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Malignant Skin Neoplasms and Associated Conditions

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Neuroradiological Imaging of Skin Diseases and Related Conditions

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Abstract

There are many types of cutaneous malignant neoplasms and associated conditions that can involve the head and neck regions. This chapter reviews the characteristic clinicopathological and imaging findings of basal cell carcinoma, squamous cell carcinoma, melanoma, cutaneous lymphomas, dermatofibrosarcoma protuberans, Kaposi sarcoma, Merkel cell carcinoma, microcystic adnexal carcinoma, sebaceous carcinoma, adenoid cystic carcinoma, angiosarcoma, and metastases.

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Suggested Reading

  • Ambujam S, Audhya M, Reddy A, Roy S. Cutaneous angiosarcoma of the head, neck, and face of the elderly in type 5 skin. J Cutan Aestheth Surg. 2013;6(1):45–7.

    Article  Google Scholar 

  • Anderson SE, Beer KT, Banic A, Steinbach LS, Martin M, Friedrich EE, Stauffer E, Vock P, Greiner RH. MRI of merkel cell carcinoma: histologic correlation and review of the literature. AJR AM J Rotentgenol. 2005;185(6):1441–8.

    Article  Google Scholar 

  • Baheti AD, Tirumani SH, Giardino A, Rosenthal MH, Tirumani H, Krajewski K, Ramaiya NH. Basal cell carcinoma: a comprehensive review for the radiologist. Am J Roentgenol. 2015;204(2):W132–40.

    Article  Google Scholar 

  • Balamucki CJ, DeJesus R, Galloway TJ, Mancuso AA, Amdur RJ, Morris CG, Kirwan JM, Mendenhall WM. Impact of radiographic findings on for prognosis skin cancer with perineural invasion. Am J Clin Oncol. 2015;38(3):248–51.

    Article  PubMed  Google Scholar 

  • Belkin DA, Wysong A. Radiographic imaging for skin cancer. Semin Cutan Med Surg. 2016;35(1):42–8.

    Article  PubMed  Google Scholar 

  • Bolm I, Babaryka G, Moergel M, Al-Nawas B, Kämmerer PW. Multifocal metastasizing extra-ocular facial sebaceous carcinoma as diagnostic challenge: case report and systematic review. J Maxillofac Oral Surg. 2015;14(Suppl 1):331–7.

    Article  PubMed  Google Scholar 

  • Cassarino DS, DeRienzo DP, Barr RJ. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. J Cutan Pathol. 2006;33(4):261–79.

    Article  PubMed  Google Scholar 

  • Chao AN, Shields CL, Krema H, Shields JA. Outcome of patients with periocular sebaceous gland carcinoma with and without conjunctival intraepithelial invasion. Ophthalmology. 2001;108(10):1877–83.

    Article  CAS  PubMed  Google Scholar 

  • Crowson AN. Basal cell carcinoma: biology, morphology and clinical implications. Mod Pathol. 2006;19:S127–47.

    Article  PubMed  Google Scholar 

  • D’Ambrosio N, Lyo JK, Young RJ, Haque SS, Karimi S. Imaging of metastatic CNS neuroblastoma. AJR Am J Roentgenol. 2010;194(5):1223–9.

    Article  PubMed  Google Scholar 

  • Dammann F, Horger M, Mueller-Berg M, et al. Rational diagnosis of squamous cell carcinoma of the head and neck region: comparative evaluation of CT, MRI and 18-FDG PET. Am J Roentgenol. 2005;184:1326–31.

    Article  Google Scholar 

  • Dong F, Gidley PW, Ho T, Luna MA, Ginsberg LE, Sturgis EM. Adenoid cystic carcinoma of the external auditory canal. Laryngoscope. 2008;118(9):1591–6.

    Article  PubMed  Google Scholar 

  • Escott EJ. A variety of appearances of malignant melanoma in the head: a review. Radiographics. 2001;21(3):625–39.

    Article  CAS  PubMed  Google Scholar 

  • Fischer S, Breuninger H, Metzler G, Hoffmann J. Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg. 2005;16(1):53–8.

    Article  CAS  PubMed  Google Scholar 

  • Fliss DM, Kraus M, Tovi F. Adenoid cystic carcinoma of the external auditory canal. Ear Nose Throat J. 1990;69(9):635, 638–9, 642 passim.

    CAS  PubMed  Google Scholar 

  • Gaballah AH, Jensen CT, Palmquist S, Pickhardt PJ, Duran A, Broering G, Elsayes KM. Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol. 2017;90(1075):20170039.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gaviani P, Mullins ME, Braga TA, Hedley-Whyte ET, Halpern EF, Schaefer PS, Henson JW. Improved detection of metastatic melanoma by T2*-weighted imaging. AJNR Am J Neuroradiol. 2006;27(3):605–8.

