Abstract
Mediastinal masses include a wide variety of entities both neoplastic and not often presenting with several clinical and pathological features thus constituting a diagnostic challenge for clinicians.
In about half of cases, a mediastinal mass can be an incidental finding in patients who undergo imaging studies for other reasons.
Local symptoms, if present, may be due to compressive or infiltrative effects of the mass, while systemic symptoms are due to release of hormones, cytokines, and antibodies. In general, malignant lesions are more likely to be symptomatic.
In most patients, a combination of demographic information, clinical presentation, and imaging features allows a presumptive diagnosis, which can be definitely addressed only after tissue biopsy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Priola AM, Priola SM, Cardinale L, et al. The anterior mediastinum: diseases. Radiol Med. 2006;111(3):312–42.
Kim Y, Lee KS, Yoo JH, et al. Middle mediastinal lesions: imaging findings and pathologic correlation. Eur J Radiol. 2000;35(1):30–8.
Occhipinti M, Heidinger BH, Franquet E, et al. Imaging the posterior mediastinum: a multimodality approach. Diagn Interv Radiol. 2015;21(4):293–306.
Athanassiadi KA. Infections of mediastinum. Thorac Surg Clin. 2009;19(1):37–45.
Davis RD Jr, Oldham HN Jr, Sabiston DC Jr. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 1987;44(3):229–37.
Wilson LD, Detterbeck FC, Yahalom J. Superior vena cava syndrome with malignant causes. N Engl J Med. 2007;356:1862–9.
Cohen R, Mena D, Carbajal-Mendoza R, et al. Superior vena cava syndrome: a medical emergency? Int J Angiol. 2008;17(1):43–6.
Shelly S, Levin NA, Altman A, et al. Thymoma and autoimmunity. Cell Mol Immunol. 2011;8(3):199–202.
Azarow KS, Pearl RH, Zurcher R, et al. Primary mediastinal masses: a comparison of adult and pediatric populations. J Thorac Cardiovasc Surg. 1993;106:67.
Barlow LJ, Badalato GM, McKiernan JM. Serum tumor markers in the evaluation of male germ cell tumors. Nat Rev Urol. 2010;7(11):610–7.
Takahashi K, Al-Janabi NJ. Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging. 2010;32(6):1325–39.
Gupta S, Seaberg K, Wallace MJ, et al. Imaging-guided percutaneous biopsy of mediastinal lesions: different approaches and anatomic considerations. Radiographics. 2005;25(3):763–86.
Strickler JG, Kurtin PJ. Mediastinal lymphoma. Semin Diagn Pathol. 1991;8:2–13.
Herrada J, Cabanillas F, Rice L, et al. The clinical behavior of localized and multicentric Castleman disease. Ann Intern Med. 1998;128(8):657–62.
Takeda S, Miyoshi S, Minami M, et al. Clinical spectrum of mediastinal cysts. Chest. 2003;124:125–32.
Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest. 2005;128(4):2893–909.
Hainsworth J. Diagnosis, staging, and clinical characteristics of the patient with mediastinal germ cell carcinoma. Chest Surg Clin N Am. 2002;12:665–72.
Reeder LB. Neurogenic tumors of the mediastinum. Semin Thorac Cardiovasc Surg. 2000;12(4):261–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
Ciardiello, F., Morgillo, F., Viscardi, G. (2018). Clinical Approach: Recommendations for the Clinicians. In: Franco, R., Zito Marino, F., Giordano, A. (eds) The Mediastinal Mass. Current Clinical Pathology. Humana, Cham. https://doi.org/10.1007/978-3-319-90368-2_2
Download citation
DOI: https://doi.org/10.1007/978-3-319-90368-2_2
Published:
Publisher Name: Humana, Cham
Print ISBN: 978-3-319-90367-5
Online ISBN: 978-3-319-90368-2
eBook Packages: MedicineMedicine (R0)