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Polyps

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Diagnosis of Endometrial Biopsies and Curettings

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Abstract

Most endometrial polyps appear to originate from localized overgrowth of the basalis with glands and stroma participating in the lesion. The pathogenesis of polyps has not been firmly established although molecular mechanisms have been invoked in several studies, and it is suggested that polyps originate as a monoclonal stromal overgrowth with secondary endometrial gland proliferation. The abnormality results in a disorganized growth comprised of endometrial glands, stroma, and vessels which may be polypoid or sessile, possibly over a large portion of the endometrium. The pathogenesis of endometrial polyps appears to be linked to imbalances between endometrial proliferation and apoptosis, as well as molecular alterations of the HMGI-C gene and specific clonal rearrangements.

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Authors and Affiliations

  1. Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA

    Tricia A. Murdock, Emanuela F. T. Veras & Robert J. Kurman

  2. Department of Pathology and Laboratory Medicine, State University of New York Upstate Medical University, Syracuse, NY, USA

    Michael T. Mazur

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  1. Tricia A. Murdock
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Murdock, T.A., Veras, E.F.T., Kurman, R.J., Mazur, M.T. (2019). Polyps. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, Cham. https://doi.org/10.1007/978-3-319-98608-1_8

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