    CAS  PubMed  Google Scholar 

  • Gershenwald JE, Scolyer RA, Hess KR, Sondak VK, Long GV, Ross MI, Lazar AJ, Faries MB, Kirkwood JM, McArthur GA, Haydu LE, Eggermont AMM, Flaherty KT, Balch CM, Thompson JF, for members of the American Joint Committee on Cancer Melanoma Expert Panel and the International Melanoma Database and Discovery Platform. Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(6):472–92.

    Article  PubMed  PubMed Central  Google Scholar 

  • Glastonbury CM, Mukherji SK, O’Sullivan B, Lydiatt WM. Setting the stage for 2018: how the changes in the American Joint Committee on Cancer/Union for International Cancer Control Cancer Staging Manual Eighth Edition Impact Radiologists. AJNR Am J Neuroradiol. 2017;38(12):2231–7.

    Article  CAS  PubMed  Google Scholar 

  • Godden D, Brennan P, Milne J. Update on melanoma: the present position. Br J Oral Maxillofac Surg. 2010;48:575–8.

    Article  PubMed  Google Scholar 

  • Goessling W, McKee PH, Mayer RJ. Merkel cell carcinoma. J Clin Oncol. 2002;20(2):588–98.

    Article  PubMed  Google Scholar 

  • Gomez-Maestra MJ, España-Gregori E, Aviñó-Martinez JA, et al. Brainstem and cavernous sinus metastases arising from a microcystic adnexal carcinoma of the eyebrow by perineural spreading. Can J Ophthalmol. 2009;44(3):17.

    Article  Google Scholar 

  • Gramolelli S, Schulz TF. The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma. J Pathol. 2015;235(2):368–80.

    Article  CAS  PubMed  Google Scholar 

  • Gufler H, Franke FE, Rau WS. High-resolution MRI of basal cell carcinomas of the face using a microscopy coil. Am J Roentgenol. 2007;188:W480–4.

    Article  Google Scholar 

  • Hoang MP, Dresser KA, Kapur P, High WA, Mahalingam M. Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol. 2008;21(2):178–85.

    Article  CAS  PubMed  Google Scholar 

  • Juan YH, Saboo SS, Tirumani SH, Khandelwal A, Shinagare AB, Ramaiya N, Krajewski KM. Malignant skin and subcutaneous neoplasms in adults: multimodality imaging with CT, MRI, and 18F-FDG PET/CT. AJR Am J Roentgenol. 2014;202(5):W422–38.

    Article  PubMed  Google Scholar 

  • Kapoor PG, Chabbra R. Neuroblastoma presenting as raccoon eyes. Cancer. 2003;98:155–65.

    Article  Google Scholar 

  • Kim EY, Kim SS, Ryoo JW, Na DG, Roh HG, Byun HS, Ko YH. Primary peripheral T-cell lymphoma of the face other than mycosis fungoides. Computed tomography and magnetic resonance findings. J Comput Assist Tomogr. 2004;28(5):670–5.

    Article  PubMed  Google Scholar 

  • Kransdorf MJ, Meis-Kindblom JM. Dermatofibrosarcoma protuberans: radiologic appearance. AJR Am J Roentgenol. 1994;163(2):391–4.

    Article  CAS  PubMed  Google Scholar 

  • Kreimer A, Clifford G, Boyle P. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev. 2005;14:467–75.

    Article  CAS  PubMed  Google Scholar 

  • Lee HJ, Im JG, Goo JM, Kim KW, Choi BI, Chang KH, Han JK, Han MH. Peripheral T-cell lymphoma: spectrum of imaging findings with clinical and pathologic features. Radiographics. 2003;23(1):7–26, discussion 26–8.

    Article  PubMed  Google Scholar 

  • Lee F, King A, Ma B, Yeung D. Dynamic contrast enhancement magnetic resonance imaging for differential diagnosis in head and neck cancers. Eur J Radiol. 2012;81:784–8.

    Article  PubMed  Google Scholar 

  • Lemm D, Mügge LO, Mentzel T, Höffken K. Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 2009;135(5):653.

    Article  PubMed  Google Scholar 

  • Li X, Zhang W, Xiao L, Zeng Q, Wu X, Qin J, Shen Y. Computed tomographic and pathological findings of dermatofibrosarcoma protuberans. J Comput Assist Tomogr. 2012;36(4):462–8. https://doi.org/10.1097/RCT.0b013e31825d5a24.

