Skip to main content

Intravitreal Injections: Techniques and Sequelae

  • Chapter
Medical Retina

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aiello LP, Brucker AJ, Chang S et al (2004) Evolving guidelines for intravitreous injections. Retina 2004;24[5 Suppl]:S3–19

    Article  PubMed  Google Scholar 

  2. Anijeet DR, Hanson RJ, Bhagey J et al (2006) National survey of the technique of intravitreal triamcinolone injection in the United Kingdom. Eye (in press)

    Google Scholar 

  3. Benz MS, Albini TA, Holz ER et al (2006) Shortterm course of intraocular pressure after intravitreal injection of triamcinolone acetonide. Ophthalmology 2006;113(7):1174–1178

    Article  PubMed  Google Scholar 

  4. Brown DM, Kaiser PK, Michels M et al (2006) Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355(14):1432–1444

    Article  PubMed  CAS  Google Scholar 

  5. Chen SD, Mohammed Q, Bowling B et al (2004) Vitreous wick syndrome—a potential cause of endophthalmitis after intravitreal injection of triamcinolone through the pars plana. Am J Ophthalmol 137(6):1159–1160; author reply 1160–1161

    Article  PubMed  Google Scholar 

  6. Chen SN, Yang TC, Ho CL et al (2003) Retinal toxicity of intravitreal tissue plasminogen activator: case report and literature review. Ophthalmology 110(4):704–708

    Article  PubMed  Google Scholar 

  7. Costa RA, Jorge R, Calucci D et al (2006) Intravitreal bevacizumab for choroidal neovascularization caused by AMD (IBeNA Study): results of a phase 1 dose-escalation study. Invest Ophthalmol Vis Sci 47(10):4569–4578

    Article  PubMed  Google Scholar 

  8. D’Amico DJ, Patel M, Adamis AP et al (2006) Pegaptanib sodium for neovascular age-related macular degeneration: two-year safety results of the two prospective, multicenter, controlled clinical trials. Ophthalmology 113(6): 992–1001.e6

    Article  PubMed  Google Scholar 

  9. Dwinger MC, Pieper-Bodeewes I, Eter N et al (2005) [Variations in intraocular pressure (IOP) and necessity for paracentesis following intravitreal triamcinolone injection]. Klin Monatsbl Augenheilkd 222(8):638–642

    Article  PubMed  CAS  Google Scholar 

  10. Fung AE, Rosenfeld PJ, Reichel E (2006) The International Intravitreal Bevacizumab Safety Survey: using the internet to assess drug safety worldwide. Br J Ophthalmol 90(11):1344–1349

    Article  PubMed  CAS  Google Scholar 

  11. Gillies MC, Kuzniarz M, Craig J et al (2005) Intravitreal triamcinolone-induced elevated intraocular pressure is associated with the development of posterior subcapsular cataract. Ophthalmology 112(1):139–143

    Article  PubMed  Google Scholar 

  12. Gillies MC, Sutter FK, Simpson JM et al (2006) Intravitreal triamcinolone for refractory diabetic macular edema: two-year results of a doublemasked, placebo-controlled, randomized clinical trial. Ophthalmology 113(9):1533–1538

    Article  PubMed  Google Scholar 

  13. Gills JP, Gills P (2005) Effect of intracameral triamcinolone to control inflammation following cataract surgery. J Cataract Refract Surg 31(8):1670–1671

    Article  PubMed  Google Scholar 

  14. Gragoudas ES, Adamis AP, Cunningham ET Jr et al (2004) Pegaptanib for neovascular agerelated macular degeneration. N Engl J Med 351(27):2805–2816

    Article  PubMed  CAS  Google Scholar 

  15. Gupta R, Negi A, Vernon SA (2005) Severe sub conjunctival haemorrhage following intravitreal triamcinolone for refractory diabetic oedema. Eye 19(5):590–591

    Article  PubMed  CAS  Google Scholar 

  16. Heier JS, Antoszyk AN, Pavan PR et al (2006) Ranibizumab for treatment of neovascular agerelated macular degeneration: a phase I/II multicenter, controlled, multidose study. Ophthalmology 113(4):633–642.e4

    Article  PubMed  Google Scholar 

  17. Jager RD, Aiello LP, Patel SC et al (2004) Risks of intravitreous injection: a comprehensive review. Retina 24(5):676–698

    Article  PubMed  Google Scholar 

  18. Jaissle GB, Szurman P, Bartz-Schmidt KU (2005) [Recommendation for the implementation of intravitreal injections—statement of the German Retina Society, the German Society of Ophthalmology (DOG) and the German Professional Association of Ophthalmologists (BVA)]. Klin Monatsbl Augenheilkd 222(5):390–395

