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Inflammation and Angiogenesis: Innate Immune Cells as Modulators of Tumor Vascularization

  • Chapter
Tumor Angiogenesis

Abstract

Inflammation is an essential process for survival and for the physiological defense against pathogens. After early reports by Virchow suggesting a functional connection between inflammation and cancer, the pathological role of inflammation in promoting tumor growth and invasion has recently again entered the focus of attention. There is now clear evidence that one essential contribution of the inflammatory infiltrate to tumor growth is the stimulation of angiogenesis. Different cell types of the innate immune system, particularly macrophages, mast cells, and neurophils, play an active role in enhancing tumor angiogenesis — either directly, via the release of vesicle-stored growth factors, cytokines and proteolytic enzymes, or indirectly, via paracrine signalling cascades. This concept of an indirect inflammation-dependent induction of angiogenesis places inflammation as a target for tumor therapy and, even better, for the prevention of tumor angiogenesis by anti-inflammatory agents.

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  1. Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Dr. MargaretaM. Mueller

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  1. Klinik für Tumorbiologie, Breisacher Str. 117, 79106, Freiburg i. Br., Germany

    Dieter Marmé PhD (Professor) (Professor)

  2. DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Norbert Fusenig MD (Professor, former Head of Division of Carcinogenesis and Differentiation) (Professor, former Head of Division of Carcinogenesis and Differentiation)

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Mueller, M. (2008). Inflammation and Angiogenesis: Innate Immune Cells as Modulators of Tumor Vascularization. In: Marmé, D., Fusenig, N. (eds) Tumor Angiogenesis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33177-3_20

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  • DOI: https://doi.org/10.1007/978-3-540-33177-3_20

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