Abstract
Prolonged unconsciousness—arbitrarily but sensibly defined as an undrugged comatose patient for at least 4 weeks after brain injury—is very. By this time, it is likely there have been conversations between clinicians and families regarding the degree of further life-sustaining treatment, and when appropriate and certain, care would have been witdrawn. How to go about that it difficult and requires expertise. Neuropalliative care in patients with devastating acute brain injury—damaging the eloquent structures, which allow us to be aware, sapient and prospective—is multifaceted. Clinicians need to master diagnostic and prognostic skills including a recognition of later complications, which may cloud the clinical picture. At the same time, clinicians need to effectively and empathetically communicate changes in neurologic status (or lack thereof) and prognosis, and support families through a difficult decision-making process. This chapter will follow the clinical course of a patient and stop along the way to discuss the pertinent issues around prolonged unconsciousness in the ICU setting. The conditions discussed in this chapter are complementary to the acute presentation of severe acute brain injury described in Chap. 2 “Severe Acute Brain Injury”, and the chronic disorders of consciousness managed in neurorehabilitation centers and elsewhere and further elaborated upon in Chap. 4 “Chronic Disorders of Consciousness”. Herein, I discuss the critical decision making in the early days of facing a comatose patient with a catastrophic brain injury.
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References
Wijdicks EFM. Why you may need a neurologist to see a comatose patient in the ICU. Crit Care. 2016;20(1):193.
Wijdicks EFM. Communicating prognosis, Core Principles of Acute Neurology. New York: Oxford University Press; 2014.
Whyte J, et al. Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: a multicenter study. Arch Phys Med Rehabil. 2005;86(3):453–62.
Henninger N, et al. “Don’t lose hope early”: hemorrhagic diffuse axonal injury on head CT is not associated with poor outcome in moderate-severe TBI patients. J Trauma Acute Care Surg. 2017.
Ryoo SM, et al. Predicting outcome with diffusion-weighted imaging in cardiac arrest patients receiving hypothermia therapy: multicenter retrospective cohort study. Crit Care Med. 2015;43(11):2370–7.
Multi-Society Task Force on, P.V.S. Medical aspects of the persistent vegetative state (1). N Engl J Med. 1994;330(21):1499–508.
Wade D. Patients with prolonged disorders of consciousness: more than a clinical challenge. Pract Neurol. 2014;14(1):2–3.
Wijdicks EFM. The bare essentials: coma. Pract Neurol. 2010;10(1):51–60.
Wijdicks EFM. Management of the comatose patient. Handb Clin Neurol. 2017;140:117–29.
Wijdicks EFM, Cranford RE. Clinical diagnosis of prolonged states of impaired consciousness in adults. Mayo Clin Proc. 2005;80(8):1037–46.
Wijdicks EFM. The comatose patient. 2nd ed. New York: Oxford University Press; 2014. 784
Laureys S, et al. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome. BMC Med. 2010;8:68.
Schiff ND. Uncovering hidden integrative cerebral function in the intensive care unit. Brain. 2017;140(9):2259–62.
Bernat JL. Nosologic considerations in disorders of consciousness. Ann Neurol. 2017;82(6):863–5.
Fernandez-Espejo D, et al. Diffusion weighted imaging distinguishes the vegetative state from the minimally conscious state. NeuroImage. 2011;54(1):103–12.
Edlow BL, Giacino JT, Wu O. Functional MRI and outcome in traumatic coma. Curr Neurol Neurosci Rep. 2013;13(9):375.
Wijdicks EFM. Being comatose: why definition matters. Lancet Neurol. 2012;11(8):657–8.
Giacino JT, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012;366(9):819–26.
Martin RT, Whyte J. The effects of methylphenidate on command following and yes/no communication in persons with severe disorders of consciousness: a meta-analysis of n-of-1 studies. Am J Phys Med Rehabil. 2007;86(8):613–20.
Chudy D, et al. Deep brain stimulation for the early treatment of the minimally conscious state and vegetative state: experience in 14 patients. J Neurosurg. 2017;128:1–10.
Boly M, et al. Perception of pain in the minimally conscious state with PET activation: an observational study. Lancet Neurol. 2008;7(11):1013–20.
Baguley IJ, et al. Dysautonomia after traumatic brain injury: a forgotten syndrome? J Neurol Neurosurg Psychiatry. 1999;67(1):39–43.
Meyfroidt G, Baguley IJ, Menon DK. Paroxysmal sympathetic hyperactivity: the storm after acute brain injury. Lancet Neurol. 2017;16(9):721–9.
Bosslet GT, et al. An official ATS/AACN/ACCP/ESICM/SCCM policy statement: responding to requests for potentially inappropriate treatments in intensive care units. Am J Respir Crit Care Med. 2015;191(11):1318–30.
Souter MJ, et al. Recommendations for the critical care management of devastating brain injury: prognostication, psychosocial, and ethical management: a position statement for Healthcare Professionals from the Neurocritical Care Society. Neurocrit Care. 2015;23(1):4–13.
Maas AI, et al. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery. 2015;76(1):67–80.
Steyerberg EW, Mushkudiani N, Perel P, Butcher I, Lu J, McHugh GS, Murray GD, Marmarou A, Roberts I, Habbema JD, Maas AIR. Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med. 2008;5(8):e165.
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Wijdicks, E.F.M. (2019). Prolonged Coma and Early Disorders of Consciousness. In: Creutzfeldt, C., Kluger, B., Holloway, R. (eds) Neuropalliative Care. Springer, Cham. https://doi.org/10.1007/978-3-319-93215-6_3
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DOI: https://doi.org/10.1007/978-3-319-93215-6_3
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