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Mucosal B Cells

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Humoral Primary Immunodeficiencies

Part of the book series: Rare Diseases of the Immune System ((RDIS))

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Abstract

Mucosal B cells are crucial for host defense. The mucosal surfaces exceed 300 m2 in humans and represent indeed the largest part of the body in which immune responses take place daily. Mucosal B cells, located in the gut, respiratory, and urogenital mucosae as well as in skin, salivary, mammary, and lacrimal glands, are very important to protect ourselves from infections. Most harmful pathogens enter the body through the mucosal surfaces by ingestion, inhalation, or sexual contact. This chapter focuses on the mechanisms that coordinate B-cell development as well as on the mechanisms used by mucosal B cells and mucosal IgA to give protection to the host.

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Medical Center – University of Freiburg, Freiburg, Germany

    Arianna Troilo

  2. Department of Clinical and Experimental Medicine, University of Florence Careggi Hospital, Firenze, Italy

    Arianna Troilo, Nagaja Capitani & Mario Milco D’Elios

  3. Department of Life Sciences, University of Siena, Siena, Italy

    Nagaja Capitani, Laura Patrussi & Cosima T. Baldari

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  1. Arianna Troilo
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  2. Nagaja Capitani
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Correspondence to Mario Milco D’Elios .

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  1. Careggi Hospital, Department of Clinical and Experimental Medicine, University of Florence, Firenze, Italy

    Mario Milco D'Elios

  2. University Medical Centre Freiburg, Department of Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency, Freiburg, Germany

    Marta Rizzi

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Troilo, A., Capitani, N., Patrussi, L., Baldari, C.T., D’Elios, M.M. (2019). Mucosal B Cells. In: D'Elios, M., Rizzi, M. (eds) Humoral Primary Immunodeficiencies. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-91785-6_2

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