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Adrenomedullin in the Treatment of Cardiovascular Dysfunction and Sepsis

  • Conference paper
Intensive Care Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2007))

Abstract

The existence of vasoactive peptide hormones was first reported more than 100 years ago [1]. Since then, several oligo- and polypeptides influencing blood pressure regulation have been identified. Some of these are direct vasoconstrictors, such as vasopressin, angiotensin II, endothelin-1, and neuropeptide Y and are classified as hypertensive agents. Other peptides, e.g., the natriuretic peptides, vasoactive intestinal peptide (VIP), and calcitonin-gene related peptide (CGRP), have direct vasodilatory properties and, thus, lower systemic blood pressure. Adrenomedullin belongs to the vasodilatory peptide hormones and plays a crucial role in the regulation and preservation of cardiovascular, endocrine and immunologic homeostasis [2].

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Authors and Affiliations

  1. Department of Anesthesiology and Intensive Care, University Hospital, Albert-Schweitzer-Str. 33, 48149, Muenster, Germany

    C. Ertmer & H. Van Aken

  2. Department of Anesthesiology and Intensive Care, University Hospital, Albert-Schweitzer-Str. 33, 48149, Münster, Germany

    M. Westphal

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Ertmer, C., Van Aken, H., Westphal, M. (2007). Adrenomedullin in the Treatment of Cardiovascular Dysfunction and Sepsis. In: Intensive Care Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49433-1_9

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  • DOI: https://doi.org/10.1007/978-3-540-49433-1_9

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