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Complications and Side Effects

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Liver Radioembolization with 90Y Microspheres

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Radioembolization represents an effective tool for the treatment of primary and secondary liver tumors. Adequate use of this therapy requires knowledge and a multidisciplinary effort in order to obtain optimal results and avoid therapy-specific complica- tions. A great deal of research has been undertaken in order to understand the angiographie, technical and safety aspects concerning liver radioembolization.

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References

  1. Lau WY, Ho S, Leung TW et al (1998) Selective internal radiation therapy for nonresectable hepatocellular carcinoma with intraarterial infusion of 90yttrium micro-spheres. Int J Radiat Oncol Biol Phys 40:583–592

    PubMed  CAS  Google Scholar 

  2. Yip D, Allen R, Ashton C et al (2004) Radiation-induced ulceration of the stomach secondary to hepatic emboliza-tion with radioactive yttrium microspheres in the treatment of metastatic colon cancer. J Gastroenterol Hepatol 19:347–349

    Article  PubMed  Google Scholar 

  3. Salem R, Thurston KG (2006) Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: Technical and methodologic considerations. J Vasc Interv Radiol 17:1251–1278

    Article  PubMed  Google Scholar 

  4. Mantravadi RV, Spigos DG, Tan WS et al (1982) Intraarte-rial yttrium 90 in the treatment of hepatic malignancy. Radiology 142:783–786

    PubMed  CAS  Google Scholar 

  5. Leung TW, Lau WY, Ho SK et al (1995) Radiation pneu-monitis after selective internal radiation treatment with intraarterial 90yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 33:919–24

    PubMed  CAS  Google Scholar 

  6. Leung WT, Lau WY, Ho SK et al (1994) Measuring lung shunting in hepatocellular carcinoma with intrahepatic-arterial technetium-99m macroaggregated albumin. J Nucl Med 35:70–73

    PubMed  CAS  Google Scholar 

  7. Carretero C, Munoz-Navas M, Betes M et al (2007) Gas-troduodenal injury after radioembolization of hepatic tumors. Am J Gastroenterol 102:1–5

    Article  Google Scholar 

  8. Ingold J, Reed G, Kaplan H, Bagshaw M (1965) Radiation hepatitis. Am J Radiol 93:200–208

    CAS  Google Scholar 

  9. Shen-Gunther J, Walker JL, Johnson GA, Mannel RS (1996) Hepatic venoocclusive disease as a complication of whole abdominopelvic irradiation and treatment with the transjuglar intrahepatic portosystemic shunt: case report and literature review. Gynocol Oncol 61:282–286

    Article  CAS  Google Scholar 

  10. Sangro B, Bilbao JI, Boan J et al (2006) Radioembolization using 90-Y resin microspheres for patients with advanced hepatocellular carcinoma. Int J Radiation Oncology Biol Phys 66:792–800

    CAS  Google Scholar 

  11. Dawson LA, McGuinn CJ, Lawrence TS (2003) Conformai chemoradiation for primary and metastatic liver malig-nancies. Semin Surg Oncol 21:249–255

    Article  PubMed  Google Scholar 

  12. Goin JE, Salem R Carr BI et al (2005) Treatment of unre-sectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities. J Vasc Interv Radiol 16:205–213

    PubMed  Google Scholar 

  13. Fajardo L, Colby T (1980) Pathogenesis of veno-occlusive liver disease after radiation. Arch Pathol Lab Med 104:584–588

    PubMed  CAS  Google Scholar 

  14. Reed G, Cox A (1966) The human liver after radiation injury: a form of veno-occlusive disease. Am J Pathol 48:597–611

    PubMed  Google Scholar 

  15. Rose PG, Nelson BE, Reale FR (1992) False-positive eleva-tion of CA-125 in papillary serous carcinoma of the endo-metrium treated with postoperative whole abdominal radiation. Gynecol Oncol 47:127–129

    Article  PubMed  CAS  Google Scholar 

  16. Murthy R, Nunez R, Szlaruk J et al (2005) Yttrium-90 microsphere therapy for hepatic malignancy: devices, indications, technical considerations and potential complications. Radiographies 25:S41–S55

    Article  Google Scholar 

  17. Nicolau C, Bru C, Carreras E et al (1993) Sonographic diagnosis and hemodynamic correlation in venoocclu-sive disease of the liver. J Ultrasound Med 12:437–440

    PubMed  CAS  Google Scholar 

  18. Brown BP, Abu-Yosef M, Farner R, LaBrecque D, Ginrich R (1990) Doppler sonography: a non-invasive method for evaluation of hepatic venoocclusive disease. Am J Radiol 154:721–724

    CAS  Google Scholar 

  19. Fried MW, Connaghan DG, Sharma S et al (1995) Tran-sjugular intrahepatic ortal-systemic shunt for the management of severe veno-occlusive disease after bone marrow transplantation. Hepatology AASLD abstracts

    Google Scholar 

  20. Szyszko T, Al-Nahhas A, Tait P et al (2007) Management and prevention of adverse effects related to treatment of liver tumours with 90Y microspheres. Nucl Med Commun 28:21–24

    Article  PubMed  CAS  Google Scholar 

  21. Covey AM, Brody LA, Maluccio MA, Getradjdman GJ, Brown KT (2002) Variant hepatic arterial anatomy revisited: digital substraction angiography performed in 600 patients. Radiology 224:542–547

    Article  PubMed  Google Scholar 

  22. Liu DM, Salem R, Bui JT et al (2005) Angiographie considerations in patients undergoing liver-directed therapy. J Vasc Interv Radiol 16:911–935

    PubMed  Google Scholar 

  23. Kim HC, Cheng JW, Lee W, Jae HJ, Park JH (2005) Recognizing extrahepatic collateral vessels that supply hepatocellular carcinoma to avid complications of transcatheter arterial chemoembolization. Radiographies 25:S25–S39

    Article  Google Scholar 

  24. Lewandosky RJ, Sato KT, Atassi B et al (2007) Radio-embolization with 90Y microspheres: angiographie and technical considerations. Cadiovasc Intervent Radiol 30:571–592

    Article  Google Scholar 

  25. Salem R, Lewandosky RJ, Atassi B et al (2005) Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities. J Vasc Interv Radiol 16:1627–1639

    PubMed  Google Scholar 

  26. Wollner IS, Knutsen CA, Ullrich KA et al (1987) Effects of hepatic arterial yttrium-90 microsphere administration alone and combined with regional bromodeoxyuridine infusion in dogs. Cancer Research 47:3285–3290

    PubMed  CAS  Google Scholar 

  27. De Luis E, Bilbao JI, Garcia-Jalon de Ciercoles JA et al (2007) In vivo evaluation of a new embolie spherical particle HepasphereV in a kidney animal model. Cardiovasc Intervent Radiol, in press

    Google Scholar 

  28. Nakamura H, Kondoh H (1986) Emphysematous cholecystitis: complications of hepatic arterial embolization. Cardiovasc Intervent Radiol 9:152–153

    Article  PubMed  CAS  Google Scholar 

  29. Northover JMA, Terblanche J (1979) A new look a the arterial supply of the bile duct in man and its surgical implications. Br J Surg 66:379–384

    Article  PubMed  CAS  Google Scholar 

  30. Kim HK, Cheng YH, Song BC et al (2001) Ischx009;mie bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. J Clin Gastroenterol 32:423–427

    Article  PubMed  CAS  Google Scholar 

  31. Makuchi M, Sukigara M, Mori T et al (1985) Bile duct necrosis: complication of transcatheter hepatic arterial embolization. Radiology 156:331–334

    Google Scholar 

  32. Ashizawa K, Matsunaga N, Aso N et al (1991) Bile lake: complication of transcatheter hepatic arterial infusion and embolization therapy. Nipon Iagaku Hoshasen Gakkai Zasshi 51:121–126

    CAS  Google Scholar 

  33. Kabayashi S, Nakamura Y, Terada T et al (1993) Postmortem survey of bile duct necrosis and biloma in hepatocellular carcinoma alter transcatheter arterial chemoembolization therapy: relevant to microvascular damages of peribiliary capillary plexus. Am J Gastroenterol 88:1410–1415

    Google Scholar 

  34. Sakamoto I, Iwanaga S, Nagaoki K et al (2003) Intrahepatic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization. AJR Am J Roentgenol 181:79–87

    PubMed  Google Scholar 

  35. Park WK, Chang JC, Lee HZ, Kim HJ, Choi JH, Gu Mj (2002) A case of resection of biloma with hepatocellular carcinoma after embolization. TaehanKan Hakhoe Chi 8:331–335

    Google Scholar 

  36. Yu JS, Kim KW, Jeong MG et al (2002) Predisposing factors of bile duct injury after transcatheter arterial chemoembolization for hepatic malignancy. Cardiovasc Intervent Radiol 25:270–274

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Clinical Radiology, University Hospital — Grosshadern, Ludwigs-Maximilians-University of Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Ralf-Thorsten Hoffman MD & Tobias F. Jakobs MD

  2. Department of Clinical Radiology, University Hospitals — Grosshadern and Innenstadt, Ludwigs-Maximilians-University of Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Maximilian F. Reiser MD (Professor and Chairman)

  3. Department of Radiology, Clínica Universitaria, Universidad de Navarra, Avenida de Pio XII, 36, 31008, Pamplona, Spain

    José I. Bilbao MD, PhD (Professor), Lourdes Diaz-Dorronsoro & Laurent Desloques

Authors
  1. Ralf-Thorsten Hoffman MD
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  2. José I. Bilbao MD, PhD
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  3. Tobias F. Jakobs MD
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  4. Lourdes Diaz-Dorronsoro
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  5. Laurent Desloques
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  6. Maximilian F. Reiser MD
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Editor information

Editors and Affiliations

  1. Department of Radiology Clínica Universitaria, Universidad de Navarra, Avenida de Pio XII, 36, 31008, Pamplona, Spain

    José I. Bilbao PhD (Professor) (Professor)

  2. Department of Clinical Radiology, University Hospitals - Grosshadern and Innenstadt Ludwig-Maximilians-University of Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Maximilian F. Reiser MD (Professor and Chairman) (Professor and Chairman)

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© 2008 Springer-Verlag Berlin Heidelberg

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Hoffman, RT., Bilbao, J.I., Jakobs, T.F., Diaz-Dorronsoro, L., Desloques, L., Reiser, M.F. (2008). Complications and Side Effects. In: Bilbao, J.I., Reiser, M.F. (eds) Liver Radioembolization with 90Y Microspheres. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-35423-9_14

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  • DOI: https://doi.org/10.1007/978-3-540-35423-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-35421-5

  • Online ISBN: 978-3-540-35423-9

  • eBook Packages: MedicineMedicine (R0)

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