Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class of prescription and over-the-counter compounds used both as for mild to moderate pain, fever, swelling and inflammation They work by inhibiting cyclooxygenase (COX) enzymes in the arachidonic acid pathway to block the production of prostaglandins. They are available for ophthalmic, otic, topical/external, parenteral, oral, and rectal routes of administration. Severe drug-class adverse effects include stroke, myocardial infarction, renal insufficiency, bleeding, and gastrointestinal bleeding.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Grosser T, Smyth E, FitzGerald GA. Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The pharmacological basis of therapeutics, 12e. New York: McGraw-Hill. http://accessmedicine.mhmedical.com.ezproxy.library.wisc.edu/content.aspx?bookid=1613§ionid=102161048. Accessed 27 Oct 2017.
Wolters Kluwer clinical drug information, Inc. Lexi-Drugs [online database]. Wolters Kluwer Clinical Drug Information, Inc.; October 28, 2017.
Fosbøl EL, Folke F, et al. Cause-specific cardiovascular risk associated with nonsteroidal antiinflammatory drugs among healthy individuals. Circ Cardiovasc Qual Outcomes. 2010;3(4):395–405.
García Rodríguez LA, Tacconelli S, Patrignani P. Role of dose potency in the prediction of risk of myocardial infarction associated with nonsteroidal anti-inflammatory drugs in the general population. J Am Coll Cardiol. 2008;52(20):1628–36.
Catella-Lawson F, Reilly MP, et al. Cyclooxygenase inhibitors and the antiplatelet effect of aspirin. N Engl J Med. 2001;345:1809–17.
Wall, CG. Eastman, DK. NSAID gastropathy in peptic ulcer disease. In: Murphy JE, Lee MW, editors. Pharmacotherapy self-assessment program, 2016 Book 2. GI/fluids and nutrition. Lenexa: American College of Clinical Pharmacy; 2016. p. 49–59.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Albert, C.A. (2019). Nonsteroidal Anti-Inflammatory Drugs. In: Abd-Elsayed, A. (eds) Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-99124-5_54
Download citation
DOI: https://doi.org/10.1007/978-3-319-99124-5_54
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-99123-8
Online ISBN: 978-3-319-99124-5
eBook Packages: MedicineMedicine (R0)