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Atopic Dermatitis

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Pediatric Allergy, Asthma and Immunology

Abstract

Among the skin allergy diseases, we distinguish atopic dermatitis (AD) and urticaria-angioedema, characterized by IgE-mediated reactions, as well as allergic contact dermatitis (ACD), with prevalent delayed-type hypersensitivity (DTH) cell-mediated reactions, where the allergens reach the skin directly (unlike AD). Urticaria, the most immediate, also occurs in the first phase of AD. Depending on its onset, AD is the first atopic disease in an absolute sense: the dendritic cells (DCs) appear first in the skin and then in the lungs (Fig. 2.24), and CLA (cutaneous lymphocyte-associated antigen) [195] is expressed by 45% of skin T cells [24], but not by lung T cells [196].

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(2008). Atopic Dermatitis. In: Pediatric Allergy, Asthma and Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33395-1_7

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