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Genetic Approach to Retinal Vascular Disease

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Retinal Vascular Disease

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Abstract

Development of novel molecular biology techniques in the 1970s and 1980s furnished scientists with new tools to advance the study and treatment of human disease. Progress in the understanding of bacterial and viral biology led to innovations in molecular cloning and chimeric plasmid construction. Advances in nucleic acid sequencing allowed researchers to gain a better understanding of genes and the ability to study gene mutations. Unraveling the minutiae of molecular events involved in gene transcription and translation furthered the analysis of cellular pathways and their complex interrelationships. Production of proteins ex vivo allowed physicians to treat diseases such as diabetes with synthetic human insulin, ending the dependency on animal sources.

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Author information

Authors and Affiliations

  1. Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd., Portland, OR, 97239, USA

    Trevor J. McFarland BS

  2. Casey Eye Institute, 3375 SW Terwilliger Blvd., Portland, OR, 97237-4197, USA

    J. Timothy Stout MD, PhD

  3. Institute of Anatomy, University of Erlangen, Universitätsstrasse 19, 91054, Erlangen, Germany

    Michael Scholz PhD

  4. Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr. 31, 93053, Regensburg, Germany

    Ernst R. Tamm MD

Authors
  1. Trevor J. McFarland BS
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  2. J. Timothy Stout MD, PhD
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  3. Michael Scholz PhD
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  4. Ernst R. Tamm MD
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Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany

    Antonia M. Joussen MD, PhD (Professor of Ophthalmology) (Professor of Ophthalmology)

  2. Department of Ophthalmology, Penn State College of Medicine, 500 University, Drive Box 850, Hershey, PA, 17033, USA

    Thomas W. Gardner MD, MS (Professor of Ophthalmology) (Professor of Ophthalmology)

  3. Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Joseph-Stelzmann-Straße 9, 50931, Cologne, Germany

    Bernd Kirchhof MD (Professor of Ophthalmology) (Professor of Ophthalmology)

  4. Doheny Eye Institute, University of Southern California, 1450 San Pablo Street, Los Angeles, CA, 90033, USA

    Stephen J. Ryan MD (Professor of Ophthalmology) (Professor of Ophthalmology)

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© 2007 Springer-Verlag Berlin Heidelberg

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McFarland, T.J., Stout, J.T., Scholz, M., Tamm, E.R. (2007). Genetic Approach to Retinal Vascular Disease. In: Joussen, A.M., Gardner, T.W., Kirchhof, B., Ryan, S.J. (eds) Retinal Vascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29542-6_10

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  • DOI: https://doi.org/10.1007/978-3-540-29542-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-29541-9

  • Online ISBN: 978-3-540-29542-6

  • eBook Packages: MedicineMedicine (R0)

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