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Inflammation as a Stimulus for Vascular Leakage and Proliferation

  • Chapter
Retinal Vascular Disease

Abstract

In the past few decades, our knowledge of the mechanisms underlying retinal vasoproliferation has increased greatly (see Chapters 2, 3.1, 3.2 and 3.3). While vasoproliferation was once considered to be mainly a consequence of ischemia, current evidence also supports a contribution of inflammatory mechanisms. Inflammation is also highly related to vascular leakage in diseases that are known to result in retinal and macular edema. Recently, inflammatory mechanisms have gained interest with respect to the retinal pathology following ischemia, as well as in diseases such as diabetic retinopathy (DR) and sickle cell retinopathy (see Chapter 27.1). In this chapter, the discussion will focus on the published data relating to the inflammatory mechanisms in ischemic retinal diseases such as DR. The definition of inflammation in this setting is the involvement of any leukocyte-mediated pathology in the course of the disease.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany

    Antonia M. Joussen MD, PhD

  2. Jerini Ophthalmic, 111 West 50th Street, 7th floor, New York, NY, 10020, USA

    Anthony P. Adamis MD

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  1. Antonia M. Joussen MD, PhD
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Editors and Affiliations

  1. Department of Ophthalmology, University of Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany

    Antonia M. Joussen MD, PhD (Professor of Ophthalmology) (Professor of Ophthalmology)

  2. Department of Ophthalmology, Penn State College of Medicine, 500 University, Drive Box 850, Hershey, PA, 17033, USA

    Thomas W. Gardner MD, MS (Professor of Ophthalmology) (Professor of Ophthalmology)

  3. Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Joseph-Stelzmann-Straße 9, 50931, Cologne, Germany

    Bernd Kirchhof MD (Professor of Ophthalmology) (Professor of Ophthalmology)

  4. Doheny Eye Institute, University of Southern California, 1450 San Pablo Street, Los Angeles, CA, 90033, USA

    Stephen J. Ryan MD (Professor of Ophthalmology) (Professor of Ophthalmology)

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© 2007 Springer-Verlag Berlin Heidelberg

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Joussen, A.M., Adamis, A.P. (2007). Inflammation as a Stimulus for Vascular Leakage and Proliferation. In: Joussen, A.M., Gardner, T.W., Kirchhof, B., Ryan, S.J. (eds) Retinal Vascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29542-6_5

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  • DOI: https://doi.org/10.1007/978-3-540-29542-6_5

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