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The Quartz Crystal Microbalance and the Electrochemical QCM: Applications to Studies of Thin Polymer Films, Electron Transfer Systems, Biological Macromolecules, Biosensors, and Cells

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Piezoelectric Sensors

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 5))

Abstract

In this chapter we focus on the application of the piezoelectric-based quartz crystal microbalance (QCM) technique to create and study thin polymeric films. The electrochemical variant of the quartz crystal microbalance technique (EQCM) allows one to study changes in the interfacial mass and physical properties associated with electron transfer processes occurring at the electrode surface, such as those accompanying electropolymerization of thin films. We have applied EQCM to study and compare the formation and properties of polymeric thin films formed from amphiphilic and non-amphiphilic phenolic and tyrosine monomers and comonomer systems. Also, we show the applicability of using EQCM to study polymeric films formed as a result of enzymatic polymerization processes, to create enzyme-entrapped polymer electrodes, and to create biosensors. Lastly, we briefly discuss QCM application to studies of cell properties such as adhesion and to create cell QCM biosensors that have interesting applications in the area of drug discovery.

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Authors and Affiliations

  1. Center for Intelligent Biomaterials, Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA

    Kenneth A. Marx

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  1. Kenneth A. Marx
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  1. Institute of Physical Chemistry, University of Mainz, Welder Weg 11, 55128, Mainz, Germany

    Andreas Janshoff

  2. Institute of Organic and Biomolecular Chemistry, Georg August University, Tammannstr. 2, 37077, Göttingen, Germany

    Claudia Steinem

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Marx, K.A. (2006). The Quartz Crystal Microbalance and the Electrochemical QCM: Applications to Studies of Thin Polymer Films, Electron Transfer Systems, Biological Macromolecules, Biosensors, and Cells. In: Janshoff, A., Steinem, C. (eds) Piezoelectric Sensors. Springer Series on Chemical Sensors and Biosensors, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36568-6_11

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