    Article  PubMed  Google Scholar 

  • Liapakis IE, Korkolis DP, Koutsoumbi A, Kokkalis G, Gherardini G, Vassilopoulos PP. Merkel cell carcinoma: clinicopathological aspects of an unusual neoplasm. J BUON. 2007;12(2):173–9.

    CAS  PubMed  Google Scholar 

  • Lomas A, Leonardi-Bee J, Btth-Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol. 2012;166:1069–80.

    Article  CAS  PubMed  Google Scholar 

  • Miketic LM, Chambers TP, Lembersky BC. Cutaneous T-cell lymphoma: value of CT in staging and determining prognosis. AJR Am J Roentgenol. 1993;160(5):1129–32.

    Article  CAS  PubMed  Google Scholar 

  • Millare GG, Guha-Thakurta N, Sturgis EM, El-Naggar AK, Debnam JM. Imaging findings of head and neck dermatofibrosarcoma protuberans. AJNR Am J Neuroradiol. 2014;35(2):373–8.

    Article  CAS  PubMed  Google Scholar 

  • Morrison WH, Byers RM, Garden AS, Evans HL, Ang KK, Peters LJ. Cutaneous angiosarcoma of the head and neck. A therapeutic dilemma. Cancer. 1995;76(2):319.

    Article  CAS  PubMed  Google Scholar 

  • Nguyen BD, McCullough AE. Imaging of Merkel cell carcinoma. Radiographics. 2002;22(2):367–76.

    Article  PubMed  Google Scholar 

  • O’Mahony D, Gandjbakhche AH, Hassan M, Vogel A, Yarchoan R. Imaging techniques for Kaposi Sarcoma (KS). J HIV Ther. 2008;13(3):65–71.

    PubMed  PubMed Central  Google Scholar 

  • O’Rorke M, Ellison M, Murray L, Moran M, James J, Anderson A. Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis. Oral Oncol. 2012;48:1191–201.

    Article  PubMed  Google Scholar 

  • Otero HJ, Jagannathan JP, Prevedello LM, Johnston CJ, Ramaiya NH, Van den Abbeele AD, DiPiro PJ. CT and PET/CT findings of T-cell lymphoma. Am J Roentgenol. 2009;193:349–58.

    Article  Google Scholar 

  • Petter G, Haustein UF. Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma. Dermatol Surg. 2000;26(6):521–30.

    Article  CAS  PubMed  Google Scholar 

  • Plaza JA, Mackinnon A, Carrillo L, Prieto VG, Sangueza M, Suster S. Role of immunohistochemistry in the diagnosis of sebaceous carcinoma: a clinicopathologic and immunohistochemical study. Am J Dermatopathol. 2015;37(11):809–21.

    Article  PubMed  Google Scholar 

  • Ramakrishnan R, Chaudhry IH, Ramdial P, Lazar AJ, McMenamin ME, Kazakov D, Brenn T, Calonje E. Primary cutaneous adenoid cystic carcinoma: a clinicopathologic and immunohistochemical study of 27 cases. Am J Surg Pathol. 2013;37(10):1603–11.

    Article  PubMed  Google Scholar 

  • Rao P, Lahat G, Arnold C, Gavino AC, Lahat S, Hornick JL, Lev D, Lazar AJ. Angiosarcoma: a tissue microarray study with diagnostic implications. Am J Dermatopathol. 2013;35(4):432–7.

    Article  PubMed  Google Scholar 

  • Restrepo CS, Ocazionez D. Kaposi’s sarcoma: imaging overview. Semin Ultrasound CT MR. 2011;32(5):456–69.

    Article  PubMed  Google Scholar 

  • Restrepo CS, Martínez S, Lemos JA, Carrillo JA, Lemos DF, Ojeda P, Koshy P. Imaging manifestations of Kaposi sarcoma. Radiographics. 2006;26(4):1169–85.

    Article  PubMed  Google Scholar 

  • Rippey JJ. Why classify basal cell carcinomas? Histopathology. 1998;32(5):393–8.

    Article  CAS  PubMed  Google Scholar 

  • Rohren EM. PET/computed tomography and patient outcomes in melanoma. PET Clin. 2015;10(2):243–54.

    Article  PubMed  Google Scholar 

  • Rubin AI, Chen EH, Ratner D. Basal-cell carcinoma. N Engl J Med. 2005;353:2262–9.

    Article  CAS  PubMed  Google Scholar 

  • Saeed S, Keehn CA, Morgan MB. Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal. J Cutan Pathol. 2004;31(6):419–30.

    Article  PubMed  Google Scholar 

  • Sanderson R, Ironside J. Squamous cell carcinomas of the head and neck. BMJ. 2002;325:822–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sariya D, Ruth K, Adams-McDonnell R, et al. Clinicopathologic correlation of cutaneous metastases: experience from a cancer center. Arch Dermatol. 2007;143(5):613–20.