    Article  PubMed  CAS  Google Scholar 

  19. Jalil A, Chaudhry NL, Gandhi JS et al (2007) Inadvertent injection of triamcinolone into the crystalline lens. Eye 21(1):152–154

    Article  PubMed  CAS  Google Scholar 

  20. Jobling AI, Augusteyn RC (2002) What causes steroid cataracts? A review of steroid-induced posterior subcapsular cataracts. Clin Exp Optom 85(2):61–75

    Article  PubMed  Google Scholar 

  21. Jonas JB, Kreissig I, Degenring R (2005) Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exudative, and neovascular diseases. Prog Retin Eye Res 24(5):587–611

    Article  PubMed  CAS  Google Scholar 

  22. Kaderli B, Avci R (2006) Comparison of topical and subconjunctival anesthesia in intravitreal injection administrations. Eur J Ophthalmol 16(5):718–721

    PubMed  CAS  Google Scholar 

  23. Kreissig I, Degenring RF, Jonas JB (2006) [Intravitreal triamcinolone acetonide. Complication of infectious and sterile endophthalmitis]. Ophthalmologe 103(1):30–34

    Article  PubMed  CAS  Google Scholar 

  24. Kuppermann BD, Thomas EL, de Smet MD et al (2005) Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage. Am J Ophthalmol 140(4):585–597

    Article  PubMed  CAS  Google Scholar 

  25. Michels S (2006) Is intravitreal bevacizumab (Avastin) safe? Br J Ophthalmol 90(11):1333–1334

    Article  PubMed  CAS  Google Scholar 

  26. Moshfeghi DM, Kaiser PK, Scott IU et al (2003) Acute endophthalmitis following intravitreal triamcinolone acetonide injection. Am J Ophthalmol 136(5):791–796

    Article  PubMed  CAS  Google Scholar 

  27. Ochoa-Contreras D, Delsol-Coronado L, Buitrago ME et al (2000) Induced posterior vitreous detachment by intravitreal sulfur hexafluoride (SF6) injection in patients with nonproliferative diabetic retinopathy. Acta Ophthalmol Scand 78(6):687–688

    Article  PubMed  CAS  Google Scholar 

  28. Rosenfeld PJ, Schwartz SD, Blumenkranz MS et al (2005) Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular agerelated macular degeneration. Ophthalmology 112(6):1048–1053

    Article  PubMed  Google Scholar 

  29. Rosenfeld PJ, Brown DM, Heier JS et al (2006) Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355(14):1419–1431

    Article  PubMed  CAS  Google Scholar 

  30. Roth DB, Scott IU, Gulati N et al (2006) Patient perceptions of discomfort and changes in vision and functional status associated with intravitreal triamcinolone injection. Am J Ophthalmol 142(3):492–494

    Article  PubMed  Google Scholar 

  31. Singh IP, Ahmad SI, Yeh D et al (2004) Early rapid rise in intraocular pressure after intravitreal triamcinolone acetonide injection. Am J Ophthalmol 138(2):286–287

    Article  PubMed  Google Scholar 

  32. Szurman P, Kaczmarek R, Spitzer MS et al (2006) Differential toxic effect of dissolved triamcinolone and its crystalline deposits on cultured human retinal pigment epithelium (ARPE19) cells. Exp Eye Res 83(3):584–592

    Article  PubMed  CAS  Google Scholar 

  33. Thompson JT (2006) Cataract formation and other complications of intravitreal triamcinolone for macular edema. Am J Ophthalmol 141(4):629–637

    Article  PubMed  CAS  Google Scholar 

  34. Ung T, Williams CP, Canning CR (2006) Globe rupture as a complication of intravitreal injection of triamcinolone. Eye (in press)

    Google Scholar 

  35. Widmer S, Helbig H (2006) Presumed macular toxicity of intravitreal antibiotics. Klin Monatsbl Augenheilkd 223(5):456–458

    Article  PubMed  CAS  Google Scholar 

  36. Yu SY, Damico FM, Viola F et al (2006) Retinal toxicity of intravitreal triamcinolone acetonide: a morphological study. Retina 26(5):531–536

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Heimann, H. (2007). Intravitreal Injections: Techniques and Sequelae. In: Holz, F.G., Spaide, R.F. (eds) Medical Retina. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33672-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-33672-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-33671-6

  • Online ISBN: 978-3-540-33672-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics