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Intestinal Neuronal Malformations (IND): Clinical Experience and Treatment

  • Chapter
Hirschsprung's Disease and Allied Disorders

Abstract

Neuronal intestinal dysplasia (IND or NID) was first described by Meier-Ruge in 1971 as a condition of unknown pathogenesis which is usually associated with obstruction of the lower intestine [1]. It may be induced, like Hirschsprung’s disease (HD), by an underlying autoimmune mechanism [2], a deficient production of trophic factors such as laminin A [3] or a genetic defect. The main problem is that it remains controversial as to whether or not there is a causal relationship between specific histological findings and clinical symptoms, in particular since so-called pathological innervation patterns have been described in the proximal colon of patients with fetal obstruction [4, 5] and in normal controls.

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Authors and Affiliations

  1. Immenzaun 6a, 51429 , Bergisch Gladbach, Germany

    A.M. Holschneider

  2. The Children’s Hospital of Cologne, Amsterdamerstr. 59, 50735, Cologne, Germany

    A.M. Holschneider & L.H. Homrighausen

  3. Children’s Research Centre, Our Lady’s Children’s Hospital, University College of Dublin, Crumlin, Dublin 12, Ireland

    P. Puri

  4. Department of Pathology, University of Basel, Schönbeinstrasse 40, 4003, Basel, Switzerland

    W. Meier-Ruge

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  1. Immenzaun 6a, 51429, Bergisch Gladbach, Germany

    Alexander Matthias Holschneider

  2. The Children’s Hospital of Cologne, Amsterdamerstr. 59, 50735 , Cologne, Germany

    Alexander Matthias Holschneider

  3. Our Lady’s Children’s Hospital, Children’s Research Centre, University College of Dublin, Crumlin, Dublin 12, Ireland

    Prem Puri

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Holschneider, A., Puri, P., Homrighausen, L., Meier-Ruge, W. (2008). Intestinal Neuronal Malformations (IND): Clinical Experience and Treatment. In: Holschneider, A., Puri, P. (eds) Hirschsprung's Disease and Allied Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33935-9_17

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