    Article  PubMed  Google Scholar 

  • Sidiropoulos KG, Martinez-Escala ME, Yelamos O, Guitart J, Sidiropoulos M. Primary cutaneous T-cell lymphomas: a review. J Clin Pathol. 2015;68:1003–10.

    Article  CAS  PubMed  Google Scholar 

  • Smith V, Walton S. Treatment of facial basal cell carcinoma: a review. J Skin Cancer. 2011;2011:Article ID 380371.

    Article  Google Scholar 

  • Snow S, Madjar DD, Hardy S, Bentz M, Lucarelli MJ, Bechard R, Aughenbaugh W, McFadden T, Sharata H, Dudley C, Landeck A. Microcystic adnexal carcinoma: report of 13 cases and review of the literature. Dermatol Surg. 2001;27(4):401–8.

    CAS  PubMed  Google Scholar 

  • Stiller CA, Trama A, Brewster DH, Verne J, Bouchardy C, Navarro C, Chirlaque MD, Marcos-Gragera R, Visser O, Serraino D, Weiderpass E, Dei Tos AP, Ascoli V, RARECARE Working Group. Descriptive epidemiology of Kaposi sarcoma in Europe. Report from the RARECARE project. Cancer Epidemiol. 2014;38(6):670–8.

    Article  CAS  PubMed  Google Scholar 

  • Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, Peris K, Becker JC, Zalaudek I, Saiag P, Middleton MR, Bastholt L, Testori A, Grob JJ, European Dermatology Forum (EDF); European Association of Dermato-Oncology (EADO); European Organization for Research and Treatment of Cancer (EORTC). Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer. 2015;51(14):1989–2007.

    Article  PubMed  Google Scholar 

  • Suárez AL, Pulitzer M, Horwitz S, Moskowitz A, Querfeld C, Myskowski PL. Primary cutaneous B-cell lymphomas: part I Clinical features, diagnosis, and classification. J Am Acad Dermatol. 2013;69(3):329.e1–13.

    Article  Google Scholar 

  • Swann MH, Yoon J. Merkel cell carcinoma. Semin Oncol. 2007;34(1):51–6.

    Article  PubMed  Google Scholar 

  • Tawfik AM, Kreft A, Wagner W, Vogl TJ. MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review. Br J Radiol. 2011;84(1002):e114–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Timmerman R. Images in clinical medicine. Raccoon eyes and neuroblastoma. J Pediatr. 2014;164(6):1495.

    Article  Google Scholar 

  • Torreggiani W, Al-Ismail K, Munk P, Nicolaou S, O’Connell J, Knowling M. Dermatofibrosarcomaprotuberans: MR imaging features. Am J Roentgenol. 2001;178:989–93.

    Article  Google Scholar 

  • Vikey A, Vikey D. Primary malignant melanoma, of head and neck: a comprehensive review of literature. Oral Oncol. 2012;48:399–403.

    Article  CAS  PubMed  Google Scholar 

  • Wick MR. Cutaneous melanoma: a current overview. Semin Diagn Pathol. 2016;33(4):225–41.

    Article  PubMed  Google Scholar 

  • Zhang L, Liu QY, Cao Y, Zhong JS, Zhang WD. Dermatofibrosarcoma protuberans: computed tomography and magnetic resonance imaging findings. Medicine (Baltimore). 2015;94(24):e1001.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker School of Medicine, Chicago, IL, USA

    Daniel Thomas Ginat

  2. Department of Pathology, University of Chicago, Chicago, IL, USA

    Nicole A. Cipriani

  3. Medical University of South Carolina, Charleston, SC, USA

    Carson Barnes

  4. Department of Radiology, University of Chicago, Chicago, IL, USA

    Judy Wu

  5. Department of Surgery, Section of Otolaryngology, University of Chicago, Chicago, IL, USA

    Elizabeth Blair

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  1. Daniel Thomas Ginat
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  2. Nicole A. Cipriani
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  3. Carson Barnes
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  4. Judy Wu
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  5. Elizabeth Blair
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Correspondence to Daniel Thomas Ginat .

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  1. Radiology, University of Chicago, Chicago, IL, USA

    Daniel Thomas Ginat

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Ginat, D.T., Cipriani, N.A., Barnes, C., Wu, J., Blair, E. (2019). Malignant Skin Neoplasms and Associated Conditions. In: Ginat, D. (eds) Neuroradiological Imaging of Skin Diseases and Related Conditions. Springer, Cham. https://doi.org/10.1007/978-3-319-90931-8_6

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  • DOI: https://doi.org/10.1007/978-3-319-90931-8_6

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