Mayer KR, Nägele T, Gur RC (1997) Functional MRI reveals left amygdala activation during emotion. Psychiatry Res 76:75–82

    PubMed  CAS  Google Scholar 

  • Schneider F, Weiss U, Kessler C, Salloum JB, Posse S, Grodd W, Müller-Gärtner HW (1998) Differential amygdala activation in schizophrenia during sadness. Schizophr Res 34:133–142

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Weiss U, Kessler C, Müller-Gärtner HW, Posse S, Salloum JB, Grodd W, Himmelmann F, Gaebel W, Birbaumer N (1999) Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol Psychiatry 45:863–871

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Habel U, Kessler C, Posse S, Grodd W, Müller-Gärtner HW (2000a) Functional imaging of conditioned aversive emotional responses in antisocial personality disorder. Neuropsychobiology 42:192–201

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Habel U, Kessler C, Salloum JB, Posse S (2000b) Gender differences in regional cerebral activity during sadness. Hum Brain Mapp 9:226–238

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ, Toni I, Sulzbach C, Hönig K, Maier W, Gaebel W, Zilles K (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiat 158:1075–1083

    Article  PubMed  CAS  Google Scholar 

  • Schneider F, Koch K, Klein M, Kellermann K, Stöcker T, Amunts K, Shah NJ, Habel U (2006) The interaction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging task. Psychiatry Res (in press)

    Google Scholar 

  • Veit R, Flor H, Erb M, Hermann, C, Lotze M, Grodd W, Birbaumer N (2002) Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 328:233–236

    Article  PubMed  CAS  Google Scholar 

  • Volz H, Gaser C, Hager F, Rzanny R, Ponisch J, Mentzel H, Kaiser WA, Sauer H (1999) Decreased frontal activation in schizophrenics during stimulation with the continuous performance test — a functional magnetic resonance imaging study. Eur Psychiatry 14:17–24

    Article  PubMed  CAS  Google Scholar 

  • Wang GJ, Volkow ND, Fowler JS, Cervany P, Hitzemann RJ, Pappas NR, Wong CT, Felder C (1999) Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sci 64:775–784

    Article  PubMed  CAS  Google Scholar 

  • Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54:1063–1070

    Article  PubMed  CAS  Google Scholar 

  • Wild B, Erb M, Lemke N, Scholz P, Bartels M, Grodd W (2000) Video camera and light system for application in magnetic resonance scanners. Magn Reson Imaging 18:893–896

    Article  PubMed  CAS  Google Scholar 

  • Wright CI, Fischer H, Whalen PJ, McInerney SC, Shin LM, Rauch SL (2001) Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli. Neuroreport 12:379–383

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Habel, U., Fink, G.R. (2007). Planung und Umsetzung experimenteller Paradigmen. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68558-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-68558-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20474-9

  • Online ISBN: 978-3-540-68558-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics