Zusammenfassung
Die Untersuchung mittels der fMRT konfrontiert den Versuchsleiter aufgrund externer aber auch interner methodischer Besonderheiten mit besonderen Untersuchungsbedingungen. Dies darf aber nicht dazu verleiten, experimentalpsychologisch wichtige Gütekriterien bei der Wahl und Umsetzung experimenteller Paradigmen außer Acht zu lassen. Hier — wie auch in anderem Kontext — beeinflusst die sorgfältige Wahl und Planung der Experimente sehr wesentlich die Ergebnisse. Die Möglichkeiten der Stimulusvorgabe und der Reaktionserfassung sollen im Folgenden vorgestellt und diskutiert werden. Im Anschluss daran werden die charakteristischen Formen des experimentellen Designs bei funktionell bildgebenden Untersuchungen erörtert. Allgemeine Planungshinweise können nur einen groben Anhalt liefern; eine intensive Beschäftigung mit inhaltlichen und methodischen Fragestellungen, den Charakteristika des interessierenden Konstruktes sowie der Messmethode ist bei der Realisierung experimentell valider funktioneller Magnetresonanzuntersuchungen unerlässlich.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
6.6 Literatur
Anders S, Lotze M, Erb M, Grodd W, Birbaumer N (2004) Brain activity underlying emotional valence and arousal: a response-related fMRI study. Hum Brain Mapp 23:200–209
Bandettini PA, Kwong KK, Davis TL, Tootell RB, Wong EC, Fox PT, Belliveau JW, Weisskoff RM, Rosen BR (1997) Characterization of cerebral blood oxygenation and flow changes during prolonged brain activation. Hum Brain Mapp 5:93–109
Birbaumer N, Grodd W, Diedrich O, Klose U, Erb M, Lotze M, Schneider F, Weiss U, Flor H (1998) fMRI reveals amygdala activation to human faces in social phobics. Neuroreport 9:1223–1226
Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen BR (1996) Response and habituation of the human amygdala during visual processing of facial expression. Neuron 17:875–887
Büchel C, Morris J, Dolan RJ. Friston KJ (1998) Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron 20:947–957
Büchel C, Dolan RJ, Armony JL, Friston K J (1999) Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci 19:10869–10876
Cahn W, Pol HE, Lems EB, van Haren NE, Schnack HG, van der Linden JA, Schothorst PF, van Engeland H, Kahn RS (2002) Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Arch Gen Psychiatry 59:1002–1010
Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O’Brien CP (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 156:11–18
Condon B, McFadzean R, Hadley DM, Bradnam MS, Shahani U (1997) Habituation-like effects cause a significant decrease in response in MRI neuroactivation during visual stimulation. Vision Res 37:1243–1247
Dolcos F, LaBar KS, Cabeza R (2004) Dissociable effects of arousal and valence on prefrontal activity indexing emotional evaluation and subsequent memory: an event-related fMRI study. NeuroImage 23:64–74
Due DL, Hall WG, Rubin DC (2000) Smoking cues induce neural activation in deprived smokers. NeuroImage 11:37
Frommann N, Streit M, Wölwer W (2003) Remediation of facial affect recognition impairments in patients with schizophrenia: a new training program. Psychiatry Res 117:281–284
Gray JR (2001) Emotional modulation of cognitive control: approach-withdrawal states double-dissociate spatial from verbal two-back task performance. J Exp Psychol Gen 130:436–452
Habel U, Klein M, Shah NJ, Toni I, Zilles K, Falkai P, Schneider F (2004) Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients. Am J Psychiatry 16:1806–1813
Habel U, Klein M, Kellermann T, Shah NJ, Schneider F (2005) Same or different? Neural correlates of happy and sad mood in healthy males. NeuroImage 26:206–214
Iriki A, Tanaka M, Iwamura Y (1996) Attention-induced neuronal activity in the monkey somatosensory cortex revealed by pupillometrics. Neurosc Res 25:173–181
Kasai K, Shenton ME, Salisbury DF, Hirayasu Y, Lee CU, Ciszewski AA, Yurgelun-Todd D, Kikinis R, Jolesz FA, McCarley RW (2003) Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. Am J Psychiatry 160:156–164
Kilzer M, Windischberger C, Moser E (2003) A quantitative comparison of algorithms for physiological artefacts correction. MAGMA 16:152
Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RS (1992) Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 160:179–186
Manoach DS, Halpern EF, Kramer TS, Chang Y, Goff DC, Rauch SL, Kennedy DN, Gollub RL (2001) Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am J Psychiatry 158:955–958
Mohr C, Binkofski F, Erdmann C, Büchel C, Helmchen C (2005) The anterior cingulate cortex contains distinct areas dissociating external from self-administered painful stimulation: a parametric fMRI study. Pain 114:347–357
Munhall KG (2001) Functional imaging during speech production. Acta Psychol (Amst) 107:95–117
Pfleiderer B, Ostermann J, Michael N, Heindel W (2002) Visualization of auditory habituation by fMRI. NeuroImage 17:1705–1710
Poellinger A, Thomas R, Lio P, Lee A, Makris N, Rosen BR, Kwong KK (2001) Activation and habituation in olfaction — an fMRI study. NeuroImage 13:547–560
Price CJ, Friston KJ (1997) Cognitive conjunction: a new approach to brain activation experiments. NeuroImage 5:261–270
Price CJ, Veltman DJ, Ashburner J, Josephs O, Friston KJ (1999) The critical relationship between the timing of stimulus presentation and data acquisition in blocked designs with fMRI. NeuroImage 10:36–44
Schneider F, Gur RC, Gur RE, Muenz LR (1994) Standardized mood induction with happy and sad facial expressions. Psychiatry Res 51:19–31
Schneider F, Gur RC, Gur RE, Shtasel DL (1995) Emotional processing in schizophrenia: neurobehavioral probes in relation to psychopathology. Schizophr Res 17:67–75
Schneider F, Grodd W, Weiss U, Klose U, Mayer KR, Nägele T, Gur RC (1997) Functional MRI reveals left amygdala activation during emotion. Psychiatry Res 76:75–82
Schneider F, Weiss U, Kessler C, Salloum JB, Posse S, Grodd W, Müller-Gärtner HW (1998) Differential amygdala activation in schizophrenia during sadness. Schizophr Res 34:133–142
Schneider F, Weiss U, Kessler C, Müller-Gärtner HW, Posse S, Salloum JB, Grodd W, Himmelmann F, Gaebel W, Birbaumer N (1999) Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol Psychiatry 45:863–871
Schneider F, Habel U, Kessler C, Posse S, Grodd W, Müller-Gärtner HW (2000a) Functional imaging of conditioned aversive emotional responses in antisocial personality disorder. Neuropsychobiology 42:192–201
Schneider F, Habel U, Kessler C, Salloum JB, Posse S (2000b) Gender differences in regional cerebral activity during sadness. Hum Brain Mapp 9:226–238
Schneider F, Habel U, Wagner M, Franke P, Salloum JB, Shah NJ, Toni I, Sulzbach C, Hönig K, Maier W, Gaebel W, Zilles K (2001) Subcortical correlates of craving in recently abstinent alcoholic patients. Am J Psychiat 158:1075–1083
Schneider F, Koch K, Klein M, Kellermann K, Stöcker T, Amunts K, Shah NJ, Habel U (2006) The interaction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging task. Psychiatry Res (in press)
Veit R, Flor H, Erb M, Hermann, C, Lotze M, Grodd W, Birbaumer N (2002) Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 328:233–236
Volz H, Gaser C, Hager F, Rzanny R, Ponisch J, Mentzel H, Kaiser WA, Sauer H (1999) Decreased frontal activation in schizophrenics during stimulation with the continuous performance test — a functional magnetic resonance imaging study. Eur Psychiatry 14:17–24
Wang GJ, Volkow ND, Fowler JS, Cervany P, Hitzemann RJ, Pappas NR, Wong CT, Felder C (1999) Regional brain metabolic activation during craving elicited by recall of previous drug experiences. Life Sci 64:775–784
Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54:1063–1070
Wild B, Erb M, Lemke N, Scholz P, Bartels M, Grodd W (2000) Video camera and light system for application in magnetic resonance scanners. Magn Reson Imaging 18:893–896
Wright CI, Fischer H, Whalen PJ, McInerney SC, Shin LM, Rauch SL (2001) Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli. Neuroreport 12:379–383
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Habel, U., Fink, G.R. (2007). Planung und Umsetzung experimenteller Paradigmen. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68558-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-540-68558-6_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20474-9
Online ISBN: 978-3-540-68558-6
eBook Packages: Medicine (German Language)