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Exportin-Mediated Nuclear Export of Proteins and Ribonucleoproteins

  • Chapter
Nuclear Transport

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 35))

Abstract

Protein export from the nucleus of eukaryotic cells serves three main purposes: (1) to remove factors that are only transiently required in the nucleus — transcriptional signaling molecules fall into this category; (2) to participate in RNA export — all RNAs that leave the nucleus, do so in complex with proteins; (3) to recycle import factors that have been dissociated from their cargoes and have to return to the cytoplasm for a further round. A fourth conceivable function is to remove proteins that have unintentionally entered the nucleus, e.g. by diffusion or by inclusion into a reforming nucleus after mitosis.

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Author notes

  1. Maarten Fornerod

    Present address: Netherlands Cancer Institute - H4, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

  2. Mutsuhito Ohno

    Present address: Institute for Virus Research, Kyoto University, Kyoto 606, Japan

Authors and Affiliations

  1. EMBL Gene Expression Programme, Meyerhofstrasse 1, 69117, Heidelberg, Germany

    Maarten Fornerod & Mutsuhito Ohno

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  1. Maarten Fornerod
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  2. Mutsuhito Ohno
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  1. Department of Molecular & Cell Biology, University of California, Berkeley, 94720-3200, Berkeley, CA, USA

    Karsten Weis

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Fornerod, M., Ohno, M. (2002). Exportin-Mediated Nuclear Export of Proteins and Ribonucleoproteins. In: Weis, K. (eds) Nuclear Transport. Results and Problems in Cell Differentiation, vol 35. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-44603-3_4

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  • DOI: https://doi.org/10.1007/978-3-540-44603-3_4

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