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Clinical Spectroscopy

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Magnetic Resonance Tomography

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Abstract

Intensive nuclear resonance signals can be gained from freely moving protons of cells and fatty acids that are used for MR imaging and can be used to receive morphologic and functional information. Metabolic processes in living tissue can be observed if the spectral resolution is improved for protons and if the frequency range is broadened also for other nuclei for example phosphorus-31 (31P), carbon-13 (13C), fluorine-19 (19F), potassium-39 (39K), and others. This experimental method, using highfrequency- resolution nuclear resonance signals, is called magnetic resonance spectroscopy (MRS). Application of this method in living tissue (in vivo) makes possible to observe non-invasive biomolecules and concentrations of metabolites as well as intracellular pH and pharmacokinetic parameters.

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Authors and Affiliations

  1. Department of Radiology, Eberhard Karl University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany

    Heinz-Peter Schlemmer

  2. Division of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Wolfhard Semmler

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  1. Heinz-Peter Schlemmer
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  2. Wolfhard Semmler
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Editors and Affiliations

  1. Institute for Clinical Radiology, Ludwig-Maximilian University of Munich, Marchioninistr. 15, 81377, Munich, Germany

    Maximilian F. Reiser

  2. Division of Medical Physics in Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Wolfhard Semmler

  3. Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., 10065, New York, NY, USA

    Hedvig Hricak

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Schlemmer, HP., Semmler, W. (2008). Clinical Spectroscopy. In: Reiser, M., Semmler, W., Hricak, H. (eds) Magnetic Resonance Tomography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29355-2_15

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